CN102784332A

CN102784332A - Medicine for treating angiitis

Info

Publication number: CN102784332A
Application number: CN2012103181207A
Authority: CN
Inventors: 张德昌
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-09-01
Filing date: 2012-09-01
Publication date: 2012-11-21
Anticipated expiration: 2032-09-01
Also published as: CN102784332B

Abstract

The invention relates to a medicine for treating angiitis. The medicine comprises following components: dandelion, bunge corydalis herb, honeysuckle, angelica sinensis, radix scrophulariae, caulis spatholobi, pubescent holly root, codonopsis pilosula, astragalus mongholicus, rhizoma atractylodis macrocephalae, rhizoma dioscoreae, peach kernel, carthamus tinctorius, ligusticum wallichii, earthworm, ground beeltle, centipede, leech, achyranthes bidentata, frankincense, myrrh, pericarpium papaveris, rhizoma corydalis, caramel malt, scorched hawthorn fruit, scorched medicated leaven, radix ophiopogonis, eucommia, semen coicis, poria cocos and liquorice; the medicine is prepared by the following steps: mixing all the medicines according to the parts by weights, adding water to submerge the mixture, decocting and boiling twice, and mixing the two liquid medicines, and then concentrating and parching and processing into medicine powder of 100 meshes, and finally preparing into active pharmaceutical ingredients which can be prepared into any pharmaceutical formulations through a common method, such as troche, pill and capsule. The medicine has functions of eliminating stasis and stopping pain, nourishing liver and kiney, invigorating spleen and replenishing qi, promoting blood circulation of qi, and dredging collaterals; and the total effective rate on treating angiitis reaches 91.5%.

Description

The vasculitic medicine of a kind of treatment

Technical field

The present invention relates to a kind of medicine, the concrete vasculitic medicine of a kind of treatment that relates to the invention still further relates to the method for preparing of this medicine.

Background technology

Vasculitis is for betiding the struvite vascular lesion of chronic progressive external segmental of middle small artery (involving vein and nerve simultaneously); Pathological changes is involved the blood vessel holostrome, causes luminal stenosis, obturation.This disease is mainly invaded limbs; Especially lower limb in, the vein and the skin superficial vein of small artery and companion thereof row; Involved vessels presents the nonsuppurative inflammation of blood vessel wall holostrome, and there have thrombosis, tube chamber to present carrying out property in the tube chamber to be narrow so that entirely shut; Cause limb ischemia and produce pain, the ulcer and the gangrene of healing can take place to be difficult in the severe patient acra.The cause of disease it be unclear that so far.Possibly cause permanent disfunction or limbs to be lost, in addition dead.

At present domestic disease for one type of treatment vasculitis, adopt usually be with injection or oral anti-inflammatory drug thing reaching antiinflammatory, but all be prone to recurrence after treating, and toxic and side effects is big, and complication and sequela are arranged more.

Summary of the invention

The purpose of this invention is to provide a kind of to the treatment vasculitis effective, the medicine that has no side effect.

Medicine of the present invention is to be that crude drug prepares with following parts by weight of traditional Chinese medicines:

Herba Taraxaci 50-80 Herba Corydalis Bungeanaes 50-80 Flos Loniceraes 50-80 Radix Angelicae Sinensis 50-80

Radix Scrophulariae 50-80 Caulis Spatholobis 50-80 Radix Ilicis Pubescentiss 50-80 Radix Codonopsis 10-30

The Radix Astragali 15-30 Rhizoma Atractylodis Macrocephalaes 10-20 Rhizoma Dioscoreaes 10-20 Semen Persicaes 15-20

Flos Carthami 15-30 Rhizoma Chuanxiongs 20-40 Pheretimas 20-30 Eupolyphaga Seu Steleophagas 9-12

Scolopendra 3-5 Hirudos 2-5 Radix Achyranthis Bidentataes 15-20 Olibanum (processed)s 9-15

Myrrha (processed) 9-15 Pericarpium Papaveriss 15-30 Rhizoma Corydalis 15-25 Fructus Hordei Germinatus (parched to brown)s 9-15

Fructus Crataegi (parched to brown) 9-15 Massa Medicata Fermentata (parched to brown) charred Cortex Eucommiae 9-12 9-15 Radix Ophiopogonis 15-20

Semen Coicis 9-15 Poria 9-12 Radix Glycyrrhizaes 15-20.

