CN112716830A - Starch-based skin repairing film and preparation method thereof - Google Patents
Starch-based skin repairing film and preparation method thereof Download PDFInfo
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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Abstract
The invention provides a starch-based skin repairing film and a preparation method thereof. The starch-based skin repairing film comprises starch (or raw materials containing starch), a pasting agent, a plasticizer, a cross-linking agent, a film forming agent, an effective component, water and the like. The starch-based skin repairing film is made of edible starch, and the raw materials are pure natural, non-toxic, harmless and biodegradable. The special product state of the starch-based skin repairing film is not only easy to maintain the activity of functional components in the film, but also can introduce different functional components according to requirements, has wide application range, and can solve different skin problems (such as face maintenance, acne removal, eczema removal, wound repair and the like). Compared with the traditional skin care film products, the starch-based skin care film does not need special packaging, and no 'white garbage' is generated; the starch-based skin repairing film is directly acted on the wet required part, and the use is convenient; a small amount of residues after the skin repairing film is used are friendly to the skin, easy to remove, excellent in biodegradation performance and friendly to the environment.
Description
Technical Field
The invention relates to the field of cosmetics and medicines, in particular to a starch-based skin repairing film and a preparation method thereof.
Background
With the increasing development of economy and the continuous progress of society, the pursuit of people for beauty never stops; the skin care is very important due to the fact that fast paced life, air pollution, air dust and the like cause damage to the skin, and the aging phenomenon of the population is serious day by day, and skin care products become necessities of life of people. The skin care products of the adhesive film type are deeply favored by the consumers due to the advantages of simple and convenient use, obvious effect, high price, and the like, and the sales of the skin care products in daily use are all top-ranked herbs.
The skin care film on the market at present is mainly applied to the aspects of skin care repair and medical dressing. The skin care and repair product comprises facial masks, eye patches, acne removal patches and the like, and has the effects of moisturizing, whitening, resisting aging, diminishing inflammation, resisting bacteria and repairing. Taking a facial mask as an example, the most popular and popular facial mask at present is a cloth-attached facial mask, namely, various base materials are supplemented with nutritional ingredients and medicines and are attached to the face, so that moisture and nutritional substances in the facial mask permeate into the horny layer of the skin epidermis in a short time to achieve certain skin care effect. Two of the most important factors of the cloth-attached facial mask are facial mask base cloth and essence. The general facial mask mainly adopts non-woven fabrics as a carrier to be matched with essence for use, the common non-woven fabrics are formed by arranging short fiber or filament raw materials in an oriented or random way to form a fiber net structure, the skin-friendly property is poor, the air permeability is general, the production process is not environment-friendly, and meanwhile, the non-woven fabrics are not easy to degrade in the environment when used, and white pollution is easy to cause. Because the disposable products seriously pollute the environment, the degradable materials are more and more valued by people. Medical dressings are articles for covering wounds, are medical materials for covering sores, wounds or other lesions, and are indispensable in the field of wound treatment as medical textiles for temporarily replacing the skin barrier function. The traditional dressings generally comprise common gauze, absorbent cotton, cotton pads and the like, and the dressings usually combine bacteriostatic medicines such as local antibiotics to achieve the bacteriostatic effect, have good air permeability and moisture permeability, but are easy to adhere to wounds, are not bacteria-isolated and cause secondary injury to the wounds. The search for a skin-care film which is mild, skin-friendly, degradable and environment-friendly is a constant pursuit of research by researchers. Starch is widely distributed in nature, is a product of green plants for photosynthesis, is also a main form of carbohydrate, exists in seeds, roots, stems, leaves, fruits and even pollen of plants, is a basic energy storage substance, is abundant in quantity and low in cost. Starch, one of the most popular polymers, not only has good film forming properties, but also can be degraded in nature. The starch as natural biological dressing has good biocompatibility, is favorable for tissue repair, and has wide application prospect in the aspects of skin care and skin repair.
