CN112602833A - Feed additive capable of replacing antibiotics - Google Patents
Feed additive capable of replacing antibiotics Download PDFInfo
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- CN112602833A CN112602833A CN202011518576.9A CN202011518576A CN112602833A CN 112602833 A CN112602833 A CN 112602833A CN 202011518576 A CN202011518576 A CN 202011518576A CN 112602833 A CN112602833 A CN 112602833A
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- powder
- feed additive
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- aspergillus niger
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- 239000003674 animal food additive Substances 0.000 title claims abstract description 54
- 239000003242 anti bacterial agent Substances 0.000 title claims abstract description 23
- 229940088710 antibiotic agent Drugs 0.000 title claims abstract description 23
- 239000000843 powder Substances 0.000 claims abstract description 58
- 241000894006 Bacteria Species 0.000 claims abstract description 30
- 241000228245 Aspergillus niger Species 0.000 claims abstract description 29
- 244000025254 Cannabis sativa Species 0.000 claims abstract description 12
- 241000195649 Chlorella <Chlorellales> Species 0.000 claims abstract description 12
- 244000183685 Citrus aurantium Species 0.000 claims abstract description 12
- 235000007716 Citrus aurantium Nutrition 0.000 claims abstract description 12
- 235000005976 Citrus sinensis Nutrition 0.000 claims abstract description 12
- 235000007164 Oryza sativa Nutrition 0.000 claims abstract description 12
- 239000003077 lignite Substances 0.000 claims abstract description 12
- 235000009566 rice Nutrition 0.000 claims abstract description 12
- 244000195896 dadap Species 0.000 claims abstract description 10
- 240000007594 Oryza sativa Species 0.000 claims abstract 4
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 20
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 20
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 20
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims description 10
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 10
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims description 10
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 10
- 239000004472 Lysine Substances 0.000 claims description 10
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims description 10
- JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 claims description 10
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims description 10
- 239000004473 Threonine Substances 0.000 claims description 10
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims description 10
- 229930003427 Vitamin E Natural products 0.000 claims description 10
- 229930003448 Vitamin K Natural products 0.000 claims description 10
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 claims description 10
- 229960002079 calcium pantothenate Drugs 0.000 claims description 10
- 229960000304 folic acid Drugs 0.000 claims description 10
- 235000019152 folic acid Nutrition 0.000 claims description 10
- 239000011724 folic acid Substances 0.000 claims description 10
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 10
- 229960000310 isoleucine Drugs 0.000 claims description 10
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims description 10
- 229930182817 methionine Natural products 0.000 claims description 10
- 229960003512 nicotinic acid Drugs 0.000 claims description 10
- 235000001968 nicotinic acid Nutrition 0.000 claims description 10
- 239000011664 nicotinic acid Substances 0.000 claims description 10
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 claims description 10
- 235000019157 thiamine Nutrition 0.000 claims description 10
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 claims description 10
- 229960003495 thiamine Drugs 0.000 claims description 10
- 239000011721 thiamine Substances 0.000 claims description 10
- 235000019165 vitamin E Nutrition 0.000 claims description 10
- 229940046009 vitamin E Drugs 0.000 claims description 10
- 239000011709 vitamin E Substances 0.000 claims description 10
- 235000019168 vitamin K Nutrition 0.000 claims description 10
- 239000011712 vitamin K Substances 0.000 claims description 10
- 150000003721 vitamin K derivatives Chemical class 0.000 claims description 10
- 229940046010 vitamin k Drugs 0.000 claims description 10
- 235000012239 silicon dioxide Nutrition 0.000 claims description 8
- 241000186018 Bifidobacterium adolescentis Species 0.000 claims description 5
- 241000112528 Ligusticum striatum Species 0.000 claims description 5
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 5
- 241000499912 Trichoderma reesei Species 0.000 claims description 5
- 240000008042 Zea mays Species 0.000 claims description 5
- 229940029982 garlic powder Drugs 0.000 claims description 5
- MFBOGIVSZKQAPD-UHFFFAOYSA-M sodium butyrate Chemical compound [Na+].CCCC([O-])=O MFBOGIVSZKQAPD-UHFFFAOYSA-M 0.000 claims description 5
- 241000903946 Clematidis Species 0.000 claims description 3
- 235000007244 Zea mays Nutrition 0.000 claims description 3
- 229940089639 cornsilk Drugs 0.000 claims description 3
- 239000001231 zea mays silk Substances 0.000 claims description 3
- 241000218158 Clematis Species 0.000 claims description 2
