CN112545957B - Essence milk with effects of moisturizing and removing red blood streak and preparation method thereof - Google Patents

Essence milk with effects of moisturizing and removing red blood streak and preparation method thereof Download PDF

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CN112545957B
CN112545957B CN202011505219.9A CN202011505219A CN112545957B CN 112545957 B CN112545957 B CN 112545957B CN 202011505219 A CN202011505219 A CN 202011505219A CN 112545957 B CN112545957 B CN 112545957B
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extract
oil
moisturizing
red blood
mixture
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CN112545957A (en
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曹铉
李载雨
刘畅
刘培玉
朱蒙
王洁
庞雪
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Belande Biotechnology Shanghai Co ltd
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Hyundai Bioland Jiangsu Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9794Liliopsida [monocotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/673Vitamin B group
    • A61K8/675Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/925Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9728Fungi, e.g. yeasts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/005Preparations for sensitive skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/85Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
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  • Biotechnology (AREA)
  • Botany (AREA)
  • Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Emergency Medicine (AREA)
  • Cosmetics (AREA)

Abstract

The invention discloses an essence milk with the functions of moisturizing and removing red blood streak and a preparation method thereof, wherein the formula comprises the following components in percentage by weight: 210.1-0.5% of carbomer U, 60-90% of schizosaccharomyces cerevisiae fermentation product filtrate, 0.01-0.5% of trehalose, 0.01-0.1% of xanthan gum, 2-10% of glycerol, 0.01-0.5% of pentanediol, 0.01-0.5% of nicotinamide, 0.1-5.0% of water-soluble silicon wax, 0.1-1.0% of tremella extract II, 0.1-1.0% of barley extract, 0.1-1.0% of pearl barley extract, 0.1-1.0% of chamomile extract, 10% of triethanolamine 1-5%, 0.1-1.0% of LC emulsifier, 200.1-0.5% of TWEEN, 0.1-1.0% of squalane, 0.1-1.0% of colorless jojoba oil, 0.1-5% of DC-20050 CP, 0.05-0.5% of green tea seed oil, 0.01-0.1% of orange sweet oil, 0.0.1% of hydrolyzed horse oil, 0.01-1% of hydrolyzed horse oil, 0.1 to 1.0 percent of 1, 2-hexanediol, 0.1 to 1.0 percent of p-hydroxyacetophenone and 1 to 5 percent of BG; the essence milk for moisturizing and removing the red blood silks prepared by the method has the effects of multiple moisturizing, nourishing skin, removing the red blood silks and improving rough, dark and fine skin.

