CN108605948A - A kind of bactericidal composition containing fluorine thiazole pyrrole ethyl ketone and amisulbrom - Google Patents

A kind of bactericidal composition containing fluorine thiazole pyrrole ethyl ketone and amisulbrom Download PDF

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Publication number
CN108605948A
CN108605948A CN201611133745.0A CN201611133745A CN108605948A CN 108605948 A CN108605948 A CN 108605948A CN 201611133745 A CN201611133745 A CN 201611133745A CN 108605948 A CN108605948 A CN 108605948A
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Prior art keywords
ethyl ketone
amisulbrom
pyrrole ethyl
fluorine thiazole
thiazole pyrrole
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葛尧伦
司国栋
白复芹
于毅
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Hailir Pesticides and Chemicals Group Co Ltd
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Hailir Pesticides and Chemicals Group Co Ltd
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
    • A01N43/78—1,3-Thiazoles; Hydrogenated 1,3-thiazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

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  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The present invention relates to a kind of bactericidal composition containing fluorine thiazole pyrrole ethyl ketone and amisulbrom, active ingredient is fluorine thiazole pyrrole ethyl ketone and amisulbrom binary built.Wherein the mass ratio of fluorine thiazole pyrrole ethyl ketone and amisulbrom is 1~40: 40~1, the quality parts ratio 1%~80% of active ingredient fluorine thiazole pyrrole ethyl ketone and amisulbrom in preparation, remaining is to allow the auxiliary element for using and receiving in pesticide, the dosage form of bactericidal composition of the present invention is missible oil, suspending agent, wettable powder, water dispersible granules, aqueous emulsion, microemulsion, is mainly used for preventing downy mildew of garpe, late blight and all kinds of powdery mildews.

