CN112641919A - Acupoint application traditional Chinese medicine composition for yang-qi deficiency and vein stasis and preparation method thereof - Google Patents
Acupoint application traditional Chinese medicine composition for yang-qi deficiency and vein stasis and preparation method thereof Download PDFInfo
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- CN112641919A CN112641919A CN202110177907.5A CN202110177907A CN112641919A CN 112641919 A CN112641919 A CN 112641919A CN 202110177907 A CN202110177907 A CN 202110177907A CN 112641919 A CN112641919 A CN 112641919A
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Abstract
The invention provides an acupoint application traditional Chinese medicine composition for yang qi deficiency and vein stasis and a preparation method thereof, wherein the traditional Chinese medicine composition is prepared by processing the following traditional Chinese medicine components in parts by weight: 12 parts of semen brassicae, 12 parts of rhizoma corydalis, 10 parts of euphorbia kansui, 3 parts of asarum, 6 parts of fructus evodiae, 6 parts of pepper, 6 parts of clove, 12 parts of rhizoma cyperi, 6 parts of pepper, 12 parts of rhizoma zingiberis, 15 parts of rhizoma typhonii, 12 parts of rhizoma atractylodis, 15 parts of cortex eucommiae, 15 parts of fructus alpiniae oxyphyllae, 10 parts of angelica sinensis, 30 parts of astragalus membranaceus, 15 parts of teasel roots, 12 parts of cynomorium songaricum, 12 parts of golden cypress, 15 parts of radix angelicae pubescentis, 12 parts of parasitic loranthus, 15 parts of glossy privet fruits and 12 parts of eclipta alba are added on the basis of tonifying qi and activating blood, warming meridians and dredging collaterals, promoting qi and relieving pain to prepare a traditional Chinese medicine application, and obtain a better curative effect through long.
Description
Technical Field
The invention belongs to the technical field of Chinese herbal medicines, and particularly relates to a traditional Chinese medicine composition for acupoint application for yang-qi deficiency and vein stasis, and a preparation method of the traditional Chinese medicine composition.
Background
The syndrome of stagnant vein due to insufficiency of yang-qi is a common clinical syndrome of traditional Chinese medicine, the etiology of which is that the yang-qi is insufficient and fails to circulate blood vessels, so that the muscles and tendons are nourished, or the patients are susceptible to cold, qi and blood stasis, and the chest is blocked, and the stagnation of vein is finally caused, and the clinical manifestations of the syndrome are listlessness, muscle atrophy, lack of qi and no speaking, preference for heat, fright, cold skin, cough, weakness, abdominal pain, diarrhea, little menstrual pain, weakness of hands and feet, discomfort of muscle during activities, dull tongue quality or petechia, ecchymosis and unsmooth pulse. The western medicine has limited understanding of the etiology and pathogenesis of the disease, and no specific and effective treatment method exists. The traditional Chinese medicine adopts a treatment method of tonifying qi and activating blood, warming and activating channels, and promoting qi circulation and relieving pain, and the oral traditional Chinese medicine decoction can achieve certain clinical effects. However, some patients cannot persist in taking the oral Chinese medicinal decoction for a long time, which increases the difficulty in treating the disease. The traditional Chinese medicine acupoint application can solve the problem instead of the traditional Chinese medicine oral administration, however, no traditional Chinese medicine acupoint application product related to the disease is available on the market at present.
Disclosure of Invention
Based on the problems in the prior art, the invention provides a traditional Chinese medicine composition for acupoint application for yang-qi deficiency and vein blood stasis, which is prepared by adding traditional Chinese medicines for invigorating yang and opening the channels and warming and tonifying spleen and kidney on the basis of benefiting qi and activating blood, warming and activating channels and collaterals, and promoting qi circulation and relieving pain under the guidance of Xuanfu theory, and achieves better curative effect through long-term clinical practice improvement.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
a Chinese medicinal composition for acupoint application for treating yang qi deficiency and vein blood stasis comprises the following Chinese medicinal components: semen Sinapis Albae, rhizoma corydalis, radix kansui, herba asari, fructus evodiae, fructus Piperis, flos Caryophylli, rhizoma Cyperi, fructus Zanthoxyli, Zingiberis rhizoma, radix Aconiti lateralis Preparata, rhizoma Atractylodis, Eucommiae cortex, fructus Alpinae Oxyphyllae, radix Angelicae sinensis, radix astragali, radix Dipsaci, herba Cynomorii, cortex Phellodendri, radix Angelicae Pubescentis, herba Taxilli, fructus Ligustri Lucidi and Ecliptae herba.
