CN112603851A - Composition containing ceramide and application of composition in eye cream - Google Patents
Composition containing ceramide and application of composition in eye cream Download PDFInfo
- Publication number
- CN112603851A CN112603851A CN202011432755.0A CN202011432755A CN112603851A CN 112603851 A CN112603851 A CN 112603851A CN 202011432755 A CN202011432755 A CN 202011432755A CN 112603851 A CN112603851 A CN 112603851A
- Authority
- CN
- China
- Prior art keywords
- ceramide
- composition
- parts
- tocopherol
- nitrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 75
- 229940106189 ceramide Drugs 0.000 title claims abstract description 70
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 title claims abstract description 67
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 title claims abstract description 67
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 title claims abstract description 67
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 title claims abstract description 67
- 239000006071 cream Substances 0.000 title claims abstract description 22
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims abstract description 34
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 claims abstract description 30
- 229960003624 creatine Drugs 0.000 claims abstract description 15
- 239000006046 creatine Substances 0.000 claims abstract description 15
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 13
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000002537 cosmetic Substances 0.000 claims abstract description 12
- -1 nitrogen-containing organic acids Chemical class 0.000 claims abstract description 12
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 10
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000002904 solvent Substances 0.000 claims abstract description 8
- 229930003799 tocopherol Natural products 0.000 claims abstract description 8
- 239000011732 tocopherol Substances 0.000 claims abstract description 8
- 235000010384 tocopherol Nutrition 0.000 claims abstract description 8
- 229960001295 tocopherol Drugs 0.000 claims abstract description 8
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 6
- 150000007524 organic acids Chemical class 0.000 claims abstract description 6
- 102000006587 Glutathione peroxidase Human genes 0.000 claims abstract description 3
- 108700016172 Glutathione peroxidases Proteins 0.000 claims abstract description 3
- 102000019197 Superoxide Dismutase Human genes 0.000 claims abstract description 3
- 108010012715 Superoxide dismutase Proteins 0.000 claims abstract description 3
- 150000001783 ceramides Chemical class 0.000 claims abstract description 3
- 235000005985 organic acids Nutrition 0.000 claims abstract description 3
- WGVKWNUPNGFDFJ-DQCZWYHMSA-N β-tocopherol Chemical compound OC1=CC(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C WGVKWNUPNGFDFJ-DQCZWYHMSA-N 0.000 claims description 26
- 229940087168 alpha tocopherol Drugs 0.000 claims description 13
- 229940066595 beta tocopherol Drugs 0.000 claims description 13
- 229960000984 tocofersolan Drugs 0.000 claims description 13
- 239000002076 α-tocopherol Substances 0.000 claims description 13
- 235000004835 α-tocopherol Nutrition 0.000 claims description 13
- 239000011590 β-tocopherol Substances 0.000 claims description 13
- 235000007680 β-tocopherol Nutrition 0.000 claims description 13
- 238000002360 preparation method Methods 0.000 claims description 11
- 238000003756 stirring Methods 0.000 claims description 11
- MIUIRGGKIICMBP-NFOZDHADSA-N [27-oxo-27-[[(2s,3s,4r)-1,3,4-trihydroxyoctadecan-2-yl]amino]heptacosyl] octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)[C@H](O)CCCCCCCCCCCCCC MIUIRGGKIICMBP-NFOZDHADSA-N 0.000 claims description 10
- 235000006708 antioxidants Nutrition 0.000 claims description 10
- 229940048864 ceramide 1 Drugs 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 10
- BBAFBDLICMHBNU-MFZOPHKMSA-N N-(2-hydroxyoctadecanoyl)-4-hydroxysphinganine Chemical compound CCCCCCCCCCCCCCCCC(O)C(=O)N[C@@H](CO)[C@H](O)[C@H](O)CCCCCCCCCCCCCC BBAFBDLICMHBNU-MFZOPHKMSA-N 0.000 claims description 9
- ATGQXSBKTQANOH-UWVGARPKSA-N N-oleoylphytosphingosine Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](CO)NC(=O)CCCCCCC\C=C/CCCCCCCC ATGQXSBKTQANOH-UWVGARPKSA-N 0.000 claims description 7
- 229940044176 ceramide 3 Drugs 0.000 claims description 7
- 239000003995 emulsifying agent Substances 0.000 claims description 6
- 239000004475 Arginine Substances 0.000 claims description 5
