CN112494632A - 一种用于治疗体腔积液的中药粉剂及其制备方法 - Google Patents
一种用于治疗体腔积液的中药粉剂及其制备方法 Download PDFInfo
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- CN112494632A CN112494632A CN202011573551.9A CN202011573551A CN112494632A CN 112494632 A CN112494632 A CN 112494632A CN 202011573551 A CN202011573551 A CN 202011573551A CN 112494632 A CN112494632 A CN 112494632A
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Abstract
本发明公开一种用于治疗体腔积液的中药粉剂及其制备方法，按照质量份数比由以下成分组成：人参4～5份、白术8～10份、茯苓8～10份、泽泻8～10份、猪苓8～10份、大黄8～10份，牵牛子15～20份、青皮8～10份、陈皮8～10份、槟榔4～5份、木香4～5份、半夏15～20份，旋复花8～10份，干姜2～3份，黄芪8～10份、附子0.3～0.4份、白芍4～5份、木瓜0.8～1份、桂枝4～5份和防己8～10份，所述中药粉剂的制备方法包括以下步骤：首先按上述质量份数比称取各组分，然后将各组分进行清、打磨，最后将打磨后的各组分混合均匀；本发明配制简单，吸收效果好，药效持续时间长、无副作用、安全性高，成本低，有利于患者及时减轻病状。
Description
技术领域
本发明涉及一种中药组合物，具体是涉及一种用于治疗体腔积液的中药粉剂及其制备方法。
背景技术
体腔积液通常包括心包积液、胸腔积液、腹腔积液、盆腔积液、全身水肿等。心包积液是以心阳亏虚，心气不足，冠脉淤阻，痰饮内停。胸腔积液原因是结核病、癌症、肿瘤，肺炎引起的渗出性胸膜炎、左心衰、低蛋白血症引起的漏出性胸腔积液等。中医悬饮胸胁饱满，咳唾引痛，喘促不能平卧，或有肺痨病史，属饮流胁下。
基本病机为肺、脾、肾三脏功能失调，三焦气化失宣，津液停积机体某部位而成。饮邪具有流动之性，饮留胃肠，则为痰饮；饮流胁下，则为悬饮；饮流肢体，则为溢饮；聚于胸肺，则为支饮。痰饮病的病变脏腑为肺、脾、肾、三焦，以脾首当其冲。痰饮病的病理性质属阳虚阴盛，输化失调，因虚致实，水饮停积为患。腹腔积液中医属于鼓胀系指肝病日久，肝脾肾功能失调，气滞、血瘀、水停于腹中所导致的以腹胀大如鼓，皮色苍黄，脉络暴露为主要临床表现的一种病证。本病在古医籍中又称单腹胀、臌、蜘蛛蛊等。
在鼓胀的病变过程中，肝脾肾三脏常相互影响，肝郁而乘脾，土壅则木郁，肝脾久病则伤肾，肾伤则火不生土或水不涵木。同时气、血、水也常相因为病，气滞则血瘀，血不利而为水，水阻则气滞；反之亦然。气血水结于腹中，水湿不化，久则实者愈实；邪气不断残正气，使正气日渐虚弱，久则虚者愈虚，故本虚标实，虚实并见为本病的主要病机特点。晚期水湿之邪，郁久化热，则可发生内扰或蒙闭心神，引动肝风，迫血妄行，络伤血溢之变。
总之，鼓胀的病变部位在肝、脾、肾，基本病机是肝脾肾三脏功能失调，气滞、血瘀、水停于腹中。病机特点为本虚标实。