Further, medicine of the present invention is to be that crude drug prepares with following parts by weight of traditional Chinese medicines:

Herba Taraxaci 60 Herba Corydalis Bungeanaes 65 Flos Loniceraes 60 Radix Angelicae Sinensis 70

Radix Scrophulariae 60 Caulis Spatholobis 65 Radix Ilicis Pubescentiss 65 Radix Codonopsis 15

The Radix Astragali 20 Rhizoma Atractylodis Macrocephalaes 15 Rhizoma Dioscoreaes 15 Semen Persicaes 18

Flos Carthami 16 Rhizoma Chuanxiongs 25 Pheretimas 25 Eupolyphaga Seu Steleophagas 10

Scolopendra 4 Hirudos 4 Radix Achyranthis Bidentataes 18 Olibanum (processed)s 10

Myrrha (processed) 12 Pericarpium Papaveriss 16 Rhizoma Corydalis 20 Fructus Hordei Germinatus (parched to brown)s 12

Fructus Crataegi (parched to brown) 12 Massa Medicata Fermentata (parched to brown) charred Cortex Eucommiae 10 12 Radix Ophiopogonis 18

Semen Coicis 12 Poria 10 Radix Glycyrrhizaes 18.

The method for preparing of medicine of the present invention is following:

(1) the Olibanum stir-fry slightly is yellow to the surface, taking-up cools subsequent use;

(2) it is yellow Myrrha being fried to the surface, and taking-up cools subsequent use;

(3) Cortex Eucommiae is fried to pitchy, take out then,, dry subsequent use with the clear water sprinkle most Mars that goes out;

(4) with said Olibanum (processed), Myrrha (processed) and charred Cortex Eucommiae with add water logging after all the other medicines mix according to said parts by weight and do not have medicine to decoct 1-1.5 hours; Filtration obtains medicinal liquid, adds water logging again and does not have medicine to decoct 40-60 minutes, filters and obtains medicinal liquid; Mix medicinal liquid twice; Concentrate the thick paste that becomes 55 ℃ of relative density 1.25-1.30, the oven dry post-treatment becomes 100 purpose medicated powder, is prepared into medicine activity component.

Can said medicine activity component be processed any pharmaceutical dosage form on the pharmaceutics with conventional method, like tablet, pill, capsule.

