CN112471168A - Bactericide composition containing triphenyltin acetate and cyproconazole and application thereof - Google Patents
Bactericide composition containing triphenyltin acetate and cyproconazole and application thereof Download PDFInfo
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- CN112471168A CN112471168A CN202011497988.9A CN202011497988A CN112471168A CN 112471168 A CN112471168 A CN 112471168A CN 202011497988 A CN202011497988 A CN 202011497988A CN 112471168 A CN112471168 A CN 112471168A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
- A01N55/02—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur containing metal atoms
- A01N55/04—Tin
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/12—Powders or granules
- A01N25/14—Powders or granules wettable
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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Abstract
The invention discloses a triphenyltin acetate and cyproconazole bactericide composition and application thereof, the composition is prepared by compounding triphenyltin acetate and cyproconazole, and has a good synergistic effect, wherein the weight ratio of the triphenyltin acetate to the cyproconazole is 1:10 to 10: 1. The composition of the invention expands the bactericidal spectrum, improves the bactericidal efficiency, avoids the drug resistance of diseases, prolongs the drug effect duration, and has good effect in preventing diseases of crops such as powdery mildew, scab, alternaria leaf spot and the like.
Description
Technical Field
The invention relates to the technical field of pesticide bactericides, and particularly relates to a bactericide composition containing triphenyltin acetate and cyproconazole and application thereof.
Background
Triphenyltin acetate (Triphenyltin acetate), commonly known as oryzanol, has a molecular formula of C20H18O2Sn with molecular weight of 409.0657 is a protective bactericide, has no systemic action, is mainly used for preventing and treating rice blast, false smut, brown spot of beet and the like, and has certain toxicity. Besides sterilization, the product can also be used for preventing and treating algae and water snails in paddy fields, and for beet and soybean, and has the effects of increasing sugar and increasing yield.
Cyproconazole (Cyproconazole), molecular formula C15H18ClN3O, molecular weight 291.78, is a triazole fungicide, is a sterol demethylation inhibitor, has preventive and therapeutic effects, and is effective on powdery mildew, rust fungi, genus Mortierella, coracocephalosporium, septoria, and Venturia of cereal crops, coffee, beet, fruit trees, and grape. When the composition is mixed with other bactericides, the composition can well prevent and treat the eyespot disease, the leaf spot disease and the net spot disease of cereals.
The single bactericide can cause the diseases to generate drug resistance after being applied for a long time, and the dosage of the single bactericide is often required to be increased in order to achieve higher effect, so that the soil burden is greatly increased, the drug resistance is more easily generated, and the problems of reduced prevention effect and shortened lasting period are caused.
Chinese patent CN106259416A discloses a method for producing triphenyltin acetate technical product, which is characterized in that: the method comprises the following steps: (1) sequentially adding methoxyphenoxyacetic acid, triphenyl tin hydroxide, an auxiliary agent and a binder into a reaction container protected by nitrogen, uniformly mixing, and carrying out superfine grinding by using an airflow grinder to obtain fine powder of 800-1000 meshes; (2) adding the obtained fine powder and an aqueous solution of an adhesive into a mixer, and reacting for 6-18 h under stirring and refluxing; and cooling, filtering, and evaporating the filtrate by using a rotary evaporator under the conditions that the pressure is 0.004-0.011 MPa and the temperature is 28-50 ℃ to obtain the crude product of the triphenyltin acetate. However, the triphenyltin acetate raw pesticide prepared by the patent is a single-component pesticide, and has large dosage, poor pesticide effect and easy generation of drug resistance.
Disclosure of Invention
In view of the above, the present invention provides a fungicide composition containing triphenyltin acetate and cyproconazole and an application thereof, so as to solve the above technical problems.
In order to achieve the purpose, the invention provides the following technical scheme: a bactericide composition containing triphenyltin acetate and cyproconazole, wherein the pharmaceutical active ingredients of the triphenyltin acetate and cyproconazole bactericide composition comprise triphenyltin acetate and cyproconazole in a weight ratio of (1:10) - (10: 1).
Further, the active pharmaceutical ingredients of the triphenyltin acetate and cyproconazole bactericide composition comprise triphenyltin acetate and cyproconazole in the weight ratio of (1:1) - (5: 1).
Furthermore, the dosage form of the triphenyltin acetate and cyproconazole bactericide composition is any one of wettable powder, water dispersible granules, aqueous emulsion, dispersible oil suspending agent and missible oil.
Furthermore, when the dosage form of the triphenyltin acetate and cyproconazole bactericide composition is a dispersible oil suspending agent, the organic solvent is used as a medium, and the content of each component is as follows: 1-60% of active ingredients of the medicine, 0.1-20% of wetting agent, 0.1-20% of dispersing agent, 0.1-20% of emulsifying agent, 0-10% of suspending aid and the balance of dispersing medium; the dispersing agent is formed by mixing an alkylphenol polyoxyethylene ether formaldehyde condensation compound and fatty alcohol polyoxyethylene ether sulfate according to the ratio of 1: 0.5-2, the wetting agent is sodium dodecyl sulfate, the emulsifying agent is formed by mixing calcium dodecyl benzene sulfonate and castor oil polyoxyethylene ether according to the ratio of 1: 0.8-1.2, the suspension aid is formed by mixing white carbon black and organic bentonite according to the ratio of 1: 0.6-1.5, and the dispersing medium is methyl oleate.