Description

Essence milk with effects of moisturizing and removing red blood streak and preparation method thereof
Technical Field
The invention relates to the technical field of skin care product preparation, in particular to essence milk with the functions of moisturizing and removing red blood streak and a preparation method thereof.
Background
The effect of water on perfect skin is undoubted. When the air temperature is reduced, the skin cuticle can not timely adjust enough moisturizing factors, the activity of oil glands is reduced, the oil and water on the face are reduced, the skin can be tightened, fine lines even appear under eyes and near the nose, and the phenomena of dry skin, yellow skin, dull skin, loose skin, early wrinkles and the like are directly caused by the large downward sliding of the water content of the skin. The product can yellow, stain, wrinkle and relax in water shortage, and the whitening and spot-lightening product can stop the effect as long as the skin is dried. All anti-wrinkle products must have sufficient moisture to penetrate deeply to smooth out dry, glandular and broken fibers. Everything cannot happen without water. Therefore, the solution of skin aging, moisturizing and moisturizing is the Wangdao.
Red blood filaments are mainly manifested by telangiectasia of skin, which is caused by low skin immunity. The common formation reason of the red blood streak is that cutin is damaged, and the natural protection of the cuticle is lost by capillary vessels, so that the red blood streak is stimulated by the external environment for a long time and is formed by blood vessel expansion/congestion/damage; the congenital capillary blood vessel on the face is shallow, so that the face phenomenon is caused, the skin is thin and sensitive, and the face is redder when the face is too cold, too hot and emotional agitation occurs, so that the red blood streak phenomenon is formed. In severe cases, sedimentary stains can also form, and healing is difficult.
Horse oil is animal oil, contains abundant natural nutrients, highly unsaturated fatty acid and vitamin E, so that horse oil can permeate into tiny gaps (strong permeability), air in pore gaps can be expelled when the horse oil is used on the skin of a human body and permeates into subcutaneous tissues, the horse oil can not obstruct skin respiration while nutrients are absorbed, the horse oil can ensure the health of the skin, moisten the skin and promote self-healing force and metabolism, and sensitive skin can be used safely. The hydrolyzed horse oil is relatively common.
Disclosure of Invention
In order to solve the problems, the invention discloses essence milk with the functions of moisturizing and removing red blood streaks and a preparation method thereof.
The technical scheme of the invention is as follows: the essence milk with the functions of moisturizing and removing red blood streak comprises the following components in percentage by weight: 210.1-0.5% of carbomer U, 60-90% of schizosaccharomyces cerevisiae fermentation product filtrate, 0.01-0.5% of trehalose, 0.01-0.1% of xanthan gum, 2-10% of glycerol, 0.01-0.5% of pentanediol, 0.01-0.5% of nicotinamide, 0.1-5.0% of water-soluble silicon wax, 0.1-1.0% of tremella extract II, 0.1-1.0% of barley extract, 0.1-1.0% of pearl barley extract, 0.1-1.0% of chamomile extract, 10% of triethanolamine 1-5%, 0.1-1.0% of LC emulsifier, 200.1-0.5% of TWEEN, 0.1-1.0% of squalane, 0.1-1.0% of colorless jojoba oil, 0.1-5% of DC-20050 CP, 0.05-0.5% of green tea seed oil, 0.01-0.1% of orange sweet oil, 0.0.1% of hydrolyzed horse oil, 0.01-1% of hydrolyzed horse oil, 0.1-1.0% of 1, 2-hexanediol, 0.1-1.0% of p-hydroxyacetophenone and 1-5% of BG.
An essence emulsion with effects of keeping moisture and removing red blood streak is prepared by hydrolyzing horse oil with lipase.
An essence emulsion with effects of keeping moisture and removing red blood streak is prepared from flos Matricariae Chamomillae extract by cleaning, oven drying, grinding, extracting with ethanol, and rotary steaming.
A preparation method of essence milk with effects of moisturizing and removing red blood streaks comprises the following steps:
(1) adding carbomer U21, trehalose, xanthan gum, glycerol, pentanediol, nicotinamide, water-soluble silicon wax, Tremella extract II, fructus Hordei vulgaris extract, Coicis semen extract, and flos Matricariae Chamomillae extract into 60-90 deg.C fermentation product filtrate, and stirring to obtain first mixture;
(2) uniformly stirring an LC emulsifier, TWEEN20, squalane, colorless jojoba oil, DC-20050 CP, green tea seed oil, sweet orange oil and hydrolyzed horse oil at 60-90 ℃ to obtain a second mixture;
(3) adding the first mixture into the second mixture, emulsifying and homogenizing at 60-90 deg.C for 5-10min, and mixing to obtain a third mixture;
(4) adding 10% triethanolamine into the third mixture, and uniformly stirring to obtain a fourth mixture;
(5) and (3) stirring and dissolving the fourth mixture completely, cooling to 60 ℃, adding 1, 2-hexanediol, p-hydroxyacetophenone and BG, stirring and mixing uniformly, and cooling to the discharge temperature to obtain a finished product.
The invention has the advantages that: according to the embodiment of the invention, horse oil is hydrolyzed, so that the horse oil is suitable for people with sensitive skin, and is more beneficial to skin absorption to achieve a better moisturizing effect; the chamomile essence is prepared by extracting the excellent components in the chamomile extract through the selected raw materials, and then is used as a cosmetic matrix to be added into various products, the health care effects of a plurality of effective components on the skin are mutually synergistic, the effect is obvious, the water content of the skin can be obviously increased, the chamomile essence is safe, has a nourishing effect on the skin, meets the requirements of people on the safety of cosmetics, and has a wide application prospect.
