CA3099701A1 - Sulforhodamine phosphoramidite dyes - Google Patents
Sulforhodamine phosphoramidite dyes Download PDFInfo
- Publication number
- CA3099701A1 CA3099701A1 CA3099701A CA3099701A CA3099701A1 CA 3099701 A1 CA3099701 A1 CA 3099701A1 CA 3099701 A CA3099701 A CA 3099701A CA 3099701 A CA3099701 A CA 3099701A CA 3099701 A1 CA3099701 A1 CA 3099701A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- optionally substituted
- attached
- atoms
- taken together
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B11/00—Diaryl- or thriarylmethane dyes
- C09B11/04—Diaryl- or thriarylmethane dyes derived from triarylmethanes, i.e. central C-atom is substituted by amino, cyano, alkyl
- C09B11/10—Amino derivatives of triarylmethanes
- C09B11/24—Phthaleins containing amino groups ; Phthalanes; Fluoranes; Phthalides; Rhodamine dyes; Phthaleins having heterocyclic aryl rings; Lactone or lactame forms of triarylmethane dyes
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B57/00—Other synthetic dyes of known constitution
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862668109P | 2018-05-07 | 2018-05-07 | |
| US62/668,109 | 2018-05-07 | ||
| PCT/US2019/031188 WO2019217470A1 (en) | 2018-05-07 | 2019-05-07 | Sulforhodamine phosphoramidite dyes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3099701A1 true CA3099701A1 (en) | 2019-11-14 |
Family
ID=66625340
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3099701A Pending CA3099701A1 (en) | 2018-05-07 | 2019-05-07 | Sulforhodamine phosphoramidite dyes |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US12071547B2 (enExample) |
| EP (1) | EP3790931B1 (enExample) |
| JP (1) | JP7399882B2 (enExample) |
| KR (1) | KR102753367B1 (enExample) |
| CN (1) | CN112533998B (enExample) |
| AU (1) | AU2019266218B2 (enExample) |
| CA (1) | CA3099701A1 (enExample) |
| ES (1) | ES2967690T3 (enExample) |
| MX (1) | MX2020011378A (enExample) |
| WO (1) | WO2019217470A1 (enExample) |
| ZA (1) | ZA202006485B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4182319A1 (en) * | 2020-07-16 | 2023-05-24 | Cepheid | Fluorescent dyes |
| CN115636843B (zh) * | 2022-09-27 | 2024-12-13 | 大连理工大学 | 一类多功能荧光染料及应用 |
| CN115414703B (zh) * | 2022-11-03 | 2023-01-17 | 百力格生物科技(上海)股份有限公司 | 染料修饰后的核酸探针纯化方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5231191A (en) * | 1987-12-24 | 1993-07-27 | Applied Biosystems, Inc. | Rhodamine phosphoramidite compounds |
| US5451463A (en) * | 1989-08-28 | 1995-09-19 | Clontech Laboratories, Inc. | Non-nucleoside 1,3-diol reagents for labeling synthetic oligonucleotides |
| US6727356B1 (en) | 1999-12-08 | 2004-04-27 | Epoch Pharmaceuticals, Inc. | Fluorescent quenching detection reagents and methods |
| US7344701B2 (en) * | 2004-02-03 | 2008-03-18 | Biosearch Technologies, Inc. | Xanthene dyes |
| WO2007115265A2 (en) | 2006-03-31 | 2007-10-11 | Applied Biosystems Inc. | Reagents useful for synthesizing rhodamine-labeled oligonucleotides |
| EP2552492A2 (en) * | 2010-04-02 | 2013-02-06 | Pharmacophotonics, Inc. | Single isomeric conjugates of rhodamine dyes |
| WO2014058535A1 (en) * | 2012-08-19 | 2014-04-17 | Michigan Technological University | Lysosomal targeting probes |
| JP6574240B2 (ja) | 2014-03-30 | 2019-09-11 | セフィエド | 修飾シトシンポリヌクレオチドオリゴマーおよび方法 |
| WO2015153496A1 (en) | 2014-03-30 | 2015-10-08 | Cepheid | Modified thymine polynucleotide oligomers and methods |
-
2019
- 2019-05-07 EP EP19725532.6A patent/EP3790931B1/en active Active
- 2019-05-07 CN CN201980030812.1A patent/CN112533998B/zh active Active
- 2019-05-07 JP JP2020562197A patent/JP7399882B2/ja active Active
- 2019-05-07 CA CA3099701A patent/CA3099701A1/en active Pending
- 2019-05-07 MX MX2020011378A patent/MX2020011378A/es unknown
- 2019-05-07 US US17/053,683 patent/US12071547B2/en active Active
- 2019-05-07 AU AU2019266218A patent/AU2019266218B2/en active Active
- 2019-05-07 WO PCT/US2019/031188 patent/WO2019217470A1/en not_active Ceased
- 2019-05-07 KR KR1020207035076A patent/KR102753367B1/ko active Active
- 2019-05-07 ES ES19725532T patent/ES2967690T3/es active Active
-
2020
- 2020-10-19 ZA ZA2020/06485A patent/ZA202006485B/en unknown
-
2024
- 2024-08-19 US US18/808,689 patent/US20250051577A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| MX2020011378A (es) | 2021-02-15 |
| CN112533998A (zh) | 2021-03-19 |
| EP3790931A1 (en) | 2021-03-17 |
| JP7399882B2 (ja) | 2023-12-18 |
| ZA202006485B (en) | 2025-07-30 |
| EP3790931B1 (en) | 2023-09-27 |
| CN112533998B (zh) | 2023-06-20 |
| JP2021523268A (ja) | 2021-09-02 |
| US12071547B2 (en) | 2024-08-27 |
| US20250051577A1 (en) | 2025-02-13 |
| KR20210035079A (ko) | 2021-03-31 |
| WO2019217470A1 (en) | 2019-11-14 |
| BR112020022684A2 (pt) | 2021-02-17 |
| AU2019266218A1 (en) | 2021-01-07 |
| US20240067824A1 (en) | 2024-02-29 |
| KR102753367B1 (ko) | 2025-01-10 |
| AU2019266218B2 (en) | 2024-08-15 |
| ES2967690T3 (es) | 2024-05-03 |
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| JP2009516715A (ja) | ポリヌクレオチド標識試薬 | |
| US10738346B2 (en) | Nitrodiarylethenes as fluorescence quenchers for nucleic acid probes | |
| Yanagi et al. | A fluorescent 3, 7-bis-(naphthalen-1-ylethynylated)-2′-deoxyadenosine analogue reports thymidine in complementary DNA by a large emission Stokes shift | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20240507 |
|
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| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20250415 |
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| D15 | Examination report completed |
Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D15-D126 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: EXAMINER'S REPORT Effective date: 20250514 |
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| P11 | Amendment of application requested |
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| P11 | Amendment of application requested |
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| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20260414 |