CN112675117A

CN112675117A - Composition containing honey extract and application thereof

Info

Publication number: CN112675117A
Application number: CN202011623021.0A
Authority: CN
Inventors: 包磊
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-12-31
Filing date: 2020-12-31
Publication date: 2021-04-20

Abstract

The invention discloses a composition containing a honey extract, which comprises the following components in parts by mass based on 100 parts by mass: 35-55 parts of honey extract, 45-65 parts of linseed extract and 0.5-2 parts of small molecular peptide, and the composition containing the honey extract can well achieve the effect of repairing skin barriers when being applied to the preparation process of skin care products.

Description

Composition containing honey extract and application thereof

Technical Field

The invention relates to the technical field of skin care products, in particular to a composition containing a honey extract and application thereof.

Background

The skin barrier is mainly composed of a sebum membrane and a horny layer, and mainly plays a role in keeping skin moisture, preventing water in vivo from evaporating, and resisting external foreign matters from invading into the body. The sebum membrane is the most important layer for water locking of skin, can effectively lock water, is formed by emulsifying sebum and water, can effectively moisten skin, can inhibit the growth of certain microorganisms as the sebum membrane of the skin epidermis immune layer, and has the function of resisting infection. The horny layer consists of a plurality of layers of horny cells and intercellular lipid, wherein the horny cells are similar to bricks, the intercellular lipid is similar to cement, and the horny cells and the intercellular lipid are combined with each other to form a wall, so that a natural protective barrier for skin is formed, the healthy horny layer has super-strong water-locking capacity, the skin is not dry even in an environment with zero humidity, the skin is thinned and damaged due to excessive frequent force stripping and removal of a skin surface sebum membrane or the horny layer, the moisture of the skin is greatly dissipated, external irritants easily penetrate the horny layer, and the problems of skin chap, allergy, redness, inflammation, skin-care product stabbing pain and the like can be easily caused.

In order to solve a series of problems caused by the skin barrier, research and development efforts are increased on how to repair the skin barrier by a plurality of cosmetic companies, and a plurality of cosmetics and skin care products for repairing the skin barrier exist in the market, but the cosmetics and the skin care products do not achieve a good effect.

Therefore, how to provide a composition capable of effectively repairing skin barrier for application in preparation of various skin care products and cosmetics is a problem to be solved by those skilled in the art.

Disclosure of Invention

In view of the above, the present invention provides a composition containing honey extract, which can effectively repair skin barrier when used in the preparation of various skin care products and cosmetics.

In order to achieve the purpose, the invention adopts the following technical scheme:

a composition containing a honey extract comprises the following components in parts by mass based on 100 parts by mass: 33-55 parts of honey extract, 43-65 parts of linseed extract and 0.5-2 parts of small molecular peptide.

Preferably, the honey extract-containing composition comprises the following components in parts by mass based on 100 parts by mass of the total mass: 40-50 parts of honey extract, 50-60 parts of linseed extract and 1-2 parts of small molecular peptide.

Preferably, the honey extract-containing composition comprises the following components in parts by mass based on 100 parts by mass of the total mass: 45 parts of honey extract, 53 parts of linseed extract and 2 parts of small molecular peptide.

The honey extract contains vitamins, fruit acids (AHA), glucose, fructose, and other saccharides. Wherein the vitamins can influence the cell metabolism process, and has certain effect on restoring skin vitality, the fruit acid (AHA) can promote normal keratinization and desquamation, and is beneficial to the growth of new cells, and the glucose and the fructose have a plurality of hydroxyl groups and are similar to the structure of the polyalcohol, so the honey extract has moisture retention property, and can be used as a good humectant; the honey extract has no irritation, is suitable for sensitive and irritant skin, contains vitamins, minerals and microelements, can effectively cure wound, has effects of resisting inflammation, killing bacteria and relieving pain, and especially has high viscosity to provide a protective barrier to prevent skin infection by pathogens in environment.

