CN112587616A - Oil for lithospermum and preparation method thereof - Google Patents

Oil for lithospermum and preparation method thereof Download PDF

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CN112587616A
CN112587616A CN202011468819.2A CN202011468819A CN112587616A CN 112587616 A CN112587616 A CN 112587616A CN 202011468819 A CN202011468819 A CN 202011468819A CN 112587616 A CN112587616 A CN 112587616A
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lithospermum
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耿晓波
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/74Rubiaceae (Madder family)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
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    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Abstract

The invention relates to oil for lithospermum and a preparation method thereof, belonging to the field of medicines. Mixing radix Arnebiae, radix Angelicae sinensis, caulis Lonicerae, Borneolum Syntheticum, radix Angelicae Dahuricae, radix Rubiae, rhizoma Bletillae and oleum Sesami, soaking for 20-30h, decocting with slow fire for 3.5-6h, controlling the oil temperature to be less than 215 deg.C, stirring continuously during decocting, cooling, and filtering to obtain radix Arnebiae oil. The method is simple, the prepared lithospermum body oil has no side effect and low cost, and has the effects of stopping bleeding and relieving pain, relieving itching and promoting tissue regeneration, diminishing inflammation and diminishing swelling, promoting blood circulation and removing blood stasis, promoting wound healing, preventing scars and the like.

Description

Oil for lithospermum and preparation method thereof
Technical Field
The invention relates to the field of medicines, and particularly relates to lithospermum oil and a preparation method thereof.
Background
Burn and scald generally refers to heat, including tissue damage caused by hot liquid (water, soup, oil, etc.), steam, high-temperature gas, flame, hot metal liquid or solid (such as molten steel, steel ingot), etc., mainly refers to skin and/or mucous membrane, serious people can also injure subcutaneous or/and submucosal tissue, such as muscle, bone, joint and even viscera, and scald is tissue damage caused by hot liquid, steam, etc.; canker sore is commonly called canker sore, is a common ulcerative injury disease occurring in oral mucosa and is mostly seen in the inner side of lips, tongue abdomen, buccal mucosa, vestibular sulcus, soft palate and other parts; otitis media is an inflammatory condition involving all or part of the structure of the middle ear (including the eustachian tube, tympanic cavity, tympanic sinus and mastoid cavity).
In the existing treatment, burn, scald, oral ulcer, otitis media, body itch, herpes, chilblain, rubella, traumatic infection and the like are singly used aiming at diseases, some medicines have not ideal medicinal effect and large side effect, and none of the medicines can simultaneously treat the oral ulcer, the otitis media, the burn, the scald, the body itch, the herpes, the chilblain, the rubella, the traumatic infection and the like.
Disclosure of Invention
The invention aims to provide the lithospermum oil which has good treatment effects on oral ulcer, herpes, chilblain, rubella, body itch, burn, scald, traumatic infection and other people, and has the functions of stopping bleeding, relieving pain, relieving itching, promoting granulation, diminishing inflammation, diminishing swelling, promoting blood circulation, dissipating blood stasis, promoting wound healing, preventing scars and the like.
The invention also aims to provide a preparation method of the oil for lithospermum, which is simple, has no side effect, is low in cost, and has the functions of stopping bleeding and relieving pain, relieving itching and promoting tissue regeneration, diminishing inflammation and swelling, promoting blood circulation and removing blood stasis, promoting wound healing, preventing scars and the like.
The technical problem to be solved by the invention is realized by adopting the following technical scheme.
The invention provides oil for lithospermum erythrorhizon bodies, which consists of the following components in parts by weight: 600 parts of lithospermum 200-containing materials, 50-150 parts of angelica sinensis, 300 parts of honeysuckle stem 100-containing materials, 50-150 parts of borneol, 50-150 parts of angelica dahurica, 50-150 parts of madder, 50-150 parts of bletilla striata and 1650-containing sesame oil 5250 parts of lithospermum, angelica sinensis, honeysuckle stem, borneol, angelica dahurica, madder, bletilla striata and sesame oil in a mass ratio of 4:1:2:1:1:1:1: 33-35.