Starch molecule film has the characteristics of transparency, no odor and the like, has attracted people's attention, and is becoming one of the hot spots of the current research and development. However, so far, starch-based films have been mainly used in medical treatment for colon-specific drug delivery and oral ulcer treatment patch materials, food packaging, and the like, and there is no report on the use of starch-based films as carrier materials for skin care films in the fields of cosmetics and medicine.
Disclosure of Invention
The invention aims to provide a starch-based skin repairing film and a preparation method thereof.
The invention uses starch as the carrier material of the skin repairing film, the raw materials are pure natural, non-toxic and harmless, no preservative is added, the film can be biologically degraded, and the grain diameter of the selected starch granules is about 1-60 mu m. The used repairing film has no residual pollutant and is environment friendly. The key of starch film forming is starch gelatinization, a large amount of water is absorbed and broken when starch granules are gelatinized, amylose and amylopectin in the starch granules are respectively dissolved out of the granules, diffuse in all directions, and then are in a gel shape after being subjected to net-shaped crosslinking.
The technical scheme of the invention is as follows:
a starch-based skin care film, which comprises the following raw materials in parts by weight:
75.0 to 90.0 portions of water
4.0 to 13.0 portions of starch
0.1 to 0.8 portion of pasting agent
2.0 to 10.0 portions of plasticizer
0.5 to 1.5 portions of cross-linking agent
0.01-0.5 part of film-forming agent
0.001-10.0 parts of functional components
Further preferably, the starch-based skin repairing film comprises the following raw materials in parts by weight:
80.0 to 82.0 portions of water
9.0 to 11.0 portions of starch
0.3 to 0.5 portion of pasting agent
4.0-6.0 parts of plasticizer
0.5 to 0.7 portion of cross-linking agent
0.1 to 0.2 portion of film forming agent
3.0-5.0 parts of functional components.
Starch-based skin repair films according to the present invention include, but are not limited to, rice starch, corn starch, wheat starch, potato starch, and other starch-containing materials.
Further preferably, the starch granule has a particle size of 1 to 60 μm.
Further preferably, the starch-based skin repairing film provided by the invention has different thicknesses according to different purposes, and the thickness is 0.2mm-3.0 mm.
The starch-based skin repair film according to the present invention, the pasting agent includes but is not limited to sodium hydroxide, potassium hydroxide; the pasting agent is more preferably sodium hydroxide.
The starch-based skin repair film according to the present invention, the plasticizer includes, but is not limited to, glycerin, sorbitol, phthalate, etc.; the plasticizer is further preferably glycerin.
The starch-based skin repair film according to the present invention, the cross-linking agent includes but is not limited to anhydrous citric acid, epichlorohydrin; the crosslinking agent is further preferably anhydrous citric acid.
The starch-based skin repair film according to the present invention, the film forming agent includes but is not limited to polyvinylpyrrolidone K30, polyvinyl alcohol, silicon acrylate, etc.; the film former is further preferably polyvinylpyrrolidone K30.
According to the starch-based skin repairing film, the functional components are one or more of moisturizing, whitening, anti-aging, anti-allergy, anti-inflammation and repairing;
the moisturizing functional component is selected from one or more of natural moisturizer and synthetic moisturizer; natural humectants include, but are not limited to, xylitol, sorbitol, mannitol, sodium hyaluronate, sodium PCA, panthenol, lactic acid, polyglutamic acid, betaine, trehalose, aloe vera extract, olive oil, shea oil, mango seed butter, camellia seed oil, jojoba seed oil, walnut seed oil, shiitake seed oil, shea butter, avocado oil, carnauba wax, olive oil, almond oil, and the like; synthetic humectants include, but are not limited to, glycerol, 1, 2-propanediol, diglycerol, 1, 3-propanediol, dipropylene glycol, 1, 3-butanediol, glyceryl polyether-26, caprylic capric triglyceride, glyceryl glucoside, hydrogenated lecithin, and the like.
