CN112842930A - Compact anti-wrinkle composite polypeptide composition and preparation method thereof - Google Patents
Compact anti-wrinkle composite polypeptide composition and preparation method thereof Download PDFInfo
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- CN112842930A CN112842930A CN202110085969.3A CN202110085969A CN112842930A CN 112842930 A CN112842930 A CN 112842930A CN 202110085969 A CN202110085969 A CN 202110085969A CN 112842930 A CN112842930 A CN 112842930A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- Gerontology & Geriatric Medicine (AREA)
- Emergency Medicine (AREA)
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Abstract
The application relates to the field of anti-wrinkle compositions, and particularly discloses a compact anti-wrinkle composite polypeptide composition and a preparation method thereof. The compact anti-wrinkle composite polypeptide composition comprises arginine/lysine polypeptide, acetyl hexapeptide-8, carnosine, sodium hyaluronate, 1, 2-pentanediol, glycerol and water; the preparation method comprises the following steps: mixing arginine/lysine polypeptide with 1, 2-pentanediol, and stirring to obtain an arginine/lysine polypeptide solution; mixing carnosine and acetyl hexapeptide-8 with water, and stirring to obtain a mixed polypeptide solution; adding the arginine/lysine polypeptide solution into the mixed polypeptide solution, stirring, and filtering to obtain a composite polypeptide solution; and adding sodium hyaluronate and glycerol into the composite polypeptide solution, and stirring to obtain the compact anti-wrinkle composite polypeptide composition. The compact anti-wrinkle composite polypeptide composition can be used for being smeared on the face to achieve the purpose of anti-wrinkle and beautifying, and has a good anti-wrinkle effect and small side effects.
Description
Technical Field
The application relates to the field of anti-wrinkle compositions, in particular to a compact anti-wrinkle composite polypeptide composition and a preparation method thereof.
Background
With the increase of living pressure and the decrease of air quality, the phenomenon of wrinkles appearing on the face of people is more common, and the age of the people who appear wrinkles is also decreased. The reason for this is that excessive contraction of facial muscles is one of the important factors, in addition to loss of skin elasticity due to water loss.
Related anti-wrinkle technologies mainly comprise injecting botulinum toxin or coating anti-oxidation skin care products, the injecting botulinum toxin has considerable risks and side effects, and the coating anti-oxidation skin care products have small side effects but poor anti-wrinkle effects.
Disclosure of Invention
In order to reduce the side effects of products while having excellent anti-wrinkle effect, the application provides a compact anti-wrinkle composite polypeptide composition and a preparation method thereof.
In a first aspect, the present application provides a compact anti-wrinkle composite polypeptide composition, which adopts the following technical scheme:
the compact anti-wrinkle composite polypeptide composition comprises the following components in percentage by mass:
preferably, the mass percentage of the arginine/lysine polypeptide is 8-10%.
Preferably, the molecular weight of the sodium hyaluronate is 10000-50000 Da.
Preferably, the compact anti-wrinkle composite polypeptide composition further comprises fibronectin, and the mass percentage of the fibronectin is 1-5%.
Preferably, the mass percentage of the fibronectin is 3-5%.
Preferably, the compact anti-wrinkle composite polypeptide composition further comprises hydrolyzed collagen, and the mass percentage of the hydrolyzed collagen is 1-5%.
Preferably, the mass percentage of the hydrolyzed collagen is 3-5%.
In a second aspect, the application provides a preparation method of a compact anti-wrinkle composite polypeptide composition, which adopts the following technical scheme:
a preparation method of a compact anti-wrinkle composite polypeptide composition comprises the following steps:
(1) mixing arginine/lysine polypeptide with 1, 2-pentanediol, and stirring for 3-5 min at a rotation speed of 100-200 r/min to obtain an arginine/lysine polypeptide solution;
(2) mixing carnosine and acetyl hexapeptide-8 with water, and stirring for 3-5 min at a rotation speed of 100-200 r/min to obtain a mixed polypeptide solution;
(3) adding the arginine/lysine polypeptide solution into the mixed polypeptide solution, stirring for 1-3 min at a rotation speed of 80-120 r/min, and filtering through a 0.22 mu m filter to obtain a composite polypeptide solution;
(4) adding sodium hyaluronate and glycerol into the composite polypeptide solution, and stirring for 3-5 min at a rotating speed of 100-200 r/min to obtain the compact anti-wrinkle composite polypeptide composition.