The suitable first clearing heat and cooling blood of treatment vasculitis is changed silt, dissipating bind, dampness removing, vein relaxing then, and in the prescription of the present invention, dandelion is clearing heat and detoxicating, dispersing swelling and dissipating binds; Corydlis bungeana is clearing heat and detoxicating, mass dissipating and swelling eliminating; Honeysuckle is clearing heat and detoxicating, dispelling wind and heat from the body; Chinese angelica blood supplementing is invigorated blood circulation, menstruction regulating and pain relieving; The radix scrophulariae clearing heat and cooling blood, replenishing the vital essence and removing heat, purging intense heat and detonicating; Reticulate millettia is enriched blood, and invigorates blood circulation vein relaxing; Ilex pubescens is clearing heat and detoxicating, blood circulation and channel invigorating; Radix Codonopsis invigorating the spleen benefit lung, nourishing blood to promote the production of body fluid; Radix Astragali tonifying Qi and lifting yang, strengthening exterior and reducing sweat, inducing diuresis for removing edema promotes the production of body fluid and nourishes blood, and row stagnates and leads to numbness, pus draining and toxin expelling, expelling pus and promoting granulation; Bighead atractylodes rhizome strengthening the spleen and replenishing qi, eliminating dampness Li Shui; Chinese yam tonifying spleen nourishing the stomach, the beneficial lung that promotes the production of body fluid, the puckery essence of kidney tonifying; The peach kernel promoting blood circulation relaxes bowel; The safflower activating blood to promote menstruation, blood stasis removing analgesic; The Ligusticum wallichii blood-activating and qi-promoting, wind-expelling pain-stopping; Earthworm heat-clearing arresting convulsion, vein relaxing; The ground bettle dissipating blood stasis with potent drugs, reunion of fractured tendons and bones; Centipede breath wind antispastic is removed obstruction in channels to relieve pain dispersing pathogen accumulation; The broken blood of leech stimulates the menstrual flow, by stagnation resolvation disease; The root of bidentate achyranthes stimulates the menstrual flow by the stasis of blood, filling liver kidney, and strengthening the bones and muscles, inducing diuresis for treating strangurtia is ensuringd proper downward flow of the blood; The frankincense analgesic therapy of invigorating blood circulation, detumescence and promoting granulation; The myrrh stasis of blood analgesic therapy of loosing, detumescence and promoting granulation; Pappy shell is astringed the lung, puckery intestines, pain relieving; Corydalis tuber is invigorated blood circulation, promoting the circulation of qi, pain relieving; The melanoidin malt promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite, delaactation dissipate-swelling; Charred FRUCTUS CRATAEGI food digesting stomach fortifying, the promoting the circulation of qi stasis of blood of loosing is changed turbid lipopenicillinase; The stir-baked MASSA FERMENTATA MEDICI-NALIS strengthening the spleen and stomach is aid digestion; The tuber of dwarf lilyturf nourishing Yin and promoting production of body fluid, moistening lung clears away heart-fire; The charred CORTEX EUCOMMIAE filling liver kidney, strengthening the bones and muscles; The coix seed clearing damp and promoting diuresis, invigorating the spleen to arrest diarrhea removes numbness, apocenosis, detoxicating and resolving a mass; The Poria cocos clearing damp and promoting diuresis, invigorating the spleen; Radix Glycyrrhizae is invigorated the spleen and benefited qi, and is clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription; All medicines share, loose stasis of blood analgesic therapy, filling liver kidney, invigorate the spleen and benefit qi, blood-activating and qi-promoting, vein relaxing.

The capsule that uses medicine activity component of the present invention to make has clinically carried out safety and observation of curative effect to the treatment vasculitis:

1, patient's situation

Select 89 routine patients, 30-65 years old ages, 38.5 years old mean age, the course of disease 3 months-5 years.Be divided into treatment group and matched group at random, 47 examples are organized in treatment, male 28 examples, women 19 examples, matched group 42 examples, male 25 examples, women 17 examples.

2, diagnostic criteria:

Formulate according to " diagnosis of common disease and efficacy determination (standard) " diagnostic criteria:

(1) is mainly in the lower limb one or both sides, can receives medical histories such as freezing, moist, long-term volume smoking, wound;

(2) toe cold type of pain originally, shank is tingle to swell and ache, and increases the weight of when walking more, alleviates when having a rest, and the limping of having a rest property of travel time is fallen YANG pulse and is alleviated; Shank can have the shallow table property vein of the. fugitive, and the pain that continues is persistence, and acra skin is sent out cold, and then skin is dark red when sagging, cream is purple, xerosis cutis, and hair comes off, and the toenail distortion thickens; Amyotrophy is fallen YANG pulse and is disappeared, and then dry gangrene takes place, and sharp ache is lain awake all night; Sit with one's arms about one's knees, when festering contamination, moist necrosis occurs, acra red and swollen heat pain, whole body heating;

(3) patient is mainly in 20-40 years old male;

(4) ultrasonic doppler, blood figure, nail fold microcirculation, angiography, X line chest are taken the photograph inspections such as sheet, blood fat, blood glucose.

3, get rid of the case standard

(1) age is below 20 years old, over-65s; Gestation or women breast-feeding their children, allergic constitution is to drug allergy or produce than first mate actor;

(2) be associated with serious primary disease person such as liver, kidney, cardiovascular and hemopoietic system;

(3) local secondary infection is swollen and ache and serious symptom dermatosis the infected;

(4) do not meet the standard of including in or, can't judge not by regulation medication person.

4, Therapeutic Method

The capsule that the oral medicine activity component of the present invention of treatment group patient makes, one day twice, each 3, be one month the course of treatment, matched group injection unfractionated heparin sodium injection 6250-12500U adds normal saline 250ml intravenous drip, once a day.