The whitening functional components include but are not limited to arbutin, ascorbic acid, vitamin C ethyl ether, sodium ascorbyl phosphate, ascorbyl glucoside, kojic acid dipalmitate, glycolic acid, malic acid, tartaric acid, glabridin, phloretin, Daisy flower extract, nicotinamide, sunflower seed oil and the like;
the anti-aging functional ingredients comprise but are not limited to tocopherol (vitamin E), tocopherol sodium phosphate, fullerene, ectoin, grape seed extract, resveratrol, retinol acetate, ginkgo biloba extract, phytosterol, ceramide, ginseng root extract, grape seed oil, evening primrose oil, wild soybean oil, cocoa butter, chamomile oil, balm essential oil, squalane and the like;
the anti-allergy functional components include but are not limited to allantoin, astragaloside, purslane, scutellaria, paeoniflorin, olive leaf extract, OPC glu' an, seabuckthorn oil, dipotassium glycyrrhizinate, biological carbohydrate gum, salvia miltiorrhiza root extract and the like;
the anti-inflammatory and antibacterial functional components comprise, but are not limited to, Piaoning, sodium azulene sulfonate, ibuprofen, tetracycline, erythromycin, aureomycin, ofloxacin, norfloxacin, lithospermum oil, ketoprofen and the like;
the repairing functional components include but are not limited to polyglycerol-26, azelaic acid, glycine, calamine mixture, salicylic acid, Chondrus crispus extract, mannitol, ammonium glycyrrhizinate, hydrogenated coconut oil glycerides, radix Puerariae extract, hydrolyzed yeast protein, EGF epidermal cell growth factor, etc.;
the efficacy ingredient is further preferably: sorbitol, sodium hyaluronate, betaine, shea butter, almond oil, glycerol, 1, 3-butanediol, glyceryl polyether-26, caprylic/capric triglyceride, glyceryl glucoside, hydrogenated lecithin, arbutin, ascorbic acid, tocopherol (vitamin E), ectoin, retinol acetate, phytosterol, ceramide, squalane, ginseng root extract, chamomile oil, melissa officinalis essential oil, allantoin, dipotassium glycyrrhizinate, bioglycasin, radix salviae miltiorrhizae extract, pininto, azulene sodium sulfonate, chlortetracycline, ofloxacin, lithospermum oil, ketoprofen, azelaic acid, glycine, salicylic acid, kudzu root extract and hydrolyzed yeast protein.
The addition of a pasting agent can increase the stability of the water and starch structure. The anions will repel OH on the starch-The cations attract OH-The magnitude of both repulsive and attractive forces is proportional to the ionic charge density, thus stabilizing and dispersing the starch particles to varying degrees, whereby NaOH or KOH is chosen as pasting agent (preferably NaOH). The addition of a small amount of a pasting agent accelerates the pasting of the starch solution, while the addition of an excessive amount makes the starch solution alkaline and unsuitable for use in skin care products.
The addition of the plasticizer can reduce the intermolecular acting force of the starch, so that the starch is easier to form a film, and the mechanical property of the starch-based film is improved. The hydrophilicity of glycerol enables the starch-based membrane to have good adsorption effect on water molecules. In addition, the glycerin can reduce the mass viscosity in the dissolving process and improve the tensile strength and flexibility of the starch-based film. The addition of glycerin also increases the moisture retention properties of the starch-based film. When the plasticizer is glycerol, the weight part of the plasticizer is less than 2.0 parts, the starch-based film cannot play a plasticizing role, and when the weight part of the plasticizer is more than 10.0 parts, the starch-based film has overhigh hygroscopicity, is too soft and is easy to break.
