CN112569259A - 血小板裂解物凝胶 - Google Patents
血小板裂解物凝胶 Download PDFInfo
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- CN112569259A CN112569259A CN202011214825.5A CN202011214825A CN112569259A CN 112569259 A CN112569259 A CN 112569259A CN 202011214825 A CN202011214825 A CN 202011214825A CN 112569259 A CN112569259 A CN 112569259A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0644—Platelets; Megakaryocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Birds (AREA)
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- Materials Engineering (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Reproductive Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gynecology & Obstetrics (AREA)
- Wood Science & Technology (AREA)
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- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1120231.4 | 2011-11-23 | ||
| GBGB1120235.5A GB201120235D0 (en) | 2011-11-23 | 2011-11-23 | Plarelet gel formulation for cosmetics |
| GB1120235.5 | 2011-11-23 | ||
| GB1120224.9 | 2011-11-23 | ||
| GBGB1120224.9A GB201120224D0 (en) | 2011-11-23 | 2011-11-23 | Platelet lysate gel for therapeutic treatments |
| GBGB1120230.6A GB201120230D0 (en) | 2011-11-23 | 2011-11-23 | Methods to produce platelet lysate gel for therapeutic treatments |
| GB1120230.6 | 2011-11-23 | ||
| GBGB1120231.4A GB201120231D0 (en) | 2011-11-23 | 2011-11-23 | Platelet gel formulation for therapeutic treatment of wound healing |
| CN201280067727.0A CN104159569A (zh) | 2011-11-23 | 2012-11-23 | 血小板裂解物凝胶 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280067727.0A Division CN104159569A (zh) | 2011-11-23 | 2012-11-23 | 血小板裂解物凝胶 |
Publications (1)
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| CN112569259A true CN112569259A (zh) | 2021-03-30 |
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ID=47278894
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011214825.5A Pending CN112569259A (zh) | 2011-11-23 | 2012-11-23 | 血小板裂解物凝胶 |
| CN201280067727.0A Pending CN104159569A (zh) | 2011-11-23 | 2012-11-23 | 血小板裂解物凝胶 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280067727.0A Pending CN104159569A (zh) | 2011-11-23 | 2012-11-23 | 血小板裂解物凝胶 |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US20140335195A1 (he) |
| EP (1) | EP2782555B1 (he) |
| JP (1) | JP6184971B2 (he) |
| CN (2) | CN112569259A (he) |
| AU (1) | AU2012342218B2 (he) |
| CA (1) | CA2856642C (he) |
| CY (1) | CY1121712T1 (he) |
| DK (1) | DK2782555T3 (he) |
| EA (1) | EA029443B1 (he) |
| ES (1) | ES2730984T3 (he) |
| HR (1) | HRP20191067T1 (he) |
| HU (1) | HUE044397T2 (he) |
| IL (1) | IL232669B (he) |
| LT (1) | LT2782555T (he) |
| MY (1) | MY173148A (he) |
| PL (1) | PL2782555T3 (he) |
| PT (1) | PT2782555T (he) |
| SG (2) | SG10201609718WA (he) |
| TR (1) | TR201908716T4 (he) |
| WO (1) | WO2013076507A2 (he) |
| ZA (1) | ZA201404554B (he) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114917180A (zh) * | 2022-04-19 | 2022-08-19 | 中国医学科学院输血研究所 | 一种复合血小板裂解液的可溶性微针的制备方法及其用途 |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI3584310T3 (fi) | 2008-09-16 | 2024-07-02 | Mayo Found Medical Education & Res | Verihiutaleiden sisältöä sisältäviä koostumuksia |
| CN103702674B (zh) | 2011-06-27 | 2018-05-29 | 爱默蕾大学 | 血小板裂解物的组合物、用途和制备 |
| WO2015031347A2 (en) * | 2013-08-27 | 2015-03-05 | Mayo Foundation For Medical Education And Research | Cross-linked platelet material |