5, efficacy assessment standard

With reference to " diagnosis of common disease and efficacy determination (standard) "

Cure: clinical symptoms disappears basically, and the limbs wound surface heals fully, and limbs peripheral blood circulatory disturbance and impedance type rheography obviously improve, and walking speed 100-120m/min also can continue the above no uncomfortable person of the about 1500m of walking;

Produce effects: clinical symptoms is obviously improved, limbs wound healing or approaching healing, and limbs peripheral blood circulatory disturbance and impedance type rheography all have improvement, and walking speed 100-120m/min also can continue the above person of the about 500m of walking;

Effectively: clinical symptom relief, the limbs wound surface is near healing or dwindling, and limbs peripheral blood circulatory disturbance and impedance type rheography slightly improve, and walking speed 100-120m/min also can continue the above person of the about 300m of walking;

Invalid: treatment back symptom and sign do not have progressive or the state of an illness continues the person of increasing the weight of.

6, therapeutic effect

Treatment is organized among the 47 routine patients, cures 28 examples, cure rate 59.6%, produce effects 8 examples, obvious effective rate 17%; Effective 4 examples, total effective rate 91.5%, invalid 4 examples, inefficiency 8.5%, treatment is organized among the 42 routine patients; Cure 17 examples, cure rate 36.2%, produce effects 6 examples, obvious effective rate 14.3%; Effective 5 examples, total effective rate 66.7%, invalid 14 examples, inefficiency 33.3%.

The specific embodiment

Embodiment 1

Get Herba Taraxaci 0.5kg; Herba Corydalis Bungeanae 0.8 kg; Flos Lonicerae 0.6 kg; Radix Angelicae Sinensis 0.7 kg; Radix Scrophulariae 0.5 kg; Caulis Spatholobi 0.7 kg; Radix Ilicis Pubescentis 0.7 kg; Radix Codonopsis 0.2 kg; The Radix Astragali 0.3 kg; The Rhizoma Atractylodis Macrocephalae 0.1 kg; Rhizoma Dioscoreae 0.15 kg; Semen Persicae 0.2 kg; Flos Carthami 0.2 kg; Rhizoma Chuanxiong 0.3 kg; Pheretima 0.3 kg; Eupolyphaga Seu Steleophaga 0.1 kg; Scolopendra 0.03 kg; Hirudo 0.05 kg; Radix Achyranthis Bidentatae 0.15kg; Olibanum (processed) 0.1kg; Myrrha (processed) 0.15 kg; Pericarpium Papaveris 0.2 kg; Rhizoma Corydalis 0.25 kg; Fructus Hordei Germinatus (parched to brown) 0.1 kg; Fructus Crataegi (parched to brown) 0.1 kg; Massa Medicata Fermentata (parched to brown) 0.1 kg; Radix Ophiopogonis 0.2 kg; Charred Cortex Eucommiae 0.09 kg; Semen Coicis 0.1 kg; Poria 0.12 kg; Radix Glycyrrhizae 0.2 kg;

Said medicine is added 25 kg decoctings boiled 1-1.5 hours, filter and obtain medicinal liquid, add 20 kg decoctings again and boiled 40-60 minutes; Filtration obtains medicinal liquid; Mix medicinal liquid twice, concentrate the thick paste that becomes 55 ℃ of relative density 1.25-1.30, the oven dry post-treatment becomes 100 purpose medicated powder; Be prepared into medicine activity component, adding starch incapsulates shell and processes capsule.

Embodiment 2

Herba Taraxaci 0.8 kg; Herba Corydalis Bungeanae 1.2 kg; Flos Lonicerae 1.1 kg; Radix Angelicae Sinensis 0.8 kg; Radix Scrophulariae 1.2 kg; Caulis Spatholobi 1.1 kg; Radix Ilicis Pubescentis 0.8 kg; Radix Codonopsis 0.45 kg; The Radix Astragali 0.32 kg; The Rhizoma Atractylodis Macrocephalae 0.2 kg; Rhizoma Dioscoreae 0.3 kg; Semen Persicae 0.25 kg; Flos Carthami 0.45 kg; Rhizoma Chuanxiong 0.35 kg; Pheretima 0.38 kg; Eupolyphaga Seu Steleophaga 0.15 kg; Scolopendra 0.05 kg; Hirudo 0.03 kg; Radix Achyranthis Bidentatae 0.3 kg; Olibanum (processed) 0.15 kg; Myrrha (processed) 0.2 kg; Pericarpium Papaveris 0.35 kg; Rhizoma Corydalis 0.08 kg; Fructus Hordei Germinatus (parched to brown) 0.15 kg; Fructus Crataegi (parched to brown) 0.15 kg; Massa Medicata Fermentata (parched to brown) 0.15 kg; Radix Ophiopogonis 0.3 kg; Charred Cortex Eucommiae 0.16 kg; Semen Coicis 0.15 kg; Poria 0.2 kg; Radix Glycyrrhizae 0.3 kg;