The cross-linking agent is used for mutually linking molecules in the system to form a net structure, so that the strength and the elasticity of the starch-based film are improved. Citric acid is a natural organic acid containing three carboxyl groups that can react with the three hydroxyl groups in the glucose monomer and the reducing end hydroxyl groups of the chain. Citric acid is added in the preparation process of the starch-based film, so that the starch can be crosslinked and esterified to form a more compact structure, thereby reducing the water solubility of the starch film and improving the water absorption performance, tensile strength and thermal stability of the starch film. The addition of citric acid can also neutralize NaOH added during starch gelatinization, and adjust pH value of starch film to be suitable for human skin environment. When the cross-linking agent is citric acid, the weight portion of the cross-linking agent is less than 0.5 portion, NaOH in the starch solution cannot be neutralized, and the weight portion of the cross-linking agent is more than 1.5 portions, so that the acidity of the starch-based membrane is too strong, and the skin irritation is strong.
A small amount of film forming agent is used in the starch solution to increase the fluidity of the starch solution, reduce the generation of bubbles and improve the integrity of a starch basement membrane, and excessive use of the film forming agent can cause adverse effects on human skin. The polyvinylpyrrolidone K30 selected from the film forming agent is a non-toxic, temperature resistant, good pH stability, high biocompatibility and biodegradable polymer.
The invention also provides a production method of the starch-based skin repairing film, which comprises the following steps:
(1) weighing the following raw materials in parts by weight, placing the raw materials into a constant-temperature water bath kettle at a certain temperature, heating and stirring at a stirring speed of 100-140rpm, wherein the stirring speed is lower than 100rpm so that the solution is not uniformly stirred, the starch is not completely gelatinized, and the stirring speed is higher than 140rpm so that excessive bubbles are generated in the starch solution to influence film formation. Heating and stirring for 20-25min to control the starch gelatinization degree;
75.0 to 90.0 portions of water
4.0 to 13.0 portions of starch
0.1 to 0.8 portion of pasting agent
2.0 to 10.0 portions of plasticizer
(2) Weighing the following raw materials in parts by weight, putting the raw materials into the solution, heating and stirring for 20-25min to fully esterify the cross-linking agent with the starch;
0.5 to 1.5 portions of cross-linking agent
(3) Weighing the following raw materials (high-temperature resistant functional components) in parts by weight, sequentially putting the raw materials into the solution, heating and stirring for 30min to enable the film-forming agent and the functional components to be completely dissolved in the starch solution;
0.01-0.5 part of film-forming agent
0.001-10.0 parts of functional components
(4) Taking the solution out of the constant-temperature water bath, stirring and cooling to a proper temperature, adding a certain weight part of raw materials (components with efficacy of not resisting high temperature), continuously stirring, and forming a film when the temperature is reduced to 30-35 ℃. If the temperature is too low, the starch solution will coagulate.
0.0-10.0 parts of functional components
The functional components can be one or more of moisturizing, whitening, anti-aging, anti-allergy, anti-inflammation, antibacterial, repairing and the like.
A starch-based skin repair film can be obtained by carrying out the method of the invention. The skin care adhesive film prepared from the starch has strong flexibility, is mild and skin-friendly, has no toxic or irritant components, is not added with a preservative, has no residual pollutants after being used, and is environment-friendly, so the skin care adhesive film has a certain potential application value in the fields of cosmetics and medicines. The method has the advantages of simple operation, mild preparation conditions, low cost, contribution to industrial production and no environmental pollution.
The special product state of the starch-based skin repairing film is easy to maintain the activity of functional components in the film, can introduce different functional components according to requirements, has a wide application range, and can solve different skin problems (such as face maintenance, acne removal, eczema removal, wound repair and the like). Compared with the traditional skin care film products, the starch-based skin care film does not need special packaging, and no 'white garbage' is generated; the starch-based skin repairing film is directly acted on the wet required part, and the use is convenient; a small amount of residues after the skin repairing film is used are friendly to the skin, easy to remove, excellent in biodegradation performance, friendly to the environment and safe to the body without harm when used.
Drawings
Fig. 1 is an SEM photograph of a starch-based skin repair film.
Fig. 2 is a digital photograph of a starch-based skin repair film.
Fig. 3 is a graph of the effect of glycerol content in starch-based skin repair films on elongation at break of the films.