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 5
- 239000012752 auxiliary agent Substances 0.000 claims description 5
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 4
- 239000004472 Lysine Substances 0.000 claims description 4
- 239000003974 emollient agent Substances 0.000 claims description 4
- 239000003906 humectant Substances 0.000 claims description 4
- 239000003755 preservative agent Substances 0.000 claims description 4
- 230000002335 preservative effect Effects 0.000 claims description 4
- 239000002562 thickening agent Substances 0.000 claims description 4
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 3
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 3
- 239000002518 antifoaming agent Substances 0.000 claims description 3
- 239000003961 penetration enhancing agent Substances 0.000 claims description 3
- 108090000526 Papain Proteins 0.000 claims description 2
- 239000004365 Protease Substances 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims description 2
- 235000010382 gamma-tocopherol Nutrition 0.000 claims description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 2
- 229940055729 papain Drugs 0.000 claims description 2
- 235000019834 papain Nutrition 0.000 claims description 2
- 239000002478 γ-tocopherol Substances 0.000 claims description 2
- QUEDXNHFTDJVIY-DQCZWYHMSA-N γ-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-DQCZWYHMSA-N 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims 1
- 239000000043 antiallergic agent Substances 0.000 claims 1
- 125000001477 organic nitrogen group Chemical group 0.000 claims 1
- 230000037303 wrinkles Effects 0.000 abstract description 39
- 230000000694 effects Effects 0.000 abstract description 16
- 230000037394 skin elasticity Effects 0.000 abstract description 6
- 241000219173 Carica Species 0.000 abstract 1
- 235000009467 Carica papaya Nutrition 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 150000003573 thiols Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 22
- 238000010438 heat treatment Methods 0.000 description 16
- 210000003491 skin Anatomy 0.000 description 15
- 239000008367 deionised water Substances 0.000 description 11
- 229910021641 deionized water Inorganic materials 0.000 description 11
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical group CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 10
- 230000000052 comparative effect Effects 0.000 description 8
- 238000002156 mixing Methods 0.000 description 8
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical group CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 7
- 235000018936 Vitellaria paradoxa Nutrition 0.000 description 5
- 241001135917 Vitellaria paradoxa Species 0.000 description 5
- 229940075507 glyceryl monostearate Drugs 0.000 description 5
- 229940119170 jojoba wax Drugs 0.000 description 5
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 5
- 229940057910 shea butter Drugs 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 239000010497 wheat germ oil Substances 0.000 description 5
- 229920002385 Sodium hyaluronate Polymers 0.000 description 4
- 229910003460 diamond Inorganic materials 0.000 description 4
- 239000010432 diamond Substances 0.000 description 4
- AMTWCFIAVKBGOD-UHFFFAOYSA-N dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane Chemical compound O=[Si]=O.CO[Si](C)(C)O[Si](C)(C)C AMTWCFIAVKBGOD-UHFFFAOYSA-N 0.000 description 4
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 4
- YPFDHNVEDLHUCE-UHFFFAOYSA-N propane-1,3-diol Chemical compound OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 description 4
- 229940083037 simethicone Drugs 0.000 description 4
- 229940010747 sodium hyaluronate Drugs 0.000 description 4
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 3
- 229920002125 Sokalan® Polymers 0.000 description 3
- 229960001631 carbomer Drugs 0.000 description 3
- 229940082500 cetostearyl alcohol Drugs 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid group Chemical group C(CC(O)(C(=O)O)CC(=O)O)(=O)O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 3
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 2
- APZYKUZPJCQGPP-UHFFFAOYSA-N Tetrahydropiperine Chemical group C=1C=C2OCOC2=CC=1CCCCC(=O)N1CCCCC1 APZYKUZPJCQGPP-UHFFFAOYSA-N 0.000 description 2
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 description 2
