CN112494629A

CN112494629A - Preparation method of cough-relieving tablet

Info

Publication number: CN112494629A
Application number: CN202011321094.4A
Authority: CN
Inventors: 许丹青; 余国新; 耿亮; 朱亚东
Original assignee: Hainan Halee Pharmaceutical Co ltd
Current assignee: Hainan Halee Pharmaceutical Co ltd
Priority date: 2020-11-23
Filing date: 2020-11-23
Publication date: 2021-03-16

Abstract

The application discloses a preparation method of cough-relieving tablets, carbon dioxide is used as an extracting agent, a proper amount of methanol or ethanol is added to be used as an entrainer to extract effective components of medicinal materials by using supercritical fluid, the extraction rate of the effective components of the medicinal materials is further improved, the effective components of the medicinal materials extracted by the supercritical fluid are highly enriched, the dosage is convenient to reduce and the quality is convenient to control, the effective components of the traditional Chinese medicines can be well preserved by the supercritical fluid extraction of the medicinal materials, the effective components contained in the obtained extracting solution are improved, and the drug effect of the prepared cough-relieving tablets is also improved. Solves the technical problems that the effective components extracted from the medicinal materials in the existing preparation process of the cough relieving tablet are low, and the drug effect of the cough relieving tablet is influenced.

Description

Preparation method of cough-relieving tablet

Technical Field

The application relates to the technical field of traditional Chinese medicine formulas, in particular to a preparation method of cough-relieving tablets.

Background

In recent years, as the atmospheric pollution of the earth is increasingly serious, the pollution sources of industry and civilian use are continuously increased, factors such as environmental treatment incapability and the like are added, the living environment of human beings is worsened, the immune function of human bodies is damaged, the morbidity of respiratory system diseases is in a remarkable rising trend, the mortality caused by respiratory system diseases is also increased year by year, and the respiratory system diseases become one of a plurality of killers of human beings at present. Cough is the most common symptom of respiratory system diseases, but causes a lot of cough, and from the perspective of traditional Chinese medicine, cough is caused by external pathogen attacking lung or internal injury of viscera affecting lung. No matter what kind of causes of the cough, clinical application has made the cough relieving tablet in the history of nearly 100 years have good cough relieving effect.

The cough-relieving tablet is a Chinese patent medicine created on the basis of recording famous prescription cough-relieving powder from medical comprehension in Qing Dynasty famous medical engineering clock age, and is a compound preparation prepared by extracting medicinal materials such as aster, exocarpium citri rubrum, platycodon grandiflorum, radix peucedani, fructus aurantii, radix stemonae, schisandra chinensis, poppy shell extract, liquorice, peppermint oil, ammonium chloride and the like, wherein the exocarpium citri rubrum in the prescription has the effects of regulating qi, relieving epigastric distention, eliminating dampness and eliminating phlegm; aster tataricus has the effects of purging lung and descending qi, and resolving phlegm and relieving cough and asthma, and the two medicines are combined to diffuse lung and resolve phlegm, and relieve cough and asthma, and are used as main medicines together. Radix Stemonae is added as adjuvant to moisten lung and relieve cough; the platycodon grandiflorum has the effects of ventilating the lung, relieving sore throat and relieving cough; poppy shell astringes lung to relieve cough and asthma; ammonium chloride is used for relieving cough. Fructus aurantii and pericarpium citri reticulatae are used for assisting in regulating qi and relieving epigastric distention, drying dampness and reducing phlegm; radix Peucedani has effects of dispersing lung qi, expelling phlegm, and relieving cough; the schisandra chinensis astringes lung to relieve cough; herba Schizonepetae can dispel wind-cold and relieve sore throat; dried ginger warms lung to dispel cold to resolve retained fluid; peppermint oil has effects of dispelling wind and dissipating heat. The liquorice is used for moistening lung and regulating the middle warmer and harmonizing the effects of the other drugs in the recipe. The medicines are combined to play the roles of regulating lung and eliminating phlegm and relieving cough and asthma. The compound preparation has good clinical cough relieving effect, but the effective components extracted from the medicinal materials in the existing preparation process of the cough relieving tablet are low, and the medicinal effect of relieving cough and reducing sputum is influenced.