- 241001604597 Pyrestini Species 0.000 claims description 2
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims description 2
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims description 2
- 235000005822 corn Nutrition 0.000 claims description 2
- 241001465754 Metazoa Species 0.000 abstract description 16
- 244000005700 microbiome Species 0.000 abstract description 8
- 208000035240 Disease Resistance Diseases 0.000 abstract description 7
- 244000144972 livestock Species 0.000 abstract description 6
- 229940088594 vitamin Drugs 0.000 abstract description 5
- 229930003231 vitamin Natural products 0.000 abstract description 5
- 235000013343 vitamin Nutrition 0.000 abstract description 5
- 239000011782 vitamin Substances 0.000 abstract description 5
- 150000001413 amino acids Chemical class 0.000 abstract description 3
- 230000008901 benefit Effects 0.000 abstract description 3
- 230000003115 biocidal effect Effects 0.000 abstract description 3
- 230000002401 inhibitory effect Effects 0.000 abstract description 3
- 235000016709 nutrition Nutrition 0.000 abstract description 3
- 244000144977 poultry Species 0.000 abstract description 3
- 239000000126 substance Substances 0.000 abstract description 3
- 150000003722 vitamin derivatives Chemical class 0.000 abstract description 3
- 240000006248 Broussonetia kazinoki Species 0.000 abstract description 2
- 230000003385 bacteriostatic effect Effects 0.000 abstract description 2
- 229940079593 drug Drugs 0.000 abstract description 2
- 239000003814 drug Substances 0.000 abstract description 2
- 235000013399 edible fruits Nutrition 0.000 abstract description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract description 2
- 239000011707 mineral Substances 0.000 abstract description 2
- 230000035764 nutrition Effects 0.000 abstract description 2
- 229930000044 secondary metabolite Natural products 0.000 abstract description 2
- 239000013589 supplement Substances 0.000 abstract description 2
- 239000000306 component Substances 0.000 description 14
- 238000012360 testing method Methods 0.000 description 13
- 241000287828 Gallus gallus Species 0.000 description 11
- 241000209094 Oryza Species 0.000 description 8
- 241000282887 Suidae Species 0.000 description 8
- 230000000694 effects Effects 0.000 description 6
- 235000013330 chicken meat Nutrition 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
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- 238000004519 manufacturing process Methods 0.000 description 4
- 230000000813 microbial effect Effects 0.000 description 4
- 235000019786 weight gain Nutrition 0.000 description 4
- 108060003951 Immunoglobulin Proteins 0.000 description 3
- 235000021050 feed intake Nutrition 0.000 description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 description 3
- 102000018358 immunoglobulin Human genes 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 230000004584 weight gain Effects 0.000 description 3
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 238000002965 ELISA Methods 0.000 description 2
- 108010074328 Interferon-gamma Proteins 0.000 description 2
- 108090000978 Interleukin-4 Proteins 0.000 description 2
- 229940024606 amino acid Drugs 0.000 description 2
- 230000002354 daily effect Effects 0.000 description 2
- -1 enzyme preparations Substances 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 235000008216 herbs Nutrition 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 235000013594 poultry meat Nutrition 0.000 description 2
- 238000009666 routine test Methods 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004388 Interleukin-4 Human genes 0.000 description 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000000507 anthelmentic effect Effects 0.000 description 1
- 229940124339 anthelmintic agent Drugs 0.000 description 1
- 239000000921 anthelmintic agent Substances 0.000 description 1
- 230000002924 anti-infective effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 235000021053 average weight gain Nutrition 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
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- 238000011161 development Methods 0.000 description 1
- 229940079919 digestives enzyme preparation Drugs 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 229940088592 immunologic factor Drugs 0.000 description 1
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- 238000000034 method Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
- A23K10/37—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms from waste material
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
- A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/20—Animal feeding-stuffs from material of animal origin
- A23K10/26—Animal feeding-stuffs from material of animal origin from waste material, e.g. feathers, bones or skin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/24—Compounds of alkaline earth metals, e.g. magnesium
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
- A23V2400/513—Adolescentes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Physiology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Birds (AREA)
- Biomedical Technology (AREA)
- Inorganic Chemistry (AREA)