Fig. 4 is a digital photograph of a starch-based moisturizing mask.
Fig. 5 is a digital photo of a starch-based acne removal patch (with size and shape prepared as required).
Fig. 6 is a picture of the efficacy of the starch-based acne removal patch (a is before use and b is after 2 days of use).
Detailed Description
The present invention is described in more detail below with reference to examples. These examples are merely illustrative of the best mode of carrying out the invention and do not limit the scope of the invention in any way. The following starch granules may have a particle size of 1 to 60 μm.
[ example 1 ]
A starch-based moisturizing mask comprises the following raw materials in parts by weight:
82.0 parts of water
10.0 parts of rice starch
0.3 part of sodium hydroxide
Glycerin 4.0 parts
0.5 part of anhydrous citric acid
300.1 portions of polyvinylpyrrolidone K
1.2 parts of butanediol
Glycerol polyether-260.5 parts
0.1 part of sodium hyaluronate
0.3 part of caprylic capric triglyceride
0.1 part of glycerol glucoside
0.2 part of dipotassium glycyrrhizinate
0.3 portion of ectoin
0.1 part of phytosterol
0.3 portion of vitamin E
The implementation steps of the formula are as follows:
(1) weighing the following raw materials in parts by weight, placing the raw materials into a constant-temperature water bath kettle at a certain temperature, heating and stirring at the stirring speed of 100-140rpm for 20-25 min;
82.0 parts of water
10.0 parts of rice starch
0.3 part of sodium hydroxide
Glycerin 4.0 parts
(2) Weighing the following raw materials in parts by weight, putting the raw materials into the solution, and heating and stirring for 20-25 min;
0.5 part of anhydrous citric acid
(3) Weighing the following raw materials in parts by weight, putting the raw materials into the solution, and heating and stirring for 30 min;
300.1 portions of polyvinylpyrrolidone K
1.2 parts of butanediol
Glycerol polyether-260.5 parts
0.1 part of sodium hyaluronate
0.3 part of caprylic capric triglyceride
0.1 part of glycerol glucoside
0.2 part of dipotassium glycyrrhizinate
0.3 portion of ectoin
0.1 part of phytosterol
Vitamin E0.3 parts
(4) Taking out the solution from the constant-temperature water bath kettle, stirring, cooling to 30-35 deg.C, forming film, and shaping.
The obtained product is a translucent film with good flexibility, mild skin-friendly property, non-toxicity and non-irritation (as shown in figure 4). The adhesive film is directly applied to the wet face for 15-25min after face cleaning (and water can be supplemented at any time according to the use requirement), the use is convenient, and no waste pollutants are generated. The small amount of residue on the face was washed directly after use. The residue can be naturally degraded, and is environment-friendly and safe.
And (3) evaluating the efficacy:
25 women of 25-45 years old were selected and faced twice a week for one month. All 20 women respond to the product with good moisturizing performance, mildness, no irritation, fresh, smooth and non-greasy skin feel. Of these 15 people belong to the mixed type skin, which is sensitive and feels fine and moist after use. And the female shows that the facial mask of the invention has obvious tightening feeling after being applied, 11 people have wrinkles in the canthus or forehead before use, and the wrinkles are faded after use.
