CN1128025A - 具有治疗活性的苯并噁嗪酮和苯并噻嗪酮 - Google Patents

具有治疗活性的苯并噁嗪酮和苯并噻嗪酮 Download PDF

Info

Publication number
CN1128025A
CN1128025A CN94192889A CN94192889A CN1128025A CN 1128025 A CN1128025 A CN 1128025A CN 94192889 A CN94192889 A CN 94192889A CN 94192889 A CN94192889 A CN 94192889A CN 1128025 A CN1128025 A CN 1128025A
Authority
CN
China
Prior art keywords
mole
compound
alkyl
dihydro
benzoxazin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN94192889A
Other languages
English (en)
Chinese (zh)
Inventor
S·莱维
F·比尼迪尼
G·博托利尼
G·格罗莫
J·米兹尔哈
A·萨拉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Italfarmaco SpA
Original Assignee
Italfarmaco SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Italfarmaco SpA filed Critical Italfarmaco SpA
Publication of CN1128025A publication Critical patent/CN1128025A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
    • C07D265/22—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
    • C07D279/08—1,3-Thiazines; Hydrogenated 1,3-thiazines condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN94192889A 1993-07-28 1994-07-18 具有治疗活性的苯并噁嗪酮和苯并噻嗪酮 Pending CN1128025A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI93A001678 1993-07-28
IT93MI001678A IT1264812B1 (it) 1993-07-28 1993-07-28 Derivati benzossazinonici e benzotiazinonici terapeuticamente attivi

Publications (1)

Publication Number Publication Date
CN1128025A true CN1128025A (zh) 1996-07-31

Family

ID=11366700

Family Applications (1)

Application Number Title Priority Date Filing Date
CN94192889A Pending CN1128025A (zh) 1993-07-28 1994-07-18 具有治疗活性的苯并噁嗪酮和苯并噻嗪酮

Country Status (13)

Country Link
EP (1) EP0711286A1 (enExample)
JP (1) JPH09500878A (enExample)
CN (1) CN1128025A (enExample)
AU (1) AU7494594A (enExample)
CA (1) CA2168099A1 (enExample)
FI (1) FI960342A7 (enExample)
HU (1) HUT74587A (enExample)
IL (1) IL110473A0 (enExample)
IT (1) IT1264812B1 (enExample)
NO (1) NO960308L (enExample)
TW (1) TW277061B (enExample)
WO (1) WO1995004048A1 (enExample)
ZA (1) ZA945555B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102367239A (zh) * 2011-07-20 2012-03-07 沈阳药科大学 2-芳基-2,3-二氢-4h-1,3-苯并噻嗪-4-酮衍生物及其用途
CN105829301A (zh) * 2013-12-19 2016-08-03 吉利德科学公司 作为离子通道调节剂的稠合杂环化合物

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6509334B1 (en) 1999-05-04 2003-01-21 American Home Products Corporation Cyclocarbamate derivatives as progesterone receptor modulators
CA2883306C (en) * 2012-08-27 2021-10-19 University Of Tennessee Research Foundation Lpa2 receptor-specific benzoic acid derivatives
ITMI20122221A1 (it) * 2012-12-21 2014-06-22 C4T S C A R L Nuovi composti del 2,3-diidro-4h-1,3-benzossazin-4-one, metodo per prepararli e forma farmaceutica che li comprende

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2443M (fr) * 1962-10-30 1964-04-06 Selvi & C Lab Bioterapico Thio-dérivés de benzo-oxazine ayant des propriétés antiphlogistiques, antipyrétiques et analgésiques.
US3459748A (en) * 1967-04-28 1969-08-05 Squibb & Sons Inc Hydroxyalkylene-substituted benzoxazines and benzothiazines
IT1136575B (it) * 1981-04-15 1986-09-03 Coli Farma Lab Esteri del 2-(2-ossietil)-2,3-diidro-h4-1,3-benzossazin-4-one ad attivita' analgesica e procedimento per la loro preparazione
IT1244472B (it) * 1990-12-14 1994-07-15 Italfarmaco Spa Benzossazinoni e benzotiazinoni ad attivita' cardiovascolare
FR2680172B1 (fr) * 1991-08-05 1993-11-19 Fabre Medicament Pierre Nouvelles piperazinylalcoyl-3 dihydro-2,3 4h-benzoxazine-1,3 ones-4 substituees, leur preparation et leur application en therapeutique.
IT1254884B (it) * 1992-04-16 1995-10-11 Italfarmaco Spa Benzossazinoni e benzotiazinoni ad attivita' cardiovascolare