- Botany (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Fodder In General (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention provides a feed additive capable of replacing antibiotics. According to the technical scheme, aspergillus niger viable bacteria are introduced into the feed additive, and a brand new formula is constructed by taking the aspergillus niger viable bacteria as a core. Specifically, the invention takes shell powder, chlorella dry powder, defatted rice bran, lignite powder and aspergillus niger live bacteria powder as main components, and adds specific amount of amino acid and vitamin, and on the basis, the invention is compounded with natural medicines such as seville orange flower, throat grass, fructus broussonetiae and the like. According to the invention, antibiotic components are abandoned, the aspergillus niger viable bacteria play a role in bacteriostasis, when the aspergillus niger viable bacteria enter the livestock and poultry bodies, the advantages of the flora established by the aspergillus niger viable bacteria can inhibit the growth of other microorganisms, and meanwhile, secondary metabolites of the aspergillus niger viable bacteria contain vitamins and mineral substances, so that nutrition supplement can be provided for animals. In addition, the components such as the papermulberry fruit, the tabasheer, the erythrina bark and the like can play a role in inhibiting prokaryotic microorganisms and can achieve good disease resistance by cooperating with the bacteriostatic action of aspergillus niger viable bacteria.
Description
Technical Field
The invention relates to the technical field of feed additives, in particular to a feed additive capable of replacing antibiotics.
Background
The feed additive is a small amount or trace substance added in the processes of feed production, use and the like, and has small dosage but remarkable effect in feed. The feed additive is an indispensable component in modern feed industry, and has important effects of enhancing feed nutritive value, improving animal production performance, ensuring animal health, saving feed cost and improving quality of livestock and poultry.
Due to the different growth characteristics and nutritional requirements of animals, the feed additive has very various components, and mainly comprises synthetic amino acids, vitamin preparations, trace elements, antibiotics, enzyme preparations, hormones, antioxidants, anthelmintics, mildewcides, colorants and the like. At present, antibiotics play an important role in feed additives and are key components for realizing anti-infection efficacy; however, the wide use of antibiotics in feed can bring about the problem of systemic resistance, and the use amount of antibiotics should be limited in the long term. Therefore, the development of ingredients or formulations with antibiotic substitution function has been a technical problem to be solved in the art.
In recent years, the use of microorganisms and Chinese herbs in feed additives has received much attention. Wherein the microbial feed additive is used for replacing or balancing one or more strains in an animal ecosystem and has an inhibitory effect on exogenous microorganisms. The Chinese herbal medicine feed additive is compounded by natural plants to form a formula with specific efficacy, thereby playing roles of promoting the growth, regulating the immunity and the like on animals. Although microorganisms and herbs are expected to perform these functions macroscopically, there are significant technical difficulties in achieving the desired biological efficacy, particularly at the level of component design. Specifically, the disease resistance of the conventional microbial feed additive to livestock needs to be improved, and the growth promoting effect of the conventional feed additive to animals needs to be improved.
Disclosure of Invention
The invention aims to provide a feed additive capable of replacing antibiotics aiming at the technical defects of the prior art so as to solve the technical problem that the conventional feed additive needs to be added with antibiotics, otherwise, the disease-resistant effect is difficult to realize.
The invention also aims to solve the technical problem that the conventional microbial feed additive has a pending improvement on the disease resistance of livestock.
The invention further solves the technical problem of how to further improve the growth promoting effect of the feed additive on the livestock.
In order to achieve the technical purpose, the invention adopts the following technical scheme:
a feed additive capable of replacing antibiotics comprises the following components in parts by weight: 10-15 parts of shell powder, 4-7 parts of chlorella dry powder, 2-5 parts of defatted rice bran, 1-3 parts of pulverized lignite, 1.5-4.5 parts of aspergillus niger viable bacteria powder, 0.2-0.8 part of calcium pantothenate, 0.6-1.5 parts of lysine, 0.2-0.7 part of methionine, 0.3-1 part of threonine, 0.2-0.5 part of tryptophan, 0.1-0.3 part of isoleucine, 0.2-0.5 part of nicotinic acid, 0.3-0.9 part of thiamine, 30.05-0.1 part of vitamin K, 0.1-0.5 part of folic acid, 0.8-1.3 part of vitamin E, 1.2-2.3 parts of seville orange, 0.5-2 parts of throat grass, 1-1.6 parts of fructus broussonetiae, 0.2-0.4 part of concretio silicea and 0.4-0.8 part of cortex erythrinae.