More particularly, when the dosage form of the triphenyltin acetate and cyproconazole bactericide composition is a dispersible oil suspending agent, the organic solvent is used as a medium, and the content of each component is as follows: 20-50% of active ingredients of the medicine, 1-5% of wetting agent, 2-8% of dispersing agent, 2-8% of emulsifying agent, 1-5% of suspension aid and the balance of dispersing medium.
Furthermore, when the dosage form of the triphenyltin acetate and cyproconazole bactericide composition is wettable powder, the composition consists of the following components in percentage by weight: 1-80% of a medicinal active ingredient, 1-10% of a dispersing agent, 1-10% of a wetting agent and the balance of a filler; the dispersing agent is formed by mixing sodium naphthalene sulfonate and sodium lignin sulfonate according to the mass ratio of 0.8-3: 1, the wetting agent is formed by mixing sodium dodecyl sulfate and sodium lignin sulfonate according to the mass ratio of 1: 0.5-1.5, and the filler is 10-40% of white carbon black and 60-90% of talcum powder.
More particularly, when the dosage form of the triphenyltin acetate and cyproconazole bactericide composition is wettable powder, the composition consists of the following components in percentage by weight: 3-70% of a medicinal active ingredient, 4-8% of a dispersing agent, 1-3% of a wetting agent and the balance of a filler.
The invention also aims to provide a preparation method of the bactericidal agent composition containing the triphenyl tin acetate and the cyproconazole, which comprises the following steps: adding the pharmaceutical active ingredients, the wetting agent, the dispersing agent, the emulsifier, the suspension auxiliary agent and the dispersion medium in percentage into a feeding kettle, and stirring and shearing for 20-40 minutes to obtain a suspension; and sanding the suspension until the particle size is 4-5 mu m to obtain the bactericide composition containing the triphenyl tin acetate and the cyproconazole.
The invention also aims to provide application of the bactericide composition containing the triphenyl tin acetate and the cyproconazole in preventing and treating diseases of vegetables and fruit trees.
Further, the composition can be applied to preventing and treating scab, alternaria leaf spot, late blight, downy mildew, rust disease, powdery mildew, banded sclerotial blight and gibberellic disease.
The technical scheme can show that the invention has the advantages that:
1. the bactericide composition containing the triphenyltin acetate and the cyproconazole prepared by the invention takes the triphenyltin acetate and the cyproconazole in a specific ratio as active components, the triphenyltin acetate and the cyproconazole have obvious synergistic effect and good bactericidal effect, and the prepared dispersible oil suspending agent and the prepared wettable powder both have excellent bactericidal effect;
2. the dispersible oil suspending agent prepared from the bactericidal composition containing tin triphenyl acetate and cyproconazole has good dispersibility on the surface of crops, high liquid medicine permeability and easy adhesion on leaves, so that a better bactericidal effect is achieved, and the wettable powder has excellent wettability and high control effect;
3. the preparation method of the bactericide composition containing the triphenyl tin acetate and the cyproconazole, which is prepared by the invention, is simple and easy to operate, low in usage amount, high in economic benefit and suitable for industrial production.
In addition to the objects, features and advantages described above, other objects, features and advantages of the present invention are also provided. The present invention will be described in further detail below.
Detailed Description
The following detailed description of embodiments of the invention, but the invention can be practiced in many different ways, as defined and covered by the claims.
Example 1
Bactericide composition containing triphenyltin acetate and cyproconazole and application thereof
The bactericide composition containing the triphenyltin acetate and the cyproconazole is a dispersible oil suspending agent, takes an organic solvent as a medium, and comprises the following components in percentage by weight: 60% of active pharmaceutical ingredients, 5% of wetting agents, 8% of dispersing agents, 8% of emulsifying agents, 5% of suspending aids and the balance of dispersing media; the active ingredients of the medicine comprise triphenyltin acetate and cyproconazole in a weight ratio of 5: 1; the dispersing agent is formed by mixing an alkylphenol polyoxyethylene ether formaldehyde condensation compound and fatty alcohol polyoxyethylene ether sulfate according to the ratio of 1:2, the wetting agent is sodium dodecyl sulfate, the emulsifying agent is formed by mixing calcium dodecyl benzene sulfonate and castor oil polyoxyethylene ether according to the ratio of 1:1.2, the suspension aid is formed by mixing white carbon black and organic bentonite according to the ratio of 1:0.6, and the dispersing medium is methyl oleate.
The bactericide composition containing the triphenyl tin acetate and the cyproconazole is prepared by the following method:
adding the active pharmaceutical ingredients, the wetting agent, the dispersing agent, the emulsifier, the suspension auxiliary agent and the dispersion medium in percentage into a feeding kettle, and stirring and shearing for 40 minutes to obtain a suspension; and sanding the suspension until the particle size is 4-5 mu m to obtain the bactericide composition containing the triphenyl tin acetate and the cyproconazole.
Example 2
Bactericide composition containing triphenyltin acetate and cyproconazole and application thereof
The bactericide composition containing the triphenyltin acetate and the cyproconazole is a dispersible oil suspending agent, takes an organic solvent as a medium, and comprises the following components in percentage by weight: 1% of active pharmaceutical ingredient, 10% of wetting agent, 20% of dispersing agent, 20% of emulsifying agent and the balance of dispersing medium; the active ingredients of the medicine comprise triphenyltin acetate and cyproconazole in a weight ratio of 5: 1; the dispersing agent is formed by mixing an alkylphenol polyoxyethylene ether formaldehyde condensation compound and fatty alcohol polyoxyethylene ether sulfate according to the ratio of 1:0.5, the wetting agent is sodium dodecyl sulfate, the emulsifying agent is formed by mixing calcium dodecyl benzene sulfonate and castor oil polyoxyethylene ether according to the ratio of 1:0.8, the suspension aid is formed by mixing white carbon black and organic bentonite according to the ratio of 1:1.5, and the dispersing medium is methyl oleate.
The bactericide composition containing the triphenyl tin acetate and the cyproconazole is prepared by the following method:
adding the pharmaceutical active ingredients, the wetting agent, the dispersing agent, the emulsifier, the suspension auxiliary agent and the dispersion medium in percentage into a feeding kettle, and stirring and shearing for 20 minutes to obtain a suspension; and sanding the suspension until the particle size is 4-5 mu m to obtain the bactericide composition containing the triphenyl tin acetate and the cyproconazole.
Example 3
Bactericide composition containing triphenyltin acetate and cyproconazole and application thereof
The bactericide composition containing the triphenyltin acetate and the cyproconazole is a dispersible oil suspending agent, takes an organic solvent as a medium, and comprises the following components in percentage by weight: 20% of active pharmaceutical ingredients, 1% of wetting agent, 10% of dispersing agent, 10% of emulsifying agent, 1% of suspending aid and the balance of dispersing medium; the active ingredients of the medicine comprise triphenyltin acetate and cyproconazole in a weight ratio of 5: 1; the dispersing agent is formed by mixing an alkylphenol polyoxyethylene ether formaldehyde condensation compound and fatty alcohol polyoxyethylene ether sulfate according to the ratio of 1:0.5, the wetting agent is sodium dodecyl sulfate, the emulsifying agent is formed by mixing calcium dodecyl benzene sulfonate and castor oil polyoxyethylene ether according to the ratio of 1:1, the suspension aid is formed by mixing white carbon black and organic bentonite according to the ratio of 1:1, and the dispersing medium is methyl oleate.
The bactericide composition containing the triphenyl tin acetate and the cyproconazole is prepared by the following method:
adding the pharmaceutical active ingredients, the wetting agent, the dispersing agent, the emulsifier, the suspension auxiliary agent and the dispersion medium in percentage into a feeding kettle, and stirring and shearing for 30 minutes to obtain a suspension; sanding the suspension until the particle size is 4-5 mu m to obtain the bactericide composition containing the triphenyl tin acetate and the cyproconazole
Example 4
Bactericide composition containing triphenyltin acetate and cyproconazole and application thereof
The bactericide composition containing the triphenyltin acetate and the cyproconazole is a dispersible oil suspending agent, takes an organic solvent as a medium, and comprises the following components in percentage by weight: 50% of active ingredients of the medicine, 20% of wetting agent, 2% of dispersing agent, 0.1% of emulsifying agent, 10% of suspending aid and the balance of dispersing medium; the active ingredients of the medicine comprise triphenyltin acetate and cyproconazole in a weight ratio of 5: 1; the dispersing agent is formed by mixing an alkylphenol polyoxyethylene ether formaldehyde condensation compound and fatty alcohol polyoxyethylene ether sulfate according to the ratio of 1:0.5, the wetting agent is sodium dodecyl sulfate, the emulsifying agent is formed by mixing calcium dodecyl benzene sulfonate and castor oil polyoxyethylene ether according to the ratio of 1:1.0, the suspension aid is formed by mixing white carbon black and organic bentonite according to the ratio of 1:2, and the dispersing medium is methyl oleate.
The bactericide composition containing the triphenyl tin acetate and the cyproconazole is prepared by the following method:
adding the pharmaceutical active ingredients, the wetting agent, the dispersing agent, the emulsifier, the suspension auxiliary agent and the dispersion medium in percentage into a feeding kettle, and stirring and shearing for 30 minutes to obtain a suspension; and sanding the suspension until the particle size is 4-5 mu m to obtain the bactericide composition containing the triphenyl tin acetate and the cyproconazole.
Example 5
Bactericide composition containing triphenyltin acetate and cyproconazole and application thereof
The bactericide composition containing the triphenyltin acetate and the cyproconazole is a dispersible oil suspending agent, takes an organic solvent as a medium, and comprises the following components in percentage by weight: 10% of active pharmaceutical ingredients, 0.1% of wetting agent, 0.1% of dispersing agent, 2% of emulsifying agent, 3% of suspending aid and the balance of dispersing medium; the active ingredients of the medicine comprise triphenyltin acetate and cyproconazole in a weight ratio of 5: 1; the dispersing agent is formed by mixing an alkylphenol polyoxyethylene ether formaldehyde condensation compound and fatty alcohol polyoxyethylene ether sulfate according to the ratio of 1:0.5, the wetting agent is sodium dodecyl sulfate, the emulsifying agent is formed by mixing calcium dodecyl benzene sulfonate and castor oil polyoxyethylene ether according to the ratio of 1:1.0, the suspension aid is formed by mixing white carbon black and organic bentonite according to the ratio of 1:2, and the dispersing medium is methyl oleate.
The bactericide composition containing the triphenyl tin acetate and the cyproconazole is prepared by the following method:
adding the pharmaceutical active ingredients, the wetting agent, the dispersing agent, the emulsifier, the suspension auxiliary agent and the dispersion medium in percentage into a feeding kettle, and stirring and shearing for 30 minutes to obtain a suspension; and sanding the suspension until the particle size is 4-5 mu m to obtain the bactericide composition containing the triphenyl tin acetate and the cyproconazole.
Example 6
Bactericide composition containing triphenyltin acetate and cyproconazole and application thereof
The bactericide composition containing the triphenyltin acetate and the cyproconazole is a dispersible oil suspending agent, takes an organic solvent as a medium, and comprises the following components in percentage by weight: 20% of active pharmaceutical ingredients, 3% of wetting agents, 6% of dispersing agents, 10% of emulsifying agents, 2% of suspending aids and the balance of dispersing media; the active ingredients of the medicine comprise triphenyltin acetate and cyproconazole in a weight ratio of 1: 10; the dispersing agent is formed by mixing an alkylphenol polyoxyethylene ether formaldehyde condensation compound and fatty alcohol polyoxyethylene ether sulfate according to the ratio of 1:0.5, the wetting agent is sodium dodecyl sulfate, the emulsifying agent is formed by mixing calcium dodecyl benzene sulfonate and castor oil polyoxyethylene ether according to the ratio of 1:1, the suspension aid is formed by mixing white carbon black and organic bentonite according to the ratio of 1:1, and the dispersing medium is methyl oleate.
The bactericide composition containing the triphenyl tin acetate and the cyproconazole is prepared by the following method:
adding the pharmaceutical active ingredients, the wetting agent, the dispersing agent, the emulsifier, the suspension auxiliary agent and the dispersion medium in percentage into a feeding kettle, and stirring and shearing for 30 minutes to obtain a suspension; and sanding the suspension until the particle size is 4-5 mu m to obtain the bactericide composition containing the triphenyl tin acetate and the cyproconazole.
Example 7
Bactericide composition containing triphenyltin acetate and cyproconazole and application thereof
The bactericide composition containing the triphenyltin acetate and the cyproconazole is a dispersible oil suspending agent, takes an organic solvent as a medium, and comprises the following components in percentage by weight: 20% of active pharmaceutical ingredients, 3% of wetting agents, 6% of dispersing agents, 10% of emulsifying agents, 2% of suspending aids and the balance of dispersing media; the active ingredients of the medicine comprise triphenyltin acetate and cyproconazole in a weight ratio of 1: 1; the dispersing agent is formed by mixing an alkylphenol polyoxyethylene ether formaldehyde condensation compound and fatty alcohol polyoxyethylene ether sulfate according to the ratio of 1:0.5, the wetting agent is sodium dodecyl sulfate, the emulsifying agent is formed by mixing calcium dodecyl benzene sulfonate and castor oil polyoxyethylene ether according to the ratio of 1:1, the suspension aid is formed by mixing white carbon black and organic bentonite according to the ratio of 1:1, and the dispersing medium is methyl oleate.
The bactericide composition containing the triphenyl tin acetate and the cyproconazole is prepared by the following method:
adding the pharmaceutical active ingredients, the wetting agent, the dispersing agent, the emulsifier, the suspension auxiliary agent and the dispersion medium in percentage into a feeding kettle, and stirring and shearing for 30 minutes to obtain a suspension; and sanding the suspension until the particle size is 4-5 mu m to obtain the bactericide composition containing the triphenyl tin acetate and the cyproconazole.
Example 8
Bactericide composition containing triphenyltin acetate and cyproconazole and application thereof
The bactericide composition containing the triphenyltin acetate and the cyproconazole is a dispersible oil suspending agent, takes an organic solvent as a medium, and comprises the following components in percentage by weight: 20% of active pharmaceutical ingredients, 3% of wetting agents, 6% of dispersing agents, 10% of emulsifying agents, 2% of suspending aids and the balance of dispersing media; the active ingredients of the medicine comprise triphenyltin acetate and cyproconazole in a weight ratio of 5: 1; the dispersing agent is formed by mixing an alkylphenol polyoxyethylene ether formaldehyde condensation compound and fatty alcohol polyoxyethylene ether sulfate according to the ratio of 1:0.5, the wetting agent is sodium dodecyl sulfate, the emulsifying agent is formed by mixing calcium dodecyl benzene sulfonate and castor oil polyoxyethylene ether according to the ratio of 1:1, the suspension aid is formed by mixing white carbon black and organic bentonite according to the ratio of 1:1, and the dispersing medium is methyl oleate.
The bactericide composition containing the triphenyl tin acetate and the cyproconazole is prepared by the following method:
adding the pharmaceutical active ingredients, the wetting agent, the dispersing agent, the emulsifier, the suspension auxiliary agent and the dispersion medium in percentage into a feeding kettle, and stirring and shearing for 30 minutes to obtain a suspension; and sanding the suspension until the particle size is 4-5 mu m to obtain the bactericide composition containing the triphenyl tin acetate and the cyproconazole.
Example 9
Bactericide composition containing triphenyltin acetate and cyproconazole and application thereof
The bactericide composition containing the triphenyltin acetate and the cyproconazole is a dispersible oil suspending agent, takes an organic solvent as a medium, and comprises the following components in percentage by weight: 20% of active pharmaceutical ingredients, 3% of wetting agents, 6% of dispersing agents, 10% of emulsifying agents, 2% of suspending aids and the balance of dispersing media; the active ingredients of the medicine comprise triphenyl tin acetate and cyproconazole in a weight ratio of 10: 1; the dispersing agent is formed by mixing an alkylphenol polyoxyethylene ether formaldehyde condensation compound and fatty alcohol polyoxyethylene ether sulfate according to the ratio of 1:0.5, the wetting agent is sodium dodecyl sulfate, the emulsifying agent is formed by mixing calcium dodecyl benzene sulfonate and castor oil polyoxyethylene ether according to the ratio of 1:1, the suspension aid is formed by mixing white carbon black and organic bentonite according to the ratio of 1:1, and the dispersing medium is methyl oleate.
The bactericide composition containing the triphenyl tin acetate and the cyproconazole is prepared by the following method:
adding the pharmaceutical active ingredients, the wetting agent, the dispersing agent, the emulsifier, the suspension auxiliary agent and the dispersion medium in percentage into a feeding kettle, and stirring and shearing for 30 minutes to obtain a suspension; and sanding the suspension until the particle size is 4-5 mu m to obtain the bactericide composition containing the triphenyl tin acetate and the cyproconazole.
Example 10
Bactericide composition containing triphenyltin acetate and cyproconazole and application thereof
The bactericide composition containing the triphenyltin acetate and the cyproconazole is wettable powder, and the composition consists of the following components in percentage by weight: 20% of a medicinal active ingredient, 6% of a dispersing agent, 3% of a wetting agent and the balance of a filler; the active ingredients of the medicine comprise triphenyl tin acetate and cyproconazole in a weight ratio of 10: 1; the dispersing agent is formed by mixing sodium naphthalene sulfonate and sodium lignin sulfonate according to the mass ratio of 1:1, the wetting agent is formed by mixing sodium dodecyl sulfate and sodium lignin sulfonate according to the mass ratio of 1:0.5, and the filler is 40% of white carbon black and 60% of talcum powder.
The bactericide composition containing the triphenyl tin acetate and the cyproconazole is prepared by the following method:
weighing the raw materials for preparing the bactericidal composition containing the triphenyl tin acetate and the cyproconazole according to the mass percentage; crushing the fillers in percentage by weight by using a crusher, and sieving the crushed fillers with a 325-mesh sieve; and (2) sequentially putting the filler, the dispersing agent, the wetting agent and the pharmaceutical active ingredients into a stirring container according to the mass percentage, stirring for 20 minutes, crushing the product, sieving by using a 30-55 nm sieve, crushing for 35 minutes by using a jet mill, cooling the product, detecting and packaging to obtain the finished product.
Example 11
Bactericide composition containing triphenyltin acetate and cyproconazole and application thereof
The bactericide composition containing the triphenyltin acetate and the cyproconazole is wettable powder, and the composition consists of the following components in percentage by weight: 1% of a medicinal active ingredient, 10% of a dispersing agent, 3% of a wetting agent and the balance of a filler; the active ingredients of the medicine comprise triphenyltin acetate and cyproconazole in a weight ratio of 1: 10; the dispersing agent is formed by mixing sodium naphthalene sulfonate and sodium lignin sulfonate according to the mass ratio of 0.8:1, the wetting agent is formed by mixing sodium dodecyl sulfate and sodium lignin sulfonate according to the mass ratio of 1:0.5, and the filler is 10% of white carbon black and 90% of talcum powder.
The bactericide composition containing the triphenyl tin acetate and the cyproconazole is prepared by the following method:
weighing the raw materials for preparing the bactericidal composition containing the triphenyl tin acetate and the cyproconazole according to the mass percentage; crushing the fillers in percentage by weight by using a crusher, and sieving the crushed fillers with a 325-mesh sieve; and (2) sequentially putting the filler, the dispersing agent, the wetting agent and the pharmaceutical active ingredients into a stirring container according to the mass percentage, stirring for 20 minutes, crushing the product, sieving by using a 30-55 nm sieve, crushing for 35 minutes by using a jet mill, cooling the product, detecting and packaging to obtain the finished product.
Example 12
Bactericide composition containing triphenyltin acetate and cyproconazole and application thereof
The bactericide composition containing the triphenyltin acetate and the cyproconazole is wettable powder, and the composition consists of the following components in percentage by weight: 80% of a medicinal active ingredient, 4% of a dispersing agent, 5% of a wetting agent and the balance of a filler; the active ingredients of the medicine comprise triphenyltin acetate and cyproconazole in a weight ratio of 1: 1; the dispersing agent is formed by mixing sodium naphthalene sulfonate and sodium lignin sulfonate according to the mass ratio of 3:1, the wetting agent is formed by mixing sodium dodecyl sulfate and sodium lignin sulfonate according to the mass ratio of 1:1.5, and the filler is 40% of white carbon black and 60% of talcum powder.
The bactericide composition containing the triphenyl tin acetate and the cyproconazole is prepared by the following method:
weighing the raw materials for preparing the bactericidal composition containing the triphenyl tin acetate and the cyproconazole according to the mass percentage; crushing the fillers in percentage by weight by using a crusher, and sieving the crushed fillers with a 325-mesh sieve; and (2) sequentially putting the filler, the dispersing agent, the wetting agent and the pharmaceutical active ingredients into a stirring container according to the mass percentage, stirring for 10 minutes, crushing the product, sieving by a 30-55 nm sieve, crushing for 30 minutes by a jet mill, cooling the product, detecting and packaging to obtain the finished product.
Example 13
Bactericide composition containing triphenyltin acetate and cyproconazole and application thereof
The bactericide composition containing the triphenyltin acetate and the cyproconazole is wettable powder, and the composition consists of the following components in percentage by weight: 30% of a medicinal active ingredient, 1% of a dispersing agent, 1% of a wetting agent and the balance of a filler; the active ingredients of the medicine comprise triphenyl tin acetate and cyproconazole in a weight ratio of 10: 1; the dispersing agent is formed by mixing sodium naphthalene sulfonate and sodium lignin sulfonate according to the mass ratio of 1:1, the wetting agent is formed by mixing sodium dodecyl sulfate and sodium lignin sulfonate according to the mass ratio of 1:1, and the filler is 20% of white carbon black and 80% of talcum powder.
The bactericide composition containing the triphenyl tin acetate and the cyproconazole is prepared by the following method:
weighing the raw materials for preparing the bactericidal composition containing the triphenyl tin acetate and the cyproconazole according to the mass percentage; crushing the fillers in percentage by weight by using a crusher, and sieving the crushed fillers with a 325-mesh sieve; and (2) sequentially putting the filler, the dispersing agent, the wetting agent and the pharmaceutical active ingredients into a stirring container according to the mass percentage, stirring for 30 minutes, crushing the product, sieving by a 30-55 nm sieve, crushing for 40 minutes by a jet mill, cooling the product, detecting and packaging to obtain the finished product.
Example 14
Bactericide composition containing triphenyltin acetate and cyproconazole and application thereof
The bactericide composition containing the triphenyltin acetate and the cyproconazole is wettable powder, and the composition consists of the following components in percentage by weight: 70% of a medicinal active ingredient, 8% of a dispersing agent, 10% of a wetting agent and the balance of a filler; the active ingredients of the medicine comprise triphenyltin acetate and cyproconazole in a weight ratio of 5: 1; the dispersing agent is formed by mixing sodium naphthalene sulfonate and sodium lignin sulfonate according to the mass ratio of 1:1, the wetting agent is formed by mixing sodium dodecyl sulfate and sodium lignin sulfonate according to the mass ratio of 1:1, and the filler is 30% of white carbon black and 70% of talcum powder.
The bactericide composition containing the triphenyl tin acetate and the cyproconazole is prepared by the following method:
weighing the raw materials for preparing the bactericidal composition containing the triphenyl tin acetate and the cyproconazole according to the mass percentage; crushing the fillers in percentage by weight by using a crusher, and sieving the crushed fillers with a 325-mesh sieve; and (2) sequentially putting the filler, the dispersing agent, the wetting agent and the pharmaceutical active ingredients into a stirring container according to the mass percentage, stirring for 20 minutes, crushing the product, sieving by using a 30-55 nm sieve, crushing for 35 minutes by using a jet mill, cooling the product, detecting and packaging to obtain the finished product.
Comparative example 1
Bactericide of triphenyltin acetate and preparation method thereof
The bactericide containing the triphenyl tin acetate is in a dispersible oil suspending agent, takes an organic solvent as a medium, and comprises the following components in percentage by weight: 20% of active pharmaceutical ingredients, 3% of wetting agents, 6% of dispersing agents, 10% of emulsifying agents, 2% of suspending aids and the balance of dispersing media; the active ingredient of the medicine is triphenyl tin acetate; the dispersing agent is formed by mixing an alkylphenol polyoxyethylene ether formaldehyde condensation compound and fatty alcohol polyoxyethylene ether sulfate according to the ratio of 1:0.5, the wetting agent is sodium dodecyl sulfate, the emulsifying agent is formed by mixing calcium dodecyl benzene sulfonate and castor oil polyoxyethylene ether according to the ratio of 1:1, the suspension aid is formed by mixing white carbon black and organic bentonite according to the ratio of 1:1, and the dispersing medium is methyl oleate.
The bactericide containing the triphenyl tin acetate is prepared by the following method:
adding the pharmaceutical active ingredients, the wetting agent, the dispersing agent, the emulsifier, the suspension auxiliary agent and the dispersion medium in percentage into a feeding kettle, and stirring and shearing for 30 minutes to obtain a suspension; and sanding the suspension until the particle size is 4-5 mu m to obtain the bactericide containing the triphenyl tin acetate.
Comparative example 2
Cyproconazole bactericide and preparation method thereof
The formulation of the cyproconazole bactericide is dispersible oil suspending agent, an organic solvent is used as a medium, and the cyproconazole bactericide comprises the following components in percentage by weight: 20% of active pharmaceutical ingredients, 3% of wetting agents, 6% of dispersing agents, 10% of emulsifying agents, 2% of suspending aids and the balance of dispersing media; the active ingredient of the medicine is cyproconazole; the dispersing agent is formed by mixing an alkylphenol polyoxyethylene ether formaldehyde condensation compound and fatty alcohol polyoxyethylene ether sulfate according to the ratio of 1:0.5, the wetting agent is sodium dodecyl sulfate, the emulsifying agent is formed by mixing calcium dodecyl benzene sulfonate and castor oil polyoxyethylene ether according to the ratio of 1:1, the suspension aid is formed by mixing white carbon black and organic bentonite according to the ratio of 1:1, and the dispersing medium is methyl oleate.
The cyproconazole bactericide is prepared by the following method:
adding the pharmaceutical active ingredients, the wetting agent, the dispersing agent, the emulsifier, the suspension auxiliary agent and the dispersion medium in percentage into a feeding kettle, and stirring and shearing for 30 minutes to obtain a suspension; and sanding the suspension until the particle size is 4-5 mu m to obtain the cyproconazole bactericide.
In order to strongly support the beneficial effects brought by the technical scheme of the embodiment of the invention, the following performance tests are provided:
experimental example 1
Determination of the Cotoxicity coefficient
50g of a mixture M was prepared according to the ratio of cyproconazole to triphenyltin acetate in examples 6 to 91、M2、M3、M450g of cyproconazole is A, 50g of triphenyl tin acetate is B, the virulence index is K, the percentage content is P, and 50g of cyproconazole is taken as a standard single agent.
Preparing a sample A from cycloconazole raw drug by using acetone, preparing a sample B from triphenyltin acetate on a super clean workbench, and preparing a mixed agent M1、M2、M3、M4Adding a sterilized culture dish into each sample conical flask, introducing downy mildew suspension as a strain, culturing for 5 days under constant-temperature dark conditions, and testing the bacteriostasis percentage of each sample.
Measuring the toxicity regression equation of the mixture, cyproconazole and triphenyltin acetate by a conventional method to obtain LC50. The actual virulence index and the theoretical virulence index of the bactericide composition containing the triphenyl tin acetate and the cyproconazole prepared in the embodiment 6-9 are calculated by taking cyproconazole as a standard medicament. The co-toxicity coefficient (CTC) was calculated and the results are shown in table 1.
The calculation method comprises the following steps: the fungicide composition containing triphenyltin acetate and cyproconazole prepared in examples 6 to 9 is M1、M2、M3、M4The cyproconazole is A, the triphenyl tin acetate is B, the toxicity index is K, the percentage content is P, and the cyproconazole is taken as a standard single agent.
Virulence index K of cyproconazoleAComprises the following steps: LC of [ cyproconazole50LC of/cyproconazole50]×100＝100；
Virulence index K of triphenyltin acetateBComprises the following steps: LC of [ cyproconazole50LC of/Triphenyl tin acetate50]×100；
Actual virulence index K of MMComprises the following steps: [ L of CycloxazolC50LC of/M50]×100；
Theoretical virulence index K of MMComprises the following steps: kA×PA+KB×PB
Co-toxicity coefficient (CTC) is: [ actual virulence index of M/theoretical virulence index of M ]. times.100
TABLE 1 virulence determination results for single prodrugs and mixtures
| LC50(mg/mL) | Measured virulence index | Theoretical virulence index | Co-toxicity coefficient | |
| Cycloxazole alcohol (A) | 16.152 | 100 | - | - |
| Triphenyltin acetate (B) | 36.438 | 44.327 | - | - |
| A:B＝1:0.1 | 11.435 | 141.251 | 94.939 | 148.781 |
| A:B＝1:1 | 18.463 | 87.483 | 72.164 | 121.229 |
| A:B＝1:5 | 20.146 | 80.175 | 53.606 | 149.563 |
| A:B＝1:10 | 16.875 | 79.285 | 49.389 | 160.534 |
Experimental example 2
And (4) indoor test: the effect of the triphenyltin acetate and cyproconazole bactericide composition prepared in the embodiment 1-5 is tested according to NYT1156.2-2206, and the test target is rice sheath blight bacterium.
Under the aseptic operation condition, adding a pre-melted sterilization medium into an aseptic conical flask, respectively adding 600 mu L of the bactericidal agent composition containing the triphenyl tin acetate and the cyproconazole prepared in the examples 1-5 into the aseptic conical flask, fully shaking up, and then pouring the mixture into 3 culture dishes with the diameter of 9cm in equal amount to prepare a drug-containing flat plate. The treatment without pesticide was run as a blank. Cutting the cultured rice Rhizoctonia solani from the edge of the bacterial colony by using a sterilization puncher with the diameter of 5mm under the aseptic condition, inoculating the bacterial cake to the center of a drug-containing flat plate by using an inoculator, covering a dish cover, and culturing in an incubator at 25 ℃. And (3) investigating the growth condition of pathogenic bacteria hyphae according to the growth condition of the rice sheath blight bacterium in a blank control culture dish, measuring the growth diameter of bacterial colonies by using calipers, wherein the unit is millimeter, and vertically measuring the diameter of each bacterial colony by using a cross method once respectively, and taking the average value. The test results are shown in table 2.
TABLE 2 Bactericide composition containing triphenyltin acetate and cyproconazole obtained in examples 1-5 has effects
As can be seen from Table 2, the triphenyltin acetate and cyproconazole bactericide composition compounded by cyproconazole and triphenyltin acetate has a good indoor bactericidal effect.
Experimental example 3
Drug effect test for preventing and controlling wheat sharp eyespot in field test
The test is arranged to be carried out in wheat fields in the new countryside city in Henan, and 2 treatments are respectively set as follows: treatment 1: spraying clear water, and blank control; and (3) treatment 2: the triphenyltin acetate and cyproconazole bactericide compositions obtained in examples 6 to 10 and comparative examples 1 and 2.
Wherein, the fungicidal composition of triphenyltin acetate and cyproconazole obtained in examples 6 to 10 and comparative example was subjected to stem and leaf spray treatment at an effective ingredient usage of 480 g/ha.
Spraying the composition once every 7 days for 2 times at the initial stage of wheat stripe blight. During the experiment, 8 parallel experimental areas were selected, and each area was administered according to table 3. The application method comprises the following steps: the dosage of the preparation required in the embodiment of each test area is calculated according to the dosage of the active ingredients, the preparation is uniformly sprayed on the test area in a manual mode (the application water dosage per hectare is 480kg), and the control preparation is applied in the same mode. The medicine is applied in the morning with a sunny day, the highest temperature of 26 ℃ and the lowest temperature of 12 ℃. Meanwhile, 1 area is selected as a blank control area, and no medicine is sprayed.
20 plants were sampled and investigated at 5 points per plot by the control line method, 4 leaves were investigated for each plant, and the total leaf number and the number of diseased leaves at each stage were recorded.
The grading method comprises the following steps:
level 0: no disease;
level 1: the area of the lesion spots accounts for less than 5% of the area of the whole leaf;
and 3, level: the area of the lesion spots accounts for 6 to 25 percent of the area of the whole leaf;
and 5, stage: the area of the lesion spots accounts for 26-50% of the area of the whole leaf;
and 7, stage: the area of the lesion spots accounts for 51-75% of the area of the whole leaf;
and 9, stage: the area of the lesion spots accounts for more than 75 percent of the area of the whole leaf;
investigation time and number of times:
the disease condition base is investigated before the application of the medicine, and the prevention and treatment effect is investigated 7 days after the last application of the medicine.
The drug effect calculation method comprises the following steps:
the experimental results are shown below:
TABLE 3 efficacy test of triphenyltin acetate and cyproconazole bactericide composition for preventing and treating wheat sharp eyespot
The above is only a preferred embodiment of the present invention, and is not intended to limit the present invention, and various modifications and changes will occur to those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. The bactericide composition containing the triphenyltin acetate and the cyproconazole is characterized in that the pharmaceutical active ingredients of the triphenyltin acetate and cyproconazole bactericide composition comprise the triphenyltin acetate and the cyproconazole in the weight ratio of (1:10) - (10: 1).
2. The bactericidal composition containing triphenyltin acetate and cyproconazole according to claim 1, wherein the pharmaceutically active ingredients of the bactericidal composition containing triphenyltin acetate and cyproconazole comprise triphenyltin acetate and cyproconazole in a weight ratio of (1:1) - (5: 1).
3. The bactericidal composition containing triphenyltin acetate and cyproconazole according to claim 1, wherein the dosage form of the bactericidal composition containing triphenyltin acetate and cyproconazole is any one of wettable powder, water dispersible granules, aqueous emulsion, dispersible oil suspending agent and missible oil.
4. The bactericidal composition containing triphenyltin acetate and cyproconazole according to claim 3, wherein when the dosage form of the bactericidal composition containing triphenyltin acetate and cyproconazole is dispersible oil suspending agent, organic solvent is used as medium, and the content of each component is as follows: 1-60% of active ingredients of the medicine, 0.1-20% of wetting agent, 0.1-20% of dispersing agent, 0.1-20% of emulsifying agent, 0-10% of suspending aid and the balance of dispersing medium; the dispersing agent is formed by mixing an alkylphenol polyoxyethylene ether formaldehyde condensation compound and fatty alcohol polyoxyethylene ether sulfate according to the ratio of 1: 0.5-2, the wetting agent is sodium dodecyl sulfate, the emulsifying agent is formed by mixing calcium dodecyl benzene sulfonate and castor oil polyoxyethylene ether according to the ratio of 1: 0.8-1.2, the suspension aid is formed by mixing white carbon black and organic bentonite according to the ratio of 1: 0.6-1.5, and the dispersing medium is methyl oleate.
5. The bactericidal composition containing triphenyltin acetate and cyproconazole according to claim 4, wherein when the dosage form of the bactericidal composition containing triphenyltin acetate and cyproconazole is dispersible oil suspending agent, organic solvent is used as medium, and the content of each component is as follows: 20-50% of active ingredients of the medicine, 1-5% of wetting agent, 2-8% of dispersing agent, 2-8% of emulsifying agent, 1-5% of suspension aid and the balance of dispersing medium.
6. The bactericidal composition containing triphenyltin acetate and cyproconazole according to claim 3, wherein when the dosage form of the bactericidal composition containing triphenyltin acetate and cyproconazole is wettable powder, the composition consists of the following components in percentage by weight: 1-80% of a medicinal active ingredient, 1-10% of a dispersing agent, 1-10% of a wetting agent and the balance of a filler; the dispersing agent is formed by mixing sodium naphthalene sulfonate and sodium lignin sulfonate according to the mass ratio of 0.8-3: 1, the wetting agent is formed by mixing sodium dodecyl sulfate and sodium lignin sulfonate according to the mass ratio of 1: 0.5-1.5, and the filler is 10-40% of white carbon black and 60-90% of talcum powder.
7. The bactericidal composition containing triphenyltin acetate and cyproconazole according to claim 6, wherein when the dosage form of the bactericidal composition containing triphenyltin acetate and cyproconazole is wettable powder, the composition consists of the following components in percentage by weight: 3-70% of a medicinal active ingredient, 4-8% of a dispersing agent, 1-3% of a wetting agent and the balance of a filler.
8. A preparation method of the bactericidal agent composition containing the triphenyl tin acetate and the cyproconazole according to any one of claims 1 to 5, which is characterized by comprising the following steps: adding the pharmaceutical active ingredients, the wetting agent, the dispersing agent, the emulsifier, the suspension auxiliary agent and the dispersion medium in percentage into a feeding kettle, and stirring and shearing for 20-40 minutes to obtain a suspension; and sanding the suspension until the particle size is 4-5 mu m to obtain the bactericide composition containing the triphenyl tin acetate and the cyproconazole.
9. The bactericidal composition containing triphenyltin acetate and cyproconazole according to any one of claims 1 to 8, wherein the bactericidal composition containing triphenyltin acetate and cyproconazole is applied to control of diseases of vegetables and fruit trees.
10. The bactericidal composition containing triphenyltin acetate and cyproconazole according to claim 9, wherein the bactericidal composition containing triphenyltin acetate and cyproconazole is used for preventing and treating scab, alternaria leaf spot, late blight, downy mildew, rust disease, powdery mildew, banded sclerotial blight and gibberellic disease.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115530171A (en) * | 2022-09-06 | 2022-12-30 | 盐城利民农化有限公司 | Bactericidal composition containing triphenyltin acetate and hexaconazole |
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