CN1125618A

CN1125618A - Oral liquid for treatment of chicken's Newcastle disease and Fabricius bursa disease

Info

Publication number: CN1125618A
Application number: CN 95115901
Authority: CN
Inventors: 孙桂昕
Original assignee: BIOLOGICAL MEDICINE INST JILIN BIOLOGICAL PRODUCT FACTORY
Current assignee: BIOLOGICAL MEDICINE INST JILIN BIOLOGICAL PRODUCT FACTORY
Priority date: 1995-09-14
Filing date: 1995-09-14
Publication date: 1996-07-03

Abstract

The veterinary oral liquid for treating avian Newcastle disease or Fabricius bursa disease with 60% cure rate and preventing effect, as well as the mixed infection of pullorum disease coccidiosis and colibacillus with distinct suppression action is prepared from 8 Chinese-medicinal materials such as coptis root, astragalus root, isatis root, pulsatilla root, white atractylodes rhizome, etc. through mixing, immersion in water, decoction, filter, concentration and adding antiseptic and stabilizer.

Description

Be used for the treatment of newcastle disease, bursal disease oral liquid and method for making

The invention relates to a kind of newcastle disease, bursal disease oral liquid and method for making of being used for the treatment of.

The existing at present pipe capsule of being made by Folium Isatidis, the Rhizoma Anemarrhenae, Rhizoma Imperatae and Radix Glycyrrhizae looses, and can treat bursal disease, but can not treat newcastle disease; Also have chicken French capsule, newcastle disease bigeminy high immunity yolk antibody biological preparation, after the injection, the virus that can neutralize can be treated newcastle disease, bursal disease, but this medicine persistent period in the chicken body is short, after antibody disappears, also can continue morbidity, and must under 4 ℃ of temperature, can only preserve six months.

The purpose of the invention is to provide a kind of newcastle disease, bursal disease oral liquid and method for making of being used for the treatment of.Can treat the oral liquid of newcastle disease, bursal disease simultaneously; Holding time and temperature requirement are not harsh; This preparation process is simple, and raw material is easy to get.

The invention provided is used for the treatment of newcastle disease, the bursal disease oral liquid is to be mixed by a certain percentage by Rhizoma Coptidis, the Radix Astragali, Radix Isatidis, the Radix Pulsatillae, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Folium Isatidis and the Radix Rehmanniae, through water logging, decoction, filtration, concentrate that adding preservative agent, stabilizing agent make again.

The invention provided is used for the treatment of newcastle disease, the bursal disease oral liquid makes by following step successively:

After getting each 150g of Rhizoma Coptidis, the Radix Astragali, Radix Isatidis, the Radix Pulsatillae, each 200g of Folium Isatidis, Rhizoma Atractylodis Macrocephalae 500g, Radix Glycyrrhizae and the Radix Rehmanniae and mixing, add the distilled water immersion 4 hours of 10 times of amounts, decocted two hours, be cooled to the room temperature filtration, filtrate for later use.Filtering residue adds the distilled water of 5 times of amounts again, decocts 1 hour, is cooled to room temperature and filters filtrate for later use.Filtering residue adds the distilled water of 2 times of amounts again, decocts half an hour, and be cooled to room temperature and filter, filtrate for later use, filtering residue is abandoned it.Three filtrates are merged, under 100 ℃ of temperature, be concentrated into every gram 1 milliliters of liquid, under 4 ℃ of temperature, quiescent setting 24 hours is got supernatant, adds 0.1% carbolic acid antiseptic and 0.3% tween 80 stabilizing agent gets the 650ml oral liquid.

The oral liquid that makes by above-mentioned steps is an amber color liquid, has fragrance, and pH value is between 4.5～7.5.

The invention provided is used for the treatment of newcastle disease, bursal disease oral liquid, in in June, 1993～October in Shenyang, animal and veterinary stations such as Changchun, Siping City, nearly 3,000,000 newcastle diseases of chicken house, bursal disease treatment and prevention, 0.19/ chicken dosage only, cure rate, prevention rate are all more than 80%.Mixed infection to coccus diseases such as Pullorum Disease, coccidiosis, escherichia coli has the obvious suppression effect.This medical instrument has safe and reliable, nontoxic, side effect, and antibacterial, antitoxin effect is obvious.Can preserve more than 2 years at normal temperatures.

The invention provided is used for the treatment of newcastle disease, bursal disease oral liquid through Jilin pharmacological room of agricultural university and the cooperation of Jilin Province's biological factory, to white mice toxicology test result:

LD ₀＝3500ml/Kg，

LD ₅₀＝5814.062ml/Kg，

LD ₁₀₀＝9216.4401ml/Kg，

Test shows: this medicine is nontoxic to white mice.

To the influence of blood parameters, the not remarkable P of difference＞0.05.

Each organ non-invasi ANOMALOUS VARIATIONS of internal organs is cutd open and pathological tissue procuratorial work in malingering understanding after the rat administration.

Claims

1, a kind of newcastle disease, bursal disease oral liquid of being used for the treatment of, it is characterized in that mixing by a certain percentage, through water logging, decoction, filtration, concentrate that adding preservative agent, stabilizing agent make again by Rhizoma Coptidis, the Radix Astragali, Radix Isatidis, the Radix Pulsatillae, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Folium Isatidis and the Radix Rehmanniae.

2, a kind of newcastle disease, bursal disease oral liquid of being used for the treatment of is characterized in that making by following step successively:

Get Rhizoma Coptidis, the Radix Astragali, Radix Isatidis, the Radix Pulsatillae, each 200g of Folium Isatidis, Rhizoma Atractylodis Macrocephalae 300g, after each 150g of the Radix Glycyrrhizae and the Radix Rehmanniae mixes, the distilled water immersion 4 hours that adds 10 times of amounts, decocted two hours, being cooled to room temperature filters, filtrate for later use, filtering residue add the distilled water of 5 times of amounts again, decoct 1 hour, being cooled to room temperature filters, filtrate for later use, filtering residue add the distilled water of 2 times of amounts again, decoct half an hour, being cooled to room temperature filters, filtrate for later use, filtering residue is abandoned it, and three filtrates are merged, under 100 ℃ of temperature, be concentrated into every gram 1 milliliters of liquid, under 4 ℃ of temperature, quiescent setting 24 hours, get supernatant, add 0.1% carbolic acid antiseptic and 0.3% tween-80 stabilizing agent gets the 650ml oral liquid.