According to the scheme, the traditional Chinese medicine composition for acupoint application for yang-qi deficiency and vein stasis comprises the following traditional Chinese medicine components in parts by weight:
10-14 parts of semen brassicae, 10-14 parts of rhizoma corydalis, 8-12 parts of euphorbia kansui, 1-5 parts of asarum, 4-8 parts of fructus evodiae, 4-8 parts of pepper, 4-8 parts of clove, 10-14 parts of rhizoma cyperi, 4-8 parts of pepper, 10-14 parts of rhizoma zingiberis, 13-17 parts of rhizoma typhonii, 10-14 parts of rhizoma atractylodis, 12-17 parts of eucommia ulmoides, 13-17 parts of fructus alpiniae oxyphyllae, 8-12 parts of angelica sinensis, 25-35 parts of astragalus membranaceus, 13-17 parts of radix dipsaci, 10-14 parts of cynomorium songaricum, 10-14 parts of cortex phellodendri, 13-17 parts of radix angelicae pubescentis, 10-14 parts of parasitic loranthus, 13-.
According to the scheme, the traditional Chinese medicine composition for acupoint application for yang-qi deficiency and vein stasis syndrome is prepared by processing the following traditional Chinese medicine components in parts by weight:
12 parts of white mustard seed, 12 parts of corydalis tuber, 10 parts of euphorbia kansui, 3 parts of asarum, 6 parts of evodia, 6 parts of pepper, 6 parts of clove, 12 parts of rhizoma cyperi, 6 parts of pepper, 12 parts of dried ginger, 15 parts of rhizoma typhonii, 12 parts of rhizoma atractylodis, 15 parts of eucommia bark, 15 parts of sharpleaf galangal fruit, 10 parts of angelica, 30 parts of astragalus root, 15 parts of teasel root, 12 parts of cynomorium songaricum, 12 parts of phellodendron, 15 parts of radix angelicae pubescentis, 12 parts of loranthus parasiticus, 15 parts of glossy privet fruit.
A preparation method of the traditional Chinese medicine composition comprises the following steps:
step S1, taking 15 parts of eucommia ulmoides, 12 parts of rhizoma cyperi, 30 parts of astragalus membranaceus, 15 parts of teasel roots, 12 parts of cynomorium songaricum, 12 parts of golden cypress, 12 parts of parasitic loranthus, 15 parts of glossy privet fruits and 12 parts of eclipta alba, adding water for decoction, filtering after decoction, taking filtrate, concentrating and drying to prepare dry paste;
step S2, grinding the dry paste prepared in step S1 into fine powder, and sieving to remove residues for later use;
step S3, respectively taking 12 parts of white mustard seed, 12 parts of corydalis tuber, 10 parts of euphorbia kansui, 3 parts of asarum, 6 parts of evodia rutaecarpa, 6 parts of pepper, 6 parts of clove, 6 parts of pepper, 12 parts of dried ginger, 15 parts of rhizoma typhonii, 12 parts of rhizoma atractylodis, 15 parts of sharpleaf galangal fruit, 10 parts of angelica and 15 parts of pubescent angelica root, crushing into fine powder, and sieving to remove residues for later use;
and step S4, uniformly mixing the fine powder prepared in the step S2 and the step S3 to obtain the finished product of the fine powder of the traditional Chinese medicine composition.
According to the scheme, in the step S1, water is added for decoction, and the water is added for decoction, wherein the water is 8 times of the total volume of the Chinese herbal medicine components.
According to the scheme, in the step S1, the water adding decoction is repeated twice, each time of the water adding decoction is firstly boiled by strong fire and then continuously decocted for one hour by low fire, and the liquid medicines obtained in the two times are combined and filtered.
