CN1125106A

CN1125106A - Chang'an capsule and its preparation method and application

Info

Publication number: CN1125106A
Application number: CN94113192A
Authority: CN
Inventors: 龙治湘; 刘焱文; 周常权; 谌新建; 杨培明; 何旭元; 何再安
Original assignee: CHANGDE TRADITIONAL CHINESE MEDICINE FACTORY HUNAN PROV; Hubei College of Chinese Medicine
Current assignee: CHANGDE TRADITIONAL CHINESE MEDICINE FACTORY HUNAN PROV; Hubei College of Chinese Medicine
Priority date: 1994-12-21
Filing date: 1994-12-21
Publication date: 1996-06-26

Abstract

The present invention relates to a proprietary Chinese medicine with the functions of antisepsis, relieving inflammation, antipyretic analgesic, improving gastrointestinal function and enhancing immunity for curing bacillary dysentery, enterogastritis, damp-heat diarrhea, common cold and jaundice due to damp-heat pathogen is made up by using natural plant origanum vulgare as raw material. Said invention uses a water vapour distillation method to extract the origanum vulgare volatile oil and origanum vulgare concentrated solution, and makes it into origanum vulgare extract, then makes the origanum vulgare volatile oil, origanum vulgare extract and dilute oil absorbent pass through such processes as mixing, pulverizing, granulating, capsulizing and packing so as to obtain the invented finished product.

Description

Chang ' an capsule and manufacture method thereof and purposes

The present invention relates to a kind of sick Chinese patent medicine chang ' an capsule and manufacture method and purposes such as bacillary dysentery, enteritis for the treatment of.

Bacillary dysentery, enteritis are the particularly high common pandemics of a kind of sickness rate of developing country of the world, and the bacillary dysentery in China every year, the sickness rate of enteritis also have 3～5,000 ten thousand person-times more than.At present, preventing, treat the method for this kind disease, except improving the whole people's health consciousness, actively improve outside the sanitary condition, mainly is to take medicine to prevent, control.Medicine commonly used is divided into two classes, and a class is the chemicals preparation, and as antibiotics, sulfonamides and chemical synthetic drug though this class medicine possesses certain curative effect, easily produce drug resistance, and toxic and side effects is obvious, and specificity is not strong; Another kind of medicine is Chinese medicine and Chinese patent medicine, as Herba Andrographis, Folium Pyrrosiae, XIANGLIAN ball, XIANGLIAN sheet (capsule), and bacillary dysentery sheet etc., the defective of this class medicine is a weak curative effect, and effect is slow, and taking dose is big, is unfavorable for industrialized great production.Therefore, efficient, low toxicity, the strong medicine of specificity of seeking to study prevention, treatment bacillary dysentery, enteritis is the emphasis research topic of current medical and health circle.

The purpose of this invention is to provide a kind of efficient, the low toxicity of diseases such as bacillary dysentery, enteritis, chang ' an capsule and manufacture method and purposes that specificity is strong for the treatment of.

The composition of chang ' an capsule content of the present invention has origanum volatile oil, Adeps Bovis seu Bubali extractum, and the dilution oil absorbent, their weight hundred is advanced proportion by subtraction and is: origanum volatile oil 8～15%, Adeps Bovis seu Bubali extractum 40～60%, dilution oil absorbent 30～45%.

The manufacture method of chang ' an capsule of the present invention is: utilize natural medicinal plant Adeps Bovis seu Bubali (Origanun Vulgre) to be raw material, earlier Adeps Bovis seu Bubali is put in the distillator, the water that adds 12 times of weight, distilled 2.5～3.5 hours, adopt the vapor distillation method, extract origanum volatile oil and Adeps Bovis seu Bubali distillate; Again Adeps Bovis seu Bubali distillate heating is made it concentrate, when being concentrated into every ML and being equivalent to 5 gram crude drugs, add 95% ethanol, make concentrated solution contain the alcohol amount to 65～75%; The concentrated solution that will contain ethanol 65～75% is again put into container and was left standstill 15～25 hours, filters, remove impurity after, adopt conventional method to reclaim ethanol, make concentrated solution become Adeps Bovis seu Bubali extractum, and with it at drying under reduced pressure below 80 ℃; Then with origanum volatile oil, Adeps Bovis seu Bubali extractum and dilution oil absorbent as: starch, magnesium stearate, hydrogen matter magnesium oxide, percentage by weight in accordance with regulations are placed in the container to be mixed, stir, pulverizes and with 70～80% alcohol granulation; Being that obtained medicine grain is carried out drying, granulate again, is to incapsulate, polish, pack and be finished product at last.