Disclosure of Invention

The embodiment of the application provides a preparation method of cough-relieving tablets, which is used for solving the technical problems that the effective components extracted from all medicinal materials in the existing preparation process of the cough-relieving tablets are low and the cough-relieving efficacy is influenced.

In view of the above, the application provides a method for preparing cough-relieving tablets, which comprises the following steps:

step 1, weighing the following medicinal materials in parts by weight: radix Asteris, exocarpium Citri rubrum, radix Platycodi, radix Peucedani, fructus Aurantii, radix Stemonae, fructus Schisandrae chinensis, plantula Papaveris, Glycyrrhrizae radix, peppermint oil, ammonium chloride, pericarpium Citri Tangerinae, herba Schizonepetae and Zingiberis rhizoma;

step 2, pulverizing the poppy shell weighed in the step 1 into powder, putting all the pulverized medicinal material powder into a supercritical fluid extraction reaction kettle, extracting by using carbon dioxide as an extracting agent and methanol and water as entrainers, collecting extract liquor, recovering methanol, and concentrating the extract liquor into extract to obtain poppy shell extract;

step 3, crushing eleven pure materials of aster, liquorice, exocarpium citri rubrum, platycodon grandiflorum, radix peucedani, fructus aurantii, radix stemonae, schisandra chinensis, pericarpium citri reticulatae, schizonepeta and dried ginger weighed in the step 1 into powder, uniformly mixing, putting all the powder into a supercritical fluid extraction reaction kettle, extracting by using carbon dioxide as an extracting agent and ethanol as an entrainer, collecting an extraction solution, recovering the ethanol, and concentrating the extraction solution into thick paste;

and 4, adding proper auxiliary materials into the thick paste obtained in the step 3, drying, crushing, adding ammonium chloride, adding the poppy shell extract obtained in the step 2, uniformly mixing, preparing into granules, drying, spraying peppermint oil, pressing into tablets and coating to obtain the cough-relieving tablet.

Optionally, in the step 2 and the step 3, the temperature during extraction is 40-60 ℃, the extraction pressure is 20-30 Mpa, the extraction time is 1-2 hours, and the flow rate of carbon dioxide is 20-30 kg/h.

Optionally, in the step 2, the methanol recovery process is to pump the extract into a vacuum concentration tank, and recover methanol under the vacuum degree of 0.07-0.1 Mpa.

Optionally, in the step 3, the ethanol recovery process is to pump the extract into a vacuum concentration tank, and recover ethanol under the vacuum degree of 0.07-0.1 Mpa.

Optionally, in step 2, the poppy shell powder is passed through a 40-60 mesh screen.

Optionally, in step 4, the excipients include one or more of diluents, disintegrants, binders and lubricants.

Optionally, the diluent comprises one or more of anhydrous lactose, microcrystalline cellulose, maltodextrin.

Optionally, the disintegrant comprises one or more of low-substituted hydroxypropyl cellulose, sodium carboxymethyl starch, croscarmellose sodium.

Optionally, the binder comprises one or more of hydroxypropyl cellulose, polyvinylpyrrolidone, cross-linked polyvinylpyrrolidone.

Optionally, the lubricant comprises one or more of magnesium stearate, talc, sodium fumarate stearate, aerosil.

According to the technical scheme, the embodiment of the application has the following advantages:

the application provides a preparation method of cough-relieving tablets, which comprises the following steps:

step 3, crushing eleven pure materials of aster, liquorice, exocarpium citri rubrum, platycodon grandiflorum, radix peucedani, fructus aurantii, radix stemonae, schisandra chinensis, pericarpium citri reticulatae, schizonepeta and dried ginger weighed in the step 1 into powder, uniformly mixing, putting all the powder into a supercritical fluid extraction reaction kettle, extracting by taking carbon dioxide as an extracting agent and an ethanol solution as an entrainer, collecting extract liquor, recovering ethanol, and concentrating the extract liquor into thick paste;

According to the preparation method of the cough relieving tablet, carbon dioxide is used as an extracting agent, a proper amount of methanol or ethanol is added to be used as an entrainer, and the supercritical fluid is used for extracting the effective components of the medicinal materials, so that the extraction rate of the effective components of the medicinal materials is further improved, the effective components of the medicinal materials extracted by the supercritical fluid are highly enriched, the dosage is reduced, the quality is controlled, the supercritical fluid extraction process is simple, the operation is convenient, the production period is short, and the labor force is saved; the supercritical fluid extraction of the medicinal materials can keep the effective components of the traditional Chinese medicine intact, the effective components contained in the obtained extracting solution are improved, and the drug effect of the prepared cough relieving tablet is also improved. Solves the technical problems that the effective components extracted from the medicinal materials in the existing preparation process of the cough relieving tablet are low, and the drug effect of the cough relieving tablet is influenced.