Detailed Description
For the purpose of enhancing understanding of the present invention, the following detailed description will be given in conjunction with examples, which are provided for illustration only and do not limit the scope of the present invention.
Example 1
The embodiment of the invention provides essence milk with the functions of moisturizing and removing red blood streak, which comprises the following components in percentage by weight: carbomer 210.26%, cracked yeast fermentation product filtrate 85.71%, trehalose 0.1%, xanthan gum 0.08%, glycerol 4%, pentanediol 0.2%, nicotinamide 0.2%, water-soluble silicon wax 0.5%, white fungus extract II 0.5%, barley extract 0.1%, pearl barley extract 0.1%, chamomile extract 0.1%, 10% triethanolamine 2.4%, LC emulsifier 0.5%, TWEEN 200.2%, squalane 0.5%, colorless jojoba oil 0.3%, DC-20050 CP 1%, green tea seed oil 0.17%, sweet orange oil 0.03%, hydrolyzed horse oil 0.1%, 1, 2-hexanediol 0.5%, p-hydroxyacetophenone 0.4%, BG 2%.
Example 2
The embodiment of the invention provides essence milk with the functions of moisturizing and removing red blood streak, which comprises the following components in percentage by weight: carbomer 210.26%, cracked yeast fermentation product filtrate 85.51%, trehalose 0.1%, xanthan gum 0.08%, glycerol 4%, pentanediol 0.2%, nicotinamide 0.2%, water-soluble silicon wax 0.5%, white fungus extract II 0.5%, barley extract 0.1%, pearl barley extract 0.1%, chamomile extract 0.2%, 10% triethanolamine 2.4%, LC emulsifier 0.5%, TWEEN 200.2%, squalane 0.5%, colorless jojoba oil 0.3%, DC-20050 CP 1%, green tea seed oil 0.17%, sweet orange oil 0.03%, hydrolyzed horse oil 0.2%, 1, 2-hexanediol 0.5%, p-hydroxyacetophenone 0.4%, BG 2%.
Example 3
The embodiment of the invention provides essence milk with the functions of moisturizing and removing red blood streak, which comprises the following components in percentage by weight: carbomer 210.26%, schizosaccharomyces cerevisiae fermentation product filtrate 85.31%, trehalose 0.1%, xanthan gum 0.08%, glycerol 4%, pentanediol 0.2%, nicotinamide 0.2%, water-soluble silicon wax 0.5%, tremella extract II 0.5%, barley extract 0.1%, pearl barley extract 0.1%, chamomile extract 0.3%, 10% triethanolamine 2.4%, LC emulsifier 0.5%, TWEEN 200.2%, squalane 0.5%, colorless jojoba oil 0.3%, DC-20050 CP 1%, green tea seed oil 0.17%, sweet orange oil 0.03%, hydrolyzed horse oil 0.3%, 1, 2-hexanediol 0.5%, p-hydroxyacetophenone 0.4%, BG 2%.
Examples 1-3 above were carried out by the following procedure:
(1) adding carbomer U21, trehalose, xanthan gum, glycerol, pentanediol, nicotinamide, water-soluble silicon wax, Tremella extract II, fructus Hordei vulgaris extract, Coicis semen extract, and flos Matricariae Chamomillae extract into 60-90 deg.C fermentation product filtrate, and stirring to obtain first mixture;
(2) uniformly stirring an LC emulsifier, TWEEN20, squalane, colorless jojoba oil, DC-20050 CP, green tea seed oil, sweet orange oil and hydrolyzed horse oil at 60-90 ℃ to obtain a second mixture;
(3) adding the first mixture into the second mixture, emulsifying and homogenizing at 60-90 deg.C for 5-10min, and mixing to obtain a third mixture;
(4) adding 10% triethanolamine into the third mixture, and uniformly stirring to obtain a fourth mixture;
(5) and (3) stirring and dissolving the fourth mixture completely, cooling to 60 ℃, adding 1, 2-hexanediol, p-hydroxyacetophenone and BG, stirring and mixing uniformly, and cooling to the discharge temperature to obtain a finished product.
To better illustrate the beneficial effects of the present invention, efficacy evaluation experiments were performed:
moisture retention test
The test principle is as follows: the water content of the horny layer of the human skin is tested by a capacitance method by using a human skin tester. The moisturizing ability of the products was evaluated by measuring the change in the water content of the stratum corneum of the skin before and after the use of the products of examples 1-3 by volunteers.
The test method comprises the following steps: 20 volunteers aged between 25-35 years were selected and used in the same amount of 2mg/cm of the product obtained in examples 1-3 in the area fixed on the inner side of the arms2The moisture content of the volunteers before and after use is tested by using a human skin tester, and the moisture retention performance of the product is evaluated by taking an average value. The test results are shown in the following table.
Figure DEST_PATH_IMAGE001
As can be seen from the above table, the use of the products provided in examples 1-3 can significantly increase the transdermal absorption of the skin, promote the penetration of the anti-redness active, and increase the bioavailability of the active.
Compared with common horse oil, the hydrolyzed horse oil has the characteristics of reducing skin irritation, better moisturizing and nourishing skin and strong permeability, so that the hydrolyzed horse oil can better perform synergistic action with the red blood streak removing active substances such as alpha-bisabolol in the chamomile extract to achieve the functions of moisturizing and removing red blood streaks. Therefore, the hydrolyzed horse oil and the chamomile extract are used as raw materials to design and produce the emulsion which can moisturize the skin, nourish the skin, remove red blood streaks and improve rough, dark and fine lines of the skin so as to meet the actual use requirement.