In summary, the present application has the following beneficial effects:
1. the arginine/lysine polypeptide in the application can penetrate the skin to quickly relax muscles, so that wrinkles generated by pulling the muscles on the face can be quickly smoothed, and the arginine/lysine polypeptide can not completely paralyze the muscles, so that side effects of causing facial paralysis and the like of a user can not be generated; the acetyl hexapeptide-8 can inhibit the transmission of neurotransmitter, further inhibit the contraction of muscles, and further achieve the effects of relaxing the muscles and reducing wrinkles; the carnosine can delay cell aging, remove free radicals to delay aging of facial skin of a user, and enable the facial skin of the user to keep a young state, so that the water storage capacity of the facial skin of the user is improved, the loss of facial water of the user is reduced, the facial skin of the user can keep elasticity, and wrinkles are reduced; the sodium hyaluronate has excellent moisturizing effect, and the sodium hyaluronate with smaller molecular weight is easier to be absorbed by the skin, so that the effect of increasing the skin elasticity is achieved; according to the compact anti-wrinkle composite polypeptide composition, the arginine/lysine polypeptide and the acetyl hexapeptide-8 relax muscles, the skin aging is delayed by the muscle peptide, the sodium hyaluronate moisturizes and replenishes water, and the skin elasticity is improved, so that a three-dimensional anti-wrinkle effect is achieved, and the anti-wrinkle effect is remarkable;
2. the fibronectin has the effects of repairing damaged cells, activating cells with insufficient activity and promoting cell proliferation, so that the effect of delaying skin aging is achieved, the facial skin can be kept elastic, and the probability of wrinkle generation is further reduced;
3. the hydrolyzed collagen stimulates the fibroblast growth of the skin, obviously increases the density of the fibroblast, increases the mechanical strength of the skin, improves the mechanical property, increases the softness and the elasticity, and has stronger moisturizing capability, thereby reducing the probability of wrinkle generation.
Detailed Description
The present application will be described in further detail with reference to examples.
Examples
Example 1
The compact anti-wrinkle composite polypeptide composition comprises the components and the mass percentage ratio of the components is shown in table 1.
The preparation method of the compact anti-wrinkle composite polypeptide composition comprises the following steps:
(1) mixing arginine/lysine polypeptide with 1, 2-pentanediol, and stirring at a rotation speed of 150r/min for 4min to obtain an arginine/lysine polypeptide solution;
(2) mixing carnosine, fibronectin and acetyl hexapeptide-8 with water, and stirring at a rotation speed of 150r/min for 4min to obtain a mixed polypeptide solution;
(3) adding the arginine/lysine polypeptide solution into the mixed polypeptide solution, stirring for 2min at the rotation speed of 100r/min, and filtering by a 0.22-micron filter to obtain a composite polypeptide solution;
(4) adding sodium hyaluronate, hydrolyzed collagen and glycerol into the composite polypeptide solution, and stirring for 4min at a rotation speed of 150r/min to obtain the compact anti-wrinkle composite polypeptide composition.
Example 2
The compact anti-wrinkle composite polypeptide composition comprises the components and the mass percentage ratio of the components is shown in table 1.
The preparation method of the compact anti-wrinkle composite polypeptide composition comprises the following steps:
(1) mixing arginine/lysine polypeptide with 1, 2-pentanediol, and stirring for 3min at a rotation speed of 100r/min to obtain an arginine/lysine polypeptide solution;
(2) mixing carnosine, fibronectin and acetyl hexapeptide-8 with water, and stirring at 100r/min for 3min to obtain a mixed polypeptide solution;
(3) adding the arginine/lysine polypeptide solution into the mixed polypeptide solution, stirring for 1min at the rotation speed of 80r/min, and filtering by a 0.22-micron filter to obtain a composite polypeptide solution;
(4) adding sodium hyaluronate, hydrolyzed collagen and glycerol into the composite polypeptide solution, and stirring for 3min at the rotating speed of 100r/min to obtain the compact anti-wrinkle composite polypeptide composition.
Example 3
The compact anti-wrinkle composite polypeptide composition comprises the components and the mass percentage ratio of the components is shown in table 1.