The invention has the beneficial effects that: the rhizoma typhonii tablet, the eucommia ulmoides, the fructus alpiniae oxyphyllae, the cynomorium songaricum, the fructus evodiae, the asarum, the pepper, the clove, the rhizoma cyperi, the pepper, the rhizoma zingiberis and the rhizoma atractylodis in the traditional Chinese medicine composition applied to the acupuncture points are monarch drugs, have the effects of warming and tonifying spleen and kidney yang, dredging channels and collaterals and relieving pain, and aim at invigorating yang, promoting blood circulation and meridian circulation, and relieving yang-qi deficiency symptoms such as cold and shy body, cool skin, numbness of hands and feet; the Chinese angelica, the astragalus, the corydalis tuber and the teasel root are ministerial medicines, have the functions of tonifying qi and activating blood, promoting qi circulation and relieving pain, promote blood circulation and dredge channels, and assist monarch medicines to eliminate meridian stasis symptoms such as mental fatigue, limb fatigue, muscle soreness and the like, the traditional Chinese medicines are warm and easy to damage yin essence due to heat, so the glossy privet fruit, the eclipta alba, the kansui root and the phellodendron bark are used as adjuvants to nourish yin essence, clear heat and dissipate stagnation; the key pathogenesis of this disease is that the Xuan Fu stagnates and the vessels are blocked because Xuan Fu fails to warm and nourish yang qi due to yang qi deficiency and the vessels are blocked, so that the three-position wind-herbs of Du Huo, sang Ji Sheng and Bai Jie Zi are used to open Xuan Fu and dredge vessels. The medicines are combined to achieve the effects of warming and invigorating spleen and kidney, tonifying qi and activating blood, and dredging collaterals and relieving pain.
Detailed Description
The technical solution of the present invention will be described below with reference to specific examples.
The first embodiment is as follows: a Chinese medicinal composition for acupoint application for treating yang qi deficiency and blood stasis in channels and collaterals is provided.
A preparation method of a Chinese medicinal composition applied to acupuncture points for treating yang qi deficiency and vein blood stasis comprises the following steps:
step S1, weighing 15 parts of eucommia ulmoides, 12 parts of rhizoma cyperi, 30 parts of astragalus membranaceus, 15 parts of teasel roots, 12 parts of cynomorium songaricum, 12 parts of golden cypress, 12 parts of loranthus parasiticus, 15 parts of glossy privet fruits and 12 parts of eclipta alba according to the mass ratio, adding water which is 8 times of the total volume of the Chinese herbal medicine components for decocting, boiling with strong fire, continuously decocting for one hour with low fire, filtering and separating decoction dregs and liquid medicine after decocting, adding water into the decoction dregs, decocting once again, filtering to obtain liquid medicine, combining the liquid medicines obtained in the two steps, concentrating and drying to prepare dry paste;
step S2, grinding the dry paste prepared in step S1 into fine powder, and sieving to remove residues for later use;
step S3, weighing 12 parts of semen Sinapis Albae, 12 parts of rhizoma corydalis, 10 parts of radix kansui, 3 parts of herba asari, 6 parts of fructus evodiae, 6 parts of pepper, 6 parts of flos Caryophylli, 6 parts of pericarpium Zanthoxyli, 12 parts of rhizoma Zingiberis, 15 parts of rhizoma Typhonii, 12 parts of rhizoma Atractylodis, 15 parts of fructus Alpinae Oxyphyllae, 10 parts of radix Angelicae sinensis and 15 parts of radix Angelicae Pubescentis respectively according to the mass ratio, crushing into fine powder, and sieving to remove residues for later use;
and step S4, uniformly mixing the fine powder prepared in the step S2 and the step S3 to obtain the finished product of the fine powder of the traditional Chinese medicine composition.
Example two: effectiveness test of the Chinese medicinal composition applied to acupuncture points for treating yang qi deficiency and meridian stasis.
Case (sample) selection correlation criteria and selection grouping method.
1. Diagnostic criteria:
the diagnosis standard of the pattern of yang-qi deficiency and venation stasis is formulated according to the definition of the pattern of yang-qi deficiency and venation stasis in TCM syndrome:
(1) yang qi deficiency manifested by lassitude, fatigue, qi deficiency, disinclination to talk, aversion to heat, cold, loose stool, etc.;
(2) the manifestations of meridian stasis, such as heavy limbs, numbness of limbs, and muscular pain;
(3) a pale tongue with petechia and ecchymosis, and a thready and unsmooth or deep and thready pulse.