The linseed extract comprises the components of flax lignan, flax polysaccharide, alpha-linolenic acid and the like. The flax lignan has an anti-aging effect, the flax seed polysaccharide is a polysaccharide component extracted from the surface of flax seeds, has extremely strong hydrophilicity, is a few polysaccharide hydrophilic colloids with emulsibility, and improves the water locking function of skin tissues by improving the hydrophilicity of cells, so that the skin can be kept moist for a long time. The moisture evaporation rate of the 0.5% flaxseed polysaccharide solution is lower than that of the sodium hyaluronate solution with the same concentration, so that an emulsification system formed by the flaxseed extract can effectively inhibit the moisture evaporation on the skin surface through the softening effect on the skin cuticle and the formation of an extremely thin breathable film on the skin surface, thereby ensuring that the skin is moist and not dry; meanwhile, based on the ultra-strong emulsifying capacity of the linseed polysaccharide, the linseed polysaccharide forms a stable oil-in-water state with oil and water in a product, can effectively inhibit the oxidation of unsaturated fatty acids such as alpha-linolenic acid and the like, and is a natural effective component for resisting oxidation and inhibiting the oxidation of the unsaturated fatty acids.

And alpha-linolenic acid in the flaxseed can protect and improve the activity of carbohydrate and protein synthetase in cells, thereby improving the autotrophic function and the regeneration capacity of skin cells. Has important effects on the aspects of regeneration of skin tissues and self-repairing of skin defects such as dry and rough skin, chap, wrinkle, pruritus, allergy, eczema, acne and the like; alpha-linolenic acid also has good skin permeability, enhances the biological absorption function of the skin, and can also enhance the elasticity of the stratum corneum of the skin.

The small molecular peptide (also called small molecular active peptide and small peptide) is a biochemical substance between amino acid and protein, and is smaller than protein molecular weight and larger than amino acid molecular weight, and is a protein fragment. The small molecular peptide has important physiological functions, relates to the fields of hormone, nerve, cell growth and reproduction of human bodies, can regulate the physiological functions of various systems and cells in the human bodies, and maintains the normal physiological activities of the systems of nerve, digestion, reproduction, growth, motor metabolism, circulation and the like of the human bodies. In the natural aging and nursing process of skin, small molecule active peptide plays an important role, such as migration, reproduction, inflammation, angiogenesis, pigment formation, protein synthesis regulation and the like of cells, and with further understanding of the microstructure and mechanism of the skin of human beings, small molecule peptide with various structures is introduced into skin care, so that the effects of promoting the synthesis of collagen, resisting free radical oxidation and the like are achieved.

In addition, the honey extract has an anti-inflammatory effect, can prevent germs from invading the inside of the skin, accelerates the self-repairing speed of the skin barrier, has a long-acting moisturizing effect on the skin cuticle, is beneficial to the permeation of the linseed extract and the small molecular peptide to the inside of the skin, and further plays respective roles, and also contains various minerals, nourishes skin cells and is beneficial to the repairing of the skin shielding layer.

Preferably, in one of the above compositions comprising honey extract, the source of the honey extract is white honey from the Wenddel garden, Canada.

The HONEY EXTRACT (components: HONEY EXTRACT, 1.3 butanediol, phenoxyethanol, CAS: 91052-92-5, Chinese name: HONEY EXTRACT, English name: HONEY EXTRACT, products in the raw material list of cosmetics) is an existing raw material, the extraction method also adopts the prior art, the selected Canadian white HONEY has richer nutrient components than other HONEY, has higher nutrient value than other HONEY, contains a large amount of minerals, vitamins and flavonoids compounds, but the obtained HONEY EXTRACT has no essential difference with the HONEY EXTRACT obtained by other types of HONEY.

Preferably, in one of the above compositions comprising honey extract, the flaxseed extract is an aqueous extract product of flaxseed canada using supercritical extraction.

The invention also discloses application of the composition containing the honey extract in skin care products, wherein the skin care products comprise cream, essence, stock solution, essence water, facial masks, eye cream and muscle foundation liquid.

Preferably, in the application of the composition containing the honey extract in the skin care product, the mass fraction of the composition in the skin care product is 0.5-5%.

Preferably, in the application of the composition containing the honey extract in the skin care product, the mass fraction of the composition in the skin care product is 1.5-4%.