The preparation method of the compact anti-wrinkle composite polypeptide composition comprises the following steps:
(1) mixing arginine/lysine polypeptide with 1, 2-pentanediol, and stirring for 5min at a rotation speed of 200r/min to obtain an arginine/lysine polypeptide solution;
(2) mixing carnosine, fibronectin and acetyl hexapeptide-8 with water, and stirring at a rotation speed of 200r/min for 5min to obtain a mixed polypeptide solution;
(3) adding the arginine/lysine polypeptide solution into the mixed polypeptide solution, stirring for 3min at the rotation speed of 120r/min, and filtering by a 0.22-micron filter to obtain a composite polypeptide solution;
(4) adding sodium hyaluronate, hydrolyzed collagen and glycerol into the composite polypeptide solution, and stirring for 5min at the rotation speed of 200r/min to obtain the compact anti-wrinkle composite polypeptide composition.
Example 4
The compact anti-wrinkle composite polypeptide composition comprises the components and the mass percentage ratio of the components is shown in table 1.
The preparation method of the compact anti-wrinkle composite polypeptide composition is the same as that of the embodiment 1.
Example 5
The compact anti-wrinkle composite polypeptide composition comprises the components and the mass percentage ratio of the components is shown in table 1.
The preparation method of the compact anti-wrinkle composite polypeptide composition is the same as that of the embodiment 1.
Example 6
The compact anti-wrinkle composite polypeptide composition comprises the components and the mass percentage ratio of the components is shown in table 1.
The preparation method of the compact anti-wrinkle composite polypeptide composition is the same as that of the embodiment 1.
Example 7
The compact anti-wrinkle composite polypeptide composition comprises the components and the mass percentage ratio of the components is shown in table 1.
The preparation method of the compact anti-wrinkle composite polypeptide composition is the same as that of the embodiment 1.
Comparative example
Comparative example 1
A compact anti-wrinkle composite polypeptide composition, which is different from that in example 5 in that arginine/lysine polypeptide is not contained, and comprises the components and the mass percentages of the components are shown in table 1.
The preparation method of the compact anti-wrinkle composite polypeptide composition is the same as that of the embodiment 5.
Comparative example 2
The composition is different from example 5 in that acetyl hexapeptide-8 is not contained, and the composition comprises the components in percentage by mass as shown in Table 1.
The preparation method of the compact anti-wrinkle composite polypeptide composition is the same as that of the embodiment 5.
Comparative example 3
A compact anti-wrinkle composite polypeptide composition is different from that of example 5 in that fibronectin is not contained, and the composition comprises the components and the mass percentages of the components are shown in Table 1.
The preparation method of the compact anti-wrinkle composite polypeptide composition is the same as that of the embodiment 5.
Comparative example 4
A compact anti-wrinkle composite polypeptide composition is different from that in example 5 in that hydrolyzed collagen is not contained, and the composition comprises the components in percentage by mass as shown in Table 1.
The preparation method of the compact anti-wrinkle composite polypeptide composition is the same as that of the embodiment 5.
TABLE 1
Performance test
According to the requirement of section 7.3.2 in the test method for anti-wrinkle efficacy of cosmetics comprising T _ ZHCA 006 and 2019, 110 volunteers are selected, wherein 10 volunteers are divided into 11 groups, the first 7 groups are test groups 1-7, and the remaining 4 groups are comparison groups 1-4.
The anti-wrinkle composite polypeptide composition is tested according to a T _ ZHCA 006-2019 cosmetic anti-wrinkle efficacy testing method, the testing period is 8 weeks, test groups 1-7 are coated with the anti-wrinkle composite polypeptide composition prepared in examples 1-7, and a comparison group is coated with the anti-wrinkle composite polypeptide composition prepared in comparative examples 1-4.
The test results are shown in table 2, where V1 is the average difference between the average of the total volume of wrinkles at the skin site with the sample applied and the average of the total volume of wrinkles without the sample applied at the fourth week after the sample is applied in table 2; v2-mean difference between the mean value of the total volume of wrinkles at the skin site of the applied sample and the mean value of the total volume of wrinkles without the applied sample at the eighth week after the application of the sample;
TABLE 2
By combining examples 1-7 and comparative examples 1-2 and table 2, it can be seen that the anti-wrinkle effect can be maximized by adding arginine/lysine polypeptide, acetyl hexapeptide-8 and carnosine, and the anti-wrinkle effect of the compact anti-wrinkle composite polypeptide composition can be remarkably improved.