| WO2015036986A2 (en) * | 2013-09-16 | 2015-03-19 | Prendergast Patrick T | Wound fluid elevated protease enzyme inhibition through camelid blood products. |
| HK1194912A2 (en) * | 2013-09-17 | 2014-10-24 | Bestop Group Holdings Ltd | Growth factor concentrate and the use thereof |
| US11891620B2 (en) * | 2014-05-16 | 2024-02-06 | Mayo Foundation For Medical Education And Research | Cell culture media compositions for primary cells |
| GB201410504D0 (en) | 2014-06-12 | 2014-07-30 | Cell Therapy Ltd | Immuno-modulaltory progenitor (IMP) cell |
| GB201504665D0 (en) * | 2015-03-19 | 2015-05-06 | Cell Therapy Ltd | Composition |
| RU2578853C1 (ru) * | 2015-04-13 | 2016-03-27 | Федеральное Государственное бюджетное учреждение "Государственный научный центр колопроктологии им. А.Н. Рыжих" Министерства здравоохранения Российской Федерации | Способ лечения острой анальной трещины и длительно незаживающих ран анального канала |
| CN104784209B (zh) * | 2015-04-27 | 2019-06-21 | 天晴干细胞股份有限公司 | 一种治疗慢性皮肤溃疡的干细胞制剂及制备方法 |
| GB201513996D0 (en) | 2015-08-07 | 2015-09-23 | Cell Therapy Ltd | Immuno-oncology mesodermal progenitor (IOMP) cell |
| GB201518263D0 (en) | 2015-10-15 | 2015-12-02 | Oxford Bioelectronics Ltd | Method |
| CN105708860A (zh) * | 2016-01-26 | 2016-06-29 | 深圳爱生再生医学科技有限公司 | 用于修复皮肤溃疡的干细胞制剂 |
| ES2633815B1 (es) * | 2016-03-23 | 2018-07-06 | Biotechnology Institute I Mas D, S.L. | Formulación de aplicación tópica, rica en plaquetas y/o factores de crecimiento y un método de preparación de la misma |
| US20200325442A1 (en) * | 2016-06-02 | 2020-10-15 | Pl Bioscience Gmbh | Method for producing a platelet-lysate-containing gel |
| EP3254684B1 (en) | 2016-06-08 | 2019-10-23 | Lysatpharma GmbH | Human platelet lysate or fraction enriched in human platelet-derived extracellular vesicles, for use in medicine |
| WO2018005751A1 (en) * | 2016-06-29 | 2018-01-04 | Arteriocyte, Inc. | Dressings comprising platelet lysate |
| JP7110360B2 (ja) | 2017-10-09 | 2022-08-01 | テルモ ビーシーティー バイオテクノロジーズ，エルエルシー | 凍結乾燥方法 |
| FI3727488T3 (fi) * | 2017-12-18 | 2023-09-07 | Univ Aveiro | Veriplasmakomponenttipohjaiset hydrogeelit, prosessi ja niiden käytöt |
| CN108715834B (zh) * | 2018-06-01 | 2021-09-14 | 天晴干细胞股份有限公司 | 一种富含cd41+、cd81+微囊的血小板裂解液制备方法 |
| AU2019317630A1 (en) * | 2018-08-07 | 2021-03-18 | iFiX Medical Pty Ltd | Platelet lysate compositions and uses thereof |
| JPWO2020067443A1 (ja) * | 2018-09-27 | 2021-08-30 | テルモ株式会社 | 体細胞のシート化方法 |
| EP3633028A1 (en) | 2018-10-02 | 2020-04-08 | PL BioScience GmbH | Method for producing a virus-free platelet lysate material |
| EP3911733A1 (en) | 2019-01-15 | 2021-11-24 | Cell Therapy Limited | Mesodermal killer (mk) cell |
| GB201900554D0 (en) | 2019-01-15 | 2019-03-06 | Cell Therapy Ltd | Mesodermal killer (mk) cell |
| US11604026B2 (en) | 2019-03-14 | 2023-03-14 | Terumo Bct Biotechnologies, Llc | Lyophilization loading tray assembly and system |
| IT201900005978A1 (it) * | 2019-04-17 | 2020-10-17 | Claudio Migliaresi | Composizione topica per il trattamento di ferite, ulcere e piaghe comprendente lisato piastrino preparata al momento dell’uso in condizioni di sterilità e dispositivo per tale preparazione |
| CN110353883A (zh) * | 2019-07-10 | 2019-10-22 | 重庆市人民医院 | 用于治疗褥疮的复合敷料层及带有复合敷料层的褥疮贴 |
| US11951134B2 (en) | 2019-09-30 | 2024-04-09 | North Carolina State University | Cationic platelet lysate compositions and related methods |
| JP7137883B2 (ja) * | 2020-07-31 | 2022-09-15 | 株式会社Rainbow | 自家血小板由来の血小板溶解物 |