The invention provides a preparation method of lithospermum oil, which comprises the following steps:
mixing radix Arnebiae, radix Angelicae sinensis, caulis Lonicerae, Borneolum Syntheticum, radix Angelicae Dahuricae, radix Rubiae, rhizoma Bletillae and oleum Sesami, and soaking for 20-30 hr;
decocting with slow fire for 3.5-6h, controlling the oil temperature to be less than 215 deg.C, stirring continuously during decocting, cooling, and filtering to obtain radix Arnebiae oil.
The lithospermum oil and the preparation method thereof provided by the invention have the beneficial effects that: the lithospermum oil for the body has good drug effect by the coordinated compatibility of lithospermum, angelica, honeysuckle stem, borneol, angelica dahurica, madder and bletilla striata, then is refined by sesame oil and is combined with active substances of all formulas, so that the prepared lithospermum oil for the body has good curative effect, can stop bleeding and relieve pain, relieve itching and promote tissue regeneration, diminish inflammation and detumescence, promote blood circulation and remove blood stasis, promote wound healing, prevent scars and the like, has good treatment effect on oral ulcer, herpes, chilblain, rubella, body itch, burn, trauma infection and other crowds, and has no side effect. The preparation method is simple, adopts soaking and decocting processes, retains the effective substances of the components as far as possible, and extracts the effective substances into the sesame oil, so that the prepared lithospermum has better effect.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
The oil for lithospermum erythrorhizon and the preparation method thereof according to the embodiment of the present invention will be specifically described below.
The lithospermum oil provided by the embodiment of the invention consists of the following components in parts by weight: 600 parts of lithospermum 200-containing materials, 50-150 parts of angelica sinensis, 300 parts of honeysuckle stem 100-containing materials, 50-150 parts of borneol, 50-150 parts of angelica dahurica, 50-150 parts of madder, 50-150 parts of bletilla striata and 1650-containing sesame oil 5250 parts of lithospermum, angelica sinensis, honeysuckle stem, borneol, angelica dahurica, madder, bletilla striata and sesame oil in a mass ratio of 4:1:2:1:1:1:1: 33-35.
The lithospermum oil for the body has good drug effect by the coordinated compatibility of lithospermum, angelica, honeysuckle stem, borneol, angelica dahurica, madder and bletilla striata, then is refined by sesame oil and is combined with active substances of all formulas, so that the prepared lithospermum oil for the body has good curative effect, can stop bleeding and relieve pain, relieve itching and promote tissue regeneration, diminish inflammation and detumescence, promote blood circulation and remove blood stasis, promote wound healing, prevent scars and the like, has good treatment effect on oral ulcer, herpes, chilblain, rubella, body itch, burn, trauma infection and other crowds, and has no side effect.
Wherein, the lithospermum has sweet and cold nature, and has the functions of cooling blood, invigorating blood circulation, detoxifying, promoting eruption, tonifying middle-jiao and Qi and benefiting nine orifices, and the lithospermum enters heart and liver channels. The radix Arnebiae has inhibitory effect on Staphylococcus aureus, Escherichia coli, Bacillus typhi, Bacillus dysenteriae, Pseudomonas aeruginosa, and certain dermatophytes and influenza virus. The lithospermum added in the invention can be used for treating exuberant blood heat and toxin, purple black macula, measles without adequate eruption, pyocutaneous disease, eczema and scald caused by water and fire, is matched with angelica and angelica dahurica, has sweet and cold properties for clearing heat and toxin, can clear heat and cool blood due to salt cold, can activate blood and reduce swelling, and has better effects on pyocutaneous disease, eczema, scald caused by water and fire and the like.
Dang Gui is bitter in taste and warm in nature, enters lung and Pi meridians, and its root can be used as a herb, one of the most commonly used Chinese herbs. Has the effects of invigorating qi, regulating menstruation, promoting blood circulation, relieving pain, moistening dryness, and smoothing intestine, and has good therapeutic effects on carbuncle, cellulitis, pyocutaneous disease, traumatic injury, bugantia, etc. The chilblain is a common cold-related skin disease and is better at the ear, nose, fingers, instep, heel, toe back and the like with poor blood circulation, and the chilblain is mostly caused by cold invasion, unsmooth qi and blood circulation and skin stagnation in traditional Chinese medicine, so that the treatment by adopting the angelica sinensis can warm channel and dispel cold, promote blood circulation and remove blood stasis, relieve swelling and pain, and has better effect on treating the chilblain.