Preferably, the feed additive also comprises 1.2-2.3 parts by weight of clematis root and 0.3-0.7 part by weight of ligusticum wallichii.
Preferably, the feed additive also comprises 0.3-1.1 parts by weight of active dry yeast, 1-1.2 parts by weight of trichoderma reesei powder and 0.2-0.3 parts by weight of bifidobacterium adolescentis powder.
Preferably, the feed additive also comprises 1-1.5 parts by weight of garlic powder.
Preferably, the feed additive also comprises 0.7-1.2 parts by weight of sodium butyrate and 1-1.8 parts by weight of corn stigma powder.
Preferably, the feed additive consists of the following components in parts by weight: 12 parts of shell powder, 5 parts of chlorella dry powder, 4 parts of defatted rice bran, 2 parts of lignite powder, 3 parts of aspergillus niger viable bacteria powder, 0.5 part of calcium pantothenate, 1 part of lysine, 0.4 part of methionine, 0.6 part of threonine, 0.3 part of tryptophan, 0.2 part of isoleucine, 0.4 part of nicotinic acid, 0.6 part of thiamine, 30.08 parts of vitamin K, 0.3 part of folic acid, 0.9 part of vitamin E, 1.7 parts of seville orange flower, 1.4 parts of throat grass, 1.3 parts of fructus broussonetiae, 0.35 part of concretio silicea bambusae and 0.6 part of erythrina bark.
Preferably, the feed additive consists of the following components in parts by weight: 12 parts of shell powder, 5 parts of chlorella dry powder, 4 parts of defatted rice bran, 2 parts of pulverized lignite, 3 parts of aspergillus niger viable bacteria powder, 0.5 part of calcium pantothenate, 1 part of lysine, 0.4 part of methionine, 0.6 part of threonine, 0.3 part of tryptophan, 0.2 part of isoleucine, 0.4 part of nicotinic acid, 0.6 part of thiamine, 30.08 parts of vitamin K, 0.3 part of folic acid, 0.9 part of vitamin E, 1.7 parts of seville orange flower, 1.4 parts of throat grass, 1.3 parts of fructus broussonetiae, 0.35 part of concretio silicea bambusae, 0.6 part of erythrina bark, 1.8 parts of radix clematidis, 0.5 part of ligusticum wallichii, 0.6 part of active dry yeast, 1.1 part of trichoderma reesei powder, 0.25 part of bifidobacterium adolescentis powder, 1.3 part of garlic powder, 0.9 part of sodium butyrate and 1.4 parts of corn silk powder.
The technical scheme takes the aspergillus niger viable bacteria as a core component, the aspergillus niger viable bacteria can be both a viable bacteria preparation and an enzyme preparation, the disease resistance of animals can be improved, the aspergillus niger viable bacteria can participate in the barrier action of the intestinal tracts of the animals after being taken into the bodies of the animals, the quantity of beneficial microorganisms in the intestinal tracts of the animals is supplemented, the colonization and the growth and the reproduction of pathogenic microorganisms are prevented through a biological competition mechanism, and the microbial ecological balance of the intestinal tracts of the animals is restored and maintained, so that the immunity and the disease resistance of the animals are improved. Meanwhile, the palatability of the feed can be improved, the appetite of animals can be improved, the utilization rate of the feed can be improved, the production performance of the animals can be improved, the production cost can be reduced, and the breeding environment can be improved.