- GORMSINSWZJIKL-UHFFFAOYSA-N [3-(2-ethylhexanoyloxy)-2,2-dimethylpropyl] 2-ethylhexanoate Chemical compound CCCCC(CC)C(=O)OCC(C)(C)COC(=O)C(CC)CCCC GORMSINSWZJIKL-UHFFFAOYSA-N 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000007957 coemulsifier Substances 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- SHZIWNPUGXLXDT-UHFFFAOYSA-N ethyl hexanoate Chemical compound CCCCCC(=O)OCC SHZIWNPUGXLXDT-UHFFFAOYSA-N 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 229960003966 nicotinamide Drugs 0.000 description 2
- 235000005152 nicotinamide Nutrition 0.000 description 2
- 239000011570 nicotinamide Substances 0.000 description 2
- 229960005323 phenoxyethanol Drugs 0.000 description 2
- 230000008591 skin barrier function Effects 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- 229940015975 1,2-hexanediol Drugs 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 208000002197 Ehlers-Danlos syndrome Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 108010038807 Oligopeptides Proteins 0.000 description 1
- 102000015636 Oligopeptides Human genes 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 108091092356 cellular DNA Proteins 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 239000013530 defoamer Substances 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 229940008099 dimethicone Drugs 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 210000000744 eyelid Anatomy 0.000 description 1
- 210000001097 facial muscle Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 210000001061 forehead Anatomy 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000013595 glycosylation Effects 0.000 description 1
- 238000006206 glycosylation reaction Methods 0.000 description 1
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- SLCVBVWXLSEKPL-UHFFFAOYSA-N neopentyl glycol Chemical compound OCC(C)(C)CO SLCVBVWXLSEKPL-UHFFFAOYSA-N 0.000 description 1
- 229940117969 neopentyl glycol Drugs 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical group O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 230000036559 skin health Effects 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention belongs to the field of cosmetics, and discloses a composition containing ceramide and application thereof in eye cream. The composition containing ceramide comprises the following components: nitrogen-containing organic acids, ceramides, antioxidants and solvents; the organic acid containing nitrogen is creatine; the antioxidant is at least one of tocopherol, superoxide dismutase, glutathione peroxidase or papaya thiol enzyme. The composition containing ceramide and the eye cream containing the composition have obvious wrinkle removing effect due to the matching use of the nitrogen-containing organic acid, ceramide and antioxidant, and particularly, the skin elasticity can be improved after the eye lines are removed. The composition has a great application prospect in preparing cosmetics with the wrinkle-removing function.
Description
Technical Field
The invention belongs to the field of cosmetics, and particularly relates to a composition containing ceramide and application thereof in eye cream.
Background
With the improvement of living standard of people, people begin to pay attention to skin care, and healthy and good skin is of great help to improve self confidence. After a person enters the age of 25, the skin health begins to decline slowly. With age, the metabolism of the body is gradually slowed down, the replacement time of the cells forming the horny layer in the epidermis is prolonged, and the content of the natural moisturizing factors is reduced. The collagen fibers in the dermis are not regenerated significantly, the hyaluronic acid content is reduced, and therefore, the moisture content of the skin is reduced, the skin becomes dry, and wrinkles begin to appear at certain specific portions of the face, such as the corners of the eyes, the forehead, and the like. In particular, eye marks are liable to occur.
In the prior art, a plurality of cosmetics for removing wrinkles exist, but the effect of removing eye wrinkles is relatively poor.
Therefore, it is highly desirable to provide a cosmetic, such as an eye cream, for removing wrinkles, particularly, for removing eye lines, which has a good effect of removing eye lines.
Disclosure of Invention
The present invention is directed to solving at least one of the problems of the prior art described above. Therefore, the invention provides a composition containing ceramide and application thereof in eye cream, the composition and the eye cream containing the composition have remarkable wrinkle removing effect, and particularly, the skin elasticity can be improved after the wrinkles are removed.