Detailed Description

In order to make the technical solutions of the present application better understood, the technical solutions in the following embodiments are clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.

Example 1

In order to facilitate understanding, one embodiment of a method for preparing cough-relieving tablets provided by the application comprises the following steps:

It should be noted that, in the prior art, the time required for decocting and extracting medicinal materials is longer, but when the medicinal materials are extracted by supercritical fluid, the process flow is simple, the operation is convenient, the production period is short, and a large amount of labor force is saved; crushing the raw medicinal materials, sieving the crushed medicinal materials by a sieve of 20-60 meshes, and then putting the sieved medicinal materials into a supercritical fluid extraction reaction kettle to facilitate the extraction of the effective components of the medicinal materials. Because the effective components of plantula Papaveris are polar alkaloids, polar entrainer methanol and water are added into the supercritical fluid extraction agent. Concentrating pericarpium Papaveris extractive solution to relative water density of 1.15 to obtain extract, and concentrating extractive solutions of other materials to relative water density of 1.27 to obtain soft extract. The carbon dioxide has better dissolving capacity, can completely retain the biological activity as a supercritical fluid, and has no toxicity, no smell, easy recovery and no pollution. The drying can be spray drying or vacuum drying, and is selected according to the actual application scene.

Example 2

As a further improvement of the embodiment 1, in the step 2 and the step 3, the temperature during extraction is 40-60 ℃, the extraction pressure is 20-30 Mpa, the extraction time is 1-2 hours, and the flow rate of carbon dioxide is 20-30 kg/h; in the step 2, the methanol recovery process is to pump the extract into a vacuum concentration tank and recover methanol under the condition that the vacuum degree is 0.07-0.1 Mpa; in the step 3, the ethanol recovery process is to pump the extract into a vacuum concentration tank and recover ethanol under the condition that the vacuum degree is 0.07-0.1 Mpa; in step 2, the poppy shell powder is sieved through a 40-60 mesh sieve.

It should be noted that the influence of temperature on solubility has a close relationship with pressure, and when the pressure is relatively low, the solubility decreases as the temperature increases; and when the pressure is relatively high, the dissolving capacity of the supercritical carbon dioxide is improved when the temperature is increased, if the temperature is 40 ℃ during extraction, the extraction pressure is 20Mpa, and if the temperature is 60 ℃ during extraction, the extraction pressure is 30 Mpa. The flow rate of the carbon dioxide is accelerated, the contact time of the carbon dioxide and the extracted medicinal materials is shortened, the solute content is reduced, the flow rate is 20-30 kg/h, and the contact time of the carbon dioxide and the extracted medicinal materials can be prolonged. The longest extraction time of the extracted medicinal materials is 1-2 hours, so the extraction time of the step 2 and the step 3 is 1-2 hours, which is 1/3 times of the time required by conventional decoction extraction, and the extraction rate is 2.4 times of that of the conventional decoction extraction. And (3) recovering methanol used as an entrainer when the extract is concentrated in the step (2), so that the methanol is prevented from remaining in the concentrated thick paste or extract, and the methanol can be volatilized when the vacuum degree is 0.07-0.1 Mpa. In the step 3, ethanol used as an entrainer needs to be recovered when the extract is concentrated, so that the ethanol is prevented from remaining in the concentrated thick paste or extract, and the ethanol volatilizes under the condition that the vacuum degree is 0.07-0.1 Mpa. The smaller the particles of the raw material, the shorter the path for transferring the solute from the raw material to the supercritical fluid, and the larger the surface area contacted with the supercritical fluid, the quicker and more complete the extraction, so that the poppy shell powder is selected to pass through a 40-60 mesh sieve to be the optimal particle size.