The invention provides a feed additive capable of replacing antibiotics. According to the technical scheme, aspergillus niger viable bacteria are introduced into the feed additive, and a brand new formula is constructed by taking the aspergillus niger viable bacteria as a core. Specifically, the invention takes shell powder, chlorella dry powder, defatted rice bran, lignite powder and aspergillus niger live bacteria powder as main components, and adds specific amount of amino acid and vitamin, and on the basis, the invention is compounded with natural medicines such as seville orange flower, throat grass, fructus broussonetiae and the like, thereby obtaining the complete formula of the invention. According to the invention, antibiotic components are abandoned, the aspergillus niger viable bacteria play a role in bacteriostasis, when the aspergillus niger viable bacteria enter the livestock and poultry bodies, the advantages of the flora established by the aspergillus niger viable bacteria can inhibit the growth of other microorganisms, and meanwhile, secondary metabolites of the aspergillus niger viable bacteria contain vitamins and mineral substances, so that nutrition supplement can be provided for animals. In addition, the components such as the papermulberry fruit, the tabasheer, the erythrina bark and the like can play a role in inhibiting prokaryotic microorganisms and can achieve good disease resistance by cooperating with the bacteriostatic action of aspergillus niger viable bacteria.
Detailed Description
Hereinafter, specific embodiments of the present invention will be described in detail. Well-known structures or functions may not be described in detail in the following embodiments in order to avoid unnecessarily obscuring the details. Approximating language, as used herein in the following examples, may be applied to identify quantitative representations that could permissibly vary in number without resulting in a change in the basic function. Unless defined otherwise, technical and scientific terms used in the following examples have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
Example 1
A feed additive capable of replacing antibiotics is composed of the following components in parts by weight: 10 parts of shell powder, 4 parts of chlorella dry powder, 2 parts of defatted rice bran, 1 part of lignite powder, 1.5 parts of aspergillus niger viable bacteria powder, 0.2 part of calcium pantothenate, 0.6 part of lysine, 0.2 part of methionine, 0.3 part of threonine, 0.2 part of tryptophan, 0.1 part of isoleucine, 0.2 part of nicotinic acid, 0.3 part of thiamine, 30.05 parts of vitamin K, 0.1 part of folic acid, 0.8 part of vitamin E, 1.2 parts of seville orange flower, 0.5 part of throat grass, 1 part of fructus broussonetiae, 0.2 part of tabasheer and 0.4 part of erythrina bark.
Example 2
A feed additive capable of replacing antibiotics is composed of the following components in parts by weight: 15 parts of shell powder, 7 parts of chlorella dry powder, 5 parts of defatted rice bran, 3 parts of lignite powder, 4.5 parts of aspergillus niger viable bacteria powder, 0.8 part of calcium pantothenate, 1.5 parts of lysine, 0.7 part of methionine, 1 part of threonine, 0.5 part of tryptophan, 0.3 part of isoleucine, 0.5 part of nicotinic acid, 0.9 part of thiamine, 30.1 parts of vitamin K, 0.5 part of folic acid, 1.3 parts of vitamin E, 2.3 parts of seville orange flower, 2 parts of throat grass, 1.6 parts of fructus broussonetiae, 0.4 part of tabasheer and 0.4-0.8 part of erythrina bark.
Example 3
A feed additive capable of replacing antibiotics is composed of the following components in parts by weight: 12 parts of shell powder, 5 parts of chlorella dry powder, 4 parts of defatted rice bran, 2 parts of lignite powder, 3 parts of aspergillus niger viable bacteria powder, 0.5 part of calcium pantothenate, 1 part of lysine, 0.4 part of methionine, 0.6 part of threonine, 0.3 part of tryptophan, 0.2 part of isoleucine, 0.4 part of nicotinic acid, 0.6 part of thiamine, 30.08 parts of vitamin K, 0.3 part of folic acid, 0.9 part of vitamin E, 1.7 parts of seville orange flower, 1.4 parts of throat grass, 1.3 parts of fructus broussonetiae, 0.35 part of concretio silicea bambusae and 0.6 part of erythrina bark.
Example 4
A feed additive capable of replacing antibiotics is composed of the following components in parts by weight: 12 parts of shell powder, 5 parts of chlorella dry powder, 4 parts of defatted rice bran, 2 parts of pulverized lignite, 3 parts of aspergillus niger viable bacteria powder, 0.5 part of calcium pantothenate, 1 part of lysine, 0.4 part of methionine, 0.6 part of threonine, 0.3 part of tryptophan, 0.2 part of isoleucine, 0.4 part of nicotinic acid, 0.6 part of thiamine, 30.08 parts of vitamin K, 0.3 part of folic acid, 0.9 part of vitamin E, 1.7 parts of seville orange flower, 1.4 parts of throat grass, 1.3 parts of fructus broussonetiae, 0.35 part of concretio silicea bambusae, 0.6 part of erythrina bark, 1.8 parts of radix clematidis, 0.5 part of ligusticum wallichii, 0.6 part of active dry yeast, 1.1 part of trichoderma reesei powder, 0.25 part of bifidobacterium adolescentis powder, 1.3 part of garlic powder, 0.9 part of sodium butyrate and 1.4 parts of corn silk powder.