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102367239A (zh) * 2011-07-20 2012-03-07 沈阳药科大学 2-芳基-2,3-二氢-4h-1,3-苯并噻嗪-4-酮衍生物及其用途
CN102367239B (zh) * 2011-07-20 2015-10-28 沈阳药科大学 2-芳基-2,3-二氢-4h-1,3-苯并噻嗪-4-酮衍生物及其用途
CN105829301A (zh) * 2013-12-19 2016-08-03 吉利德科学公司 作为离子通道调节剂的稠合杂环化合物

Also Published As

Publication number Publication date
TW277061B (enExample) 1996-06-01
AU7494594A (en) 1995-02-28
FI960342L (fi) 1996-01-25
JPH09500878A (ja) 1997-01-28
FI960342A0 (fi) 1996-01-25
IT1264812B1 (it) 1996-10-10
CA2168099A1 (en) 1995-02-09
NO960308L (no) 1996-03-13
IL110473A0 (en) 1994-10-21
ITMI931678A1 (it) 1995-01-28
WO1995004048A1 (en) 1995-02-09
ZA945555B (en) 1995-03-03
HUT74587A (en) 1997-01-28
EP0711286A1 (en) 1996-05-15
ITMI931678A0 (it) 1993-07-28
NO960308D0 (no) 1996-01-25
HU9600165D0 (en) 1996-03-28
FI960342A7 (fi) 1996-01-25

Similar Documents

Publication Publication Date Title
CN1027068C (zh) α-取代的4-(喹啉-2-基-甲氧基)苯乙酸和酯的制备方法
CN87102891A (zh) 硫化内酰胺-n-乙酸衍生物的生产及使用
CN1212691A (zh) 三环化合物及其制备和用途
CN1280575A (zh) 新型三环化合物和其作为药物的用途;其制备方法和包含该化合物的药物组合物
CN1906180A (zh) 新的长效β－2－激动剂及其作为药物的用途
CN1083062A (zh) 异羟肟酸衍生物
CN1034918A (zh) 化学化合物
CN1160402A (zh) 用作pnp抑制剂的嘌呤和鸟嘌呤化合物
CN1430609A (zh) 取代的1－氨基烷基内酰胺化合物及其作为毒蕈碱受体拮抗剂的用途
CN1653054A (zh) 作为5－ht6调节剂的苯并噁嗪衍生物及其用途
CN1226825A (zh) 胺化合物用于制备阻止肿瘤细胞增殖的药物
CN1054980A (zh) 具有旋光活性的8-甲氧基喹诺酮羧酸衍生物，它们的制备方法以及它们的中间体
CN1125575A (zh) 粘附受体拮抗剂
CN1128025A (zh) 具有治疗活性的苯并噁嗪酮和苯并噻嗪酮
CN1842517A (zh) 芴衍生物
CN1751059A (zh) 具有抗肿瘤活性的2－取代的雌－1,3,5(10)－三烯－3－基氨基磺酸酯
JP2512845B2 (ja) 心血管作動活性を有するベンゾキサジノンおよびベンゾチアジノン誘導体
CN1111620A (zh) 新的烷氨基茚满化合物，其制备方法，含这类化合物的药物组合物
CN1063443C (zh) 新的苯并噻唑衍生物
HK1044947B (zh) 苯甲酰胺衍生物及含有它们的药物
CN1871013A (zh) 作为mao－b抑制剂的苯并氮杂䓬衍生物
CN1878766A (zh) 合成喹啉酮化合物的方法
CN1202819C (zh) 眼压降低剂
CN1023479C (zh) 乙二胺的单酰胺衍生物的制备方法
CN1049659A (zh) 治疗药

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C01 Deemed withdrawal of patent application (patent law 1993)
WD01 Invention patent application deemed withdrawn after publication