CN102564877A - Artificial blood vessel torsional fatigue simulating device for endovascular graft exclusion and testing method thereof - Google Patents
Artificial blood vessel torsional fatigue simulating device for endovascular graft exclusion and testing method thereof Download PDFInfo
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- CN102564877A CN102564877A CN2012100018434A CN201210001843A CN102564877A CN 102564877 A CN102564877 A CN 102564877A CN 2012100018434 A CN2012100018434 A CN 2012100018434A CN 201210001843 A CN201210001843 A CN 201210001843A CN 102564877 A CN102564877 A CN 102564877A
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Abstract
The invention relates to an artificial blood vessel torsional fatigue simulating device for endovascular graft exclusion and a testing method thereof. The device comprises a liquid storage box, an electronic peristaltic pump, a pressure monitor, a current limiter and a flow guide silicone tube; and the device is characterized by further comprising an artificial blood vessel torsion simulating device. The invention further discloses a testing method using the device. By using the method, the in vivo torsion motion of the artificial blood vessel is simulated through the engagement between a rack and a gear which rotate in a horizontal way; the artificial blood vessel test sample is simulated in different in vivo positions through a horizontal or L-shaped hollow metal conduit; and factors affecting the torsional fatigue resistance of the artificial blood vessel are obtained through comparison test of the artificial blood vessels with different structures. By using the artificial blood vessel torsional fatigue simulating device for endovascular graft exclusion, provided by the invention, a gap in the traditional vitro simulation of the artificial blood vessel torsional fatigue for endovascular graft exclusion is filled and more scientific basis is provided for completing the structure of the artificial blood vessel.
Description
Technical field
The present invention relates to a kind of endovascular graft with tired analogue means of artificial blood tubotorsion and method of testing thereof, belong to the bio-medical textile field.
Background technology
The thoracoabdominal aorta hemangioma belongs to common disease clinically, and endovascular graft is adopted by increasing hospital as the effective technology of treatment thoracoabdominal aortic aneurysm disease.Endovascular graft is with the gordian technique of artificial blood vessel as treatment, and its fatigue behaviour evaluation seems particularly important, and wherein in-vitro simulated is the most effectively one of means of estimating artificial blood vessel fatigue performance.Through in a large number the artificial blood vessel that is used for the aneurysm of thoracic aorta clinical treatment being transplanted the follow-up investigation of appearance and discovering; In the graft exclusion clinical treatment Failure cases of thoracic cavity; Artificial blood vessel has all shown torsional fatigue phenomenon in various degree, and this torsional fatigue might be to cause one of main reason of artificial blood vessel inefficacy.Therefore, be necessary very much to carry out with the torsional fatigue performance of artificial blood vessel to endovascular graft in-vitro simulated, reaching anti-torsional fatigue performance through external torsional fatigue Simulation evaluation artificial blood vessel, thus the body of prediction artificial blood vessel interior serviceable life.
Through the discovery of consulting of lot of documents and data, though at present both at home and abroad for the existing relevant report in the external tired simulation of artificial blood vessel aspect, the test that external torsional fatigue is simulated for artificial blood vessel is still blank.The ELF9100 series blood vessel graft test macro of producing like external aspect U.S. Endura TEC company; The external fatigue test system of artificial blood vessel of people such as late 1980s American scholar Pourdeyhimi design; And the domestic aspect patent No. is that the patent endovascular graft of ZL 200510010636.2 uses the artificial blood vessel abrasion resistance properties proving installation and the patent No. to be ZL 200710043812.4 Weave type artificial blood vessel fatigue performance simulation testing devices etc.; Though all artificial blood vessel has been carried out external simulation, has not been directed against the test of torsional fatigue aspect of performance.What deserves to be mentioned is in-vitro simulated bending fatigue aging equipment of disclosed patent CN102175541A artificial blood vessel on September 7th, 2011 and method of testing thereof; To the bending that occurs in the clinical use of intraperitoneal artificial blood vessel aging carried out in-vitro simulated; But, do not retrieve the report of domestic and international data of literatures at present for the aging aspect of in-vitro simulated artificial blood vessel torsional fatigue.
Summary of the invention
Technical matters to be solved by this invention provides a kind of endovascular graft with tired analogue means of artificial blood tubotorsion and method of testing thereof; Be used to remedy the blank of present in-vitro simulated test endovascular graft with artificial blood tubotorsion fatigue behaviour; And combine of the design of different endovascular grafts with the artificial blood vessel parameter; Comparative analysis influences the factor of blood vessel torsional fatigue performance, has realized that endovascular graft reverses the test of simulation outward with the artificial blood body.
In order to achieve the above object; A kind of technical scheme of the present invention has provided a kind of endovascular graft with the tired analogue means of artificial blood tubotorsion; Comprise the liquid reserve tank that has heating arrangement, liquid reserve tank connects electronic peristaltic pump through the water conservancy diversion silicone tube, and pressure monitor connects restrictor through the water conservancy diversion silicone tube; Restrictor connects liquid reserve tank through the water conservancy diversion silicone tube; It is characterized in that the output terminal of electronic peristaltic pump connects artificial blood vessel and reverses analogue means, the output terminal that artificial blood vessel reverses analogue means connects pressure monitor;
Said artificial blood vessel reverses analogue means and comprises worktable; Be fixed with sheet metal on the worktable, the upper end of sheet metal is provided with chute, and the slide block that can move horizontally is housed in the chute; One end of said slide block links to each other with the head end of connecting rod through pin; The tail end of connecting rod is connected on the disk that has elongated slot through pin, and the disk that has elongated slot links to each other with motor, and motor links to each other with frequency converter; Said motor and frequency converter all are fixedly mounted on the worktable; The other end of said slide block links to each other with tooth bar, the rack and pinion engagement, and vertical hollow metal conduit is equipped with at the center bore place of gear; The lower end of vertical hollow metal conduit links to each other with the upper end of artificial blood vessel sample; The lower end of artificial blood vessel sample links to each other with the head end of horizontal hollow metal conduit or L type hollow metal conduit, and horizontal hollow metal conduit or L type hollow metal conduit are installed on the sidewall of the tank that has heating arrangement and put in the tank, the said tank that has heating arrangement be installed on the worktable and and sheet metal between leave the space; Insert the bevel protractor that movably indicates 0-180 ° of angle in the space, the tail end of the upper end of said vertical hollow metal conduit and horizontal hollow metal conduit or L type hollow metal conduit all is communicated with the water conservancy diversion silicone tube.