Claims (4)

1. The essence milk with the functions of moisturizing and removing red blood streak is characterized by comprising the following components in percentage by weight: 210.1-0.5% of carbomer U, 60-90% of schizosaccharomyces cerevisiae fermentation product filtrate, 0.01-0.5% of trehalose, 0.01-0.1% of xanthan gum, 2-10% of glycerol, 0.01-0.5% of pentanediol, 0.01-0.5% of nicotinamide, 0.1-5.0% of water-soluble silicon wax, 0.1-1.0% of tremella extract II, 0.1-1.0% of barley extract, 0.1-1.0% of pearl barley extract, 0.3-1.0% of chamomile extract, 10% of triethanolamine 1-5%, 0.1-1.0% of LC emulsifier, 200.1-0.5% of TWEEN, 0.1-1.0% of squalane, 0.1-1.0% of colorless jojoba oil, 0.1-5% of DC-20050 CP, 0.05-0.5% of green tea seed oil, 0.01-0.1% of orange sweet oil, 0.3-1% of hydrolyzed horse oil, 0.1 to 1.0 percent of 1, 2-hexanediol, 0.1 to 1.0 percent of p-hydroxyacetophenone and 1 to 5 percent of butanediol.
2. The essence milk with the functions of moisturizing and removing red blood streak according to claim 1, characterized in that: the hydrolyzed horse oil is prepared by hydrolyzing with lipase.
3. The essence milk with the effects of moisturizing and removing red blood streaks as claimed in claim 1, is characterized in that: the chamomile extract is prepared by cleaning, drying, grinding, alcohol extracting and rotary steaming.
4. The preparation method of the essential milk with the functions of moisturizing and removing the red blood streak according to any one of claims 1 to 3, which is characterized by comprising the following steps:
(1) adding carbomer U21, trehalose, xanthan gum, glycerol, pentanediol, nicotinamide, water-soluble silicon wax, Tremella extract II, fructus Hordei vulgaris extract, Coicis semen extract, and flos Matricariae Chamomillae extract into 60-90 deg.C fermentation product filtrate, and stirring to obtain first mixture;
(2) uniformly stirring an LC emulsifier, TWEEN20, squalane, colorless jojoba oil, DC-20050 CP, green tea seed oil, sweet orange oil and hydrolyzed horse oil at 60-90 ℃ to obtain a second mixture;
(3) adding the first mixture into the second mixture, emulsifying and homogenizing at 60-90 deg.C for 5-10min, and mixing to obtain third mixture;
(4) adding 10% triethanolamine into the third mixture, and uniformly stirring to obtain a fourth mixture;
(5) and (3) stirring and dissolving the fourth mixture completely, cooling to 60 ℃, adding 1, 2-hexanediol, p-hydroxyacetophenone and butanediol, stirring and mixing uniformly, and cooling to the discharging temperature to obtain a finished product.
CN202011505219.9A 2020-12-18 2020-12-18 Essence milk with effects of moisturizing and removing red blood streak and preparation method thereof Active CN112545957B (en)

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CN115813837A (en) * 2022-11-28 2023-03-21 现代百朗德生物科技(江苏)有限公司 Bletilla striata hydrolyzed horse oil chilblain cream and preparation method thereof
CN116211723B (en) * 2023-04-07 2024-05-03 江西广恩和药业股份有限公司 Nourishing and moisturizing lotion and preparation method thereof

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天芳集薰衣草洋甘菊精油马油膏;上海颜姿贸易有限公司;《国产非特殊用途化妆品备案信息服务平台》;20171019;网页正文 *

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