2. Inclusion (selection) criteria.
The patients who meet the diagnosis standard and are 18-80 years old and willing to receive acupuncture point application treatment.
3. Exclusion criteria.
Patients accompanying the following should be excluded from the subject: (1) allergic constitution and people allergic to various drugs; (2) the patient is not suitable for the acupoint application due to the self reasons (such as skin damage or inflammation at the acupoint part); (3) patients with serious diseases such as cardiovascular and cerebrovascular diseases, gastrointestinal tract, liver, kidney, hematopoietic system and endocrine system; (4) patients with diabetic peripheral neuropathy or limb venous thrombosis; (5) patients with mental illness or other conditions that lead to poor compliance; (6) the study panel did not scale to the number of patients undergoing the study.
4. And (5) removing, dropping and stopping test standards.
Rejection standard: patients who did not follow the study protocol during treatment.
Shedding standard: patients who did not complete the entire course of treatment and follow-up observations.
The abort criterion is: severe adverse reactions or severe complications occur in the implementation process of clinical trials.
5. A grouping situation.
All the cases are patients with yang qi deficiency and vein stasis syndrome, which are diagnosed in traditional Chinese medicine hospitals in 2016 (1) to 2020 (12), and the total number of the cases is 179. Subjects were randomized into treatment and control groups using randomization software. The patients in the treatment group are divided into a treatment group 1, a treatment group 2 and a treatment group 3 according to the sequence of the treatment group 1:1: 1.
Second, therapeutic (test) methods.
1. The acupoint application is carried out.
The acupuncture points are selected from Dazhui acupuncture point, Shenyu acupuncture point, Lung acupuncture point, Gaohuang acupuncture point, Tiantu acupuncture point, Shenque acupuncture point, Guanyuan acupuncture point and Zusanli acupuncture point, wherein calf nose acupuncture point and Xuehai acupuncture point are added for arthralgia patients, Sanyinjiao acupuncture point is added for dysmenorrhea patients, and Zhongwan acupuncture point is added for diarrhea and epigastric pain patients.
After selecting the acupuncture points, taking a certain amount of the fine powder of the traditional Chinese medicine composition and purified water with the temperature of 60-80 ℃, and mixing the following traditional Chinese medicine compositions in percentage by mass: purified water =2 g: 3ml of the mixture is fully and uniformly mixed to prepare medicinal mud; taking a proper amount of medicinal mud, rubbing into medicinal mud balls with the diameter of 1.0-1.5 cm, placing the medicinal mud balls in a plaster, and directly sticking the medicinal mud balls on the selected acupuncture points, wherein one plaster is stuck on each acupuncture point.
2. The Chinese medicinal composition components of different treatment groups and control groups are compared and tested.
The traditional Chinese medicine composition of the treatment group 1 comprises 12 parts of white mustard seed, 12 parts of corydalis tuber, 10 parts of euphorbia kansui, 3 parts of asarum, 6 parts of evodia rutaecarpa, 6 parts of pepper, 6 parts of clove, 12 parts of rhizoma cyperi, 6 parts of pepper, 12 parts of dried ginger, 15 parts of rhizoma typhonii, 12 parts of rhizoma atractylodis, 15 parts of eucommia bark, 15 parts of sharpleaf galangal fruit, 10 parts of angelica, 30 parts of astragalus root, 15 parts of teasel root, 12 parts of cynomorium songaricum, 12 parts of phellodendron bark, 15 parts of radix angelicae pubescentis, 12 parts of loranthus. The acupoint application is carried out for 4-6 h/time, every other day is 1 time, 5 times are 1 treatment course, and 2 treatment courses are total.