The honeysuckle stem is sweet in taste and cold in nature, enters heart and lung channels, has the effects of clearing heat, detoxifying and dredging collaterals, and can be used for treating warm disease fever, heat-toxin bloody dysentery, infectious hepatitis, carbuncle swelling and sore toxin, arthralgia and myalgia and other diseases. The traditional Chinese medicine composition is matched with angelica, angelica dahurica and borneol, has the effects of clearing away heat and toxic materials, cooling blood and dredging collaterals, clearing away blood heat, removing blood toxin, expelling toxin and expelling surficial evils, detoxifying and inducing resuscitation, and reducing swelling and expelling pus, and has a better treatment effect on otitis media.
Borneol is bitter in taste and cold in nature, enters spleen and lung channels, has faint scent and dispersion, has the effects of inducing resuscitation, refreshing, clearing heat, removing toxicity, improving eyesight and removing nebula, and is mainly used for treating obstruction, orifice clearing, throat obstruction, deafness, aphtha, swollen teeth, sore, carbuncle, malnutrition, hemorrhoid and the like. The borneol is compatible with sesame oil, has the functions of clearing away heat and toxic material, preventing corrosion and promoting tissue regeneration, has better efficacy on sore and ulcer gall, unhealing after ulceration and canker sore, and has better efficacy on acute and chronic suppurative otitis media.
The angelica dahurica is pungent in flavor and warm in nature, enters lung, spleen and stomach meridians, and has the effects of dispelling wind, eliminating dampness, reducing swelling and relieving pain. It can be used for treating headache, supercilium pain, odontalgia, nasosinusitis, cold-dampness, abdominal pain, intestinal wind, hemorrhoid, leucorrhea with red and white discharge, carbuncle, skin ulcer, pruritus, scabies, and tinea.
Rubia cordifolia is bitter in taste and cold in nature, enters liver channel, and has effects of cooling blood, stopping bleeding, promoting blood circulation and removing blood stasis. It is mainly used for treating hemoptysis due to blood heat, hematemesis, epistaxis, hematuria, hematochezia, metrorrhagia, amenorrhea, puerperal stagnation and abdominal pain, traumatic injury, rheumatalgia, jaundice, skin sore, carbuncle, hemorrhoid, etc. It is combined with Dang Gui to activate blood and dredge collaterals.
Bletilla striata is bitter in taste and cold in nature, enters liver and lung channels, has the effects of tonifying lung, stopping bleeding, diminishing swelling, promoting tissue regeneration and healing sores, has various carbuncle swellings, ulcer pain, burns and scalds and hand and foot rhagadia, and has good effects when being used.
Sesame oil is also called sesame oil and sesame oil, has sweet and cool nature, enters the yangming channel of hand, and has the effects of moistening dryness, relaxing bowels, detoxifying, promoting granulation, clearing heat and cooling blood and the like. Can be used for treating constipation due to intestinal dryness, ascariasis, abdominal pain due to dyspepsia, sore, ulcer, scabies, tinea, and chapped skin.
The lithospermum, the angelica, the bletilla striata, the borneol, the honeysuckle stem and the sesame oil are compatible, and have the effects of cooling blood, promoting eruption, clearing heat, relieving pain, stopping bleeding, promoting granulation, activating blood and promoting wound healing.
The lithospermum, the madder, the angelica, the bletilla striata, the angelica dahurica, the honeysuckle stem and the sesame oil are compatible, and have the effects of stopping bleeding, clearing away heat and toxic materials, promoting blood circulation and relieving pain.
The lithospermum, the borneol, the angelica dahurica, the honeysuckle stem and the sesame oil are compatible, and have the effects of relieving swelling and pain, activating blood, removing stasis and promoting tissue regeneration, promoting granulation and promoting wound healing.
The mass ratio of the lithospermum to the Chinese angelica to the honeysuckle stem to the borneol to the angelica dahurica to the madder to the bletilla striata to the sesame oil is 4:1:2:1:1:1:1: 33-35, and the lithospermum to the Chinese angelica to the honeysuckle stem to the borneol to the dahurian angelica to the madder to the bletilla striata to the sesame oil can be coordinated and matched to achieve a better effect.
Further, the lithospermum oil consists of the following components in parts by weight: 320 portions of gromwell, 80 to 130 portions of angelica, 260 portions of honeysuckle stem, 80 to 130 portions of borneol, 80 to 130 portions of angelica dahurica, 80 to 130 portions of madder, 80 to 130 portions of bletilla striata and 2640 portions of balsam and 4550 portions.