Preferably, the diameter that said artificial blood vessel reverses in the analogue means vertical hollow metal conduit and horizontal hollow metal conduit or L type hollow metal conduit is 6-45mm, and the length of tooth bar is 40-100mm, and the diameter of gear is 25-100mm.
Preferably; Said artificial blood vessel reverses the material selection copper of slide block in the analogue means; The material selection aluminium alloy of connecting rod and disk; The material selection stainless steel of vertical hollow metal conduit and horizontal hollow metal conduit or L type hollow metal conduit, the material selection nylon of rack and pinion has the material selection organic glass of the tank of heating arrangement.
Another technical scheme of the present invention has provided the method for testing of a kind of endovascular graft with the tired analogue means of artificial blood tubotorsion, it is characterized in that, concrete testing procedure is following:
1) preparation of experiment material: preparing diameter is the vertical hollow metal conduit of 6-45mm, horizontal hollow metal conduit or L type hollow metal conduit, and preparing length is the tooth bar of 40-100mm, and diameter is the gear of 25-100mm; Prepare artificial blood vessel sample and internal lining pipe, the artificial blood vessel sample adopts straight shape tubulose, and the fabric covering material is selected polyester weaving base or teflon or polyurethane material for use; Fabric overlay film length is 70-250mm, and diameter is 6-45mm, internal lining pipe material selection silica gel material; With the supporting use of artificial blood vessel sample; Internal lining pipe length is the 105-120% of sample fabric overlay film length, and its diameter is the 80-98% of fabric overlay film diameter, and it is inner that internal lining pipe is inserted in artificial blood vessel sample fabric overlay film; Two ends respectively grow 3-5mm; With suture 3 separate metal supports are arranged on the fabric overlay film, suture way has conventional two through types stitchings, irregular single through types to sew up and the most advanced and sophisticated concentrated type of support is sewed up three kinds of modes, and metal support tip angle α is 20-70 °;
2) check system: before beginning test, inspection and debugging apparatus make its operate as normal, if any unusually, in time adjust;
3) be installed in ready horizontal hollow metal conduit or L type hollow metal conduit on the sidewall of the tank that has heating arrangement and put in the tank;
4) adjust the rack and pinion initial position, the vertical hollow metal conduit of gear is housed, gear center lucky and tooth bar is meshed;
5) position of adjustment pin in the disk elongated slot; Change is connected the traverse of the connecting rod on the disk that has elongated slot through pin; The tooth bar that links to each other with connecting rod through slide block is moved back and forth as level; And make with the tooth bar meshed gears and rotate 0-90 ° (not comprising 0 °), the windup-degree scope of artificial blood vessel during this test windup-degree scope is corresponding clinical;
6) the artificial blood vessel sample is installed: the lower end that the upper end of ready artificial blood vessel sample is enclosed within vertical hollow metal conduit with rubber band; The lower end of artificial blood vessel sample is enclosed within the head end of horizontal hollow metal conduit or L type hollow metal conduit; Horizontal hollow metal conduit of adjustment or L type hollow metal conduit stretch into the length of the tank that has heating arrangement; The contrast bevel protractor, make artificial blood vessel sample clamping up and down the angle at two ends be 20-180 °, this angular range correspondence is transplanted the angle at two ends up and down of the artificial blood vessel of placement clinically; Regulate the artificial blood vessel sample, make it not produce distortion;
7) in the liquid reserve tank that has heating arrangement, fill with liquid, have and inject 2/3 liquid in the tank of heating arrangement, guarantee that liquid level covered the upper end of artificial blood vessel sample, regulate the heating arrangement of liquid reserve tank and tank, make 37 ± 0.5 ℃ of fluid temperature maintenances;
8) open electronic peristaltic pump, regulating its frequency is 1-10Hz, makes in the liquid reserve tank liquid become stable pulsating flow through electronic peristaltic pump and feeds vertical hollow metal conduit 312 through the water conservancy diversion silicone tube;
9) regulate restrictor, make pressure monitor show that pressure limit is 16-100KPa;
10) regulating frequency converter frequency is 1-60Hz, the control motor speed;
11) test and record: treat system stability, liquid continuous flow after pipeline does not have bubble, picks up counting, and the damaged situation of Real Time Observation artificial blood vessel sample when breakage appears in the artificial blood vessel sample, then stops experiment immediately, the record failure time;
12) estimate the anti-torsional fatigue performance of artificial blood vessel sample: under the same test condition; Through this device and this method of testing; Artificial blood vessel to different windup-degrees, artificial blood vessel sample clamping state, suture way and metal support tip angle α is tested, and estimates the anti-torsional fatigue performance of artificial blood vessel.Under the same test condition, artificial blood vessel sample failure time is long more, and its anti-torsional fatigue property is good more, and corresponding artificial blood vessel sample structure is more reasonable effectively.
The invention has the beneficial effects as follows:
1) device of the present invention and method of testing can effectively be simulated the fatigue aging state that graft exclusion occurs behind the human body intort with artificial blood vessel in the simulated environment cavity of resorption; Pulsation through electronic peristaltic pump provides is pressed; Realized radial dilatation effect to artificial blood vessel; The gear through doing horizontal rotation motion and the engagement of tooth bar have realized the stressed motion of anthropomorphic dummy's hematopoiesis body intort.