The invention conception of the invention is as follows: activating skin cells with organic acid containing nitrogen (such as creatine, arginine or lysine), and then using the combined action of antioxidant tocopherol and ceramide, thereby effectively removing fine lines of skin, improving skin elasticity, and establishing good skin barrier. Oligopeptide-29 is further introduced into the composition, so that the wrinkle removing effect of the composition can be further improved.
In a first aspect of the invention, a ceramide-containing composition is provided.
Specifically, the composition containing ceramide comprises the following components: nitrogen-containing organic acids, ceramides, antioxidants and solvents.
The nitrogen-containing organic acid is nitrogen-containing organic acid with cell activating function.
Preferably, the organic acid containing nitrogen is at least one of creatine, arginine or lysine. Creatine promotes the synthesis of intracellular proteins and repairs cellular DNA.
Preferably, the ceramide is selected from at least one of ceramide 1, ceramide 3 or ceramide 6.
Further preferably, the ceramide is ceramide 1, ceramide 3 and ceramide 6, and the mass ratio of ceramide 1 to ceramide 6 is 1: (0.8-1.2): (0.8-1.5) in proportion. The ceramide has effects of repairing skin barrier and improving skin resistance to external adverse stimulus.
Preferably, the antioxidant is at least one of tocopherol, superoxide dismutase, glutathione peroxidase or papain.
Preferably, the tocopherol is selected from at least one of alpha-tocopherol, beta-tocopherol or gamma-tocopherol; further preferably, the tocopherol is selected from alpha-tocopherol and/or beta-tocopherol. The alpha-tocopherol and/or beta-tocopherol can be selected to be better matched with other components in the composition, so that the skin elasticity is further improved, and fine wrinkles are reduced.
Preferably, the solvent is selected from water and/or an alcohol. Further preferably, the water is deionized water.
Preferably, the ceramide-containing composition further comprises oligopeptide-29. Oligopeptide-29 can resist glycosylation, and can further improve wrinkle removing effect of the composition.
Preferably, the ceramide-containing composition further comprises an adjuvant.
Preferably, the auxiliary agent comprises at least one of an emulsifier, a co-emulsifier, an emollient, an antifoaming agent, a thickener, a humectant, a preservative, an anti-sensitivity agent, a penetration enhancer or a pH adjuster.
Preferably, the emulsifier is glyceryl monostearate (i.e. a165) or polyethylene glycol.
Preferably, the co-emulsifier is cetostearyl alcohol.
Preferably, the emollient is selected from at least one of jojoba oil, wheat germ oil, shea butter, or neopentylglycol bis (ethylhexanoate).
Preferably, the defoamer is dimethicone (i.e., DC 200).
Preferably, the thickener is xanthan gum or carbomer.
Preferably, the humectant is enzyme-cleaved oligomeric sodium hyaluronate, sodium hyaluronate or 1, 3-propylene glycol.
Preferably, the preservative is benzyl alcohol, 1,2 hexanediol or phenoxyethanol.
Preferably, the anti-sensitivity agent is a lysine polypeptide.
Preferably, the penetration enhancer is tetrahydropiperine.
Preferably, the pH regulator is citric acid or sodium citrate.
Preferably, the ceramide-containing composition further comprises at least one of gold foil, diamond dust, niacinamide, amino acids, or fragrances. The niacinamide acts to brighten the eye.
Preferably, the composition containing ceramide comprises the following components in parts by weight: 0.1-2 parts of organic acid containing nitrogen, 0.1-3 parts of ceramide, 0.05-1 part of antioxidant and 50-70 parts of solvent.
Further preferably, the composition containing ceramide comprises the following components in parts by weight: 0.1-1 part of organic acid containing nitrogen, 0.1-2 parts of ceramide, 0.05-0.3 part of antioxidant and 50-60 parts of solvent.
Preferably, the composition containing ceramide also comprises 20-40 parts of auxiliary agent; further preferably 23 to 35 parts. The content of the preservative in the auxiliary agent accounts for less than 1% of the total mass of the composition. The addition amount of each component in the auxiliary agent meets the requirement of the cosmetic industry standard.