Preferably, in the application of the composition containing the honey extract in the skin care product, the skin care product further comprises an oil phase component and a water phase component, wherein the oil phase component is one or more of squalane, avocado oil, meadowfoam oil, acetic acid capric acid triglyceride, dioctyl carbonate, cetearyl alcohol, behenyl alcohol and the like, and the water phase component is one or more of purified water, carbomer, hyaluronic acid, betaine, xanthan gum, trehalose and the like.

Preferably, in the application of the composition containing the honey extract in the skin care product, the skin care product further comprises a preservative and a pH regulator.

According to the technical scheme, compared with the prior art, the composition containing the honey extract has the following beneficial effects:

(1) the components adopted by the composition are natural products or natural extracts, so that the composition has no stimulation and no harm to the skin.

(2) Both the honey extract and the linseed extract have good moisturizing effects. The linseed extract has strong hydrophilicity, can soften the horny layer, is beneficial to the nutrient substances such as small molecular peptide and honey extract to enter the inside of the skin through the horny layer in a certain range, enhances the autotrophic function and the regeneration capacity of skin cells, and further realizes the function of repairing the skin barrier. Meanwhile, the honey extract has the anti-inflammatory and bactericidal effects, so that the further damage to the skin caused by bacteria entering the skin through the skin barrier can be reduced, the inflammation generated by the skin can be effectively relieved, and the good moisturizing effect is also beneficial to the recovery of the skin barrier function; in a reasonable range, the honey extract and the linseed extract can also enhance the metabolism and the emulsifying capacity of cells, can coordinate and enhance the synthesis function of small molecular peptides for promoting collagen, and further enhances the repair of skin barriers.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

The honey extracts in the following examples are obtained from white honey, and may be obtained from other types of honey.

Example 1

Example 1 discloses a composition containing a white honey extract, comprising the following components by weight, based on 100g of the prepared composition: 45g of white honey extract, 53g of linseed extract and 2g of small molecular peptide, and mixing the components to obtain the composition.

Examples 2-7 and comparative examples 1-18 were obtained by varying the amount of molasses extract, flax seed extract, small molecule peptides added to the composition, see table 1 for details.

TABLE 1

The composition prepared by the embodiment of the invention can be used in skin care products and can be used as an active ingredient of the skin care products. The skin care product can be prepared by selecting the common base materials of different types of cosmetics according to the prior art, and the preparation method of the cosmetics can be prepared according to the conventional method of the prior art.

In the embodiment of the present invention, the composition is applied to the cream base as an example, the cream base is firstly prepared, and the specific formula of the cream base is shown in table 2.

TABLE 2 cream base formula

The preparation method of the cream base comprises the following steps:

(1) respectively mixing and heating the raw materials in the group A and the raw materials in the group B to 75-80 ℃;

(2) adding the mixed raw materials of group A into the mixed raw materials of group B, homogenizing, stirring at 3000rpm for 3min, and cooling;

(3) cooling to 40 deg.C under stirring, adding group C materials, and stirring to obtain cream matrix.

And (3) taking a proper amount of the cream base prepared above, adding a certain amount of the composition prepared in the example 1, and uniformly stirring to obtain the cream containing the composition. Examples 8-19 were obtained by varying the ratio of the composition added to the cream, see in particular table 3.

TABLE 3

	Composition (mass fraction%)
		Example 8	0.5
Example 9	1
		Example 10	1.5
Example 11	2
		Example 12	2.5
Example 13	3
		Example 14	3.5
Example 15	4
		Example 16	4.5
Example 17	5
		Example 18	5.5
Example 19	0

Test verification:

the compositions of examples 1 to 7 and comparative examples 1 to 18 were added to the cream bases prepared in Table 2, respectively, in amounts of 3% by mass of the cream, to obtain test samples.

Firstly, verifying the repairing effect: barrier repair effect of skin (TEWL value)

30 volunteers were recruited and did not participate in the repair test within 1 month, and the inner sides of the forearms of the left and right hands were marked with square areas of 4cm in both length and width, and the sample amount was 4.0 + -0.1 mg/cm²The amount of (A) was uniformly applied to the test area. And measuring the skin moisture loss of volunteers in the tested area and the control area by using a Tewanmeter TM300 instrument before smearing and 3h and 6h after smearing respectively, wherein the test requires the operation of the same measuring person, the result is analyzed by adopting SPSS software, and the effective value of the significant difference is determined as the P value less than 0.05.