Example 3

As a further improvement of example 1, in step 4, the auxiliary materials include one or more of diluents, disintegrants, binders and lubricants; the diluent comprises one or more of anhydrous lactose, microcrystalline cellulose and maltodextrin; the disintegrating agent comprises one or more of low-substituted hydroxypropyl cellulose, sodium carboxymethyl starch and cross-linked sodium carboxymethyl cellulose; the adhesive comprises one or more of hydroxypropyl cellulose, polyvinylpyrrolidone and crosslinked polyvinylpyrrolidone; the lubricant comprises one or more of magnesium stearate, pulvis Talci powder, sodium fumarate stearate, and silica gel micropowder.

In addition, the diluent is preferably maltodextrin because maltodextrin has the characteristics of good stability and difficult deterioration, contains a large amount of polysaccharides, contains trace elements and minerals beneficial to human bodies such as calcium, iron and the like, and can promote normal substance metabolism of the human bodies. When the low-substituted hydroxypropyl cellulose is used for the tablet, the tablet can be quickly disintegrated, and meanwhile, the coarse structure of the low-substituted hydroxypropyl cellulose is greatly embedded with the medicament and the granules, so that the hardness of the tablet can be obviously improved, and the disintegration is not influenced, so that the low-substituted hydroxypropyl cellulose is preferably used as the disintegrant. Hydroxypropyl cellulose is preferred as the binder because of its thermoplastic, film forming properties, cohesiveness, latex stability and dispersibility. Magnesium stearate has a lubricating effect in vivo and can improve the digestion capability of intestines and stomach, so magnesium stearate is preferably used as the lubricant.

Example 4

The preparation method of cough-relieving tablets in the prior art comprises the following steps:

the feed is prepared from the following raw materials in parts by weight: 6 parts of aster, 4 parts of exocarpium citri rubrum, 6 parts of platycodon grandiflorum, 8 parts of radix peucedani, 1 part of fructus aurantii, 4 parts of radix stemonae, 1 part of schisandra chinensis, 52.5 parts of poppy shell, 18 parts of liquorice, 0.1ml of peppermint oil, 16g of ammonium chloride, 6 parts of pericarpium citri reticulatae, 3 parts of schizonepeta and 1 part of dried ginger. Specifically, the preparation process of the original Zhikebao tablet comprises the following steps:

step 1, preparation of No. I extract powder: extracting pericarpium Papaveris with ethanol under reflux for 4 hr for 2 times, mixing extractive solutions, recovering ethanol, concentrating, vacuum drying by stages, and pulverizing to obtain No. I extract powder;

step 2, preparation of No. II extract powder: extracting exocarpium Citri rubrum coarse powder, radix Platycodi coarse powder, fructus Aurantii coarse powder, radix Stemonae coarse powder, fructus Schisandrae chinensis coarse powder, pericarpium Citri Tangerinae coarse powder, Zingiberis rhizoma coarse powder, herba Schizonepetae coarse powder, and radix Peucedani coarse powder with 8 times of ethanol at 60 + -5 deg.C for 2 times, 48 hr each time, mixing extractive solutions, recovering ethanol, and concentrating to obtain extract A No. II; decocting radix Asteris and radix Glycyrrhizae in 8 times of water for 2 times (each for 2 hr), mixing extractive solutions, and concentrating to obtain No. II extract B; uniformly mixing the No. II extract A and the No. II extract B, and then performing vacuum drying and crushing by stages to obtain No. II extract crushed powder;

step 3, preparation of tablets: pulverizing the extract I, pulverizing the extract II, mixing ammonium chloride and pharmaceutically acceptable adjuvants, granulating, adding peppermint oil and lubricant, mixing for 20min, tabletting, and coating to obtain the final product.