目前，体腔积液通常采用西医进行治疗，而西医只能有积液就给引流、抽水等对症治疗，导致患者身体越来越虚弱，个别给与输入白蛋白，但是患者肺、脾、肾三脏功能失调，吸收能力受限，所以在治疗的领域只能说明缓解一时症状，无法从根本上进行治疗。
发明内容
本发明为了解决上述技术问题，提供一种用于治疗体腔积液的中药粉剂及其制备方法，其配制简单，吸收效果好，药效持续时间长、无副作用、安全性高，成本低，有利于患者及时减轻病状。
为了实现上述技术问题，本发明所采用的技术方案是：一种用于治疗体腔积液的中药粉剂，按照质量份数比由以下成分组成：人参4～5份、白术8～10份、茯苓8～10份、泽泻8～10份、猪苓8～10份、大黄8～10份，牵牛子15～20份、青皮8～10份、陈皮8～10份、槟榔4～5份、木香4～5份、半夏15～20份，旋复花8～10份，干姜2～3份，黄芪8～10份、附子0.3～0.4份、白芍4～5份、木瓜0.8～1份、桂枝4～5份和防己8～10份。
所述中药粉剂由以下质量份数的中药原材料组成：所述人参为5份、白术为10份、茯苓为10份、泽泻为10份、猪苓为10份、大黄为10份，牵牛子为20份、青皮为10份、陈皮为10份、槟榔为5份、木香为5份、半夏为20份，旋复花为10份，干姜为3份，黄芪为10份、附子为0.4份、白芍为5份、木瓜为1份、桂枝为5份和防己为10份。
一种用于治疗体腔积液的中药粉剂的制备方法，包括以下步骤：首先按照权利要求1所述的质量份数比称取各组分，然后将各组分进行清洗，再次，清洗完成后将各组分进行打磨，最后将打磨后的各组分混合均匀。
所述各组分的打磨粒度为1～5μm。
本发明的有益效果：
1、本发明制作为散剂，相比较传统的丸剂的缓慢以及汤剂的猛烈而言，更加适用于患者的需求；
2、本发明原料价格低廉，且炮制方便，吸收效果好，药效持续时间长，无毒副作用，安全性高，有利于患者及时减轻病状；
3、本发明中大黄、牵牛子，荡涤肠胃，泻水泄热，为君药，泽泻、猪苓为臣药，清热利湿，通利水道，君臣药相辅相成，使水热之邪从二便分消而去，但水停气亦阻，气机不行，又可致水湿不去，人参、白术、茯苓补中益气，健脾渗湿，旋复花降气消痰，行气止吐，半夏燥湿化痰，和胃止吐，加干姜温胃祛寒；黄芪甘温入脾，健脾益气，入脾胃肺经，可补虚养五脏；桂枝通阳化气、降逆平冲；木瓜味酸入肝、平肝木以防克土；防己祛寒除湿；附子以温水土、温补元阳；白芍胸腹胀痛、肝气不疏；故以青皮舒肝气而破结，陈皮行肺脾之气而畅胸膈，槟榔下气利水而破坚，木香疏通三焦而导滞，使气畅水行则肿胀可消，均为佐使药。诸药合用，健脾利水，行气破结之功。
具体实施方式
以下结合具体实施例进一步阐述本发明。
实施例1
一种用于治疗体腔积液的中药粉剂，按照质量份数比由以下成分组成：所述人参为5份、白术为10份、茯苓为10份、泽泻为10份、猪苓为10份、大黄为10份，牵牛子为20份、青皮为10份、陈皮为10份、槟榔为5份、木香为5份、半夏为20份，旋复花为10份，干姜为3份，黄芪为10份、附子为0.4份、白芍为5份、木瓜为1份、桂枝为5份和防己为10份。
一种用于治疗体腔积液的中药粉剂的制备方法，包括以下步骤：首先按照权利要求1所述的质量份数比称取各组分，然后将各组分进行清洗，再次，清洗完成后将各组分进行打磨，最后将打磨后的各组分混合均匀。
所述各组分的打磨粒度为1～5μm。
实施例2
一种用于治疗体腔积液的中药粉剂，按照质量份数比由以下成分组成：人参4份、白术8份、茯苓8份、泽泻8份、猪苓8份、大黄8份，牵牛子15份、青皮8份、陈皮8份、槟榔4份、木香4份、半夏15份，旋复花8份，干姜2份，黄芪8份、附子0.3份、白芍4份、木瓜0.8份、桂枝4份和防己8份。