Furthermore, the lithospermum body oil consists of the following components in parts by weight: 400 parts of lithospermum 340-.
More specifically, the lithospermum body oil consists of the following components in parts by weight: 360 parts of lithospermum, 90 parts of angelica, 180 parts of honeysuckle stem, 90 parts of borneol, 90 parts of angelica dahurica, 90 parts of madder, 90 parts of bletilla striata and 3000 parts of sesame oil.
A method for preparing oil for radix Arnebiae comprises the following steps:
mixing radix Arnebiae, radix Angelicae sinensis, caulis Lonicerae, Borneolum Syntheticum, radix Angelicae Dahuricae, radix Rubiae, rhizoma Bletillae and oleum Sesami, and soaking for 20-30 hr; the sesame oil is soaked in the lithospermum, the angelica, the honeysuckle stem, the borneol, the angelica dahurica, the madder and the bletilla striata, and during decoction, effective components in the lithospermum, the angelica, the honeysuckle stem, the borneol, the angelica dahurica, the madder and the bletilla striata can be quickly soaked in the sesame oil, so that the extraction effect of the effective components is improved.
Further, the lithospermum, the angelica, the honeysuckle stem, the borneol, the angelica dahurica, the madder, the bletilla striata and the sesame oil are mixed and soaked for 24 hours, and the extraction effect is good.
Decocting with slow fire for 3.5-6h, controlling the oil temperature to be less than 215 deg.C, stirring continuously during decocting, cooling, and filtering to obtain radix Arnebiae oil.
Wherein, the decoction time is not too long, the effective components in the lithospermum, the angelica, the honeysuckle stem, the borneol, the angelica dahurica, the madder and the bletilla striata can be damaged if the decoction time is too long, the effective components in the lithospermum, the angelica, the honeysuckle stem, the borneol, the angelica dahurica, the madder and the bletilla striata can not be too short, the effective components in the lithospermum, the angelica, the honeysuckle stem, the borneol, the angelica dahurica, the madder and the bletilla striata can be insufficiently extracted, and the drug effect can be influenced, so the decoction time in.
Wherein, the oil temperature is controlled to be less than 215 ℃, 215 ℃ is the boiling point of the sesame oil, and the sesame oil is kept not to be boiled during the boiling process. The oil temperature is not too high, which can destroy the effective components, and not too low, which can not extract the effective components sufficiently, so the oil temperature is controlled to be 110-150 ℃ in the invention.
Wherein, the purpose of stirring continuously during the decoction period is to heat the whole formula evenly and avoid the medicinal materials from being burnt.
The lithospermum oil and the preparation method thereof provided by the invention have the beneficial effects that: the lithospermum oil for the body has good drug effect by the coordinated compatibility of lithospermum, angelica, honeysuckle stem, borneol, angelica dahurica, madder and bletilla striata, then is refined by sesame oil and is combined with active substances of all formulas, so that the prepared lithospermum oil for the body has good curative effect, can stop bleeding and relieve pain, relieve itching and promote tissue regeneration, diminish inflammation and detumescence, promote blood circulation and remove blood stasis, promote wound healing, prevent scars and the like, has good treatment effect on oral ulcer, herpes, chilblain, rubella, body itch, burn, trauma infection and other crowds, and has no side effect. The preparation method is simple, adopts soaking and decocting processes, retains the effective substances of the components as far as possible, and extracts the effective substances into the sesame oil, so that the prepared lithospermum has better effect.
The features and properties of the present invention are described in further detail below with reference to examples.
Example 1
A method for preparing oil for radix Arnebiae comprises the following steps:
200 parts by weight of lithospermum erythrorhizon, 50 parts by weight of angelica sinensis, 100 parts by weight of honeysuckle stem, 50 parts by weight of borneol, 50 parts by weight of angelica dahurica, 50 parts by weight of madder, 50 parts by weight of bletilla striata and 1650 parts by weight of sesame oil are mixed and soaked for 20 hours, and the mass ratio of the lithospermum erythrorhizon, the angelica sinensis, the honeysuckle stem, the borneol, the angelica dahurica, the madder, the bletilla striata and the sesame oil is 4:1:2:1:1:1:1:33.