[ example 2 ]
The starch-based acne removing patch comprises the following raw materials in parts by weight:
82.697 portions of water
9.0 parts of corn starch
0.3 part of sodium hydroxide
Glycerin 4.0 parts
0.5 part of anhydrous citric acid
300.1 portions of polyvinylpyrrolidone K
1.5 parts of butanediol
Glycerol polyether-260.5 parts
0.1 part of sodium hyaluronate
0.2 part of glycerol glucoside
0.2 part of dipotassium glycyrrhizinate
Betaine 0.3 part
0.1 part of phytosterol
Azelaic acid 0.2 part
Salicylic acid 0.3 part
0.003 portion of Piaoning
The implementation steps of the formula are as follows:
(1) weighing the following raw materials in parts by weight, placing the raw materials into a constant-temperature water bath kettle at a certain temperature, heating and stirring at the stirring speed of 100-140rpm for 20-25 min;
82.697 portions of water
9.0 parts of corn starch
0.3 part of sodium hydroxide
Glycerin 4.0 parts
(2) Weighing the following raw materials in parts by weight, putting the raw materials into the solution, and heating and stirring for 20-25 min;
0.5 part of anhydrous citric acid
(3) Weighing the following raw materials in parts by weight, putting the raw materials into the solution, and heating and stirring for 30 min;
300.1 portions of polyvinylpyrrolidone K
1.5 parts of butanediol
Glycerol polyether-260.5 parts
0.1 part of sodium hyaluronate
0.2 part of glycerol glucoside
Dipotassium glycyrrhizinate 0.2
Betaine 0.3 part
0.1 part of phytosterol
Azelaic acid 0.2 part
Salicylic acid 0.3 part
0.003 portion of Piaoning
(4) Taking out the solution from the constant-temperature water bath kettle, stirring, cooling to 30-35 deg.C, forming film, and shaping.
The obtained product is a transparent film (as shown in figure 5) with good flexibility, and is mild, skin-friendly, nontoxic and nonirritating. When in use, the anti-acne adhesive film is directly stuck to the moistened acne-growing part for about 6 hours (and water can be supplemented at any time according to the use requirement), the use is convenient, no waste pollutant is generated, a small amount of residues can be naturally degraded, and the anti-acne adhesive film is environment-friendly and safe.
And (3) evaluating the efficacy:
20 volunteers of 17-22 years old are selected, and the starch-based acne removal paste is used as a skin repairing paste and is pasted on the moistened acne-growing skin to be used as a mask (and water can be supplemented at any time according to the use requirement). After the functional components in the adhesive film are fully absorbed by the skin (6 hours), the skin around the acne is reduced in red color, and the effects of diminishing inflammation, resisting bacteria and repairing are achieved. After the patients with severe symptoms are used for a plurality of days (generally three days), the pox tends to be obviously eliminated, and the health state of the skin is obviously improved (as shown in figure 6). Moreover, the volunteers reflect that the starch-based acne removal adhesive film has no uncomfortable feeling after being pasted, and the appearance is not influenced because the adhesive film is transparent or semitransparent.
[ example 3 ]
The starch-based wound repairing film comprises the following raw materials in parts by weight:
80.0 parts of water
Wheat starch 11.0 parts
0.3 part of sodium hydroxide
Glycerin 4.0 parts
0.5 part of anhydrous citric acid
300.1 portions of polyvinylpyrrolidone K
1.3 parts of butanediol
Glycerol polyether-260.5 parts
0.1 part of sodium hyaluronate
0.1 part of glycerol glucoside
0.2 part of dipotassium glycyrrhizinate
0.4 part of squalane
0.6 part of shea butter
Betaine 0.3 part
0.1 part of phytosterol
0.1 portion of ceramide
Hydrogenated lecithin 0.1 part
0.1 portion of ketoprofen
Sodium azulene sulfonate 0.2 parts
The implementation steps of the formula are as follows:
(1) weighing the following raw materials in parts by weight, placing the raw materials into a constant-temperature water bath kettle at a certain temperature, heating and stirring at the stirring speed of 100-140rpm for 20-25 min;
80.0 parts of water
Wheat starch 11.0 parts
0.3 part of sodium hydroxide
Glycerin 4.0 parts
(2) Weighing the following raw materials in parts by weight, putting the raw materials into the solution, and heating and stirring for 20-25 min;
0.5 part of anhydrous citric acid
(3) Weighing the following raw materials in parts by weight, putting the raw materials into the solution, and heating and stirring for 30 min;
300.1 portions of polyvinylpyrrolidone K
1.3 parts of butanediol
Glycerol polyether-260.5 parts
0.1 part of sodium hyaluronate
0.1 part of glycerol glucoside
0.2 part of dipotassium glycyrrhizinate
0.4 part of squalane
0.6 part of shea butter
Betaine 0.6 part
0.1 part of phytosterol
0.1 portion of ceramide
Hydrogenated lecithin 0.1 part
0.1 portion of ketoprofen
Sodium azulene sulfonate 0.2 parts
(4) Taking out the solution from the constant-temperature water bath kettle, stirring, cooling to 30-35 deg.C, forming film, and shaping.
