CN112494138B

CN112494138B - Die body for MR-DTI

Info

Publication number: CN112494138B
Application number: CN202011279690.0A
Authority: CN
Inventors: 冯刚; 高欣
Original assignee: Shanghai Universal Medical Imaging Diagnosis Center Co ltd
Current assignee: Shanghai Universal Medical Imaging Diagnosis Center Co ltd
Priority date: 2020-11-16
Filing date: 2020-11-16
Publication date: 2021-10-01
Anticipated expiration: 2040-11-16
Also published as: CN112494138A

Abstract

The invention relates to the technical field of diffusion tensor imaging, in particular to a die body for MR-DTI (magnetic resonance-data acquisition), which comprises a die body and a tubule channel arranged in the die body, wherein a liquid storage tank is hermetically arranged at the bottom of the die body, the tubule channel comprises an imaging tubule and a flow-limiting tubule, one end of the imaging tubule penetrates through the upper part of the die body, one end of the imaging tubule, which is far away from the upper part of the die body, is communicated with one end of the flow-limiting tubule, which is far away from the imaging tubule, is communicated with the liquid storage tank, and the imaging tubule is used for simulating the distribution of cerebral vessels or nerve fibers. The method has the advantage of being capable of observing the dispersion condition of the die body in all directions, and can obtain a more accurate nuclear magnetic resonance dispersion tensor imaging result.

Description

Die body for MR-DTI

Technical Field

The invention belongs to the technical field of diffusion tensor imaging, and particularly relates to a motif for MR-DTI.

Background

Diffusion Tensor Imaging (DTI), a new method of describing brain structures, is a special form of Magnetic Resonance Imaging (MRI). The nuclear magnetic resonance diffusion tensor imaging (MR-DTI) is the development and deepening of Diffusion Weighted Imaging (DWI), and is currently the only non-invasive examination method capable of effectively observing and tracking white matter fiber tracts. By 2015, the method is mainly used for observation and tracking of white matter tracts in the brain, research on brain development and brain cognitive function, pathological changes of brain diseases, preoperative planning and postoperative evaluation of brain surgery. However, the current die body container can only observe the disordered brownian motion of the integral uniform water die body and cannot display the dispersion condition in all directions.

Disclosure of Invention

1. Technical problem to be solved by the invention

The invention aims to solve the problem that the existing die body container can only observe the disordered brownian motion of the integral uniform water die body and cannot display the dispersion condition in all directions.

2. Technical scheme

In order to achieve the purpose, the technical scheme provided by the invention is as follows: the utility model provides a die body for MR-DTI includes the die body and sets up the tubule passageway in the die body, the sealed liquid storage tank that is provided with in bottom of die body, the tubule passageway includes formation of image tubule and current-limiting tubule, formation of image tubule one end links through out the upper portion of die body, the one end intercommunication that die body upper portion was kept away from to the formation of image tubule has the one end of current-limiting tubule, the one end and the liquid storage tank intercommunication of formation of image tubule are kept away from to the current-limiting tubule, the formation of image tubule is used for simulating cerebral vessels or nerve fiber's distribution.

Preferably, the die body is externally wrapped by a shell, the shell is used for accommodating and supporting the die body and the liquid storage tank, a through hole is formed in the upper portion of the shell, a sealing device is arranged in the through hole in a matched mode, the imaging thin tube penetrates through one end of the upper portion of the die body and is connected with the through hole in a sealing mode, the shell is provided with a liquid inlet communicated with the inside of the liquid storage tank, and a sealing device II is arranged in the liquid inlet in a matched mode.

Preferably, the imaging tubule is formed by sequentially communicating a plurality of sections of circulation sections end to end, and the circulation directions of the plurality of sections of circulation sections in a three-dimensional space are different.

Preferably, the flow direction of the flow-through sections at least comprises the flow direction of an X axial direction, a Y axial direction, a Z axial direction, an XY axial direction, an XZ axial direction and a YZ axial direction.