Said medicine is added 37 kg decoctings boiled 1-1.5 hours, filter and obtain medicinal liquid, add 30 kg decoctings again and boiled 40-60 minutes; Filtration obtains medicinal liquid, mixes medicinal liquid twice, concentrates the thick paste that becomes 55 ℃ of relative density 1.25-1.30; The oven dry post-treatment becomes 100 purpose medicated powder; Be prepared into medicine activity component, add starch, dextrin, Icing Sugar and calcium sulfate two water things, compacting in flakes.

Embodiment 3

Herba Taraxaci 1 kg; Herba Corydalis Bungeanae 1.4 kg; Flos Lonicerae 1.6 kg; Radix Angelicae Sinensis 1 kg; Radix Scrophulariae 1.4 kg; Caulis Spatholobi 1.6 kg; Radix Ilicis Pubescentis 1.5 kg; Radix Codonopsis 0.2 kg; The Radix Astragali 0.5 kg; The Rhizoma Atractylodis Macrocephalae 0.4 kg; Rhizoma Dioscoreae 0.3 kg; Semen Persicae 0.35 kg; Flos Carthami 0.3 kg; Rhizoma Chuanxiong 0.8 kg; Pheretima 0.4 kg; Eupolyphaga Seu Steleophaga 0.2 kg; Scolopendra 0.1 kg; Hirudo 0.06 kg; Radix Achyranthis Bidentatae 0.3 kg; Olibanum (processed) 0.2 kg; Myrrha (processed) 0.3 kg; Pericarpium Papaveris 0.5 kg; Rhizoma Corydalis 0.5 kg; Fructus Hordei Germinatus (parched to brown) 0.2 kg; Fructus Crataegi (parched to brown) 0.2 kg; Massa Medicata Fermentata (parched to brown) 0.2 kg; Radix Ophiopogonis 0.2 kg; Charred Cortex Eucommiae 0.18 kg; Semen Coicis 0.3 kg; Poria 0.2 kg; Radix Glycyrrhizae 0.4 kg;

Said medicine is added 50 kg decoctings boiled 1-1.5 hours, filter and obtain medicinal liquid, add 45 kg decoctings again and boiled 40-60 minutes; Filtration obtains medicinal liquid; Mix medicinal liquid twice, concentrate the thick paste that becomes 55 ℃ of relative density 1.25-1.30, the oven dry post-treatment becomes 100 purpose medicated powder; Be prepared into medicine activity component, the Mel that adding can make active component be mixed into ball is processed pill.

Claims

1. treat vasculitic medicine for one kind, it is characterized in that it is that crude drug prepares by the Chinese medicine of following portions by weight:

Semen Coicis 9-15 Poria 9-12 Radix Glycyrrhizaes 15-20.

2. the vasculitic medicine of treatment according to claim 1 is characterized in that by following parts by weight of traditional Chinese medicines being that crude drug prepares:

Semen Coicis 12 Poria 10 Radix Glycyrrhizaes 18.

3. claim 1 or the vasculitic medicine of 2 said treatments, its preparation method is following:

(4) with said Olibanum (processed), Myrrha (processed) and charred Cortex Eucommiae with add water logging after all the other medicines mix according to said parts by weight and do not have medicine to decoct 1-1.5 hours; Filtration obtains medicinal liquid; Add water logging again and do not have medicine to decoct 40-60 minutes, mix medicinal liquid twice, concentrate the thick paste that becomes 55 ℃ of relative density 1.25-1.30; The oven dry post-treatment becomes 100 purpose medicated powder, is prepared into medicine activity component.