Example 5
This example is used to examine the efficacy of the above feed additives.
1. Pig feeding test
The feed additive provided by the invention is used for carrying out experiments in pig farms, and single-factor experiments are adopted. 90 commercial pigs with the weight of about 15kg are selected for the test and randomly divided into 3 groups, 30 pigs in each group, and the proportion of male pigs to female pigs among the groups is the same. The control group was fed with a normal pig feed, the experimental group 1 was fed with a normal pig feed mixed with the feed additive of example 4 (added at 50g/kg), and the experimental group 2 was fed with a feed additive of "pig" manufactured by Liehjian Biotechnology Ltd of Henan province, Yongmu (added at 50 g/kg). The test adopts free food intake and drinking water, the temperature, the humidity and the illumination of the test pigsty are determined according to the routine test field, and the epidemic prevention system is operated according to the routine test field. The feed intake of each group is recorded every day, the state of the test pigs is observed and recorded, diseases are timely treated, and the record is well made. The test results are shown in table 1 below:
TABLE 1 pig feeding test results
| Control group | Experimental group 1 | Experimental group 2 | |
| Daily average feed intake (kg) | 1.14 | 1.20 | 1.17 |
| Daily average weight gain (kg) | 0.51 | 0.97 | 0.75 |
| Material to weight ratio | 2.24 | 1.24 | 1.56 |
| Rate of diarrhea | 13.3％ | 0 | 6.7％ |
The test results show that the feed additive can obviously improve the growth condition of pigs, the weight gain effect is obviously enhanced under the condition of slightly increasing the feed intake, and the feed-weight ratio is obviously lower than that of a blank control and an experimental group 2. In addition, 30 pigs of experimental group 1 did not show symptoms of diarrhea during the trial and were in good overall mental status and mobility.
In addition, the levels of the immune factors of the pigs were investigated before and after the above experiments, respectively. Sterile collection of whole blood by jugular vein, separation of serum, ELISA detection of immunoglobulin IgA and IgE in pig serum of a control group, an experimental group 1 and an experimental group 2, IgG subclass IgG1, IgG2a and IgG2b levels, ELISA detection of cytokine IFN-gamma, IL-4, TNF-alpha and other levels; and comparing and analyzing each detection index of the test group with the control group. The detection result shows that the experimental group 1 can obviously improve the levels of immunoglobulin IgA, IgE, IgG2a and cytokine IFN-gamma in serum and can improve the levels of immunoglobulin IgG2b and cytokine IL-4, so that the feed additive can effectively improve the immune level and has a definite immune enhancement effect.
2. Chicken feeding test
300 broilers with uniform body types and good vitality and weighing about 160g and 12 days old are selected as experimental objects and randomly divided into 3 groups of 100 broilers, and the groups are respectively used as a control group, an experimental group 1 and an experimental group 2. During the experiment, a control group was fed with a common chicken feed, an experimental group 1 was fed with a common chicken feed mixed with the feed additive of example 4 (added at 40g/kg), and an experimental group 2 was fed with a mixed feed additive of "Jizhuangyuan" brand, which is produced by Henan Xumutong Biotech Co., Ltd. The feeding times, feeding amount and feeding time are the same every day, and the growth condition of the broilers after 30 days is shown in table 2, wherein the weight gain ratio (%) (the weight of the tail of the broilers to the initial weight of the broilers)/the initial weight of the broilers is multiplied by 100%.
TABLE 2 Chicken feeding test results
| Control group | Experimental group 1 | Experimental group 2 | |
| Incidence of disease | 12％ | 0 | 5％ |
| Survival rate | 92％ | 100％ | 98％ |
| Rate of body weight gain | 12.85％ | 19.77％ | 16.54％ |
The test data show that the feed additive can obviously promote the weight gain of the broiler chickens, effectively avoid the occurrence of diseases in the test period and fully ensure the survival rate. Compared with the conventional feed additive sold in the market, the feed additive has comprehensive advantages in the aspects of weight increment range, disease resistance effect and the like.