Decocting with slow fire for 3.5h, controlling the oil temperature at 110 deg.C, stirring continuously during decocting, cooling, and filtering to obtain radix Arnebiae oil.
Example 2
A method for preparing oil for radix Arnebiae comprises the following steps:
mixing 320 parts by weight of lithospermum erythrorhizon, 80 parts by weight of angelica sinensis, 160 parts by weight of honeysuckle stem, 80 parts by weight of borneol, 80 parts by weight of angelica dahurica, 80 parts by weight of madder, 80 parts by weight of bletilla striata and 2640 parts by weight of sesame oil, and soaking for 23 hours, wherein the mass ratio of the lithospermum erythrorhizon, the angelica sinensis, the honeysuckle stem, the borneol, the angelica dahurica, the madder, the bletilla striata and the sesame oil is 4:1:2:1:1:1:1:33.
Decocting with slow fire for 3.8h, controlling the oil temperature at 120 deg.C, stirring continuously during decocting, cooling, and filtering to obtain radix Arnebiae oil.
Example 3
A method for preparing oil for radix Arnebiae comprises the following steps:
340 parts of lithospermum erythrorhizon, 85 parts of angelica sinensis, 170 parts of honeysuckle stem, 85 parts of borneol, 85 parts of angelica dahurica, 85 parts of madder, 85 parts of bletilla striata and 2805 parts of sesame oil are mixed and soaked for 26 hours, and the mass ratio of the lithospermum erythrorhizon, the angelica sinensis, the honeysuckle stem, the borneol, the angelica dahurica, the madder, the bletilla striata and the sesame oil is 4:1:2:1:1:1: 33.
Decocting with slow fire for 4 hr, controlling oil temperature at 120 deg.C, stirring, cooling, and filtering to obtain oil for radix Arnebiae.
Example 4
A method for preparing oil for radix Arnebiae comprises the following steps:
mixing 400 parts by weight of lithospermum erythrorhizon, 100 parts by weight of angelica sinensis, 200 parts by weight of honeysuckle stem, 100 parts by weight of borneol, 100 parts by weight of angelica dahurica, 100 parts by weight of madder, 100 parts by weight of bletilla striata and 3500 parts by weight of sesame oil, and soaking for 28 hours, wherein the mass ratio of the lithospermum erythrorhizon, the angelica sinensis, the honeysuckle stem, the borneol, the angelica dahurica, the madder, the bletilla striata and the sesame oil is 4:1:2:1:1:1:1: 35.
Decocting with slow fire for 5h, controlling the oil temperature at 130 deg.C, stirring continuously during decocting, cooling, and filtering to obtain radix Arnebiae oil.
Example 5
A method for preparing oil for radix Arnebiae comprises the following steps:
mixing 520 parts by weight of lithospermum erythrorhizon, 130 parts by weight of angelica sinensis, 260 parts by weight of honeysuckle stem, 130 parts by weight of borneol, 130 parts by weight of angelica dahurica, 130 parts by weight of madder, 130 parts by weight of bletilla striata and 4550 parts by weight of sesame oil, and then soaking for 30 hours, wherein the mass ratio of the lithospermum erythrorhizon, the angelica sinensis, the honeysuckle stem, the borneol, the angelica dahurica, the madder, the bletilla striata and the sesame oil is 4:1:2:1:1:1:1: 35.
Decocting with slow fire for 6h, controlling the oil temperature at 140 deg.C, stirring continuously during decocting, cooling, and filtering to obtain radix Arnebiae oil.
Example 6
A method for preparing oil for radix Arnebiae comprises the following steps:
mixing 600 parts by weight of lithospermum erythrorhizon, 150 parts by weight of angelica sinensis, 300 parts by weight of honeysuckle stem, 150 parts by weight of borneol, 150 parts by weight of angelica dahurica, 150 parts by weight of madder, 150 parts by weight of bletilla striata and 5250 parts by weight of sesame oil, and then soaking for 24 hours, wherein the mass ratio of the lithospermum erythrorhizon, the angelica sinensis, the honeysuckle stem, the borneol, the angelica dahurica, the madder, the bletilla striata and the sesame oil is 4:1:2:1:1:1:1: 35.
Decocting with slow fire for 6h, controlling the oil temperature at 150 deg.C, stirring continuously during decocting, cooling, and filtering to obtain radix Arnebiae oil.