The obtained product is a transparent adhesive film with good flexibility, is mild and skin-friendly, and is non-toxic and non-irritant. When in use, the starch-based wound repairing film is directly pasted on a cleaned wound or a damaged part of skin, and the pasting time is determined according to the severity of the wound. After the wound dressing is used, tearing is not needed, a small amount of residues can fall off automatically or be removed easily, and the problems of secondary injury and the like caused by wound adhesion are solved.
And (3) evaluating the efficacy:
10 volunteers of different ages (10-65 years) with skin lesions were recruited and starch-based wound repair films were applied to the cleaned wounds. After the functional components in the adhesive film are slowly absorbed by the skin (8 hours), the skin red and swollen around the wound can be removed, and the anti-inflammatory and repairing effects are generated. After being used for several days (according to the severity and time of skin injury), the skin injury of volunteers in different age groups has obvious healing tendency. And the volunteers reflect that the starch-based wound repairing film has no discomfort after being pasted, and the repairing film can effectively absorb tissue fluid flowing out of the wound while releasing functional components, so that the wound is in a proper environment and the skin repair is facilitated. Therefore, the wound repairing film has good biocompatibility, is beneficial to tissue repair, and has no problem of secondary damage to the wound caused by wound adhesion because the wound repairing film has few residues after use, is easy to remove and does not need to be torn.
Claims (9)
1. The starch-based skin repairing film is characterized by comprising the following raw materials in parts by weight:
75.0 to 90.0 portions of water
4.0 to 13.0 portions of starch
0.1 to 0.8 portion of pasting agent
2.0 to 10.0 portions of plasticizer
0.5 to 1.5 portions of cross-linking agent
0.01-0.5 part of film-forming agent
0.001-10.0 parts of functional components.
2. The starch-based skin care film of claim 1, wherein said starch-based skin care film comprises the following parts by weight of raw materials:
80.0 to 82.0 portions of water
9.0 to 11.0 portions of starch
0.3 to 0.5 portion of pasting agent
4.0-6.0 parts of plasticizer
0.5 to 0.7 portion of cross-linking agent
0.1 to 0.2 portion of film forming agent
3.0-5.0 parts of functional components.
3. The starch-based skin repair film according to claim 1 or 2, wherein said starch includes, but is not limited to, rice starch, corn starch, wheat starch, potato starch, and other starch-containing materials.
4. The starch-based skin repair film of claim 1 or 2, wherein the pasting agent includes, but is not limited to, sodium hydroxide, potassium hydroxide.
5. The starch-based skin repair film according to claim 1 or 2, wherein said plasticizer includes, but is not limited to, glycerin, sorbitol, phthalate esters, and the like.
6. The starch-based skin repair film according to claim 1 or 2, wherein said cross-linking agent includes, but is not limited to, anhydrous citric acid, epichlorohydrin.
7. The starch-based skin repair film according to claim 1 or 2, wherein said film forming agent includes but is not limited to polyvinylpyrrolidone K30, polyvinyl alcohol, silicon acrylate, and the like.
8. The starch-based skin care film according to claim 1 or 2, wherein the functional ingredients are one or more of moisturizing, whitening, anti-aging, anti-allergy, anti-inflammatory, antibacterial, and repairing;
the moisturizing functional component is selected from one or more of natural moisturizers or synthetic moisturizers; natural humectants include, but are not limited to, xylitol, sorbitol, mannitol, sodium hyaluronate, sodium PCA, panthenol, lactic acid, polyglutamic acid, betaine, trehalose, aloe vera extract, olive oil, shea oil, mango seed butter, camellia seed oil, jojoba seed oil, walnut seed oil, shiitake seed oil, shea butter, avocado oil, carnauba wax, olive oil, almond oil, and the like; synthetic humectants include, but are not limited to, glycerol, 1, 2-propanediol, diglycerol, 1, 3-propanediol, dipropylene glycol, 1, 3-butanediol, glyceryl polyether-26, caprylic capric triglyceride, glyceryl glucoside, hydrogenated lecithin, and the like.