一种用于治疗体腔积液的中药粉剂的制备方法，包括以下步骤：首先按照权利要求1所述的质量份数比称取各组分，然后将各组分进行清洗，再次，清洗完成后将各组分进行打磨，最后将打磨后的各组分混合均匀。
所述各组分的打磨粒度为1～5μm。
实施例3
一种用于治疗体腔积液的中药粉剂，按照质量份数比由以下成分组成：人参1.5份、白术9份、茯苓9份、泽泻9份、猪苓9份、大黄9份，牵牛子17份、青皮9份、陈皮9份、槟榔4.5份、木香4.5份、半夏17份，旋复花9份，干姜2.5份，黄芪9份、附子0.4份、白芍4.5份、木瓜0.9份、桂枝4.5份和防己9份。
一种用于治疗体腔积液的中药粉剂的制备方法，包括以下步骤：首先按照权利要求1所述的质量份数比称取各组分，然后将各组分进行清洗，再次，清洗完成后将各组分进行打磨，最后将打磨后的各组分混合均匀。
所述各组分的打磨粒度为1～5μm。
为了进一步考察本发明药物的临床疗效和安全性，本申请从2005年至今对1326例胸腔积液、腹腔积液患者进行临床观察治疗。治疗方法：
口服，一次3g，每日两次饭后服用，根据患者病情轻重计算治疗时间，轻度患者服用10-15天]痊愈，重病患者连服60-90天痊愈。
疗效判定标准
疗效标准参照《中医病症判断疗效标准》中有关疗效标准。
治愈：临床症状全部消失，实验室检查正常；
显效：临床症状基本消失，试验室检查各相关指标接近正常水平；有效：临床症状减轻，试验室检查各相关指标有所改善，体征有改善；无效：临床症状无明显好转或加重。
临床结果
临床治愈1046例(78.88％)，显效151例(11.38％)，有效101例(7.61％)，无效28例(2.11％)，总有效率为97.87％。
下面结合具体病例对本发明的中药粉剂疗效进一步进行验证。病例1：张某，女52岁，吉林省双辽市四平。简要病史：患者通过体检发现左侧胸腔积液。诊断治疗结果：左侧胸腔积液。超声检查：左侧胸腔脊柱旁线至肩胛线第7-9肋间，可探及93.9mm液性暗区。称取人参五钱、白术一两、茯苓一两、泽泻一两、猪苓一两、大黄一两，牵牛子二两、青皮一两、陈皮一两、槟榔五钱、木香五钱、半夏二两，旋复花一两，干姜三钱，黄芪一两半、附子四分、白芍五钱、木瓜一钱、桂枝半两、防己一两；将各原药进行清洗打磨粉剂，一次4g/日三次饭后服用，10日后，症状明显减轻，呼吸均匀，无胸闷疼痛，可以左侧卧位睡觉。续服用4天后基本痊愈，再7天彻底痊愈，随访半年未见复发。
病例2：谢某，男，91岁，玉田县人。简要病史：老人走路气喘吁吁，翻身费劲，胸闷气短。在当地医院抗菌消炎等对症治疗两月余无效。诊断治疗结果：右侧胸腔积液、冠心病、慢性阻塞性肺气肿、肝囊肿。诊断为右侧胸腔积液(中医辩证：胸胁疼痛，咳唾引痛，痛势逐渐减轻，而呼吸困难加重，咳逆气喘，息促不能平卧，或仅能偏卧于停饮的一侧，病侧肋间胀满，甚则可见病侧胸廓隆起，舌苔白，脉沉弦或弦滑)。称取人参五钱、白术一两、茯苓一两、泽泻一两、猪苓一两、大黄一两，牵牛子二两、青皮一两、陈皮一两、槟榔五钱、木香五钱、半夏二两，旋复花一两，干姜三钱，黄芪一两半、附子四分、白芍五钱、木瓜一钱、桂枝半两、防己一两；将各原药进行清洗打磨粉剂，一次2g/日二次饭后服用，7日后，,症状明显减轻，老人精神头明显好转，呼吸均匀，饮食增加，大便一天12次，小便3-4次，睡眠质量提高，说话语气有力，续服用14天后，经过复查积液没有了，基本痊愈。