Example 7
A method for preparing oil for radix Arnebiae comprises the following steps:
mixing 360 parts by weight of lithospermum erythrorhizon, 90 parts by weight of angelica sinensis, 180 parts by weight of honeysuckle stem, 90 parts by weight of borneol, 90 parts by weight of angelica dahurica, 90 parts by weight of madder, 90 parts by weight of bletilla striata and 3000 parts by weight of sesame oil, and soaking for 24 hours, wherein the mass ratio of the lithospermum erythrorhizon, the angelica sinensis, the honeysuckle stem, the borneol, the angelica dahurica, the madder, the bletilla striata and the sesame oil is 4:1:2:1:1:1:1: 33.3.
Decocting with slow fire for 4 hr, controlling oil temperature at 120 deg.C, stirring, cooling, and filtering to obtain oil for radix Arnebiae.
Test protocol
1. Case selection: selecting 30 patients with little difference of burn and scald degrees, with no limit of age and sex.
The treatment scheme comprises the following steps: the arnebia oil prepared in example 1 was applied once in the morning, at noon and at night, shaken up and then applied to the skin for a retention time of 45 minutes or more.
Observe and record: the state of illness is observed after being smeared for 28 days, and the treatment effect of the lithospermum physical oil is evaluated according to four grades of recovery, remarkable effect, effectiveness, ineffectiveness and deterioration.
Clinical evaluation criteria: and (3) healing: the wound at the burn and scald position is healed after being smeared for 28 days.
The effect is remarkable: the wound condition of the burn and scald part is obviously improved after the plaster is applied for 28 days.
The method has the following advantages: after the plaster is applied for 28 days, the wound condition of the burn and scald part is improved to a certain extent, and subsequent application is required.
And (4) invalidation: the symptoms of the wound at the burn and scald part are not obviously changed after the plaster is applied for 28 days.
Deterioration: other adverse reactions appear after the oil for lithospermum is smeared.
And (3) test results: as shown in table 1:
TABLE 1
Figure BDA0002835449140000111
As can be seen from the table, the lithospermum oil has obvious effect on treating burns and scalds, the effective rate is 100 percent, and no adverse reaction exists.
2. Case selection: 20 patients with oral ulcer were selected, with no restriction on age and no restriction on sex.
The treatment scheme comprises the following steps: the arnebia oil prepared in example 7 was applied once in the morning, at noon and at night, and then shaken up to be applied to the affected area of oral ulcer of a patient and kept for 45 minutes or more.
Observe and record: the state of illness is observed after being smeared for 5 days, and the treatment effect of the lithospermum physical oil is evaluated according to four grades of recovery, remarkable effect, effectiveness, ineffectiveness and deterioration.
Clinical evaluation criteria: and (3) healing: the oral ulcer heals after being smeared for 5 days.
The effect is remarkable: the oral ulcer condition is obviously improved after 5 days of smearing.
The method has the following advantages: after 5 days of smearing, the situation of oral ulcer is improved to a certain extent, and subsequent smearing is required to be continued.
And (4) invalidation: the symptoms of the oral ulcer after 5 days of smearing have no obvious change.
Deterioration: other adverse reactions appear after the oil for lithospermum is smeared.
And (3) test results: as shown in table 2:
TABLE 2
Figure BDA0002835449140000131
As can be seen from the table, the lithospermum oil has obvious effect on treating oral ulcer, the effective rate is 100 percent, and no adverse reaction exists.
3. Case selection: the patients with otitis were selected for 10 patients, with no restriction on age and no restriction on sex.
The treatment scheme comprises the following steps: the arnebia oil prepared in example 7 was applied once in the morning, at noon and at night, and after shaking, the arnebia oil was dropped onto the affected part of the ear and remained there for more than 45 minutes.
Observe and record: the condition of the patient is observed after dripping the lithospermum physical oil for 15 days, and the treatment effect of the lithospermum physical oil is evaluated according to four grades of recovery, remarkable effect, effectiveness, ineffectiveness and deterioration.
Clinical evaluation criteria: and (3) healing: the otitis media heals after 15 days of the lithospermum erythrorhizon body oil.
The effect is remarkable: the condition of otitis media after 15 days of the lithospermum trichotomum body oil is obviously improved.