The embodiments of the present invention have been described in detail, but the description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention. Any modification, equivalent replacement, and improvement made within the scope of the application of the present invention should be included in the protection scope of the present invention.
Claims (7)
1. The feed additive capable of replacing antibiotics is characterized by comprising the following components in parts by weight: 10-15 parts of shell powder, 4-7 parts of chlorella dry powder, 2-5 parts of defatted rice bran, 1-3 parts of pulverized lignite, 1.5-4.5 parts of aspergillus niger viable bacteria powder, 0.2-0.8 part of calcium pantothenate, 0.6-1.5 parts of lysine, 0.2-0.7 part of methionine, 0.3-1 part of threonine, 0.2-0.5 part of tryptophan, 0.1-0.3 part of isoleucine, 0.2-0.5 part of nicotinic acid, 0.3-0.9 part of thiamine, 30.05-0.1 part of vitamin K, 0.1-0.5 part of folic acid, 0.8-1.3 part of vitamin E, 1.2-2.3 parts of seville orange, 0.5-2 parts of throat grass, 1-1.6 parts of fructus broussonetiae, 0.2-0.4 part of concretio silicea and 0.4-0.8 part of cortex erythrinae.
2. The feed additive capable of replacing antibiotics according to claim 1, wherein the feed additive further comprises 1.2-2.3 parts by weight of clematis root and 0.3-0.7 part by weight of ligusticum wallichii.
3. The feed additive capable of replacing antibiotics according to claim 1, wherein the feed additive further comprises 0.3-1.1 parts by weight of active dry yeast, 1-1.2 parts by weight of trichoderma reesei powder and 0.2-0.3 parts by weight of bifidobacterium adolescentis powder.
4. The feed additive capable of replacing antibiotics according to claim 1, characterized in that the feed additive further comprises 1-1.5 parts by weight of garlic powder.
5. The feed additive capable of replacing antibiotics according to claim 1, characterized in that the feed additive further comprises 0.7-1.2 parts by weight of sodium butyrate and 1-1.8 parts by weight of corn stigma powder.
6. The feed additive capable of replacing antibiotics according to claim 1, is characterized by comprising the following components in parts by weight: 12 parts of shell powder, 5 parts of chlorella dry powder, 4 parts of defatted rice bran, 2 parts of lignite powder, 3 parts of aspergillus niger viable bacteria powder, 0.5 part of calcium pantothenate, 1 part of lysine, 0.4 part of methionine, 0.6 part of threonine, 0.3 part of tryptophan, 0.2 part of isoleucine, 0.4 part of nicotinic acid, 0.6 part of thiamine, 30.08 parts of vitamin K, 0.3 part of folic acid, 0.9 part of vitamin E, 1.7 parts of seville orange flower, 1.4 parts of throat grass, 1.3 parts of fructus broussonetiae, 0.35 part of concretio silicea bambusae and 0.6 part of erythrina bark.
7. The feed additive capable of replacing antibiotics according to claim 1, is characterized by comprising the following components in parts by weight: 12 parts of shell powder, 5 parts of chlorella dry powder, 4 parts of defatted rice bran, 2 parts of pulverized lignite, 3 parts of aspergillus niger viable bacteria powder, 0.5 part of calcium pantothenate, 1 part of lysine, 0.4 part of methionine, 0.6 part of threonine, 0.3 part of tryptophan, 0.2 part of isoleucine, 0.4 part of nicotinic acid, 0.6 part of thiamine, 30.08 parts of vitamin K, 0.3 part of folic acid, 0.9 part of vitamin E, 1.7 parts of seville orange flower, 1.4 parts of throat grass, 1.3 parts of fructus broussonetiae, 0.35 part of concretio silicea bambusae, 0.6 part of erythrina bark, 1.8 parts of radix clematidis, 0.5 part of ligusticum wallichii, 0.6 part of active dry yeast, 1.1 part of trichoderma reesei powder, 0.25 part of bifidobacterium adolescentis powder, 1.3 part of garlic powder, 0.9 part of sodium butyrate and 1.4 parts of corn silk powder.
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