Its effect of chang ' an capsule of the present invention is a clearing away heat and eliminating dampness, and detoxifcation is regulated the flow of vital energy, and administration dispels; Purposes is to cure mainly diarrhea due to damp-heat, hygropyretic dysentery, and gastroenteritis, Common Cold was affixed one's name in summer, diseases such as jaundice due to damp-heat.

Advantage of the present invention: 1, the raw material abundance of this medicine, production method is simple, is convenient to implement; 2, the dosage taken of this medicine is little, and general is 60% of Chinese patent medicine common dose only; 3, this medical instrument have antibiotic, antiinflammatory, analgesic, ease pain, improve gastrointestinal function and raise immunity effect, and be better than XIANGLIAN sheet (capsule), toxicity is the result show: the LD50 of animal is 502.25 ± 0.0313g/ biology/body weight, credible limit value 436～578.52g crude drug/Kg body weight.The mice maximum tolerated dose is 264.11g biology/Kg/ day, and its maximum tolerance multiple is 366.8 times of clinical medicine dose.XIANGLIAN sheet animal LD50 is 4.68g crude drug/Kg.4, this medicine shows through clinical application; This medicine is in curative effect, and dose, toxic and side effects all are better than matched group medicine XIANGLIAN sheet (capsule) and SMZ.Total effective rate is 96.4%, and cure rate is 92.8%.

Introduce an example below:

Get 6 kilograms of Adeps Bovis seu Bubalis, add 12 times in water, distillation is 3 hours in distillator, extract volatile oil, after distillate filters, when adopting heating to be concentrated into every milliliter (ML) to be equivalent to 5 gram Adeps Bovis seu Bubalis, add 95% ethanol and make concentrated solution contain the alcohol amount, left standstill again 24 hours, filter to 70%.Filtrate recycling ethanol, make concentrated solution become extractum, at drying under reduced pressure below 80 ℃, get origanum volatile oil 10% then by weight percentage, Adeps Bovis seu Bubali extractum 45%, dilution oil absorbent 45% (starch and suitable magnesium stearate, hydrogen matter magnesium oxide) mixes, stirs, with 70～80% alcohol granulations, drying, granulate; Dress up 1000 capsules, polishing, packing at last and be finished product.Make in the finished product every to contain content 0.21～0.25 gram, during use: oral, three times on the one, each 2,4～6 days is a course of treatment, and a general course of treatment can be effectively, most can the recovery from illness.

Claims

1, a kind of chang ' an capsule comprises capsule and capsule 's content, it is characterized in that: the composition of content is: origanum volatile oil, Adeps Bovis seu Bubali extractum, the dilution oil absorbent, their percentage by weight is: origanum volatile oil 8～15%, Adeps Bovis seu Bubali extractum 40～60%, dilution oil absorbent 30～45%.

2, a kind of method of making the described chang ' an capsule of claim 1: it is characterized in that: adopting the natural plants Adeps Bovis seu Bubali is raw material, earlier Adeps Bovis seu Bubali is put in the distillator, add the water of 12 times of weight, distilled 2.5～3.5 hours, adopt steam distillation to extract origanum volatile oil and Adeps Bovis seu Bubali distillate; Adeps Bovis seu Bubali distillate heating is made it concentrate again, when being concentrated to every milliliter (ML) when being equivalent to 5 gram crude drugs, add 95% ethanol, making concentrated solution contain amount of alcohol is 65～75%; The concentrated solution that will contain ethanol 65～75% is again put into container and was left standstill 15～24 hours, filters, and adopts conventional method to reclaim ethanol after the removal of impurity, makes concentrated solution become Adeps Bovis seu Bubali extractum, and with it at drying under reduced pressure below 80 ℃; Then with origanum volatile oil, Adeps Bovis seu Bubali extractum and dilution oil absorbent, percentage by weight in accordance with regulations are placed in the container and mix, stir, pulverize, and with 70～80% alcohol granulation; Being that prepared medicine grain is carried out drying, granulate again, is to incapsulate, polish at last, and packing is finished product.

3, the purposes of the described chang ' an capsule of a kind of claim 1 is characterized in that its purposes is: cure mainly diarrhea due to damp-heat, and hygropyretic dysentery, gastroenteritis, Common Cold was affixed one's name in summer, the jaundice due to damp-heat disease.