The whitening functional components include but are not limited to arbutin, ascorbic acid, vitamin C ethyl ether, sodium ascorbyl phosphate, ascorbyl glucoside, kojic acid dipalmitate, glycolic acid, malic acid, tartaric acid, glabridin, phloretin, Daisy flower extract, nicotinamide, sunflower seed oil and the like;
the anti-aging functional ingredients comprise but are not limited to tocopherol (vitamin E), tocopherol sodium phosphate, fullerene, ectoin, grape seed extract, resveratrol, retinol acetate, ginkgo biloba extract, phytosterol, ceramide, ginseng root extract, grape seed oil, evening primrose oil, wild soybean oil, cocoa butter, chamomile oil, balm essential oil, squalane and the like;
the anti-allergy functional components include but are not limited to allantoin, astragaloside, purslane, scutellaria, paeoniflorin, olive leaf extract, OPC glu' an, seabuckthorn oil, dipotassium glycyrrhizinate, biological carbohydrate gum, salvia miltiorrhiza root extract and the like;
the anti-inflammatory and antibacterial functional components comprise, but are not limited to, Piaoning, sodium azulene sulfonate, ibuprofen, tetracycline, erythromycin, aureomycin, ofloxacin, norfloxacin, lithospermum oil, ketoprofen and the like;
the repairing functional components include, but are not limited to, polyglycerol-26, azelaic acid, glycine, calamine mixture, salicylic acid, Chondrus crispus extract, mannitol, ammonium glycyrrhizinate, hydrogenated coconut oil glycerides, kudzu root extract, hydrolyzed yeast protein, EGF pericyte growth factor, etc.
9. The method of producing a starch-based skin repair film according to claim 1, comprising the steps of:
(1) weighing the following raw materials in parts by weight, placing the raw materials into a constant-temperature water bath kettle at a certain temperature, heating and stirring at the stirring speed of 100-140rpm for 20-25 min;
75.0 to 90.0 portions of water
4.0 to 13.0 portions of starch
0.1 to 0.8 portion of pasting agent
2.0 to 10.0 portions of plasticizer
(2) Weighing the following raw materials in parts by weight, putting the raw materials into the solution, and heating and stirring for 20-25 min;
0.5 to 1.5 portions of cross-linking agent
(3) Weighing the following raw materials in parts by weight, putting the raw materials into the solution, and heating and stirring for 30 min;
0.01-0.5 part of film-forming agent
0.001-10.0 parts of functional components, wherein the functional components are high-temperature resistant functional components;
(4) taking the solution out of the constant-temperature water bath kettle, stirring and cooling to a proper temperature, adding a certain weight part of raw materials, continuously stirring, and forming a film when the temperature is reduced to 30-35 ℃;
0.0-10.0 parts of functional components which are not high temperature resistant functional components.
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| CN114671703A (en) * | 2022-04-01 | 2022-06-28 | 东北大学 | Preparation method of silicon carbide grade porous ceramic |
| CN116173289A (en) * | 2022-12-29 | 2023-05-30 | 海南众森生物科技有限公司 | Functional dressing containing recombinant human collagen and preparation method and application thereof |
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| CN114671703A (en) * | 2022-04-01 | 2022-06-28 | 东北大学 | Preparation method of silicon carbide grade porous ceramic |
| CN116173289A (en) * | 2022-12-29 | 2023-05-30 | 海南众森生物科技有限公司 | Functional dressing containing recombinant human collagen and preparation method and application thereof |
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