The traditional Chinese medicine composition of the treatment group 2 comprises 10 parts of white mustard seed, 12 parts of corydalis tuber, 10 parts of euphorbia kansui, 3 parts of asarum, 6 parts of evodia rutaecarpa, 4 parts of pepper, 6 parts of clove, 12 parts of rhizoma cyperi, 4 parts of pepper, 10 parts of dried ginger, 15 parts of rhizoma typhonii, 12 parts of rhizoma atractylodis, 12 parts of eucommia bark, 15 parts of sharpleaf galangal fruit, 10 parts of angelica, 30 parts of astragalus root, 15 parts of teasel root, 10 parts of cynomorium songaricum, 12 parts of phellodendron bark, 15 parts of radix angelicae pubescentis, 12 parts of loranthus. The acupoint application is carried out for 4-6 h/time, every other day is 1 time, 5 times are 1 treatment course, and 2 treatment courses are total.
The traditional Chinese medicine composition of the treatment group 3 comprises 10 parts of white mustard seed, 12 parts of corydalis tuber, 10 parts of euphorbia kansui, 3 parts of asarum, 6 parts of evodia rutaecarpa, 6 parts of pepper, 6 parts of clove, 12 parts of rhizoma cyperi, 6 parts of pepper, 12 parts of dried ginger, 15 parts of rhizoma typhonii, 12 parts of rhizoma atractylodis, 15 parts of eucommia bark, 15 parts of sharpleaf galangal fruit, 10 parts of angelica, 30 parts of astragalus root, 15 parts of teasel root, 12 parts of cynomorium songaricum, 12 parts of phellodendron bark, 12 parts of radix angelicae pubescentis, 10 parts of loranthus. The acupoint application is carried out for 4-6 h/time, every other day is 1 time, 5 times are 1 treatment course, and 2 treatment courses are total.
The composition in the control group comprises a mixture of food pigment, dextrin and starch, and is applied to acupuncture points for 4-6 h/time, 1 time every other day, and 5 times of the composition are 1 treatment course for 2 treatment courses.
3. The evaluation standard of the curative effect of the syndrome of yang-qi deficiency and vein blood stasis.
The traditional Chinese medicine is formulated according to the traditional Chinese medicine syndrome curative effect standard in the clinical research guiding principle of new traditional Chinese medicines issued by the ministry of health of China.
(1) And (3) healing: the original symptoms completely disappear, and no relapse occurs within 6 months after the treatment is stopped;
(2) the effect is shown: the original symptoms are obviously improved, and only slight numbness, pain or discomfort is left;
(3) the method has the following advantages: the original symptoms are slightly relieved;
(4) and (4) invalidation: the original symptoms are not obviously improved or are aggravated.
And thirdly, testing results.
1. Clinical curative effect
The total effective rate of the treatment group is 84.44% (76 cases/90 cases), the total effective rate of the control group is 5.62% (5 cases/90 cases), the comparison difference of the two groups has statistical significance (P is less than 0.01), namely, the curative effect of the treatment group is obviously better than that of the control group, and detailed results are shown in table 1.
TABLE 1 comparative therapeutic effect of each group (example)
Group of | Number of examples | Recovery method | Show effect | Is effective | Invalidation | High efficiency |
Treatment group 1 | 30 | 4 | 16 | 7 | 3 | 90.00% |
Treatment group 2 | 30 | 2 | 14 | 9 | 5 | 83.33% |
Treatment group 3 | 30 | 6 | 10 | 8 | 6 | 80.00% |
Control group 1 | 89 | 0 | 0 | 5 | 84 | 5.62% |
2. Adverse reaction
No obvious adverse reaction is seen in the control group; in the treatment group, only 2 patients showed local skin redness after 6h of application, and all of the redness resolved within 24 hours after drug withdrawal without other adverse effects.
The above embodiments are only used for illustrating but not limiting the technical solutions of the present invention, and although the above embodiments describe the present invention in detail, those skilled in the art should understand that: modifications and equivalents may be made thereto without departing from the spirit and scope of the invention and any modifications and equivalents may fall within the scope of the claims.
Claims (6)
1. A traditional Chinese medicine composition for acupoint application for yang-qi deficiency and vein stasis syndrome is characterized by comprising the following traditional Chinese medicine components: semen Sinapis Albae, rhizoma corydalis, radix kansui, herba asari, fructus evodiae, fructus Piperis, flos Caryophylli, rhizoma Cyperi, fructus Zanthoxyli, Zingiberis rhizoma, radix Aconiti lateralis Preparata, rhizoma Atractylodis, Eucommiae cortex, fructus Alpinae Oxyphyllae, radix Angelicae sinensis, radix astragali, radix Dipsaci, herba Cynomorii, cortex Phellodendri, radix Angelicae Pubescentis, herba Taxilli, fructus Ligustri Lucidi and Ecliptae herba.