Example 5

The preparation method of the cough-relieving tablet provided by the embodiment of the application comprises the following steps:

the feed is prepared from the following raw materials in parts by weight: 6 parts of aster, 4 parts of exocarpium citri rubrum, 6 parts of platycodon grandiflorum, 8 parts of radix peucedani, 1 part of fructus aurantii, 4 parts of radix stemonae, 1 part of schisandra chinensis, 52.5 parts of poppy shell, 18 parts of liquorice, 0.1ml of peppermint oil, 16g of ammonium chloride, 6 parts of pericarpium citri reticulatae, 3 parts of schizonepeta and 1 part of dried ginger. Specifically, the preparation process of the cough-relieving tablet comprises the following steps:

step 1, removing impurities from poppy shells, crushing to obtain poppy shell powder, sieving with a 40-mesh sieve, placing the poppy shell powder in a supercritical fluid extraction reaction kettle, extracting with carbon dioxide as an extracting agent, methanol and water as entrainers at the temperature of 60 ℃, the extraction pressure of 30MPa, the extraction time of 1 hour and the carbon dioxide flow rate of 20kg/h, collecting extract liquor, pumping the extract liquor into a vacuum concentration tank, recovering the methanol at the vacuum degree of 0.1MPa, and concentrating the extract liquor into extract to obtain poppy shell extract;

step 2, crushing eleven pure materials of aster, liquorice, exocarpium citri rubrum, platycodon grandiflorum, radix peucedani, fructus aurantii, radix stemonae, schisandra chinensis, pericarpium citri reticulatae, schizonepeta and dried ginger into powder, mixing uniformly, sieving with a 40-mesh sieve, putting all the powder into a supercritical fluid extraction reaction kettle, extracting with carbon dioxide as an extracting agent and ethanol as an entrainer at the temperature of 60 ℃, the extraction pressure of 30Mpa, the extraction time of 1 hour and the flow rate of 20kg/h, collecting an extract, pumping the extract into a vacuum concentration tank, recovering the ethanol at the vacuum degree of 0.07Mpa, and concentrating the extract into thick paste;

and 3, adding a proper amount of low-substituted hydroxypropyl cellulose and maltodextrin into the thick paste obtained in the step 2, drying, crushing, adding ammonium chloride, adding the poppy shell extract obtained in the step 1, uniformly mixing, adding a proper amount of hydroxypropyl cellulose to prepare granules, drying, spraying peppermint oil, adding a proper amount of magnesium stearate to press the mixture into tablets, and coating to obtain the cough-relieving tablet.

Example 6

The curative effect detection method according to the existing preparation method of the cough relieving tablet in the embodiment 4 and the preparation method of the cough relieving tablet in the embodiment 5 comprises the following steps:

1. general data: a. example 4 the existing antitussive tablet is applied to 50 clinical observation cases, wherein 25 men and 25 women are aged 20-60 years, the patient with the shortest disease course is half a month, and the patient with the longest disease course is one year; b. The antitussive tablet of example 5 is applied to 50 clinical observation cases, wherein 25 men and 25 women are aged 20-60 years, the patient with the shortest disease course is half a month, and the patient with the longest disease course is one year;

2. the basis of diagnosis is as follows: a. cough, excessive and thin phlegm and even cough and asthma caused by external wind-cold are main symptoms; b. Cough and excessive phlegm caused by chronic bronchitis and upper respiratory infection can be seen in patients with serious diseases;

3. the usage and dosage are as follows: in clinical application, the medicine is taken three times a day, 2 tablets are taken each time, raw, cold and spicy materials are not eaten during the medicine taking period, and 7 days is a treatment course.

4. The curative effect standard is as follows: a. and (3) curing: the symptoms and physical signs disappear, and the laboratory, X-ray and other examinations recover to normal; b. improvement: symptoms and signs, laboratory examinations, etc. are improved; c. the disease is not cured: the disease condition is not well changed. The results of the clinical experiments are shown in Table 1.

TABLE 1 table of results of clinical experiments

The treatment results are as follows:

the total effective rate of the existing antitussive tablet in example 4 is 84%, while the total effective rate of the antitussive tablet in example 5 is up to 98%, so that the antitussive tablet of the invention can improve the cure rate of patients suffering from cough, excessive and thin sputum, even asthma and the like.

Example 7

And (3) clinical trials:

case 1: xue Zhi, male, 25 years old. Cough due to wind-cold. After taking the cough-relieving tablet of the invention for one course of treatment, the subjective symptoms and physical signs disappear and are cured. The agent of the present invention was proved to be effective for cough.

Case 2: xie somewhat, woman, 50 years old. Cough and profuse sputum caused by wind-cold. After taking the cough-relieving tablet of the invention for one course of treatment, the cough is obviously relieved, and the sputum is less; after the medicine is taken for 3 days, all symptoms disappear and are cured. The medicament of the invention is proved to be effective for cough and excessive phlegm.