2) through this device and this method of testing, the artificial blood vessel of different windup-degrees, artificial blood vessel sample clamping state, suture way and metal support tip angle α is tested, estimated the anti-torsional fatigue performance of artificial blood vessel.Under the same test condition, T is long more for artificial blood vessel sample failure time, and its anti-torsional fatigue property is good more, and corresponding artificial blood vessel sample structure is more reasonable effectively.
Description of drawings
Fig. 1 is that endovascular graft of the present invention is with the tired analogue means synoptic diagram of artificial blood tubotorsion;
Fig. 2 A is the schematic top plan view that artificial blood vessel reverses analogue means;
Fig. 2 B is the synoptic diagram that artificial blood vessel reverses artificial blood vessel style clamp position in the analogue means;
Fig. 3 is artificial blood vessel sample and internal lining pipe package assembly synoptic diagram.
Embodiment
For making the present invention more obviously understandable, now with a preferred embodiment, and conjunction with figs. elaborates as follows.Should be understood that these embodiment only to be used to the present invention is described and be not used in the restriction scope of the present invention.Should be understood that in addition those skilled in the art can do various changes or modification to the present invention after the content of having read the present invention's instruction, these equivalent form of values fall within the application's appended claims institute restricted portion equally.
The endovascular graft that uses among the embodiment is as shown in Figure 1 with the tired analogue means of artificial blood tubotorsion; Comprise the liquid reserve tank 1 that has heating arrangement; Liquid reserve tank 1 connects electronic peristaltic pump 2 through water conservancy diversion silicone tube 6, and pressure monitor 4 connects restrictor 5 through water conservancy diversion silicone tube 6, and restrictor 5 connects liquid reserve tank 1 through water conservancy diversion silicone tube 6; The output terminal of electronic peristaltic pump 2 connects artificial blood vessel and reverses analogue means 3, and the output terminal that artificial blood vessel reverses analogue means 3 connects pressure monitor 4.
Shown in Fig. 2 A and Fig. 2 B; Said artificial blood vessel reverses analogue means 3 and comprises worktable 31; Be fixed with sheet metal 32 on the worktable, the upper end of sheet metal is provided with chute 33, and the slide block 34 that can move horizontally is housed in the chute 33; One end of said slide block 34 links to each other with the head end of connecting rod 36 through pin 351; The tail end of connecting rod 36 352 is connected on the disk 37 that has elongated slot through pinning, and the disk 37 that has elongated slot links to each other with motor 38, and motor 38 links to each other with frequency converter 39; Said motor 38 all is fixedly mounted on the worktable 31 with frequency converter 39; The other end of said slide block 34 links to each other with tooth bar 310, tooth bar 310 and gear 311 engagements, and vertical hollow metal conduit 312 is equipped with at the center bore place of gear 311; The lower end of vertical hollow metal conduit 312 links to each other with the upper end of artificial blood vessel Sample A; The lower end of artificial blood vessel Sample A and horizontal hollow metal conduit 313' or L type hollow metal conduit 313 " head end link to each other horizontal hollow metal conduit 313' or L type hollow metal conduit 313 " are installed on the sidewall of the tank 314 that has heating arrangement and put in the tank 314, the said tank 314 that has heating arrangement be installed on the worktable 31 and and sheet metal 32 between leave the space; Insert the bevel protractor 315 movably indicate 0-180 ° of angle in the space, the upper end of said vertical hollow metal conduit 312 and horizontal hollow metal conduit 313' or L type hollow metal conduit 313 " tail end all be communicated with water conservancy diversion silicone tube 6.Said vertical hollow metal conduit 312 and horizontal hollow metal conduit 313' or L type hollow metal conduit 313 " diameter be 6-45mm; its material selection stainless steel, the length of tooth bar 310 are 40-100mm, and the diameter of gear 311 is 25-100mm; the material selection nylon of tooth bar 310 and gear 311; the material selection copper of slide block 34, and the material selection aluminium alloy of connecting rod 36 and disk 37 has the material selection organic glass of the tank 314 of heating arrangement.Have in the tank 314 of heating arrangement contain fluid and keep fluid temperature at 37 ± 0.5 ℃, the liquid here can be water, can be artificial blood, also can be genuine blood of human body, and the experimenter can select according to experiment condition.
As shown in Figure 3, the artificial blood vessel Sample A adopts straight shape tubulose, fabric overlay film A
1Material selection polyester weaving base or teflon or polyurethane material, fabric overlay film A-
1Length L
1Be 70-250mm, diameter D
1Be 6-45mm, internal lining pipe A
2The material selection silica gel material is with the supporting use of artificial blood vessel Sample A, internal lining pipe A
2Length L
2Be sample fabric overlay film A
1Length L
1105-120%, its diameter D
2Be fabric overlay film A
1Diameter D
180-98%, internal lining pipe A
2Be inserted in artificial blood vessel Sample A fabric overlay film A
1Inside, two ends respectively grow 3-5mm, fabric overlay film A
1The last suture line A that uses
3Be sewed with 3 separate metal support A
4, suture way has conventional two through types stitchings, irregular single through types to sew up and the most advanced and sophisticated concentrated type of support is sewed up three kinds of modes, metal support A
4Tip angle α is 20-70 °.
A kind of endovascular graft that present embodiment is put down in writing is with the method for testing of the tired analogue means of artificial blood tubotorsion, and its concrete steps are following:
1) preparation of experiment material: preparing diameter is the vertical hollow metal conduit 312 of 6mm, the L type hollow metal conduit 313 that diameter is 6mm ", length is the tooth bar 310 of 55mm, diameter is the gear 311 of 52mm, prepares artificial blood vessel Sample A and internal lining pipe A
2, the artificial blood vessel Sample A adopts straight shape tubulose, fabric overlay film A
1Select polyester weaving base for use, length L
1Be 70mm, diameter D
1Be 6mm, internal lining pipe A
2The material selection silica gel material is with the supporting use of artificial blood vessel Sample A, internal lining pipe A
2Length L
2Be 80mm, its diameter D
2Be 5mm, internal lining pipe A
2Be inserted in artificial blood vessel Sample A fabric overlay film A
1Inside, two ends respectively grow 5mm, fabric overlay film A
1The last suture line A that uses
3Be sewed with 3 separate metal support A
4, suture way selects conventional two through types to sew up metal support A
4Material selection Nitinol, tip angle α are 40 °.