| RU2754415C1 (ru) * | 2020-09-22 | 2021-09-02 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Ижевская государственная медицинская академия" Министерства здравоохранения Российской Федерации | Способ лечения нейроишемической формы синдрома диабетической стопы |
| CN115957368B (zh) * | 2022-12-20 | 2024-04-12 | 重庆大学附属肿瘤医院 | 一种皮肤创伤修复的细菌纤维素膜及其制备方法和应用 |
| US20240218323A1 (en) | 2022-12-30 | 2024-07-04 | Dao-Lung Lin | Platelets-containing composition and preparation process thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010064267A1 (en) * | 2008-12-05 | 2010-06-10 | Universita' Degli Studi Di Pavia | Platelets lysate and bioadesive compositions thereof for the treatment of mucositis |
| US20100278783A1 (en) * | 2009-05-01 | 2010-11-04 | Biocardia, Inc. | Method of Preparing Autologous Cells and Method of Use for Therapy |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5457093A (en) * | 1987-09-18 | 1995-10-10 | Ethicon, Inc. | Gel formulations containing growth factors |
| SE8801537D0 (sv) | 1988-04-26 | 1988-04-26 | Ellco Food Ab | Cellodlingsmedium samt forfarande for dess framstellning |
| IE70217B1 (en) * | 1990-08-15 | 1996-10-30 | British Bio Technology | Benzimidazole derivatives process for their preparation and application |
| RU2138162C1 (ru) | 1997-04-17 | 1999-09-27 | Суханов Владимир Александрович | Способ криоконсервации богатой тромбоцитами плазмы |
| WO2008108412A1 (ja) * | 2007-03-07 | 2008-09-12 | Jms Co., Ltd. | 血清調製方法及び血清調製装置 |
| FI3584310T3 (fi) | 2008-09-16 | 2024-07-02 | Mayo Found Medical Education & Res | Verihiutaleiden sisältöä sisältäviä koostumuksia |
| JP2011219428A (ja) * | 2010-04-13 | 2011-11-04 | Tokyo Metropolitan Univ | 医療用材料、その製造方法およびそれを含む医薬組成物 |
| DK2729562T3 (en) * | 2011-07-06 | 2018-07-23 | Cell Therapy Ltd | Progenitor cells of mesodermal origin |
| EP2574350A1 (en) * | 2011-09-29 | 2013-04-03 | Biorigen S.r.l | Medical uses of lyophilized polymeric membranes containing blood derivatives |
| WO2013045689A1 (en) * | 2011-09-29 | 2013-04-04 | BIORIGEN Srl | Therapeutic use of gelatin hydrogels with a gel-sol transition at body temperature |
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- 2012-11-23 CN CN202011214825.5A patent/CN112569259A/zh active Pending
- 2012-11-23 US US14/360,286 patent/US20140335195A1/en not_active Abandoned
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- 2012-11-23 PL PL12795041T patent/PL2782555T3/pl unknown
- 2012-11-23 CN CN201280067727.0A patent/CN104159569A/zh active Pending
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010064267A1 (en) * | 2008-12-05 | 2010-06-10 | Universita' Degli Studi Di Pavia | Platelets lysate and bioadesive compositions thereof for the treatment of mucositis |
| US20100278783A1 (en) * | 2009-05-01 | 2010-11-04 | Biocardia, Inc. | Method of Preparing Autologous Cells and Method of Use for Therapy |
Non-Patent Citations (2)
| Title |
|---|
| E.RANZATO等: "Platelet lysate stimulates wound repair of HaCaT keratinocytes", 《BRITISH JOURNAL OF DERMATOLOGY》, vol. 159, pages 1023 - 545 * |
| KARIN PLÖDERL等: "Development and validation of a production process of platelet lysate for autologous use", 《PLATELETS》, vol. 22, no. 3, pages 204 - 209, XP008172706, DOI: 10.3109/09537104.2010.531304 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114917180A (zh) * | 2022-04-19 | 2022-08-19 | 中国医学科学院输血研究所 | 一种复合血小板裂解液的可溶性微针的制备方法及其用途 |
| CN114917180B (zh) * | 2022-04-19 | 2023-11-14 | 中国医学科学院输血研究所 | 一种复合血小板裂解液的可溶性微针的制备方法及其用途 |
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