The test principle of the instrument is FICK Fick diffusion law: dm/dt ═ d.a.dp/dx. Two groups of temperature and humidity sensors are used for measuring the water vapor pressure gradient formed by the loss of moisture in the near epidermis (within about 1 cm) from the cuticle at different bright points, and the moisture content of the percutaneous emission is directly measured. The TEWL value is an important indicator of the quality of the skin barrier, and a lower TEWL value indicates a better barrier function of the skin, whereas a worse.

And (3) testing environment: the testing environment temperature is 22 +/-1 ℃, the humidity is 50 +/-5%, and real-time dynamic detection is carried out;

the above experiments were performed 7 times, 1-5 times, 6 groups per test, 4 groups for the sixth test, and 3 groups for the 7 th test, with the experiments performed every other day.

In the formula: phi- - - - - -TWEL value change rate;

MMV₀TEWL value of the skin before application;

MMV_tTEWL values of the skin during the application period.

TABLE 4

Second, measuring the water content of stratum corneum

30 volunteers were recruited and marked with a square area of 4cm in length and width on the inner side of the forearm of the left and right hands, respectively, and the amount of the sample was 4.0. + -. 0.1mg/cm²The amount of (A) was uniformly applied to the test area. The moisture content of the skin of the tested area and the skin of the control area are measured by a Corneometer CM 825 instrument before smearing and after smearing for 1h, 3h and 6h, the test requires the same measuring personnel to operate, the subjective feeling of the testee after smearing is collected, the result is analyzed by SPSS software, and the effective value of the significant difference is determined as the P value less than 0.05.

Wherein the skin moisture growth rate is calculated according to the following formula:

in the formula: phi-skin moisture growth rate;

MMV₀-moisture content of the skin before application;

MMV_t-water content of the skin during the application period t.

TABLE 5

The embodiments in the present description are described in a progressive manner, each embodiment focuses on differences from other embodiments, and the same and similar parts among the embodiments are referred to each other. For the scheme disclosed by the embodiment, the scheme corresponds to the method disclosed by the embodiment, so that the description is simple, and the relevant points can be referred to the method part for description.

The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. The composition containing the honey extract is characterized by comprising the following components in parts by mass based on 100 parts by mass of the total mass: 33-55 parts of honey extract, 43-65 parts of linseed extract and 0.5-2 parts of small molecular peptide.

2. A composition containing a honey extract according to claim 1, characterized by comprising the following components in a total amount of 100 parts by mass: 40-50 parts of honey extract, 50-60 parts of linseed extract and 1-2 parts of small molecular peptide.

3. A composition containing a honey extract according to claim 1, characterized by comprising the following components in a total amount of 100 parts by mass: 45 parts of honey extract, 53 parts of linseed extract and 2 parts of small molecular peptide.

4. A composition containing a honey extract according to any one of claims 1-3, wherein the source of the honey extract is white honey from the Wenddel garden, Canada.

5. A composition comprising a honey extract according to any one of claims 1-3, wherein the linseed extract is an aqueous extract product of Canadian linseed using a supercritical extraction.

6. Use of a honey extract containing composition according to any one of claims 1-5 in a skin care product comprising cream, essence, stock solution, essence water, mask, eye cream, skin lotion.

7. Use of a composition comprising honey extract in a skin care product according to claim 6, wherein the composition is present in the skin care product in an amount of 0.5-5% by weight.

8. Use of a composition comprising honey extract in a skin care product according to claim 7, wherein the composition is present in the skin care product in an amount of 1.5-4% by weight.

9. The use of a composition containing honey extract in a skin care product according to claim 7 or 8, wherein the skin care product further comprises an oil phase component and a water phase component, the oil phase component comprises one or more of squalane, avocado oil, meadowfoam oil, acetic and capric triglyceride, dioctyl carbonate, cetearyl alcohol and behenyl alcohol, and the water phase component comprises one or more of purified water, carbomer, hyaluronic acid, betaine, xanthan gum and trehalose.

10. Use of a composition comprising honey extract in a skin care product according to claim 9, wherein the skin care product further comprises preservatives, pH adjusting agents.