In a second aspect, the present invention provides a method for preparing a ceramide-containing composition.
Specifically, the preparation method of the composition containing ceramide comprises the following steps:
stirring and dissolving the components to prepare the composition containing ceramide.
Further preferably, a method for preparing a ceramide-containing composition comprises the following steps:
(1) heating and mixing emulsifier, auxiliary emulsifier, emollient, antifoaming agent and antioxidant to obtain phase A;
(2) adding thickener, humectant, gold foil and diamond powder into solvent, heating and mixing to obtain phase B, heating phase A into phase B, stirring, and homogenizing to obtain phase C;
(3) heating nitrogen-containing organic acid, ceramide and the rest components in water bath to dissolve, adding phase C, homogenizing, and stirring to obtain the composition containing ceramide.
Preferably, the temperature for heating and mixing in the step (1) and the step (2) is 75-85 ℃; further preferably 75 to 80 ℃.
Preferably, the water bath heating temperature in the step (3) is below 40 ℃; further preferably 30 to 40 ℃.
In a third aspect, the present invention provides an eye cream comprising the above composition.
An eye cream comprises the composition.
The invention also provides an application of the composition in preparing cosmetics.
A cosmetic comprises the above composition.
The cosmetic has wrinkle removing effect.
Compared with the prior art, the invention has the following beneficial effects:
the composition containing the ceramide and the eye cream containing the composition have obvious wrinkle removing effect due to the matched use of the nitrogen-containing organic acid, the ceramide and the antioxidant (tocopherol), and particularly, the skin elasticity can be improved after the eye cream is removed. The composition has a great application prospect in preparing cosmetics with the wrinkle removing function.
Detailed Description
In order to make the technical solutions of the present invention more apparent to those skilled in the art, the following examples are given for illustration. It should be noted that the following examples are not intended to limit the scope of the claimed invention.
The starting materials, reagents or apparatuses used in the following examples are conventionally commercially available or can be obtained by conventionally known methods, unless otherwise specified.
Example 1: preparation of ceramide-containing compositions
The composition containing ceramide comprises the following components in parts by weight: 0.8 part of creatine, 10.5 parts of ceramide, 30.5 parts of ceramide, 0.08 part of alpha-tocopherol, 290.5 parts of oligopeptide and 55 parts of deionized water.
A method for preparing a ceramide-containing composition, comprising the steps of:
mixing creatine, ceramide 1, ceramide 3, alpha-tocopherol and deionized water, heating in water bath at 35 deg.C for dissolving, homogenizing, stirring at 30 r/min to obtain composition containing ceramide.
Example 2: preparation of ceramide-containing compositions
The composition containing ceramide comprises the following components in parts by weight: 1 part of creatine, 10.5 parts of ceramide, 30.5 parts of ceramide, 60.5 parts of ceramide, 0.08 part of beta-tocopherol and 60 parts of deionized water.
A method for preparing a ceramide-containing composition, comprising the steps of:
mixing creatine, ceramide 1, ceramide 3, ceramide 6, beta-tocopherol and deionized water, heating in water bath at 40 deg.C for dissolving, homogenizing, stirring at 30 r/min to obtain composition containing ceramide.
Example 3: preparation of ceramide-containing compositions
The composition containing ceramide comprises the following components in parts by weight: 2 parts of creatine, 10.5 parts of ceramide, 61 parts of ceramide, 0.5 part of alpha-tocopherol, 0.08 part of beta-tocopherol and 70 parts of deionized water.
A method for preparing a ceramide-containing composition, comprising the steps of:
mixing creatine, ceramide 1, ceramide 6, alpha-tocopherol, beta-tocopherol and deionized water, heating in water bath at 30 deg.C for dissolving, homogenizing, stirring at 30 r/min to obtain composition containing ceramide.
