CN112513087A - 抗cd38抗体、其抗原结合片段及医药用途 - Google Patents

抗cd38抗体、其抗原结合片段及医药用途 Download PDF

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CN112513087A
CN112513087A CN201980049843.1A CN201980049843A CN112513087A CN 112513087 A CN112513087 A CN 112513087A CN 201980049843 A CN201980049843 A CN 201980049843A CN 112513087 A CN112513087 A CN 112513087A
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seq
sequence
amino acid
antibody
light chain
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CN112513087B (zh
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叶鑫
孙乐
宋明娟
傅蓓蓓
王小华
张蕾
陶维康
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Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
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Shanghai Hengrui Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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Abstract

本公开提供了抗CD38抗体、其抗原结合片段及医药用途。具体的，本公开涉及包含所述抗CD38抗体CDR区的鼠源抗体、嵌合抗体或人源化抗体，以及包含抗CD38抗体或其抗原结合片段的药物组合物，以及其作为药物的用途。特别地，本公开提供了一种人源化的抗CD38抗体在制备用于治疗CD38阳性疾病或病症的药物中的用途。

Description

PCT国内申请，说明书已公开。

Claims (23)

  1. PCT国内申请，权利要求书已公开。
CN201980049843.1A 2018-09-11 2019-09-10 抗cd38抗体、其抗原结合片段及医药用途 Active CN112513087B (zh)

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Application Number Priority Date Filing Date Title
CN201811060341 2018-09-11
CN2018110603412 2018-09-11
PCT/CN2019/105119 WO2020052546A1 (zh) 2018-09-11 2019-09-10 抗cd38抗体、其抗原结合片段及医药用途

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CN112513087A true CN112513087A (zh) 2021-03-16
CN112513087B CN112513087B (zh) 2023-01-24

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US (1) US20220275100A1 (zh)
EP (1) EP3851456A4 (zh)
JP (1) JP2021536254A (zh)
KR (1) KR20210057752A (zh)
CN (1) CN112513087B (zh)
AU (1) AU2019338999A1 (zh)
BR (1) BR112021004130A2 (zh)
CA (1) CA3111651A1 (zh)
MX (1) MX2021002531A (zh)
TW (1) TW202035454A (zh)
WO (1) WO2020052546A1 (zh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114409788A (zh) * 2022-03-04 2022-04-29 四川大学华西医院 抗cd38的抗体及其应用
WO2023045859A1 (zh) * 2021-09-23 2023-03-30 非同（成都）生物科技有限公司 Cd38单克隆抗体及其应用

Families Citing this family (4)

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Publication number Priority date Publication date Assignee Title
CN114075283A (zh) * 2020-08-12 2022-02-22 三生国健药业（上海）股份有限公司 结合人cd38的抗体、其制备方法和用途
TW202325743A (zh) * 2021-07-14 2023-07-01 大陸商江蘇恆瑞醫藥股份有限公司 特異性結合ｃｄ３８、ｂｃｍａ和ｃｄ３的抗原結合分子及其醫藥用途
CN113912727B (zh) * 2021-11-16 2023-05-02 福州迈新生物技术开发有限公司 抗cd38蛋白单克隆抗体、细胞系及其制备方法和应用
WO2024131849A1 (zh) * 2022-12-21 2024-06-27 非同（成都）生物科技有限公司 Cd38单克隆抗体及其应用

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CN101218256A (zh) * 2005-03-23 2008-07-09 根马布股份公司 用于治疗多发性骨髓瘤的cd38抗体
CN109053892A (zh) * 2018-09-19 2018-12-21 苏州思坦维生物技术股份有限公司 特异结合人及猴cd38抗原的单克隆抗体及其制备方法与应用
CN112154156A (zh) * 2018-03-28 2020-12-29 武田药品工业株式会社 抗cd38抗体的皮下给药

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Publication number Priority date Publication date Assignee Title
CN101218256A (zh) * 2005-03-23 2008-07-09 根马布股份公司 用于治疗多发性骨髓瘤的cd38抗体
CN112154156A (zh) * 2018-03-28 2020-12-29 武田药品工业株式会社 抗cd38抗体的皮下给药
CN109053892A (zh) * 2018-09-19 2018-12-21 苏州思坦维生物技术股份有限公司 特异结合人及猴cd38抗原的单克隆抗体及其制备方法与应用

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023045859A1 (zh) * 2021-09-23 2023-03-30 非同（成都）生物科技有限公司 Cd38单克隆抗体及其应用
CN114409788A (zh) * 2022-03-04 2022-04-29 四川大学华西医院 抗cd38的抗体及其应用
CN114409788B (zh) * 2022-03-04 2022-10-04 四川大学华西医院 抗cd38的抗体及其应用

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AU2019338999A1 (en) 2021-03-18
TW202035454A (zh) 2020-10-01
EP3851456A1 (en) 2021-07-21
BR112021004130A2 (pt) 2021-05-25
US20220275100A1 (en) 2022-09-01
KR20210057752A (ko) 2021-05-21
MX2021002531A (es) 2021-04-28
WO2020052546A1 (zh) 2020-03-19
CA3111651A1 (en) 2020-03-19
JP2021536254A (ja) 2021-12-27
EP3851456A4 (en) 2022-06-08
CN112513087B (zh) 2023-01-24

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