As can be seen from the combination of examples 1, 3 and 5 and examples 2 and 4 and the combination of table 2, the anti-wrinkle compact composite polypeptide compositions prepared in examples 1, 3 and 5 have better anti-wrinkle effect, and therefore, the appropriate mass percentage of arginine/lysine polypeptide is 5-10%.
By combining examples 1-7 and comparative example 3 and table 2, it can be seen that the anti-wrinkle effect of the compact anti-wrinkle composite polypeptide composition can be remarkably improved by adding fibronectin.
As can be seen from the combination of examples 3, 5 and 7 and example 2 and table 2, the anti-wrinkle effect of the compact anti-wrinkle composite polypeptide compositions prepared in examples 3, 5 and 7 is better, and therefore, the appropriate mass percentage of fibronectin to be added is 3-5%.
By combining examples 1-7 and comparative example 4 and table 2, it can be seen that the anti-wrinkle effect of the compact anti-wrinkle composite polypeptide composition can be remarkably improved by adding hydrolyzed collagen.
As can be seen from the combination of examples 3, 5 and 6 and example 2 and table 2, the anti-wrinkle effect of the compact anti-wrinkle composite polypeptide compositions prepared in examples 3, 5 and 6 is better, and therefore, the suitable mass percentage of the hydrolyzed collagen is 3-5%.
The present embodiment is only for explaining the present application, and it is not limited to the present application, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present application.
Claims (8)
1. The compact anti-wrinkle composite polypeptide composition is characterized by comprising the following components in percentage by mass:
2. the compact anti-wrinkle composite polypeptide composition according to claim 1, wherein: the mass percentage of the arginine/lysine polypeptide is 5-10%.
3. The compact anti-wrinkle composite polypeptide composition according to claim 1, wherein: the molecular weight of the sodium hyaluronate is 10000-50000 Da.
4. The compact anti-wrinkle composite polypeptide composition according to claim 1, wherein: the compact anti-wrinkle composite polypeptide composition further comprises fibronectin, and the mass percentage of the fibronectin is 1-5%.
5. The method of claim 2, wherein: the mass percent of the fibronectin is 3-5%.
6. The compact anti-wrinkle composite polypeptide composition according to claim 1, wherein: the compact anti-wrinkle composite polypeptide composition further comprises hydrolyzed collagen, and the mass percentage of the hydrolyzed collagen is 1-5%.
7. The compact anti-wrinkle composite polypeptide composition according to claim 4, wherein: the mass percentage of the hydrolyzed collagen is 3-5%.
8. A method for preparing the compact anti-wrinkle composite polypeptide composition as claimed in any one of claims 1 to 3, comprising the steps of:
(1) mixing arginine/lysine polypeptide with 1, 2-pentanediol, and stirring for 3-5 min at a rotation speed of 100-200 r/min to obtain an arginine/lysine polypeptide solution;
(2) mixing carnosine and acetyl hexapeptide-8 with water, and stirring for 3-5 min at a rotation speed of 100-200 r/min to obtain a mixed polypeptide solution;
(3) adding the arginine/lysine polypeptide solution into the mixed polypeptide solution, stirring for 1-3 min at the rotation speed of 80-120 r/min, and filtering through a 0.22 mu m filter to obtain a composite polypeptide solution;
(4) adding sodium hyaluronate and glycerol into the composite polypeptide solution, and stirring for 3-5 min at a rotating speed of 100-200 r/min to obtain the compact anti-wrinkle composite polypeptide composition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110085969.3A CN112842930A (en) | 2021-01-22 | 2021-01-22 | Compact anti-wrinkle composite polypeptide composition and preparation method thereof |
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| CN202110085969.3A CN112842930A (en) | 2021-01-22 | 2021-01-22 | Compact anti-wrinkle composite polypeptide composition and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113648235A (en) * | 2021-08-24 | 2021-11-16 | 广州优然生物科技有限公司 | Composition for instantly removing wrinkles, eye mask essence, wrinkle removing cosmetic and application |
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