CN112513057B - 供在由衰老细胞引起或介导的状况的临床管理中使用和用于治疗癌症的作为Bcl家族拮抗剂的酰基氨基膦酸酯和酰基苄胺 - Google Patents
供在由衰老细胞引起或介导的状况的临床管理中使用和用于治疗癌症的作为Bcl家族拮抗剂的酰基氨基膦酸酯和酰基苄胺 Download PDFInfo
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- CN112513057B CN112513057B CN201980034704.1A CN201980034704A CN112513057B CN 112513057 B CN112513057 B CN 112513057B CN 201980034704 A CN201980034704 A CN 201980034704A CN 112513057 B CN112513057 B CN 112513057B
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- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
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- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410023605.6A CN117866015A (zh) | 2018-04-30 | 2019-04-30 | 一种临床管理中使用的化合物及其用途 |
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| US201862664891P | 2018-04-30 | 2018-04-30 | |
| US201862664850P | 2018-04-30 | 2018-04-30 | |
| US201862664860P | 2018-04-30 | 2018-04-30 | |
| US201862664863P | 2018-04-30 | 2018-04-30 | |
| US62/664,860 | 2018-04-30 | ||
| US62/664,863 | 2018-04-30 | ||
| US62/664,850 | 2018-04-30 | ||
| US62/664,891 | 2018-04-30 | ||
| PCT/US2019/030039 WO2019213160A1 (en) | 2018-04-30 | 2019-04-30 | Acyl phosphonamidates and acyl benzylamines that are bcl family antagonists for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202410023605.6A Division CN117866015A (zh) | 2018-04-30 | 2019-04-30 | 一种临床管理中使用的化合物及其用途 |
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| Publication Number | Publication Date |
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| CN112513057A CN112513057A (zh) | 2021-03-16 |
| CN112513057B true CN112513057B (zh) | 2024-01-05 |
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Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
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| CN201980034704.1A Active CN112513057B (zh) | 2018-04-30 | 2019-04-30 | 供在由衰老细胞引起或介导的状况的临床管理中使用和用于治疗癌症的作为Bcl家族拮抗剂的酰基氨基膦酸酯和酰基苄胺 |
| CN202410023605.6A Pending CN117866015A (zh) | 2018-04-30 | 2019-04-30 | 一种临床管理中使用的化合物及其用途 |
| CN201980034780.2A Active CN112469411B (zh) | 2018-04-30 | 2019-04-30 | 供在由衰老细胞引起或介导的状况的临床管理中使用和用于治疗癌症的作为Bcl家族拮抗剂的氨基膦酸酯 |
| CN201980002328.8A Active CN110662752B (zh) | 2018-04-30 | 2019-04-30 | 用于临床管理由衰老细胞引起或介导的病症以及治疗癌症的Bcl家族拮抗剂磷杂环化合物 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202410023605.6A Pending CN117866015A (zh) | 2018-04-30 | 2019-04-30 | 一种临床管理中使用的化合物及其用途 |
| CN201980034780.2A Active CN112469411B (zh) | 2018-04-30 | 2019-04-30 | 供在由衰老细胞引起或介导的状况的临床管理中使用和用于治疗癌症的作为Bcl家族拮抗剂的氨基膦酸酯 |
| CN201980002328.8A Active CN110662752B (zh) | 2018-04-30 | 2019-04-30 | 用于临床管理由衰老细胞引起或介导的病症以及治疗癌症的Bcl家族拮抗剂磷杂环化合物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10703745B2 (https=) |
| EP (3) | EP3787626B1 (https=) |
| JP (3) | JP7080346B2 (https=) |
| CN (4) | CN112513057B (https=) |
| WO (3) | WO2019213160A1 (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2020140005A2 (en) | 2018-12-29 | 2020-07-02 | Newave Pharmaceutical Inc. | Bcl-2 inhibitors |
| EP3906235B1 (en) | 2019-01-04 | 2023-03-15 | Ascentage Pharma (Suzhou) Co., Ltd. | Method for preparing sulfonamides drugs |
| CN113248415B (zh) * | 2021-05-26 | 2022-08-09 | 苏州正永生物医药有限公司 | 一种abt-737关键中间体的制备方法以及abt-737的制备方法 |
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| EP3787626B1 (en) | 2023-06-07 |
| US20190367496A1 (en) | 2019-12-05 |
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