2) check system: before beginning test, inspection and debugging apparatus make its operate as normal, if any unusually, in time adjust.
3) " be installed on the sidewall of the tank 314 that has heating arrangement and put in the tank 314 ready L type hollow metal conduit 313.
4) adjust tooth bar 310 and gear 311 initial positions, the vertical hollow metal conduit 312 of gear 311 is housed, gear 311 centers lucky and tooth bar 310 are meshed.
5) position of adjustment pin 352 in disk 37 elongated slots; Change through pin 352 be connected the connecting rod 36 on the disk 37 that has elongated slot traverse; The tooth bar that links to each other with connecting rod 36 through slide block 34 310 is moved back and forth as level, and make and tooth bar 310 meshed gears 311 rotate 30 °.
6) the artificial blood vessel Sample A is installed: the lower end that the upper end of ready artificial blood vessel Sample A is enclosed within vertical hollow metal conduit 312 with rubber band; The lower end of artificial blood vessel Sample A is enclosed within L type hollow metal conduit 313 " head end; adjustment L type hollow metal conduit 313 " stretches into the length of the tank 314 that has heating arrangement; Contrast bevel protractor 315, make artificial blood vessel Sample A clamping up and down the angle at two ends be 180 °, promptly be the vertical state of nature; Regulate the artificial blood vessel Sample A, make it not produce distortion.
7) in the liquid reserve tank that has heating arrangement 1, fill with liquid; Have and inject 2/3 liquid in the tank 314 of heating arrangement; Guarantee that liquid level covered the upper end of artificial blood vessel Sample A, regulate the heating arrangement of liquid reserve tank 1 and tank 314, make fluid temperature keep 37 ± 0.5 ℃.
8) open electronic peristaltic pump 2, regulating its frequency is 10Hz, makes in the liquid reserve tank 1 liquid become stable pulsating flow through electronic peristaltic pump 2 and feeds vertical hollow metal conduit 312 through water conservancy diversion silicone tube 6.
9) regulate restrictor 5, make pressure monitor 4 show that pressure limit is 48KPa.
10) regulating frequency converter 38 frequencies is 20Hz, control motor 37 rotating speeds.
11) test and record: treat system stability, liquid continuous flow after pipeline does not have bubble, picks up counting, and the damaged situation of Real Time Observation artificial blood vessel Sample A when breakage appears in the artificial blood vessel Sample A, then stops experiment immediately, record failure time T
1=79h.
12) contrast test: at testing procedure 5), the position of adjustment pin 352 in disk 37 elongated slots makes with tooth bar 310 meshed gears 311 and rotates 60 °, and other experiment materials and test condition remain unchanged, repeating step 1) to 11), record failure time T
2=72h.
13) contrast test: at testing procedure 5), the position of adjustment pin 352 in disk 37 elongated slots makes with tooth bar 310 meshed gears 311 and rotates 90 °, and other experiment materials and test condition remain unchanged, repeating step 1) to 11), record failure time T
3=57h.
14) estimate the anti-torsional fatigue performance of artificial blood vessel Sample A:
Through this device and this method of testing, the artificial blood vessel Sample A of different windup-degrees to be tested, under the same test condition, artificial blood vessel Sample A failure time is long more, and its anti-torsional fatigue property is good more; Through test, T
1(79h)>T
2(72h)>T
3(57h), explain that windup-degree is influential to the anti-torsional fatigue performance of artificial blood vessel sample, and windup-degree hour, the anti-torsional fatigue better performances of artificial blood vessel sample.
When artificial blood vessel is transplanted in vivo, reverse 90 ° and be limiting case, and according to above-mentioned test result, the anti-torsional fatigue performance of artificial blood vessel sample is the poorest in the case; So when different clamping states are tested with the artificial blood vessel sample of different suture ways and support tip angle; Should estimate the anti-torsional fatigue performance of artificial blood vessel sample under the poorest relatively in vivo transplanting environment; Promptly under artificial blood vessel sample windup-degree is 90 ° prerequisite, the different clamping states of artificial blood vessel sample and suture way and support tip angle are tested.
A kind of endovascular graft that present embodiment is put down in writing is with the method for testing of the tired analogue means of artificial blood tubotorsion, and its concrete steps are following:
1) preparation of experiment material: preparing diameter is the vertical hollow metal conduit 312 of 15mm, the L type hollow metal conduit 313 that diameter is 15mm "; length is the tooth bar 310 of 55mm; diameter is the gear 311 of 52mm, prepares artificial blood vessel Sample A and internal lining pipe A
2, the artificial blood vessel Sample A adopts straight shape tubulose, fabric overlay film A
1Select polyester weaving base for use, length L
1Be 70mm, diameter D
1Be 15mm, internal lining pipe A
2The material selection silica gel material, length L
2Be 80mm, diameter D
2Be 14mm, internal lining pipe A
2Be inserted in artificial blood vessel Sample A fabric overlay film A
1Inside, two ends respectively grow 5mm, fabric overlay film A
1The last suture line A that uses
3Be sewed with 3 separate metal support A
4, suture way selects conventional two through types to sew up metal support A
4Material selection Nitinol, tip angle α are 40 °.
2) check system: before beginning test, inspection and debugging apparatus make its operate as normal, if any unusually, in time adjust.
3) " be installed on the sidewall of the tank 314 that has heating arrangement and put in the tank 314 ready L type hollow metal conduit 313.
4) adjust tooth bar 310 and gear 311 initial positions, the vertical hollow metal conduit 312 of gear 311 is housed, gear 311 centers lucky and tooth bar 310 are meshed.