The method has the following advantages: the condition of otitis media after the lithospermum erythrorhizon body is oiled for 15 days is improved to a certain extent, and the subsequent smearing is needed.
And (4) invalidation: the symptoms of otitis media after 15 days of the lithospermum trichotomum body oil are not obviously changed.
Deterioration: after the lithospermum body oil is dripped, other adverse reactions occur.
And (3) test results: as shown in table 3:
TABLE 3
Figure BDA0002835449140000141
As can be seen from the table, the lithospermum oil has obvious effect on treating otitis media, the effective rate is 100%, and no adverse reaction exists.
4. Case selection: the 20 patients with herpes are selected, without limitation to age and gender.
The treatment scheme comprises the following steps: the arnebia oil prepared in example 7 was applied once in the morning, at noon and at night, shaken up, and applied to the affected area of herpes and kept for 45 minutes or more.
Observe and record: the condition of the patient is observed after the oil for lithospermum is smeared for 5 days, and the treatment effect of the oil for lithospermum is evaluated according to four grades of recovery, remarkable effect, effectiveness, ineffectiveness and deterioration.
Clinical evaluation criteria: and (3) healing: the herpes can be cured after 5 days after applying the oil to radix Arnebiae body.
The effect is remarkable: the herpes condition is obviously improved after 5 days of applying the lithospermum body oil.
The method has the following advantages: the situation of herpes is improved after applying the lithospermum oil for 5 days, and the subsequent application is required.
And (4) invalidation: the symptoms of herpes do not change obviously after the oil for lithospermum body is applied for 5 days.
Deterioration: other adverse reactions appear after the oil for lithospermum is smeared.
And (3) test results: as shown in table 4:
TABLE 4
Figure BDA0002835449140000151
As can be seen from the table, the lithospermum oil has obvious effect on treating herpes, the effective rate is 100 percent, and no adverse reaction exists.
5. Case selection: 20 chilblain persons are selected, and the age and the sex are not limited.
The treatment scheme comprises the following steps: the oil for lithospermum prepared in example 7 was applied once in the morning, at noon and at night, shaken up and applied to the affected area of chilblain for more than 45 minutes.
Observe and record: the condition of the patient is observed after the oil for lithospermum is smeared for 10 days, and the treatment effect of the oil for lithospermum is evaluated according to four grades of recovery, remarkable effect, effectiveness, ineffectiveness and deterioration.
Clinical evaluation criteria: and (3) healing: the chilblain can be cured after applying the oil for lithospermum body for 10 days.
The effect is remarkable: the chilblain condition is obviously improved after the oil for lithospermum body is applied for 10 days.
The method has the following advantages: the chilblain condition is improved to a certain extent after the oil for lithospermum is applied for 10 days, and the subsequent application is required.
And (4) invalidation: the chilblain symptoms are not obviously changed after the oil for lithospermum body is applied for 10 days.
Deterioration: other adverse reactions appear after the oil for lithospermum is smeared.
And (3) test results: as shown in table 5:
TABLE 5
Figure BDA0002835449140000161
As can be seen from the table, the lithospermum oil has obvious effect on treating chilblain, the effective rate is 100%, and no adverse reaction exists.
6. Case selection: the people with rubella are 20 people, and the age and the sex are not limited.
The treatment scheme comprises the following steps: the arnebia oil prepared in example 7 was applied once in the morning, at noon and at night, shaken up and applied to the affected area of rubella and kept for over 45 minutes.
Observe and record: the condition of the patient is observed after the oil for lithospermum is smeared for 20 days, and the treatment effect of the oil for lithospermum is evaluated according to four grades of recovery, remarkable effect, effectiveness, ineffectiveness and deterioration.
Clinical evaluation criteria: and (3) healing: the rubella can be cured after applying the oil for lithospermum body for 20 days.
The effect is remarkable: the rubella condition is obviously improved after applying the lithospermum oil for 20 days.
The method has the following advantages: the condition of rubella after applying the lithospermum oil for 20 days is improved to a certain extent, and the subsequent application is required.
And (4) invalidation: the chilblain symptoms are not obviously changed after the oil for lithospermum body is applied for 20 days.
Deterioration: other adverse reactions appear after the oil for lithospermum is smeared.
