CN112739714A - 含单株抗体或其抗原结合片段的医药组合物及其用途 - Google Patents

含单株抗体或其抗原结合片段的医药组合物及其用途 Download PDF

Info

Publication number
CN112739714A
CN112739714A CN201980058876.2A CN201980058876A CN112739714A CN 112739714 A CN112739714 A CN 112739714A CN 201980058876 A CN201980058876 A CN 201980058876A CN 112739714 A CN112739714 A CN 112739714A
Authority
CN
China
Prior art keywords
monoclonal antibody
antigen
binding fragment
seq
ptx3
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201980058876.2A
Other languages
English (en)
Other versions
CN112739714B (zh
Inventor
王育民
李尹甄
萧郁韦
纪智瑛
杜军毅
梁馨尹
郑朝峻
柯琼媛
陈丰炜
刘芷妘
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yuanjian Biomedical Technology Suzhou Co ltd
Original Assignee
Yuanjian Biomedical Technology Suzhou Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CN2018/105733 external-priority patent/WO2019056991A1/zh
Application filed by Yuanjian Biomedical Technology Suzhou Co ltd filed Critical Yuanjian Biomedical Technology Suzhou Co ltd
Priority to CN202311402782.7A priority Critical patent/CN117417443A/zh
Publication of CN112739714A publication Critical patent/CN112739714A/zh
Application granted granted Critical
Publication of CN112739714B publication Critical patent/CN112739714B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

本发明提供了一种PTX3单株抗体或其抗原结合片段及其用途。前述单株抗体或其抗原结合片段专一性抑制或减缓PTX3与PTX3受体的结合,可应用于检测PTX3的套组及其检测方法,以及抑制或减缓PTX3与PTX3受体结合相关的疾病或症状的医药组合物及其用途。

Description

PCT国内申请,说明书已公开。

Claims (52)

  1. PCT国内申请,权利要求书已公开。
CN201980058876.2A 2018-09-14 2019-09-13 含单株抗体或其抗原结合片段的医药组合物及其用途 Active CN112739714B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202311402782.7A CN117417443A (zh) 2018-09-14 2019-09-13 含单株抗体或其抗原结合片段的医药组合物及其用途

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CNPCT/CN2018/105733 2018-09-14
PCT/CN2018/105733 WO2019056991A1 (zh) 2017-09-19 2018-09-14 单克隆抗体或其抗原结合片段及其用途
CNPCT/CN2018/106144 2018-09-18
PCT/CN2018/106144 WO2019057024A1 (zh) 2017-09-19 2018-09-18 含单克隆抗体或其抗原结合片段的医药组成物及其用途
US201962867244P 2019-06-27 2019-06-27
US62/867,244 2019-06-27
PCT/CN2019/105824 WO2020052675A1 (zh) 2018-09-14 2019-09-13 含单株抗体或其抗原结合片段的医药组合物及其用途

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202311402782.7A Division CN117417443A (zh) 2018-09-14 2019-09-13 含单株抗体或其抗原结合片段的医药组合物及其用途

Publications (2)

Publication Number Publication Date
CN112739714A true CN112739714A (zh) 2021-04-30
CN112739714B CN112739714B (zh) 2023-11-14

Family

ID=69777381

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202311402782.7A Pending CN117417443A (zh) 2018-09-14 2019-09-13 含单株抗体或其抗原结合片段的医药组合物及其用途
CN201980058876.2A Active CN112739714B (zh) 2018-09-14 2019-09-13 含单株抗体或其抗原结合片段的医药组合物及其用途

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN202311402782.7A Pending CN117417443A (zh) 2018-09-14 2019-09-13 含单株抗体或其抗原结合片段的医药组合物及其用途

Country Status (14)

Country Link
US (1) US20220119507A1 (zh)
EP (1) EP3862363A4 (zh)
JP (1) JP2022500503A (zh)
KR (1) KR20210062036A (zh)
CN (2) CN117417443A (zh)
AU (1) AU2019337248A1 (zh)
BR (1) BR112021004586A2 (zh)
CA (1) CA3112678A1 (zh)
MX (1) MX2021003032A (zh)
PH (1) PH12021550529A1 (zh)
SG (1) SG11202102514QA (zh)
TW (1) TWI754171B (zh)
WO (1) WO2020052675A1 (zh)
ZA (1) ZA202101755B (zh)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1947018A (zh) * 2004-04-29 2007-04-11 法玛发展有限公司 单克隆抗体、杂交瘤、测定ptx3蛋白质的改进方法以及用于上述测定的试剂盒
EP1947460A1 (en) * 2005-11-11 2008-07-23 The University of Tokyo Method of measuring ptx3 with high sensitivity
CN104231064A (zh) * 2013-06-07 2014-12-24 王育民 抑制ptx3治疗鼻咽癌的氨基酸序列
TW201532611A (zh) * 2014-02-26 2015-09-01 Univ Nat Cheng Kung 醫藥組成物用以製備治療癌症藥物之用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0571442A4 (en) * 1991-01-14 1995-05-03 Univ New York CYTOKIN INDUCIBLE PROTEIN TSG-14, ITS ENCODING DNA AND THEIR USE.
TWI531375B (zh) * 2015-05-29 2016-05-01 國立成功大學 抑制癌細胞活性之短肽治療劑及含此之醫藥組成物
CN106188244B (zh) * 2015-05-29 2019-12-27 王育民 抑制癌细胞活性的短肽治疗剂及含有它的医药组合物
TWI741216B (zh) * 2017-09-19 2021-10-01 臻崴生物科技有限公司 專一性抑制或減緩ptx3與ptx3受體結合之單株抗體或其抗原結合片段及其用途