2. The traditional Chinese medicine composition for acupoint application for yang qi deficiency and vein stasis syndrome according to claim 1, which comprises the following traditional Chinese medicine components in parts by weight:
10-14 parts of semen brassicae, 10-14 parts of rhizoma corydalis, 8-12 parts of euphorbia kansui, 1-5 parts of asarum, 4-8 parts of fructus evodiae, 4-8 parts of pepper, 4-8 parts of clove, 10-14 parts of rhizoma cyperi, 4-8 parts of pepper, 10-14 parts of rhizoma zingiberis, 13-17 parts of rhizoma typhonii, 10-14 parts of rhizoma atractylodis, 12-17 parts of eucommia ulmoides, 13-17 parts of fructus alpiniae oxyphyllae, 8-12 parts of angelica sinensis, 25-35 parts of astragalus membranaceus, 13-17 parts of radix dipsaci, 10-14 parts of cynomorium songaricum, 10-14 parts of cortex phellodendri, 13-17 parts of radix angelicae pubescentis, 10-14 parts of parasitic loranthus, 13-.
3. The traditional Chinese medicine composition for acupoint application for yang qi deficiency and vein stasis syndrome according to claim 2, which is prepared by processing the following traditional Chinese medicine components in parts by weight into fine powder and mixing the fine powder:
12 parts of white mustard seed, 12 parts of corydalis tuber, 10 parts of euphorbia kansui, 3 parts of asarum, 6 parts of evodia, 6 parts of pepper, 6 parts of clove, 12 parts of rhizoma cyperi, 6 parts of pepper, 12 parts of dried ginger, 15 parts of rhizoma typhonii, 12 parts of rhizoma atractylodis, 15 parts of eucommia bark, 15 parts of sharpleaf galangal fruit, 10 parts of angelica, 30 parts of astragalus root, 15 parts of teasel root, 12 parts of cynomorium songaricum, 12 parts of phellodendron, 15 parts of radix angelicae pubescentis, 12 parts of loranthus parasiticus, 15 parts of glossy privet fruit.
4. A method for preparing a Chinese medicinal composition as claimed in any one of claims 1 to 3, comprising the steps of:
step S1, taking 15 parts of eucommia ulmoides, 12 parts of rhizoma cyperi, 30 parts of astragalus membranaceus, 15 parts of teasel roots, 12 parts of cynomorium songaricum, 12 parts of golden cypress, 12 parts of parasitic loranthus, 15 parts of glossy privet fruits and 12 parts of eclipta alba, adding water for decoction, filtering after decoction, taking filtrate, concentrating and drying to prepare dry paste;
step S2, grinding the dry paste prepared in step S1 into fine powder, and sieving to remove residues for later use;
step S3, respectively taking 12 parts of white mustard seed, 12 parts of corydalis tuber, 10 parts of euphorbia kansui, 3 parts of asarum, 6 parts of evodia rutaecarpa, 6 parts of pepper, 6 parts of clove, 6 parts of pepper, 12 parts of dried ginger, 15 parts of rhizoma typhonii, 12 parts of rhizoma atractylodis, 15 parts of sharpleaf galangal fruit, 10 parts of angelica and 15 parts of pubescent angelica root, crushing into fine powder, and sieving to remove residues for later use;
and step S4, uniformly mixing the fine powder prepared in the step S2 and the step S3 to obtain the finished product of the fine powder of the traditional Chinese medicine composition.
5. The method of claim 4, wherein in step S1, the decoction is carried out with water in an amount 8 times the total volume of the herbs.
6. The method of claim 4, wherein the water decoction is repeated twice in step S1, each time the water decoction is boiled with strong fire and then decocted with low fire for one hour, and the two decoctions are combined and filtered.
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CN104013605A (en) * | 2014-06-17 | 2014-09-03 | 上海中医药大学附属曙光医院 | Traditional Chinese medicinal patch as well as preparation method and use thereof |
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