Preferably, the inner wall of the imaging tubule is a smooth curved surface, and the section of the inner wall of the imaging tubule is in a circular arrangement.

Preferably, the length of the inner diameter of the imaging tubule is continuously changed, and the change range of the length of the inner diameter of the imaging tubule is 0.5 mm-4 mm.

Preferably, be provided with the stock solution tubule between through-hole and the formation of image tubule, stock solution tubule one end is connected the through-hole, the other end and the one end sealing connection of formation of image tubule, the middle section of stock solution tubule is provided with the stock solution storehouse.

Preferably, the middle section of the flow limiting tubule is provided with a flow limiting device.

3. Advantageous effects

Compared with the prior art, the technical scheme provided by the invention has the following beneficial effects: the utility model provides a die body for MR-DTI includes the die body and sets up the tubule passageway in the die body, the sealed liquid storage tank that is provided with in bottom of die body, the tubule passageway includes formation of image tubule and current-limiting tubule, formation of image tubule one end links through out the upper portion of die body, the one end intercommunication that die body upper portion was kept away from to the formation of image tubule has the one end of current-limiting tubule, the one end and the liquid storage tank intercommunication of formation of image tubule are kept away from to the current-limiting tubule, the formation of image tubule is used for simulating cerebral vessels or nerve fiber's distribution.

The die body for the MR-DTI has the advantage of being capable of observing the diffusion condition of the die body in all directions, and a more accurate nuclear magnetic resonance diffusion tensor imaging result is obtained.

Drawings

FIG. 1 is a schematic structural view of the present invention as a whole;

fig. 2 is a schematic structural diagram of a current limiting device according to the present invention.

The reference numerals in the schematic drawings illustrate:

100. a mold body; 200. a thin tube channel; 210. a liquid storage thin tube; 211. a liquid storage bin; 220. an imaging tubule; 221. a flow-through section; 230. a current-limiting tubule; 231. a current limiting device; 300. a water storage tank; 400. a housing; 410. a through hole; 411. a first sealing device; 420. a liquid inlet; 421. and a second sealing device.

Detailed Description

In order to facilitate an understanding of the invention, the invention will now be described more fully hereinafter with reference to the accompanying drawings, in which several embodiments of the invention are shown, but which may be embodied in many different forms and are not limited to the embodiments described herein, but rather are provided for the purpose of providing a more thorough disclosure of the invention.

It will be understood that when an element is referred to as being "secured to" another element, it can be directly on the other element or intervening elements may also be present; when an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present; the terms "vertical," "horizontal," "left," "right," and the like as used herein are for illustrative purposes only.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs; the terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention; as used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.

Example 1

Referring to fig. 1-2, the present embodiment provides a technical solution: the utility model provides a die body for MR-DTI includes die body 100 and sets up the tubule passageway 200 in die body 100, the sealed liquid storage tank 300 that is provided with in bottom of die body 100, tubule passageway 200 includes formation of image tubule 220 and current-limiting tubule 230, formation of image tubule 220 one end link up out the upper portion of die body 100, formation of image tubule 220 keeps away from the one end intercommunication on die body 100 upper portion has the one end of current-limiting tubule 230, the one end and the liquid storage tank 300 intercommunication of formation of image tubule 220 are kept away from to current-limiting tubule 230, formation of image tubule 220 is used for simulating cerebral vessels or nerve fiber's distribution. The current-limiting tubule 230 is vertically arranged, and one end of the current-limiting tubule 230 connected with the imaging tubule 220 is lower than the lowest point of the imaging tubule 220. The current limiting tubule 230 and the imaging tubule 220 are integrally formed.

In a preferred scheme, the outer parcel of die body 100 is provided with shell 400, shell 400 adopts the setting of organic glass, just shell 400 is used for holding the support die body 100 with liquid storage tank 300, the upper portion of shell 400 is provided with through-hole 410, through-hole 410 fit in is provided with sealing device 411, sealing device 411 adopts the rubber buffer setting to guarantee the gas tightness after sealing device 411 and through-hole 410 cooperate, formation of image tubule 220 link up out the one end on die body 100 upper portion with through-hole 410 sealing connection, formation of image tubule 220 with link up out the one end on die body 100 upper portion with through-hole 410 adopts integrated into one piece setting, shell 400 is provided with the inside inlet 420 of intercommunication liquid storage tank 300, inlet 420 cooperation is provided with sealing device 421 two, sealing device 421 two adopts the setting of soft rubber buffer, so as to ensure the air tightness after the second sealing device 421 is matched with the liquid inlet 420.

In a preferable scheme, the imaging tubule 220 is formed by sequentially communicating a plurality of sections of flow sections 221 end to end, and the flow directions of the plurality of sections of flow sections 221 in a three-dimensional space are different. In the scanning process, dispersion-sensitive gradients are applied in the flowing directions of different flowing sections 221, so that the scanner can quantitatively scan the anisotropy of the liquid from different directions, and an accurate and comprehensive scanning result of the liquid is obtained. And the more the flow direction of the flow sections 221 in the three-dimensional space, the more accurate and comprehensive scanning results are obtained.

When the liquid storage device is used, the liquid storage tank 300 is filled with liquid to be analyzed through the liquid inlet 420, then the liquid inlet 420 is sealed through the second sealing device 421, then the outside of the liquid storage tank 300 is heated, so that the liquid in the liquid storage tank 300 is heated and expanded, the heated and expanded liquid enters the imaging tubule 220 along the flow limiting tubule 230 extending into the liquid storage tank 300, when the liquid overflows from one end of the imaging tubule 220, which is connected with the through hole 410, the heating on the outside of the liquid storage tank 300 is stopped, meanwhile, the through hole is sealed through the first sealing device 411, so that the imaging tubule 220 and the flow limiting tubule 230 are both filled with the liquid, then the shell 400 and the internal device are placed into a scanner, the first sealing device 411 is pulled out before scanning starts, meanwhile, the liquid in the liquid storage tank 300 begins to shrink due to the temperature reduction, the pressure in the liquid storage tank 300 is reduced, so that the liquid in the imaging tubule 220 and the flow limiting tubule 230 flows back into the liquid storage tank 300 under the action of atmospheric pressure and the self gravity of the liquid, meanwhile, scanning is performed on the liquid flowing in the imaging tubule 220, and scanning results of the liquid in different flowing directions are obtained.

In a preferred embodiment, the flow direction of the flow-through sections 221 at least includes the flow directions of an X-axis direction, a Y-axis direction, a Z-axis direction, an XY-axis direction, an XZ-axis direction, and a YZ-axis direction.

In a preferred scheme, the inner wall of the imaging tubule 220 is a smooth curved surface, and the cross section of the inner wall of the imaging tubule 220 is in a circular arrangement, which is beneficial to free circulation of liquid in the imaging tubule 220.

In a preferable scheme, the imaging tubule 220 is provided with six sections of flow-through sections 221, the six sections of flow-through sections 221 include an X-axis flow-through section 221, a Y-axis flow-through section 221, a Z-axis flow-through section 221, an XY-axis flow-through section 221, an XZ-axis flow-through section 221 and a YZ-axis flow-through section 221, while the scanning result of scanning the imaging tubule 220 is ensured to include 6 basic flow-through directions, the structure of the imaging tubule 220 is simplified, the imaging tubule 220 is easy to produce and manufacture, and the production cost is reduced, the inner diameters of the imaging tubules 220 are all set to be 1mm, so that liquid generates capillary action in the imaging tubule 220, when the liquid in the liquid storage tank 300 is heated and enters the imaging tubule 220 along the flow limiting tubule 230, when the liquid flows in the flow-through sections 221 in different flow-through directions due to the capillary action of the imaging tubule 220, the liquid level can be kept in a state perpendicular to the inner wall of the imaging tubule 220, thereby being beneficial to avoiding the generation of bubbles and avoiding the influence of the bubble scanning imaging result. Meanwhile, the imaging tubules 220 with uniform inner diameters are adopted, which is beneficial to reducing the manufacturing cost.

In a preferable scheme, the length of the inner diameter of the imaging tubule 220 is continuously changed, and the change range of the length of the inner diameter of the imaging tubule 220 is 0.5 mm-4 mm, so as to simulate the change of the inner diameter of a cerebral blood vessel, so that the flow condition of liquid in the imaging tubule 220 is close to the flow condition of blood in the cerebral blood vessel, and the imaging result of the liquid in the scanning imaging tubule 220 is more accurate. In addition, the inner diameter length of the joint between the adjacent flow sections 221 is smaller than 1.2mm, so that the joint between the adjacent flow sections 221 forms a capillary tube, when liquid in the liquid storage tank 300 is heated, the liquid enters the imaging thin tube 220 along the flow limiting thin tube 230, and when the liquid flows through the joint between the adjacent flow sections 221, bubbles are prevented from being generated under the capillary action of the capillary tube at the joint, and the scanning imaging effect is improved.

In a preferred scheme, the middle section of current-limiting tubule 230 is provided with current limiting device 231, current limiting device 231 is to leak hopper-shaped the inner wall that sets up in current-limiting tubule 230, just the internal diameter length at current limiting device 231 middle part is less than the internal diameter length of current-limiting tubule 230 for liquid is flowing through flow path reduces when current limiting device 231, thereby reduces liquid flow and passes through current limiting device 231's flow, reaches the flow velocity that slows down liquid at formation of image tubule 220, makes liquid increase at the flow time of formation of image tubule 220, ensures that the scanner has sufficient time and scans formation of image tubule 220, obtains best scanning result.

Example 2

Referring to fig. 1 to 2, the other structure of the present embodiment is the same as that of embodiment 1, except that: be provided with stock solution tubule 210 between through-hole 410 and the formation of image tubule 220, stock solution tubule 210 one end is connected through-hole 410, the other end and the one end sealing connection of formation of image tubule 220, stock solution tubule 210 is vertical tubulose setting, just the one end that through-hole 410 was kept away from to stock solution tubule 210 sets up with the one end integrated into one piece of formation of image tubule 220. The middle section of stock solution tubule 210 is provided with stock solution storehouse 211, the one end that through-hole 410 was kept away from in stock solution storehouse 211 is higher than the peak of formation of image tubule 220, the length of stock solution storehouse 211 internal diameter reaches the biggest at the middle part, just the maximum internal diameter length of stock solution storehouse 211 is greater than the length of stock solution tubule 210 internal diameter, the length of stock solution storehouse 211 internal diameter reduces along stock solution storehouse 211 both ends from the middle section gradually, just the internal diameter length at stock solution storehouse 211 both ends equals the length of stock solution tubule 210 internal diameter makes stock solution storehouse 211 can store certain capacity's liquid. Meanwhile, the inner wall of the liquid storage bin 211 is provided with a smooth curved surface, so that the liquid is prevented from generating vortex when flowing through the liquid storage bin 211, the liquid is kept in a stable flowing state and flows into the imaging thin tube, and the imaging effect of the liquid in the imaging thin tube is optimal.

