CN112533998B - 磺酰罗丹明亚磷酰胺染料 - Google Patents

磺酰罗丹明亚磷酰胺染料 Download PDF

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CN112533998B
CN112533998B CN201980030812.1A CN201980030812A CN112533998B CN 112533998 B CN112533998 B CN 112533998B CN 201980030812 A CN201980030812 A CN 201980030812A CN 112533998 B CN112533998 B CN 112533998B
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CN112533998A (zh
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K·P·伦德
D·塞尔盖耶夫
M·N·卡巴尔
A·高尔
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Cepheid
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Cepheid
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B11/00—Diaryl- or thriarylmethane dyes
    • C09B11/04—Diaryl- or thriarylmethane dyes derived from triarylmethanes, i.e. central C-atom is substituted by amino, cyano, alkyl
    • C09B11/10—Amino derivatives of triarylmethanes
    • C09B11/24—Phthaleins containing amino groups ; Phthalanes; Fluoranes; Phthalides; Rhodamine dyes; Phthaleins having heterocyclic aryl rings; Lactone or lactame forms of triarylmethane dyes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201980030812.1A 2018-05-07 2019-05-07 磺酰罗丹明亚磷酰胺染料 Active CN112533998B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862668109P 2018-05-07 2018-05-07
US62/668109 2018-05-07
PCT/US2019/031188 WO2019217470A1 (en) 2018-05-07 2019-05-07 Sulforhodamine phosphoramidite dyes

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CN112533998A CN112533998A (zh) 2021-03-19
CN112533998B true CN112533998B (zh) 2023-06-20

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US (2) US12071547B2 (enExample)
EP (1) EP3790931B1 (enExample)
JP (1) JP7399882B2 (enExample)
KR (1) KR102753367B1 (enExample)
CN (1) CN112533998B (enExample)
AU (1) AU2019266218B2 (enExample)
CA (1) CA3099701A1 (enExample)
ES (1) ES2967690T3 (enExample)
MX (1) MX2020011378A (enExample)
WO (1) WO2019217470A1 (enExample)
ZA (1) ZA202006485B (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4182319A1 (en) * 2020-07-16 2023-05-24 Cepheid Fluorescent dyes
CN115636843B (zh) * 2022-09-27 2024-12-13 大连理工大学 一类多功能荧光染料及应用
CN115414703B (zh) * 2022-11-03 2023-01-17 百力格生物科技(上海)股份有限公司 染料修饰后的核酸探针纯化方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5231191A (en) * 1987-12-24 1993-07-27 Applied Biosystems, Inc. Rhodamine phosphoramidite compounds
US5451463A (en) * 1989-08-28 1995-09-19 Clontech Laboratories, Inc. Non-nucleoside 1,3-diol reagents for labeling synthetic oligonucleotides
CN101454315A (zh) * 2006-03-31 2009-06-10 应用生物系统有限公司 用于合成罗丹明-标记的寡核苷酸的试剂
CN103079598A (zh) * 2010-04-02 2013-05-01 药物影像股份有限公司 罗丹明(rhodamine)染料的单一同分异构结合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6727356B1 (en) 1999-12-08 2004-04-27 Epoch Pharmaceuticals, Inc. Fluorescent quenching detection reagents and methods
US7344701B2 (en) * 2004-02-03 2008-03-18 Biosearch Technologies, Inc. Xanthene dyes
WO2014058535A1 (en) * 2012-08-19 2014-04-17 Michigan Technological University Lysosomal targeting probes
JP6574240B2 (ja) 2014-03-30 2019-09-11 セフィエド 修飾シトシンポリヌクレオチドオリゴマーおよび方法
WO2015153496A1 (en) 2014-03-30 2015-10-08 Cepheid Modified thymine polynucleotide oligomers and methods

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5231191A (en) * 1987-12-24 1993-07-27 Applied Biosystems, Inc. Rhodamine phosphoramidite compounds
US5451463A (en) * 1989-08-28 1995-09-19 Clontech Laboratories, Inc. Non-nucleoside 1,3-diol reagents for labeling synthetic oligonucleotides
CN101454315A (zh) * 2006-03-31 2009-06-10 应用生物系统有限公司 用于合成罗丹明-标记的寡核苷酸的试剂
CN103079598A (zh) * 2010-04-02 2013-05-01 药物影像股份有限公司 罗丹明(rhodamine)染料的单一同分异构结合物

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Chemistry of Sulforhodamine-Amine Conjugates;John E. T. Corrie等;《Bioconjugate Chem.》;20011231(第12期);186-194 *
Substituent effects on the apparent pK of the reversible open-to-closed transition of sultams derived from sulforhodamine dyes;John E.T. Corrie等;《Dyes and Pigments》;20081231;第79卷;76-82 *

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Publication number Publication date
MX2020011378A (es) 2021-02-15
CN112533998A (zh) 2021-03-19
EP3790931A1 (en) 2021-03-17
JP7399882B2 (ja) 2023-12-18
ZA202006485B (en) 2025-07-30
EP3790931B1 (en) 2023-09-27
JP2021523268A (ja) 2021-09-02
US12071547B2 (en) 2024-08-27
CA3099701A1 (en) 2019-11-14
US20250051577A1 (en) 2025-02-13
KR20210035079A (ko) 2021-03-31
WO2019217470A1 (en) 2019-11-14
BR112020022684A2 (pt) 2021-02-17
AU2019266218A1 (en) 2021-01-07
US20240067824A1 (en) 2024-02-29
KR102753367B1 (ko) 2025-01-10
AU2019266218B2 (en) 2024-08-15
ES2967690T3 (es) 2024-05-03

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