Description

A kind of bactericidal composition containing fluorine thiazole pyrrole ethyl ketone and amisulbrom
Technical field
The present invention relates to technical field of pesticide combination, containing fluorine thiazole pyrrole ethyl ketone and amisulbrom more particularly to one kind Bactericidal composition.
Background technology
Fluorine thiazole pyrrole ethyl ketone is a kind of new piperidine series bactericidal agent of E.I.Du Pont Company's exploitation.It is formulated reports in Merck ＆ Co., Inc. Medicinal actives compound (IV), find that there is preferable Fungicidal active compound (V), and then optimizing research through high flux screening It is found that Oxathi-apiprolin specific to downy mildew.Active constituent Bao Han oxazole rings in the molecular structure, pyrazole ring, Thiazole ring can significantly reinforce the prevention to the specialties corps diseases such as potato, grape, vegetables.Obtain within 2012 the approval of ISO common names New varieties of pesticides [2], will be in the prevention for being widely used in crop germ in the future.
Amisulbrom belongs to contact killing type fungicide, has very high activity to epidemic disease and downy mildew, especially to germ Free spore activity is very high, can inhibit fungi breathing and spore germination, is a medicament aimed at prevention.Mainly act on horse Bell potato epidemic disease, downy mildew of garpe, cucurbit downy mildew, vegetables clubroot etc..
It is the most effective means of controlling plant diseases using chemical agent.But it applies to long-term continuous high dose single Chemical bactericide, be easy to cause the problems such as residual of medicament, environmental pollution and drug-resistant fungi develop.Rational chemistry Bactericide compounded or mixture have expand fungicidal spectrum, improve control effect, extend the optimum period for applying fertilizer, reduce dosage, reduce poisoning, The positive features such as residual, the generation for delaying drug resistance of fungi and development are reduced, bactericide compounded is to solve above-mentioned ask One of the maximally efficient method of topic.Develop new product fungicide price is constantly soaring, and in contrast, exploitation with research efficiently, Low toxicity, the compounding of low-residual and mixture have that small investment, the lead time is short and is paid attention to both at home and abroad, and increasing one after another develops Dynamics.We filter out fluorine thiazole pyrrole ethyl ketone and are compounded with amisulbrom based on the indoor screening and field trials, With apparent synergistic effect.And the compounding about fluorine thiazole pyrrole ethyl ketone and amisulbrom bactericidal composition and application it is current People there is no to report.
Invention content
Based on the above circumstances, present invention aims at provide a kind of new and effective pesticide sterilizing composite.It is mainly used for Prevent downy mildew of garpe, late blight and all kinds of powdery mildews.
The technical solution of the present invention is achieved by the following measures：
One kind containing fluorine thiazole pyrrole ethyl ketone and amisulbrom bactericidal composition, the active ingredient fluorine thiophene of the bactericidal composition Azoles pyrrole ethyl ketone is compounded with amisulbrom two-spot, remaining is auxiliary element.Active ingredient fluorine thiophene in the wherein described Pesticidal combination The mass ratio of azoles pyrrole ethyl ketone and amisulbrom is 1~40: 40~1, and the bactericidal composition of the present invention is through toxicity test reality When the mass ratio of verification, fluorine thiazole pyrrole ethyl ketone and amisulbrom is 1~40: 40~1, synergistic effect is preferable.
The formulations of pesticide that the bactericidal composition of the present invention can be prepared are missible oil, suspending agent, wettable powder, moisture Shot agent, aqueous emulsion, microemulsion.Wherein active ingredient fluorine thiazole pyrrole ethyl ketone accounts for whole with amisulbrom total quality in preparation The 1%~80% of a quality of the pharmaceutical preparations, wherein when accounting for 15%~50%, toxicity and residues achieve a better balance, and cost is relatively low.
The specific embodiment for the formulations of pesticide that bactericidal composition of the present invention is configured to is as follows：
The bactericidal composition is cream preparation, and the mass fraction of component is：1~40 part of fluorine thiazole pyrrole ethyl ketone；Indazole 1~40 part of flusulfamide；10~30 parts of conventional emulsifier；20~50 parts of Conventional solvents；1~5 part of conventional synergist.The cream preparation Specific production stage be first active ingredient fluorine thiazole pyrrole ethyl ketone and amisulbrom are added in solvent be completely dissolved after again plus Enter emulsifier, after synergist stirs evenly at homogeneous and transparent oily liquids, it is filling, you can the missible oil of the present composition is made Preparation.