Example 4: preparation of ceramide-containing compositions
The composition containing ceramide comprises the following components in parts by weight: 2 parts of creatine, 10.5 parts of ceramide, 61 parts of ceramide, 0.5 part of alpha-tocopherol, 0.08 part of beta-tocopherol, 3 parts of glyceryl monostearate, 1 part of octadecanol, 3 parts of jojoba oil, 3 parts of wheat germ oil, 3 parts of shea butter, 3 parts of neopentyl glycol di (ethyl hexanoate), 1 part of simethicone and 70 parts of deionized water.
A method for preparing a ceramide-containing composition, comprising the steps of:
heating glyceryl monostearate, cetostearyl alcohol, jojoba oil, wheat germ oil, shea butter, neopentyl glycol di (ethyl hexanoate) ester, simethicone, alpha-tocopherol and beta-tocopherol to 85 ℃ for dissolving, and cooling to 80 ℃ to prepare phase A for later use; and mixing the creatine, the ceramide 1 and the ceramide 6 with deionized water, heating in a water bath to dissolve, wherein the heating temperature in the water bath is 36 ℃, adding the phase A, homogenizing, stirring, and stirring at the speed of 30 revolutions per minute to obtain the composition containing the ceramide.
Example 5: preparation of ceramide-containing compositions
The composition containing ceramide comprises the following components in parts by weight: 1 part of arginine, 10.5 parts of ceramide, 30.5 parts of ceramide, 60.5 parts of ceramide, 0.5 part of alpha-tocopherol, 0.08 part of beta-tocopherol, 3 parts of glyceryl monostearate, 1 part of octadecanol, 3 parts of jojoba oil, 3 parts of wheat germ oil, 3 parts of shea butter, 3 parts of neopentyl glycol di (ethyl hexanoate), 1 part of simethicone, 0.35 part of carbomer, 3 parts of nicotinamide, 4.06 parts of sodium hyaluronate, 0.001 part of arginine, 2 parts of gold foil, 0.01 part of diamond powder, 0.02 part of tetrahydropiperine, 1 part of 1, 3-propylene glycol, 0.3 part of phenoxyethanol, and 70 parts of deionized water.
A method for preparing a ceramide-containing composition, comprising the steps of:
(1) heating glyceryl monostearate, cetostearyl alcohol, jojoba oil, wheat germ oil, shea butter, neopentyl glycol di (ethyl hexanoate) ester, simethicone, alpha-tocopherol and beta-tocopherol to 85 ℃ for dissolving, and then cooling to 80 ℃ to obtain phase A;
(2) adding carbomer, nicotinamide, sodium hyaluronate, gold foil and diamond powder into deionized water, heating and mixing to obtain phase B, heating phase A into phase B, stirring, and homogenizing to obtain phase C;
(3) heating creatine, ceramide 1, ceramide 3, ceramide 6 and the rest components in water bath at 35 deg.C, adding phase C, homogenizing, and stirring to obtain the composition containing ceramide.
Comparative example 1
In comparison with example 1, creatine was not added in comparative example 1, and the remaining components and preparation method were the same as in example 1.
Comparative example 2
In comparison with example 2, in comparative example 2, ceramide 1, ceramide 3 and ceramide 6 were not added, and the remaining components and the preparation method were the same as example 2.
Comparative example 3
In comparison with example 3, in comparative example 3, α -tocopherol and β -tocopherol were not added, and the remaining components and the preparation method were the same as in example 3.