And (3) test results: as shown in table 5:
TABLE 5
Figure BDA0002835449140000171
As can be seen from the table, the lithospermum oil has obvious effect on treating rubella, the effective rate is 100 percent, and no adverse reaction exists.
The oil for lithospermum has good efficacy, can stop bleeding and relieve pain, relieve itching and promote granulation, diminish inflammation and reduce swelling, promote blood circulation and remove stasis, promote wound healing, prevent scars and the like, and has good treatment effect on oral ulcer, herpes, chilblain, rubella, body itch, burn, scald, traumatic infection and other crowds without any side effect. The preparation method is simple, adopts soaking and decocting processes, retains the effective substances of the components as far as possible, and extracts the effective substances into the sesame oil, so that the prepared lithospermum has better effect.
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (8)

1. The lithospermum oil is characterized by comprising the following components in parts by weight: 600 parts of lithospermum 200-containing material, 50-150 parts of angelica sinensis, 300 parts of honeysuckle stem 100-containing material, 50-150 parts of borneol, 50-150 parts of angelica dahurica, 50-150 parts of madder, 50-150 parts of bletilla striata and 5250 parts of sesame oil 1650-containing material, wherein the mass ratio of the lithospermum to the angelica sinensis to the honeysuckle stem to the borneol to the angelica dahurica to the madder to the bletilla striata to the sesame oil is 4:1:2:1:1:1:1: 33-35.
2. The oil for lithospermum erythrorhizon of claim 1, which is prepared from the following components in parts by weight: 320 portions of gromwell, 80 to 130 portions of angelica, 260 portions of honeysuckle stem, 80 to 130 portions of borneol, 80 to 130 portions of angelica dahurica, 80 to 130 portions of madder, 80 to 130 portions of bletilla striata and 2640 portions of balsam and 4550 portions.
3. The oil for lithospermum erythrorhizon as claimed in claim 2, which is prepared from the following components in parts by weight: 400 parts of lithospermum 340-.
4. The oil for lithospermum erythrorhizon as claimed in claim 3, which is prepared from the following components in parts by weight: 360 parts of lithospermum, 90 parts of angelica, 180 parts of honeysuckle stem, 90 parts of borneol, 90 parts of angelica dahurica, 90 parts of madder, 90 parts of bletilla striata and 3000 parts of sesame oil.
5. A method for preparing the oil for lithospermum erythrorhizon according to claim 1, comprising the steps of:
mixing the lithospermum, the angelica, the honeysuckle stem, the borneol, the angelica dahurica, the madder, the bletilla striata and the sesame oil, and soaking for 20-30 h;
and then decocting with slow fire for 3.5-6h, controlling the oil temperature to be less than 215 ℃, continuously stirring during the decocting period, and then cooling and filtering to obtain the lithospermum oil.
6. The method for preparing oil for lithospermum erythrorhizon according to claim 5, wherein the lithospermum erythrorhizon, the angelica sinensis, the honeysuckle stem, the borneol, the angelica dahurica, the madder, the bletilla striata and the sesame oil are mixed and soaked for 24 hours.
7. The method for preparing oil for lithospermum erythrorhizon according to claim 5, wherein the decocting time is 4 hours.
8. The method for preparing oil for lithospermum erythrorhizon as claimed in claim 5, wherein the oil temperature is controlled to be 110-150 ℃.
CN202011468819.2A 2020-12-15 2020-12-15 Oil for lithospermum and preparation method thereof Pending CN112587616A (en)

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Citations (3)

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Publication number Priority date Publication date Assignee Title
CN101219190A (en) * 2007-01-09 2008-07-16 李保力 Traditional Chinese medicine preparation and medical ointment for treating empyrosis
CN102008575A (en) * 2010-11-18 2011-04-13 刘宏伟 Traditional Chinese medicine for curing burns, scalds and chronic fester and preparation method thereof
CN102441020A (en) * 2010-10-08 2012-05-09 何晓磊 Preparation method of compound radix arnebiae oil

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101219190A (en) * 2007-01-09 2008-07-16 李保力 Traditional Chinese medicine preparation and medical ointment for treating empyrosis
CN102441020A (en) * 2010-10-08 2012-05-09 何晓磊 Preparation method of compound radix arnebiae oil
CN102008575A (en) * 2010-11-18 2011-04-13 刘宏伟 Traditional Chinese medicine for curing burns, scalds and chronic fester and preparation method thereof

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