Case 3: chua, male, 23 years old. Upper respiratory tract infections lead to coughing, often asthma. After taking the cough-relieving tablet of the invention for one course of treatment, the cough is obviously relieved, and the occasional asthma is avoided; after a treatment course, all symptoms disappear and are cured. The medicament of the present invention is proved to be effective for cough and frequent asthma caused by upper respiratory tract infection.

Case 4: chen is certain, female, 26 years old. As long as the patient can inevitably cough after catching a cold, asthma can be caused in severe cases, and the patient can not sleep at night sometimes, the cough can be basically stopped after taking the medicament of the cough relieving tablet disclosed by the invention for 6 days, and the patient can be basically cured after taking the medicament of the cough relieving tablet disclosed by the invention for 11 days. The pharmaceutical agent of the present invention was proved to be effective for cough and asthma.

Case 5: mo Zhi, male, 56 years old. Cough, profuse sputum and asthma caused by external wind-cold. After taking the medicament of the cough-relieving tablet of the invention for one course of treatment, the cough is obviously relieved, the sputum is less, and the occasional asthma is caused; after the medicine is taken for 10 days, all symptoms disappear and are cured. The medicament of the invention is proved to be effective for cough, excessive phlegm and asthma.

The above embodiments are only used for illustrating the technical solutions of the present application, and not for limiting the same; although the present application has been described in detail with reference to the foregoing embodiments, it should be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions in the embodiments of the present application.

Claims

1. The preparation method of the cough-relieving tablet is characterized by comprising the following steps:

step 2, pulverizing the poppy capsules weighed in the step 1 into powder, putting all the pulverized medicinal material powder into a supercritical fluid extraction reaction kettle, extracting by taking carbon dioxide as an extracting agent and methanol and water as entrainers, collecting extract liquor, recovering the methanol, and concentrating the extract liquor into extract to obtain poppy capsule extract;

step 3, crushing eleven pure materials of the aster, the liquorice, the exocarpium citri rubrum, the platycodon grandiflorum, the radix peucedani, the fructus aurantii, the radix stemonae, the schisandra chinensis, the pericarpium citri reticulatae, the schizonepeta and the dried ginger weighed in the step 1 into powder, uniformly mixing, putting all the powder into a supercritical fluid extraction reaction kettle, extracting by using carbon dioxide as an extracting agent and ethanol as an entrainer, collecting extract liquor, recovering the ethanol, and concentrating the extract liquor into thick paste;

2. The method for preparing cough suppressing tablets as claimed in claim 1, wherein in step 2 and step 3, the temperature is 40-60 ℃, the pressure is 20-30 Mpa, the time is 1-2 hours, and the flow rate of carbon dioxide is 20-30 kg/h.

3. The method for preparing cough suppressing tablets as claimed in claim 1, wherein in step 2, the methanol recovery process is to pump the extract into a vacuum concentration tank and recover methanol under a vacuum degree of 0.07-0.1 Mpa.

4. The method for preparing cough suppressing tablets as claimed in claim 1, wherein in step 3, the ethanol recovery process is to pump the extract into a vacuum concentration tank and recover ethanol under a vacuum degree of 0.07-0.1 Mpa.

5. The method for preparing cough suppressing tablets as claimed in claim 1, wherein in step 2, the poppy shell powder is passed through a 40-60 mesh sieve.

6. The method of preparing antitussive tablet according to claim 1, wherein in step 4, the excipients include one or more of diluents, disintegrants, binders and lubricants.

7. The method of claim 6, wherein the diluent comprises one or more of anhydrous lactose, microcrystalline cellulose, and maltodextrin.

8. The method for preparing antitussive tablet according to claim 6, wherein the disintegrant comprises one or more of low-substituted hydroxypropyl cellulose, sodium carboxymethyl starch, and croscarmellose sodium.

9. The method for preparing antitussive tablet according to claim 6, wherein the binder comprises one or more of hydroxypropyl cellulose, polyvinylpyrrolidone, and cross-linked polyvinylpyrrolidone.

10. The method for preparing antitussive tablet according to claim 6, wherein the lubricant comprises one or more of magnesium stearate, talc, sodium fumarate stearate, and aerosil.