病例3：吴某，男32岁，广东阳江人。简要病史：肝硬化做TPS手术后，无法走路，当年4月查出5.0ml腹水，经过当地西医给与利尿，输白蛋白等对症治疗一个月后，治疗无效。诊断：肝硬化腹水。中医诊断：鼓胀系指肝病日久，肝脾肾功能失调，气滞、血瘀、水停于腹中。称取人参五钱、白术一两、茯苓一两、泽泻一两、猪苓一两、大黄一两，牵牛子二两、青皮一两、陈皮一两、槟榔五钱、木香五钱；将各原药进行清洗打磨粉剂，一次4g/日三次饭后服用，14日后，症状明显减轻，腹围见小，黄疸消退，饮食有所增加，大小便增加。续服用14天后基本痊愈，复查腹腔0.1mm积液。
病例4：王某，男93岁，黑龙江省哈尔滨市人。简要病史：患者喘咳，不能平卧，咳嗽有痰，嘴唇青紫，端坐位。经过当地西医给与强心利尿等缓解症状，出院后一周多次发病，到诊反反复复住院，治疗无效。诊断：心衰，二尖瓣返流、三尖瓣返流、主动脉返流、心包积液等。中医诊断：心阳亏虚，心气不足，冠脉淤阻，痰饮内停。称取人参五钱、白术一两、茯苓一两、泽泻一两、猪苓一两、大黄一两，牵牛子二两、青皮一两、陈皮一两、槟榔五钱、木香五钱、半夏二两，旋复花一两，干姜三钱，黄芪一两半；将各原药进行清洗打磨粉剂，一次1g/日三次饭后服用，14日后，症状明显减轻，能平卧睡眠，饮食有所增加，喘咳减轻，大小便增加。续服用一个月后基本痊愈，继而继续巩固一个月。
Claims (4)
1.一种用于治疗体腔积液的中药粉剂，其特征在于：按照质量份数比由以下成分组成：人参4～5份、白术8～10份、茯苓8～10份、泽泻8～10份、猪苓8～10份、大黄8～10份，牵牛子15～20份、青皮8～10份、陈皮8～10份、槟榔4～5份、木香4～5份、半夏15～20份，旋复花8～10份，干姜2～3份，黄芪8～10份、附子0.3～0.4份、白芍4～5份、木瓜0.8～1份、桂枝4～5份和防己8～10份。
2.如权利要求1所述的一种用于治疗体腔积液的中药粉剂，其特征在于：所述中药粉剂由以下质量份数的中药原材料组成：所述人参为5份、白术为10份、茯苓为10份、泽泻为10份、猪苓为10份、大黄为10份，牵牛子为20份、青皮为10份、陈皮为10份、槟榔为5份、木香为5份、半夏为20份，旋复花为10份，干姜为3份，黄芪为10份、附子为0.4份、白芍为5份、木瓜为1份、桂枝为5份和防己为10份。
3.一种用于治疗体腔积液的中药粉剂的制备方法，其特征在于：包括以下步骤：首先按照权利要求1所述的质量份数比称取各组分，然后将各组分进行清洗，再次，清洗完成后将各组分进行打磨，最后将打磨后的各组分混合均匀。
4.如权利要求3所述的中药粉剂的制备方法，其特征在于：所述各组分的打磨粒度为1～5μm。
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| CN102908480A (zh) * | 2012-09-20 | 2013-02-06 | 李承平 | 一组芫花行气利水片 |
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| CN102908480A (zh) * | 2012-09-20 | 2013-02-06 | 李承平 | 一组芫花行气利水片 |
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