Product effectiveness testing
Eye creams were prepared from the ceramide-containing compositions prepared in examples 1 to 5 and comparative examples 1 to 3, respectively (the technique for preparing eye creams from the ceramide-containing compositions is a conventional technique), 24 subjects were randomly divided into 8 groups of 3 persons, each group was tested for wrinkle removal effect with one eye cream (for example, the subject numbered 1,2, 3 was tested for wrinkle removal effect with the eye cream prepared from the composition of example 1), the subjects were 25 to 35 years old, the conditions for wrinkle removal were 25 ℃ at constant temperature and 40 to 60% relative humidity, the apparatus for testing eye wrinkles was the C-Cube multifunctional skin imaging analysis system of PIXIENCE, and the test procedure was: 1. after cleaning the face with warm water, the subject had a rest in a constant temperature and humidity room for 0.5-1h, and then evaluated the skin wrinkle grade and the average value of the test wrinkle depth using the C-Cube multifunctional skin imaging analysis system of PIXIENCE; 2. the eye cream was applied to the lower eyelid and the outer canthus of the subject, followed by slight massage from inside to outside in the direction of the texture of the skin on the eyes, and the skin wrinkle level and the average value of the test wrinkle depth were evaluated after 30 minutes, and the skin wrinkle level and the average value of the test wrinkle depth were measured at the sixth week after 6 weeks of continuous use of the eye cream, once a day, morning and evening, and the results are shown in table 1. Wherein the wrinkle grade is: level 0: no wrinkles, a ruddy complexion and elastic skin; level 1: fine false wrinkles; and 2, stage: fine real wrinkles; and 3, level: slight real wrinkles; 4, level: moderate real wrinkles; and 5, stage: severe true wrinkles; and 6, level: the skin with extremely severe true wrinkles has poor elasticity. Mild wrinkles below grade 2, which are visible as fine and shallow wrinkles during facial muscle activity, and wrinkles which disappear after the activity stops; 3. grade 4 is medium wrinkles, which are already visible when the face is inactive, but disappear when the skin is stretched and stretched on both sides of the wrinkles; grade 5 or above is a severe wrinkle, which does not disappear when the skin is stretched on both sides.
Table 1: wrinkle removing effect
As can be seen from Table 1, the eye creams prepared using the compositions prepared in examples 1 to 5 according to the present invention have significantly better effects on the improvement of eye wrinkles than the eye creams prepared using the compositions prepared in comparative examples 1 to 3. Furthermore, the eye creams prepared using the compositions prepared in examples 1 to 5 of the present invention also have the effect of improving skin elasticity.
Claims (10)
1. A ceramide-containing composition comprising the following components: nitrogen-containing organic acids, ceramides, antioxidants and solvents.
2. The composition of claim 1, wherein the organic nitrogen-containing acid is at least one of creatine, arginine, or lysine.
3. The composition of claim 1, wherein the ceramide is selected from at least one of ceramide 1, ceramide 3, or ceramide 6.
4. The composition of claim 1, wherein the antioxidant is at least one of tocopherol, superoxide dismutase, glutathione peroxidase, or papain; the tocopherol is selected from at least one of alpha-tocopherol, beta-tocopherol or gamma-tocopherol.
5. The composition of claim 1, further comprising oligopeptide-29 and/or adjuvants; the auxiliary agent comprises at least one of an emulsifier, an auxiliary emulsifier, an emollient, a defoaming agent, a thickening agent, a humectant, a preservative, an anti-allergy agent, a penetration enhancer or a pH regulator.
6. The composition according to claim 1, characterized by comprising the following components in parts by weight: 0.1-2 parts of organic acid containing nitrogen, 0.1-3 parts of ceramide, 0.05-1 part of antioxidant and 50-70 parts of solvent.
7. A process for the preparation of a composition according to any one of claims 1 to 6, characterized in that it comprises the following steps:
and stirring and dissolving the components to prepare the composition.
8. An eye cream comprising the composition of any one of claims 1 to 6.
9. A cosmetic comprising the composition according to any one of claims 1 to 6.
10. Use of a composition according to any one of claims 1 to 6 for the preparation of a cosmetic product.
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| CN114652660A (en) * | 2022-05-20 | 2022-06-24 | 广州优理氏生物科技有限公司 | Peptide composition with antiallergic effect and application thereof in preparation of skin care product |
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| CN111686029A (en) * | 2020-07-28 | 2020-09-22 | 广州市柏亚化妆品有限公司 | Anti-aging wrinkle-removing composition |
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| CN114652660A (en) * | 2022-05-20 | 2022-06-24 | 广州优理氏生物科技有限公司 | Peptide composition with antiallergic effect and application thereof in preparation of skin care product |
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