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1947018A (zh) * 2004-04-29 2007-04-11 法玛发展有限公司 单克隆抗体、杂交瘤、测定ptx3蛋白质的改进方法以及用于上述测定的试剂盒
JP2007534951A (ja) * 2004-04-29 2007-11-29 ファーマ ディヴェロップメント ソシエタ ア レスポンサビリタ リミタータ タンパク質ptx3測定用の単クローン抗体、ハイブリドーマ、改良方法、及び前記測定用キット
EP1947460A1 (en) * 2005-11-11 2008-07-23 The University of Tokyo Method of measuring ptx3 with high sensitivity
CN104231064A (zh) * 2013-06-07 2014-12-24 王育民 抑制ptx3治疗鼻咽癌的氨基酸序列
TW201532611A (zh) * 2014-02-26 2015-09-01 Univ Nat Cheng Kung 醫藥組成物用以製備治療癌症藥物之用途

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BENEDETTA BUSSOLATI等: "The Long Pentraxin Ptx3 Is Synthesized in IgA Glomerulonephritis and Activates Mesangial Cells", 《THE JOURNAL OF IMMUNOLOGY》 *
N BASSI等: "IgG anti-pentraxin 3 antibodies in systemic lupus erythematosus", 《ANN RHEUM DIS》 *
TUNG-WEI HUNG等: "Pentraxin 3 Activates JNK Signaling and Regulates the Epithelial-To-Mesenchymal Transition in Renal Fibrosis", 《CELL PHYSIOL BIOCHEM》 *

Also Published As

Publication number Publication date
PH12021550529A1 (en) 2022-02-21
AU2019337248A1 (en) 2021-04-08
WO2020052675A1 (zh) 2020-03-19
TWI754171B (zh) 2022-02-01
EP3862363A4 (en) 2022-06-08
KR20210062036A (ko) 2021-05-28
TW202023616A (zh) 2020-07-01
JP2022500503A (ja) 2022-01-04
BR112021004586A2 (pt) 2021-05-25
CN112739714B (zh) 2023-11-14
SG11202102514QA (en) 2021-04-29
ZA202101755B (en) 2024-06-26
US20220119507A1 (en) 2022-04-21
CN117417443A (zh) 2024-01-19
MX2021003032A (es) 2021-05-27
CA3112678A1 (en) 2020-03-19
EP3862363A1 (en) 2021-08-11

Similar Documents

Publication Publication Date Title
US7731963B2 (en) TWEAK receptor agonists as anti-angiogenic agents
CN105884895B (zh) 抗人ccr7抗体、杂交瘤、核酸、载体、细胞、医药组合物和抗体固定化担载体
CN109071646A (zh) TGFβ1-结合免疫球蛋白及其用途
CN102614521A (zh) 利用白蛋白-结合蛋白作为靶标的治疗方法
CN103781494A (zh) 针对表皮生长因子受体(egfr)的抗体及其用途
US20100008911A1 (en) Use of tgf-beta antagonists to treat infants at risk of developing bronchopulmonary dysplasia
AU2001289019B2 (en) Tweak receptor agonists as anti-angiogenic agents
JPWO2005018671A1 (ja) 癌転移阻害剤
AU2001289019A1 (en) Tweak receptor agonists as anti-angiogenic agents
EP3261672B1 (en) Molecules disrupting pyruvate kinase m2 and integrin interaction and uses thereof
CN112739714A (zh) 含单株抗体或其抗原结合片段的医药组合物及其用途
CN115814076A (zh) 抗人vegf抗体与化药联用在制备治疗卵巢癌的药物中的应用
EP4437002A1 (en) Anti-hsp90? antibody and uses thereof
US11084879B2 (en) Compositions and methods for treating pancreatitis and pain with death receptor agonists
TW202417491A (zh) 用於治療癌症的結合chi3l1抗體、其醫藥組成物、其抗體藥物複合體、其核酸分子及其用途
KR20130135869A (ko) 항 단쇄 제4형 콜라겐 폴리펩타이드 항체 및 이를 포함하는 종양의 진단, 예방 또는 치료용 약제

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40041717

Country of ref document: HK

SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant