CN104886137B - Prochloraz-manganese chloride complex carbendazim water dispersing granule and its production and use - Google Patents
Prochloraz-manganese chloride complex carbendazim water dispersing granule and its production and use Download PDFInfo
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Abstract
The present invention provides a kind of prochloraz-manganese chloride complex carbendazim water dispersing granule, including following component and parts by weight thereof: prochloraz-manganese chloride complex 20 ~ 25 parts, carbendazim 3 ~ 8 parts, dispersant 1 ~ 8 part, wetting agent 1 ~ 5 part and filler 65 ~ 85 parts. The invention belongs to technical field of pesticide, Fructus Cucumidis sativi anthrax is had excellent preventive effect by prochloraz-manganese chloride complex carbendazim water dispersing granule provided by the invention, and wheat scab also has good preventive effect.
Description
Technical field
The invention belongs to technical field of pesticide, particularly relate to a kind of prochloraz-manganese chloride complex carbendazim water dispersing granule and its production and use.
Background technology
Prochloraz-manganese chloride complex be by Prochloraz withManganese chlorideIt is composited, chemistry N-propyl group-N-[2-(2,4,6-Trichlorophenoxy) ethyl]-1H imidazoles-1-Methanamide-manganese chloride by name, ascus microbial various crop disease there is is good curative effect. The mechanism of action of prochloraz-manganese chloride complex is similar to Prochloraz, by suppressing the biosynthesis of sterol, plays bactericidal action.
Carbendazim is a kind of broad-spectrum germicide, and N-(2-benzimidazolyl)-methyl carbamate, the disease that various crop is caused by fungus (such as Fungi Imperfecti, many ascomycetess) has prevention effect. Carbendazim, by disturbing the formation of spindle in pathogen mitosis, affects cell division, plays bactericidal action.
Chinese patent application 201010526616.4 discloses a kind of prochloraz-manganese chloride complex carbendazim water dispersing granule, this water dispersible granules comprises the former medicine of prochloraz-manganese chloride complex of 10-30% mass percent and the carbendazim active compound of 10-30% mass percent, by making the problem that water dispersible granules can effectively solve wettable powder and suspending agent dosage form, there is good flowing properties, the advantage such as easy to use. Additionally, this patent application also discloses 30% prochloraz-manganese chloride complex carbendazim water dispersing granule (comprising the carbendazim active compound of 20% and the former medicine of prochloraz-manganese chloride complex of 10%), and Fructus Cucumidis sativi anthrax is had good preventive effect.
The antibacterial such as prochloraz-manganese chloride complex and carbendazim, owing to being used alone for a long time, makes disease develop immunity to drugs, and causes the problems such as dosage increasing, preventive effect reduction. In recent years, peasant household generally reflects that carbendazim is ineffective, and the preventive effect of wheat scab is deteriorated, and the preventive effect of prochloraz-manganese chloride complex is also deteriorated, it is impossible to exclusive segment medicament would be likely to occur quality problems, but being deteriorated main or caused by resistant strain of preventive effect. Under the reality that new drug development difficulty is bigger, existing pesticide is carried out rational composite use, has great importance.
Summary of the invention
For solving problems of the prior art, inventor has carried out lot of experiments research to the composition of prochloraz-manganese chloride complex and carbendazim is composite, unforeseeable discovery: Fructus Cucumidis sativi anthrax is had excellent preventive effect with the composite prepared water dispersible granules of special ratios by prochloraz-manganese chloride complex and carbendazim, and wheat scab also has good preventive effect. Based on above-mentioned discovery, thus completing the present invention.
The purpose of the present invention will be further described in detail below reflect and description.
The present invention provides a kind of prochloraz-manganese chloride complex carbendazim water dispersing granule, including following component and parts by weight thereof: prochloraz-manganese chloride complex 20 ~ 25 parts, carbendazim 3 ~ 8 parts, dispersant 1 ~ 8 part, wetting agent 1 ~ 5 part and filler 65 ~ 85 parts.
The combination of said components and the above-mentioned weight range of each component, be that inventor is determined by lot of experiments, and the above-mentioned weight range of each component makes prochloraz-manganese chloride complex carbendazim water dispersing granule provided by the invention have excellent preventive effect. The auxiliary agents such as particular types and the dispersant of content, wetting agent and filler make finished product have excellent dispersibility and suspension.
Preferably, described prochloraz-manganese chloride complex carbendazim water dispersing granule includes following component and mass percent thereof: prochloraz-manganese chloride complex 22 ~ 24 parts, carbendazim 5 ~ 7 parts, dispersant 1 ~ 8 part, wetting agent 1 ~ 5 part and filler 65 ~ 85 parts.
It is highly preferred that include following component and mass percent thereof: prochloraz-manganese chloride complex 24 parts, carbendazim 6 parts, dispersant 3 parts, wetting agent 2 parts and filler 65 parts.
Preferably, described dispersant is the mixture of sodium metnylene bis-naphthalene sulfonate, alkyl naphthalene sulfonic acid condensation polymer or alkyl naphthalene sulfonic acid polycondensation sodium salt and sodium lignin sulfonate.
It is highly preferred that the mixture that described dispersant is sodium metnylene bis-naphthalene sulfonate and sodium lignin sulfonate, the weight ratio of sodium metnylene bis-naphthalene sulfonate and sodium lignin sulfonate is 2 ~ 3:1.
Preferably, described wetting agent is selected from one or more in alkylnaphthalene sulfonate, anion wetting agent and dodecyl sodium sulfate. Described filler is selected from one or more in Kaolin, corn starch and kieselguhr.
Preferably, described prochloraz-manganese chloride complex carbendazim water dispersing granule also includes helping and collapses agent 0.1 ~ 5 part, described in help and collapse one or more in glucose and carbamide of agent.
Correspondingly, the preparation method that the present invention also provides for prochloraz-manganese chloride complex carbendazim water dispersing granule, comprise the steps: A) prochloraz-manganese chloride complex, carbendazim, dispersant and wetting agent are stirred, pulverize, obtain mixture; B) in described mixture, add filler again, stir, carry out wet granulation, dry, sieve, obtain prochloraz-manganese chloride complex carbendazim water dispersing granule.
Preferably, described dispersant is the mixture of sodium metnylene bis-naphthalene sulfonate, alkyl naphthalene sulfonic acid condensation polymer or alkyl naphthalene sulfonic acid polycondensation sodium salt and sodium lignin sulfonate; Described wetting agent is selected from one or more in alkylnaphthalene sulfonate, anion wetting agent and dodecyl sodium sulfate; Described filler is selected from one or more in Kaolin, corn starch and kieselguhr.
Preferably, the particle diameter of described mixture is 10 ~ 20 ��m, and the particle diameter of described filler is 30 ~ 60 ��m.
Additionally, the present invention also provides for prochloraz-manganese chloride complex carbendazim water dispersing granule purposes in preventing and treating wheat scab. The wheat scab producing drug resistance is also had good preventive effect by prochloraz-manganese chloride complex carbendazim water dispersing granule provided by the invention.
Compared with prior art, the invention has the beneficial effects as follows: the invention provides a kind of new prochloraz-manganese chloride complex carbendazim water dispersing granule, there is excellent dispersibility and suspension, the prochloraz-manganese chloride complex of special ratios and carbendazim generation synergism, Fructus Cucumidis sativi anthrax had excellent preventive effect, wheat scab also has good preventive effect in addition, and the preventing and treating for producing the wheat scab of drug resistance provides new selection. Preparation method provided by the invention is simple, the prochloraz-manganese chloride complex carbendazim water dispersing granule steady quality prepared.
Detailed description of the invention
Below by specific embodiment, the present invention is described in further detail.
Embodiment one prochloraz-manganese chloride complex carbendazim water dispersing granule
Prochloraz-manganese chloride complex carbendazim water dispersing granule includes following component and parts by weight thereof: prochloraz-manganese chloride complex 24 parts, carbendazim 6 parts, sodium metnylene bis-naphthalene sulfonate 2 parts, sodium lignin sulfonate 1 part, dodecyl sodium sulfate 2 parts and corn starch 15 parts and 50 parts of kieselguhr.
Preparation method: prochloraz-manganese chloride complex, carbendazim, sodium metnylene bis-naphthalene sulfonate, sodium lignin sulfonate and dodecyl sodium sulfate are stirred in container, pulverizes through jet mill, obtains mixture, and the particle diameter of mixture is 12 ~ 15 ��m; Adding corn starch and kieselguhr again in mixture as filler, the particle diameter of filler is 40 ~ 50 ��m, stirs, and adds wet, carries out wet granulation, dry, crosses 600 mesh sieves, obtains prochloraz-manganese chloride complex carbendazim water dispersing granule.
Embodiment two prochloraz-manganese chloride complex carbendazim water dispersing granule
Prochloraz-manganese chloride complex carbendazim water dispersing granule includes following component and parts by weight thereof: prochloraz-manganese chloride complex 25 parts, carbendazim 5 parts, sodium metnylene bis-naphthalene sulfonate 2 parts, sodium lignin sulfonate 1 part, dodecyl sodium sulfate 1 part, alkylnaphthalene sulfonate 1 part and 65 parts of kieselguhr.
Preparation method: prochloraz-manganese chloride complex, carbendazim, sodium metnylene bis-naphthalene sulfonate, sodium lignin sulfonate, dodecyl sodium sulfate and alkylnaphthalene sulfonate are stirred in container, pulverize through jet mill, obtaining mixture, the particle diameter of mixture is 15 ~ 20 ��m; Adding corn starch and kieselguhr again in mixture as filler, the particle diameter of filler is 50 ~ 55 ��m, stirs, and licks wet, carries out wet granulation, dry, crosses 600 mesh sieves, obtains prochloraz-manganese chloride complex carbendazim water dispersing granule.
Embodiment three prochloraz-manganese chloride complex carbendazim water dispersing granule
Prochloraz-manganese chloride complex carbendazim water dispersing granule includes following component and parts by weight thereof: prochloraz-manganese chloride complex 22 parts, carbendazim 8 parts, alkyl naphthalene sulfonic acid polycondensation sodium salt 2 parts, sodium lignin sulfonate 1 part, alkylnaphthalene sulfonate 1 part, 1 part of carbamide, Kaolin 30 parts and 35 parts of kieselguhr.
Preparation method: prochloraz-manganese chloride complex, carbendazim, alkyl naphthalene sulfonic acid polycondensation sodium salt, sodium lignin sulfonate, dodecyl sodium sulfate and carbamide are stirred in container, pulverizes through jet mill, obtains mixture, and the particle diameter of mixture is 15 ~ 20 ��m; Adding corn starch and kieselguhr again in mixture as filler, the particle diameter of filler is 40 ~ 50 ��m, stirs, and licks wet, carries out wet granulation, dry, crosses 600 mesh sieves, obtains prochloraz-manganese chloride complex carbendazim water dispersing granule.
Comparative example 1
Prochloraz-manganese chloride complex carbendazim water dispersing granule includes following component and parts by weight thereof: prochloraz-manganese chloride complex 20 parts, carbendazim 10 parts, sodium metnylene bis-naphthalene sulfonate 2 parts, sodium lignin sulfonate 1 part, dodecyl sodium sulfate 2 parts and corn starch 15 parts and 50 parts of kieselguhr.
Preparation method is similar with embodiment one.
Comparative example 2
Prochloraz-manganese chloride complex carbendazim water dispersing granule includes following component and parts by weight thereof: prochloraz-manganese chloride complex 10 parts, carbendazim 20 parts, sodium metnylene bis-naphthalene sulfonate 2 parts, sodium lignin sulfonate 1 part, dodecyl sodium sulfate 2 parts and corn starch 15 parts and 50 parts of kieselguhr.
Preparation method is similar with embodiment one.
Comparative example 3
Prochloraz-manganese chloride complex carbendazim water dispersing granule includes following component and parts by weight thereof: prochloraz-manganese chloride complex 28 parts, carbendazim 2 parts, sodium metnylene bis-naphthalene sulfonate 2 parts, sodium lignin sulfonate 1 part, dodecyl sodium sulfate 2 parts and corn starch 20 parts and 50 parts of kieselguhr.
Preparation method is similar with embodiment one.
Comparative example 4
Prochloraz-manganese chloride complex carbendazim water dispersing granule includes following component and parts by weight thereof: prochloraz-manganese chloride complex 24 parts, carbendazim 6 parts, sodium metnylene bis-naphthalene sulfonate 3 parts, dodecyl sodium sulfate 2 parts and corn starch 20 parts and 50 parts of kieselguhr.
Preparation method is similar with embodiment one.
The prochloraz-manganese chloride complex carbendazim water dispersing granule field control effectiveness test to Fructus Cucumidis sativi anthrax
The prochloraz-manganese chloride complex carbendazim water dispersing granule that embodiment one, embodiment two, embodiment three, comparative example 1, comparative example 2, comparative example 3 and comparative example 4 are prepared, with 50% prochloraz-manganese chloride complex wettable powder for matched group medicament, carry out the drug effect test of field zone to Fructus Cucumidis sativi anthrax. Application method is spraying, starts medication in their early stage, and consumption is 90g/ mu, altogether dispenser 3 times, and after third time dispenser, 7 days preventive effect results are as shown in table 1.
Cucumber anthracnose grade scale: 0 grade: without scab; 1 grade: lesion area accounts for less than the 5% of the leaf gross area; 3 grades: lesion area accounts for the 6 ~ 10% of the leaf gross area; 5 grades: lesion area accounts for the 11 ~ 25% of the leaf gross area; 7 grades: lesion area accounts for the 26 ~ 50% of the leaf gross area; 9 grades: lesion area accounts for more than the 50% of the leaf gross area.
As known from Table 1, the preventive effect aspect to Fructus Cucumidis sativi anthrax, the prochloraz-manganese chloride complex carbendazim water dispersing granule that embodiment one to embodiment three prepares has the effect being better than comparative example 1 to comparative example 4, and wherein the effect of embodiment one is optimum.
The prochloraz-manganese chloride complex carbendazim water dispersing granule mycelial growth inhibition test to wheat scab
Prochloraz-manganese chloride complex carbendazim water dispersing granule embodiment one, embodiment two, embodiment three, comparative example 1, comparative example 2, comparative example 3 and comparative example 4 prepared, carries out the mycelial growth inhibition test to wheat scab.
Test method adopts Activities, particularly as follows: add 60mLPSA culture medium respectively in triangular flask, PSA culture medium is cooled to 50 DEG C after adding heat fusing, it is separately added into the medicament that 8mg embodiment one, embodiment two, embodiment three, comparative example 1, comparative example 2, comparative example 3 and comparative example 4 prepare, culture medium containing medicament is poured in culture dish, making the experimental group medicament flat board of respective concentration, the PSA flat board simultaneously setting not adding medicine compares group, adds equivalent solvent in matched group. For preventing germ contamination, the sterilized water of configuration medicament adds streptomycin sulfate. Use 5mm card punch, the bacterium colony of head blight strain is got 5mm bacterium sheet (ensureing that the cell age for examination pathogenic bacteria of same repetition is identical). Aseptically, bacterium sheet accessing the toxic culture medium central authorities of culture dish, mycelia faces up, and covers ware lid, and 25 DEG C of lucifuges are cultivated. After cultivating 7 days, the growth diameter of bacterium colony in experiments of measuring group flat board, calculate mycelial growth inhibition rate, the average results that three times are repeated is as shown in table 2.