When the liquid storage device is used, the liquid storage tank 300 is filled with liquid to be analyzed through the liquid inlet 420, then the liquid inlet 420 is sealed through the second sealing device 421, then the outside of the liquid storage tank 300 is heated, so that the liquid in the liquid storage tank 300 is heated and expanded, the heated and expanded liquid enters the imaging tubule 220 along the flow limiting tubule 230 extending into the liquid storage tank 300, when the liquid reaches the liquid storage bin 211, the heating on the outside of the liquid storage tank 300 is stopped, the heat preservation is carried out on the liquid storage tank 300, meanwhile, the liquid is poured into the liquid storage bin 211 from the through hole 410, when the liquid in the liquid storage bin 211 is filled, the through hole 410 is sealed through the first sealing device 411, so that the imaging tubule 220 and the flow limiting tubule 230 are both filled with the liquid, then the shell 400 and the internal device are placed into a scanner, the first sealing device 411 is pulled out before scanning starts, meanwhile, the heat preservation on the liquid storage tank 300 is stopped, and the liquid in the liquid storage tank 300 begins to be cooled and shrink, the pressure in the liquid storage tank 300 is reduced, so that the liquid in the imaging tubule 220 and the flow limiting tubule 230 flows back to the liquid storage tank 300 under the hydraulic action of the liquid in the atmospheric pressure and the liquid storage bin 211, and simultaneously, the liquid flowing in the imaging tubule 220 starts to be scanned, and because a certain amount of liquid is stored in the liquid storage bin 211, the liquid flows back, the state of the liquid can be continuously kept full of in the imaging tubule 220 and the flow limiting tubule 230, and the state of the imaging tubule 220 can be completely scanned by a scanner during scanning.

The above-mentioned embodiments only express a certain implementation mode of the present invention, and the description thereof is specific and detailed, but not construed as limiting the scope of the present invention; it should be noted that, for those skilled in the art, without departing from the concept of the present invention, several variations and modifications can be made, which are within the protection scope of the present invention; therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims

1. A phantom for MR-DTI, wherein: including die body (100) and setting up tubule passageway (200) in die body (100), the sealed liquid storage tank (300) that can be heated that is provided with in bottom of die body (100), tubule passageway (200) are including formation of image tubule (220) and current-limiting tubule (230), formation of image tubule (220) one end is link up out the upper portion of die body (100), one end intercommunication that die body (100) upper portion was kept away from in formation of image tubule (220) has the one end of current-limiting tubule (230), the one end and the liquid storage tank (300) intercommunication of formation of image tubule (220) are kept away from in current-limiting tubule (230), formation of image tubule (220) are used for simulating cerebral vessels or nerve fiber's distribution, die body (100) outsourcing is provided with shell (400), just shell (400) are used for holding the support die body (100) with liquid storage tank (300), the upper portion of shell (400) is provided with through-hole (410), through-hole (410) fit in is provided with sealing device (411), formation of image tubule (220) link up out the one end on die body (100) upper portion with through-hole (410) sealing connection, shell (400) are provided with inside inlet (420) of intercommunication liquid storage tank (300), inlet (420) cooperation is provided with sealing device two (421).

2. The phantom for MR-DTI according to claim 1, characterized in that: the formation of image tubule (220) is passed through the formation of end to end in proper order by a plurality of sections circulation section (221), and a plurality of sections the circulation direction of circulation section (221) in three-dimensional space is different.

3. The phantom for MR-DTI according to claim 2, characterized in that: the flow direction of the flow sections (221) at least comprises the flow directions of an X axial direction, a Y axial direction, a Z axial direction, an XY axial direction, an XZ axial direction and a YZ axial direction.

4. The phantom for MR-DTI according to claim 1, characterized in that: the inner wall of formation of image tubule (220) is smooth curved surface, just the cross-section of formation of image tubule (220) inner wall is circular setting.

5. The phantom for MR-DTI according to claim 2, characterized in that: the length of the inner diameter of the imaging tubule (220) keeps changing continuously, and the change range of the length of the inner diameter of the imaging tubule (220) is 0.5 mm-4 mm.

6. The phantom for MR-DTI according to claim 1, characterized in that: be provided with stock solution tubule (210) between through-hole (410) and formation of image tubule (220), stock solution tubule (210) one end is connected through-hole (410), the one end sealing connection of the other end and formation of image tubule (220), the middle section of stock solution tubule (210) is provided with stock solution storehouse (211).

7. The phantom for MR-DTI according to claim 1, characterized in that: the middle section of the flow limiting tubule (230) is provided with a flow limiting device (231).