5) position of adjustment pin 352 in disk 37 elongated slots; Change through pin 352 be connected the connecting rod 36 on the disk 37 that has elongated slot traverse; The tooth bar that links to each other with connecting rod 36 through slide block 34 310 is moved back and forth as level, and make and tooth bar 310 meshed gears 311 rotate 90 °.
6) the artificial blood vessel Sample A is installed: the lower end that the upper end of ready artificial blood vessel Sample A is enclosed within vertical hollow metal conduit 312 with rubber band; The lower end of artificial blood vessel Sample A is enclosed within L type hollow metal conduit 313 " head end; adjustment L type hollow metal conduit 313 " stretches into the length of the tank 314 that has heating arrangement; Contrast bevel protractor 315, make artificial blood vessel Sample A clamping up and down the angle at two ends be 180 °, promptly be the vertical state of nature; Regulate the artificial blood vessel Sample A, make it not produce distortion.
7) in the liquid reserve tank that has heating arrangement 1, fill with liquid; Have and inject 2/3 liquid in the tank 314 of heating arrangement; Guarantee that liquid level covered the upper end of artificial blood vessel Sample A, regulate the heating arrangement of liquid reserve tank 1 and tank 314, make fluid temperature keep 37 ± 0.5 ℃.
8) open electronic peristaltic pump 2, regulating its frequency is 10Hz, makes in the liquid reserve tank 1 liquid become stable pulsating flow through electronic peristaltic pump 2 and feeds vertical hollow metal conduit 312 through water conservancy diversion silicone tube 6.
9) regulate restrictor 5, make pressure monitor 4 show that pressure limit is 48KPa.
10) regulating frequency converter 38 frequencies is 20Hz, control motor 37 rotating speeds.
11) test and record: treat system stability, liquid continuous flow after pipeline does not have bubble, picks up counting, and the damaged situation of Real Time Observation artificial blood vessel Sample A when breakage appears in the artificial blood vessel Sample A, then stops experiment immediately, record failure time T
1=61h.
12) during contrast test: at testing procedure 1) experiment material was prepared, preparing diameter was the horizontal hollow metal conduit 313' of 15mm, artificial blood vessel Sample A fabric overlay film A
1Length L
1Be 114mm, diameter D
1Be 15mm, internal lining pipe A
2Length L
2Be 124mm, diameter D
2Be 14mm, internal lining pipe A
2Be inserted in artificial blood vessel Sample A fabric overlay film A
1Inside, two ends respectively grow 5mm; At testing procedure 6) in, adjust horizontal hollow metal conduit 313 " stretch into the length in the tank 314, contrast bevel protractor 315; make artificial blood vessel Sample A clamping up and down the angle at two ends be 135 °; other experiment materials and test condition remain unchanged, repeating step 1) to 11), write down failure time T
2=54h.
13) during contrast test: at testing procedure 1) experiment material was prepared, preparing diameter was the horizontal hollow metal conduit 313' of 15mm, artificial blood vessel Sample A fabric overlay film A
1Length L
1Be 150mm, diameter D
1Be 15mm, internal lining pipe A
2Length L
2Be 160mm, diameter D
2Be 14mm, internal lining pipe A
2Be inserted in artificial blood vessel Sample A fabric overlay film A
1Inside, two ends respectively grow 5mm; At testing procedure 6) in, adjust horizontal hollow metal conduit 313 " stretch into the length in the tank 314, contrast bevel protractor 315; make artificial blood vessel Sample A clamping up and down the angle at two ends be 90 °; other experiment materials and test condition remain unchanged, repeating step 1) to 11), write down failure time T
3=36h.
14) during contrast test: at testing procedure 1) experiment material was prepared, preparing diameter was the horizontal hollow metal conduit 313' of 15mm, artificial blood vessel Sample A fabric overlay film A
1Length L
1Be 215mm, diameter D
1Be 15mm, internal lining pipe A
2Length L
2Be 225mm, diameter D
2Be 14mm, internal lining pipe A
2Be inserted in artificial blood vessel Sample A fabric overlay film A
1Inside, two ends respectively grow 5mm; At testing procedure 6) in, adjust horizontal hollow metal conduit 313 " stretch into the length in the tank 314, contrast bevel protractor 315; make artificial blood vessel Sample A clamping up and down the angle at two ends be 45 °; other experiment materials and test condition remain unchanged, repeating step 1) to 11), write down failure time T
4=24h.
15) estimate the anti-torsional fatigue performance of artificial blood vessel Sample A:
Through this device and this method of testing, the artificial blood vessel Sample A of different clamping states to be tested, under the same test condition, artificial blood vessel Sample A failure time is long more, and its anti-torsional fatigue property is good more; Through test, T
1(61h)>T
2(54h)>T
3(36h)>T
4(24h), explain that different clamping states are influential to the anti-torsional fatigue performance of artificial blood vessel sample, and the artificial blood vessel sample is when being the vertical state of nature and installing, promptly artificial blood vessel is straight clinically when not bending, the anti-torsional fatigue better performances of artificial blood vessel sample.
According to above-mentioned test result, it is the poorest relatively that artificial blood vessel is transplanted when being 45 ° anti-torsional fatigue performance in vivo; So when the artificial blood vessel sample of different suture ways and support tip angle is tested; Should estimate the anti-torsional fatigue performance of artificial blood vessel sample under the poorest relatively in vivo transplanting environment; Be 90 ° promptly at artificial blood vessel sample windup-degree, when clamping is 45 °; Artificial blood vessel sample to different suture ways and support tip angle is tested, and obtains rational and effective artificial blood vessel structure.
A kind of endovascular graft that present embodiment is put down in writing is with the method for testing of the tired analogue means of artificial blood tubotorsion, and its concrete steps are following:
1) preparation of experiment material: the preparation diameter is that vertical hollow metal conduit 312, the diameter of 30mm is the horizontal hollow metal conduit 313' of 30mm; Length is the tooth bar 310 of 55mm; Diameter is the gear 311 of 52mm, prepares artificial blood vessel Sample A and internal lining pipe A
2, the artificial blood vessel Sample A adopts straight shape tubulose, fabric overlay film A
1Select polyester weaving base for use, length L
1Be 215mm, diameter D
1Be 30mm, internal lining pipe A
2The material selection silica gel material, length L
2Be 225mm, diameter D
2Be 29mm, internal lining pipe A
2Be inserted in artificial blood vessel Sample A fabric overlay film A
1Inside, two ends respectively grow 5mm, fabric overlay film A
1The last suture line A that uses
3Be sewed with 3 separate metal support A
4, suture way selects conventional two through types to sew up metal support A
4Material selection Nitinol, tip angle α are 40 °.
2) check system: before beginning test, inspection and debugging apparatus make its operate as normal, if any unusually, in time adjust.
3) be installed in ready horizontal hollow metal conduit 313' on the sidewall of the tank 314 that has heating arrangement and put in the tank 314.
4) adjust tooth bar 310 and gear 311 initial positions, the vertical hollow metal conduit 312 of gear 311 is housed, gear 311 centers lucky and tooth bar 310 are meshed.
5) position of adjustment pin 352 in disk 37 elongated slots; Change through pin 352 be connected the connecting rod 36 on the disk 37 that has elongated slot traverse; The tooth bar that links to each other with connecting rod 36 through slide block 34 310 is moved back and forth as level, and make and tooth bar 310 meshed gears 311 rotate 90 °.
6) the artificial blood vessel Sample A is installed: the lower end that the upper end of ready artificial blood vessel Sample A is enclosed within vertical hollow metal conduit 312 with rubber band; The lower end of artificial blood vessel Sample A is enclosed within the head end of horizontal hollow metal conduit 313'; The horizontal hollow metal conduit of adjustment 313' stretches into the length of the tank 314 that has heating arrangement, contrast bevel protractor 315, make artificial blood vessel Sample A clamping up and down the angle at two ends be 45 °; Regulate the artificial blood vessel Sample A, make it not produce distortion.
7) in the liquid reserve tank that has heating arrangement 1, fill with liquid; Have and inject 2/3 liquid in the tank 314 of heating arrangement; Guarantee that liquid level covered the upper end of artificial blood vessel Sample A, regulate the heating arrangement of liquid reserve tank 1 and tank 314, make fluid temperature keep 37 ± 0.5 ℃.
8) open electronic peristaltic pump 2, regulating its frequency is 10Hz, makes in the liquid reserve tank 1 liquid become stable pulsating flow through electronic peristaltic pump 2 and feeds vertical hollow metal conduit 312 through water conservancy diversion silicone tube 6.
9) regulate restrictor 5, make pressure monitor 4 show that pressure limit is 48KPa.
10) regulating frequency converter 38 frequencies is 20Hz, control motor 37 rotating speeds.
11) test and record: treat system stability, liquid continuous flow after pipeline does not have bubble, picks up counting, and the damaged situation of Real Time Observation artificial blood vessel Sample A when breakage appears in the artificial blood vessel Sample A, then stops experiment immediately, record failure time T
1=26h.
12) during contrast test: at testing procedure 1) experiment material is prepared, artificial blood vessel Sample A metal support A
4With fabric overlay film A
1Suture way select for use irregular single through type to sew up, other experiment materials and test condition remain unchanged, repeating step 1) to 11), write down failure time T
2=16h.
13) during contrast test: at testing procedure 1) experiment material is prepared, artificial blood vessel Sample A metal support A
4With fabric overlay film A
1Suture way select for use the most advanced and sophisticated concentrated type of support to sew up, other experiment materials and test condition remain unchanged, repeating step 1) to 11), write down failure time T
3=39h
14) estimate the anti-torsional fatigue performance of artificial blood vessel Sample A:
Through this device and this method of testing, the artificial blood vessel Sample A of different suture ways to be tested, under the same test condition, artificial blood vessel Sample A failure time is long more, and its anti-torsional fatigue property is good more; Through test, T
3(39h)>T
1 (26h)>T
2(16h), explain that different suture ways are influential to the anti-torsional fatigue performance of artificial blood vessel sample, and suture way is most advanced and sophisticated concentrated type when sewing up, the anti-torsional fatigue better performances of artificial blood vessel sample.
A kind of endovascular graft that present embodiment is put down in writing is with the method for testing of the tired analogue means of artificial blood tubotorsion, and its concrete steps are following:
1) preparation of experiment material: the preparation diameter is that vertical hollow metal conduit 312, the diameter of 45mm is the horizontal hollow metal conduit 313' of 45mm; Length is the tooth bar 310 of 55mm; Diameter is the gear 311 of 52mm, prepares artificial blood vessel Sample A and internal lining pipe A
2, the artificial blood vessel Sample A adopts straight shape tubulose, fabric overlay film A
1Select polyester weaving base for use, length L
1Be 215mm, diameter D
1Be 45mm, internal lining pipe A
2The material selection silica gel material, length L
2Be 225mm, diameter D
2Be 44mm, internal lining pipe A
2Be inserted in artificial blood vessel Sample A fabric overlay film A
1Inside, two ends respectively grow 5mm, fabric overlay film A
1The last suture line A that uses
3Be sewed with 3 separate metal support A
4, suture way selects the most advanced and sophisticated concentrated type of support to sew up metal support A
4Material selection Nitinol, tip angle α are 40 °.
2) check system: before beginning test, inspection and debugging apparatus make its operate as normal, if any unusually, in time adjust.
3) be installed in ready horizontal hollow metal conduit 313' on the sidewall of the tank 314 that has heating arrangement and put in the tank 314.
4) adjust tooth bar 310 and gear 311 initial positions, the vertical hollow metal conduit 312 of gear 311 is housed, gear 311 centers lucky and tooth bar 310 are meshed.
5) position of adjustment pin 352 in disk 37 elongated slots; Change through pin 352 be connected the connecting rod 36 on the disk 37 that has elongated slot traverse; The tooth bar that links to each other with connecting rod 36 through slide block 34 310 is moved back and forth as level, and make and tooth bar 310 meshed gears 311 rotate 90 °.
6) the artificial blood vessel Sample A is installed: the lower end that the upper end of ready artificial blood vessel Sample A is enclosed within vertical hollow metal conduit 312 with rubber band; The lower end of artificial blood vessel Sample A is enclosed within the head end of horizontal hollow metal conduit 313'; The horizontal hollow metal conduit of adjustment 313' stretches into the length of the tank 314 that has heating arrangement, contrast bevel protractor 315, make artificial blood vessel Sample A clamping up and down the angle at two ends be 45 °; Regulate the artificial blood vessel Sample A, make it not produce distortion.
7) in the liquid reserve tank that has heating arrangement 1, fill with liquid; Have and inject 2/3 liquid in the tank 314 of heating arrangement; Guarantee that liquid level covered the upper end of artificial blood vessel Sample A, regulate the heating arrangement of liquid reserve tank 1 and tank 314, make fluid temperature keep 37 ± 0.5 ℃.
8) open electronic peristaltic pump 2, regulating its frequency is 10Hz, makes in the liquid reserve tank 1 liquid become stable pulsating flow through electronic peristaltic pump 2 and feeds vertical hollow metal conduit 312 through water conservancy diversion silicone tube 6.
9) regulate restrictor 5, make pressure monitor 4 show that pressure limit is 48KPa.
10) regulating frequency converter 38 frequencies is 20Hz, control motor 37 rotating speeds.
11) test and record: treat system stability, liquid continuous flow after pipeline does not have bubble, picks up counting, and the damaged situation of Real Time Observation artificial blood vessel Sample A when breakage appears in the artificial blood vessel Sample A, then stops experiment immediately, record failure time T
1=38h.
12) during contrast test: at testing procedure 1) experiment material is prepared, artificial blood vessel Sample A metal support A
4Tip angle α select 20 ° for use, other experiment materials and test condition remain unchanged, repeating step 1) to 11), record failure time T
2=27h.
13) during contrast test: at testing procedure 1) experiment material is prepared, artificial blood vessel Sample A metal support A
4Tip angle α select 70 ° for use, other experiment materials and test condition remain unchanged, repeating step 1) to 11), record failure time T
3=48h.
14) estimate the anti-torsional fatigue performance of artificial blood vessel Sample A:
Through this device and this method of testing, the artificial blood vessel Sample A of different support tip angle α to be tested, under the same test condition, artificial blood vessel Sample A failure time is long more, and its anti-torsional fatigue property is good more; Through test, T
3(48h)>T
1(38h)>T
2(27h), explain that different support tip angle α is influential to the anti-torsional fatigue performance of artificial blood vessel sample, and within the specific limits, support tip angle α is big more, the anti-torsional fatigue performance of artificial blood vessel sample is good more.
Claims (4)
1. an endovascular graft is with the tired analogue means of artificial blood tubotorsion; Comprise the liquid reserve tank (1) that has heating arrangement; Liquid reserve tank (1) connects electronic peristaltic pump (2) through water conservancy diversion silicone tube (6); Pressure monitor (4) connects restrictor (5) through water conservancy diversion silicone tube (6), and restrictor (5) connects liquid reserve tank (1) through water conservancy diversion silicone tube (6), it is characterized in that; The output terminal of electronic peristaltic pump (2) connects artificial blood vessel and reverses analogue means (3), and the output terminal that artificial blood vessel reverses analogue means (3) connects pressure monitor (4);
Said artificial blood vessel reverses analogue means (3) and comprises worktable (31); Be fixed with sheet metal (32) on the worktable (31); The upper end of sheet metal (32) is provided with chute (33); The slide block (34) that can move horizontally is housed in the chute (33); One end of said slide block (34) links to each other with the head end of connecting rod (36) through pin (351); The tail end of connecting rod (36) is connected on the disk (37) that has elongated slot through pin (352); The disk (37) that has elongated slot links to each other with motor (38); Motor (38) links to each other with frequency converter (39), and said motor (38) and frequency converter (39) all are fixedly mounted on the worktable (31), and the other end of said slide block (34) links to each other with tooth bar (310); Tooth bar (310) and gear (311) engagement; Vertical hollow metal conduit (312) is equipped with at the center bore place of gear (311), and the lower end of vertical hollow metal conduit (312) links to each other with the upper end of artificial blood vessel sample (A), and (head end of 313 ") links to each other; (313 ") are installed on the sidewall of the tank (314) that has heating arrangement and put in the tank (314) for horizontal hollow metal conduit (313') or L type hollow metal conduit for the lower end of artificial blood vessel sample (A) and horizontal hollow metal conduit (313') or L type hollow metal conduit; The said tank (314) that has heating arrangement be installed in that worktable (31) is gone up and and sheet metal (32) between leave the space, insert the bevel protractor (315) that movably indicates 0-180 ° of angle in the space, (tail end of 313 ") all is communicated with water conservancy diversion silicone tube (6) for the upper end of said vertical hollow metal conduit (312) and horizontal hollow metal conduit (313') or L type hollow metal conduit.
2. a kind of endovascular graft as claimed in claim 1 is with the tired analogue means of artificial blood tubotorsion; It is characterized in that: said artificial blood vessel reverses in the analogue means (3) vertical hollow metal conduit (312) and horizontal hollow metal conduit (313') or L type hollow metal conduit, and (diameter of 313 ") is 6-45mm; the length of tooth bar (310) is 40-100mm, and the diameter of gear (311) is 25-100mm.
3. a kind of endovascular graft as claimed in claim 1 is with the tired analogue means of artificial blood tubotorsion; It is characterized in that: said artificial blood vessel reverses the material selection copper of slide block (34) in the analogue means (3); The material selection aluminium alloy of connecting rod (36) and disk (37); (the material selection stainless steel of 313 "); the material selection nylon of tooth bar (310) and gear (311) has the material selection organic glass of the tank (314) of heating arrangement for vertical hollow metal conduit (312) and horizontal hollow metal conduit (313') or L type hollow metal conduit.
4. a method of testing of using the described endovascular graft of claim 1 with the tired analogue means of artificial blood tubotorsion is characterized in that, concrete testing procedure is following:
1) preparation of experiment material: preparing diameter is vertical hollow metal conduit (312), horizontal hollow metal conduit (313') or L type hollow metal conduit (313 "); preparing length is the tooth bar (310) of 40-100mm; diameter is the gear (311) of 25-100mm, preparation artificial blood vessel sample (A) and the internal lining pipe (A of 6-45mm
2), artificial blood vessel sample (A) adopts straight shape tubulose, fabric overlay film (A
1) material selection polyester weaving base or teflon or polyurethane material, fabric overlay film (A
1) length (L
1) be 70-250mm, diameter (D
1) be 6-45mm, internal lining pipe (A
2) the material selection silica gel material, with the supporting use of artificial blood vessel sample (A), internal lining pipe (A
2) length (L
2) be sample fabric overlay film (A
1) length (L
1) 105-120%, its diameter (D
2) be fabric overlay film (A
1) diameter (D
1) 80-98%, internal lining pipe (A
2) be inserted in artificial blood vessel sample (A) fabric overlay film (A
1) inside, two ends respectively grow 3-5mm, fabric overlay film (A
1) go up with suture line (A
3) be sewed with 3 separate metal support (A
4), suture way has conventional two through types stitchings, irregular single through types to sew up and the most advanced and sophisticated concentrated type of support is sewed up three kinds of modes, metal support (A
4) tip angle (α) is 20-70 °;
2) check system: before beginning test, inspection and debugging apparatus make its operate as normal, if any unusually, in time adjust;
3) (313 ") are installed on the sidewall of the tank (314) that has heating arrangement and put in the tank (314) ready horizontal hollow metal conduit (313') or L type hollow metal conduit;
4) adjust tooth bar (310) and gear (311) initial position, the vertical hollow metal conduit (312) of gear (311) is housed, gear (311) center lucky and tooth bar (310) is meshed;
5) adjustment pin (352) position in disk (37) elongated slot; Change the traverse that is connected the connecting rod (36) on the disk (37) that has elongated slot through pin (352); The tooth bar (310) that links to each other with connecting rod (36) through slide block (34) is moved back and forth as level, and make and tooth bar (310) meshed gears (311) rotates 0-90 ° (not comprising 0 °);
6) artificial blood vessel sample (A) is installed: the lower end that the upper end of ready artificial blood vessel sample (A) is enclosed within vertical hollow metal conduit (312) with rubber band; The lower end of artificial blood vessel sample (A) is enclosed within horizontal hollow metal conduit (313') or the L type hollow metal conduit (head end of 313 "); (313 ") are stretched into the length of the tank (314) that has heating arrangement to adjust horizontal hollow metal conduit (313') or L type hollow metal conduit; Contrast bevel protractor (315); Make artificial blood vessel sample (A) clamping up and down the angle at two ends be 20-180 °, regulate artificial blood vessel sample (A), make it not produce distortion;
7) in the liquid reserve tank that has heating arrangement (1), fill with liquid; Middle 2/3 liquid that injects of tank (314) that has heating arrangement; Guarantee that liquid level covered the upper end of artificial blood vessel sample (A); Regulate the heating arrangement of liquid reserve tank (1) and tank (314), make fluid temperature keep 37 ± 0.5 ℃;
8) open electronic peristaltic pump (2), regulating its frequency is 1-10Hz, makes the middle liquid of liquid reserve tank (1) become stable pulsating flow through electronic peristaltic pump (2) and feeds vertical hollow metal conduit (312) through water conservancy diversion silicone tube (6);
9) regulate restrictor (5), make pressure monitor (4) show that pressure limit is 16-100KPa;
10) regulating frequency converter (38) frequency is 1-60Hz, control motor (37) rotating speed;
11) test and record: treat system stability, liquid continuous flow after pipeline does not have bubble, picks up counting, and the damaged situation of Real Time Observation artificial blood vessel sample (A) when breakage appears in artificial blood vessel sample (A), then stops experiment immediately, record failure time T;
12) estimate the anti-torsional fatigue performance of artificial blood vessel sample (A): under the same test condition; Through this device and this method of testing; Artificial blood vessel Sample A to different windup-degrees, clamping state, suture way and metal support tip angle (α) is tested; Estimate the anti-torsional fatigue performance of artificial blood vessel Sample A, under the same test condition, T is long more for artificial blood vessel sample (A) failure time; Its anti-torsional fatigue property is good more, and corresponding artificial blood vessel sample structure is more reasonable effectively.
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| CN201210001843.4A CN102564877B (en) | 2012-01-05 | 2012-01-05 | Artificial blood vessel torsional fatigue simulating device for endovascular graft exclusion and testing method thereof |
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| CN105388076A (en) * | 2015-12-25 | 2016-03-09 | 江阴法尔胜佩尔新材料科技有限公司 | Automatic counting device for hyperelastic wire fatigue test and using method thereof |
| CN105388076B (en) * | 2015-12-25 | 2018-06-08 | 江阴法尔胜佩尔新材料科技有限公司 | The robot scaler and its application method of super-elasticity silk material testing fatigue |
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| CN112485132B (en) * | 2020-11-19 | 2024-01-19 | 东莞市镁安医疗器械有限公司 | Vascular stent torsion testing device |
| CN112630064A (en) * | 2020-12-17 | 2021-04-09 | 东华大学 | Artificial ligament multi-degree-of-freedom online fatigue simulation testing device and testing method thereof |
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