As known from Table 2, the mycelial growth suppression aspect to wheat scab, the prochloraz-manganese chloride complex carbendazim water dispersing granule that embodiment one to embodiment three prepares has the effect being better than comparative example 1 to comparative example 4, and wherein the effect of embodiment one is optimum.
The prochloraz-manganese chloride complex carbendazim water dispersing granule field control effectiveness test to wheat scab
Use the prochloraz-manganese chloride complex carbendazim water dispersing granule that embodiment one, embodiment two, embodiment three, comparative example 1, comparative example 2, comparative example 3 and comparative example 4 prepare, with 50% prochloraz-manganese chloride complex wettable powder for matched group medicament, the drug effect test of field zone to wheat scab. Application method is spraying, and in Semen Tritici aestivi flowering initial stage dispenser 1 time, consumption is 28g/ mu, and the preventive effect result after dispenser 15 days is as shown in table 1.
Investigation method: blank group is fully fallen ill " Invest, Then Investigate ", the sampling of 5, every community, every some investigation 100 fringes.Wheat scab grade scale: 0 grade: anosis; 1 grade: sick fringe area accounts for less than the 1/4 of the fringe gross area; 3 grades: sick fringe area accounts for less than the 1/4 ~ 1/2 of the fringe gross area; 5 grades: sick fringe area accounts for less than the 1/2 ~ 3/4 of the fringe gross area; 7 grades: sick fringe area accounts for more than the 3/4 of the fringe gross area.
PT refers to disease index after process group medicine, and CK refers to disease index after matched group medicine.
As known from Table 3, the preventive effect aspect to wheat scab, the prochloraz-manganese chloride complex carbendazim water dispersing granule that embodiment one to embodiment three prepares has the effect being better than comparative example 1 to comparative example 4, and wherein the effect of embodiment one is optimum.
Above content is in conjunction with concrete preferred implementation further description made for the present invention, it is impossible to assert that specific embodiment of the invention is confined to these explanations. For general technical staff of the technical field of the invention, without departing from the inventive concept of the premise, it is also possible to make some simple deduction or replace, protection scope of the present invention all should be considered as belonging to.
Claims (4)
1. a prochloraz-manganese chloride complex carbendazim water dispersing granule, it is characterised in that: include following component and parts by weight thereof: prochloraz-manganese chloride complex 24 parts, carbendazim 6 parts, dispersant 3 parts, wetting agent 2 parts and filler 65 parts; Described dispersant is the weight ratio of the mixture of sodium metnylene bis-naphthalene sulfonate and sodium lignin sulfonate, sodium metnylene bis-naphthalene sulfonate and sodium lignin sulfonate is 2 ~ 3:1; Described wetting agent is selected from one or more in alkylnaphthalene sulfonate and dodecyl sodium sulfate; Described filler is selected from one or more in Kaolin, corn starch and kieselguhr.
2. prochloraz-manganese chloride complex carbendazim water dispersing granule according to claim 1, it is characterised in that: also include helping and collapse agent 0.1 ~ 5 part, described in help and collapse one or more in glucose and carbamide of agent.
3. the preparation method of prochloraz-manganese chloride complex carbendazim water dispersing granule according to claim 1, it is characterised in that: comprise the steps: A) prochloraz-manganese chloride complex, carbendazim, dispersant and wetting agent are stirred, pulverize, obtain mixture; B) in described mixture, add filler again, stir, carry out wet granulation, dry, sieve, obtain prochloraz-manganese chloride complex carbendazim water dispersing granule; Described dispersant is the weight ratio of the mixture of sodium metnylene bis-naphthalene sulfonate and sodium lignin sulfonate, sodium metnylene bis-naphthalene sulfonate and sodium lignin sulfonate is 2 ~ 3:1; Described wetting agent is selected from one or more in alkylnaphthalene sulfonate and dodecyl sodium sulfate; Described filler is selected from one or more in Kaolin, corn starch and kieselguhr.
4. the prochloraz-manganese chloride complex carbendazim water dispersing granule according to claim 1 and 2 purposes in preventing and treating wheat scab.
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