The bactericidal composition is suspending agent, and the mass fraction of component is：1~40 part of fluorine thiazole pyrrole ethyl ketone；Indazole sulphur 1~40 part of bacterium amine；5~20 parts of dispersant；1~5 part of antifreezing agent；0.1~2 part of thickener；0.1~0.8 part of antifoaming agent；Penetrating agent 0~10 part；0.1~5 part of pH adjusting agent；Water, surplus.The specific production stage of the suspending agent is first to mix other auxiliary agents, It is uniformly mixed through high speed shear, active ingredient fluorine thiazole pyrrole ethyl ketone and amisulbrom is added, abrading-ball 2~3 is small in ball crusher When, so that a diameter is below 5mm, you can the aqueous suspension formulations of the present composition are made.
The bactericidal composition is wettable powder, and the mass fraction of component is：1~40 part of fluorine thiazole pyrrole ethyl ketone；Yin 1~40 part of azoles flusulfamide；3~10 parts of dispersant；1~5 part of wetting agent；Filler, surplus.The specific production of the wettable powder walks Suddenly it is：Active ingredient fluorine thiazole pyrrole ethyl ketone is mixed with amisulbrom and dispersant, wetting agent and filler by above-mentioned formula, Uniform stirring in a stirring kettle is being uniformly mixed, you can the wettable powder of the present composition is made after airslide disintegrating mill.
The bactericidal composition is water dispersible granules, and the mass fraction of component is：1~40 part of fluorine thiazole pyrrole ethyl ketone；Yin 1~40 part of azoles flusulfamide；3~10 parts of dispersant；1~10 part of wetting agent；1~5 part of disintegrant；Filler, surplus.The water-dispersible grain The specific production stage of agent is：By above-mentioned formula by active ingredient fluorine thiazole pyrrole ethyl ketone and amisulbrom and dispersant, wetting Agent, disintegrant and filler are uniformly mixed, and are crushed with micro jet, and through mediating, fluidized bed prilling drying is then added Be granulated, dried in machine, sieve after through sampling analysis, you can the water dispersible granules of the present composition are made.
The bactericidal composition is aqueous emulsion, and the mass fraction of component is：1~40 part of fluorine thiazole pyrrole ethyl ketone；Indazole sulphur 1~40 part of bacterium amine；3~30 parts of emulsifier；5~15 parts of solvent；2~15 parts of stabilizer；1~5 part of antifreezing agent；Antifoaming agent 0.1~8 Part；0.2~2 part of thickener；Water, surplus.The specific production stage of the aqueous emulsion is：First by fluorine thiazole pyrrole ethyl ketone and indazole sulphur Bacterium amine, solvent and emulsifier, cosolvent are added together, and make to be dissolved into uniform oil phase；By part water, antifreeze is antimicrobial The others insecticides adjuvant such as agent mixes into uniform water phase；Water is added in oil phase while being stirred in the reactor at high speed Phase, slowly plus water is until reach phase inversion point, and unlatching cutter carries out high speed shear, and remaining water is added, shearing about half an hour, Form the aqueous emulsion of oil-in-water type, you can the aqueous emulsion of the present composition is made.
The bactericidal composition is microemulsion, and the mass fraction of component is：1~40 part of fluorine thiazole pyrrole ethyl ketone；Indazole sulphur 1~40 part of bacterium amine；10~30 parts of emulsifier, 1~8 part of antifreezing agent, 0.5~10 part of stabilizer, Conventional solvents cosolvent 20~50 Part.Fluorine thiazole pyrrole ethyl ketone is completely dissolved with amisulbrom with cosolvent, add emulsifier, antifreezing agent stabilizer etc. other Ingredient uniformly mixes, is eventually adding water, microemulsion can be made into after being sufficiently stirred.
Wherein above-described emulsifier is selected from calcium dodecyl benzene sulfonate and aliphatic acid polyethenoxy ether, alkyl phenol polyoxy Ethylene ether sulfosuccinates, styrylphenol polyoxyethylene ether, nonylphenol polyoxyethylene ether, castor oil polyoxyethylene ether, Aliphatic acid polyethenoxy base ester, any one of polyoxyethylene aliphatic alcohol ether or more than one a mixture of arbitrary proportions.
The solvent is xylene or biodiesel, toluene, diesel oil, methanol, ethyl alcohol, n-butanol, isopropanol, turpentine Oil, solvent naphtha, dimethylformamide, dimethyl sulfoxide (DMSO), the one or more in water equal solvent are arbitrarily than the mixing of composition Object.
The dispersant is selected from polycarboxylate, lignosulfonates, alkyl phenol polyoxyethylene ether methyl ether condensation product sulfuric acid Salt, alkylsulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkyl phenol polyoxyethylene ether, polyoxyethylene carboxylate, fat Amine polyoxyethylene ether, one or more of glycerol fatty acid ester polyoxyethylene ethe.
The wetting agent is selected from lauryl sodium sulfate, calcium dodecyl benzene sulfonate, and Nekal BX moistens bleeding agent F, Alkylbenzene sulfonate polyoxyethylene triphen phosphenylic acid salt dimly, spaonin powder, silkworm excrement are one or more in spaonin powder.
The disintegrant is selected from bentonite, urea, ammonium sulfate, aluminium chloride, citric acid, succinic acid, in sodium bicarbonate It is one or more.
The thickener be selected from xanthans, carboxymethyl cellulose, carboxyethyl cellulose, methylcellulose, aluminum magnesium silicate, It is one or more in polyvinyl alcohol.
The stabilizer is selected from sodium citrate, one kind in resorcinol.
The antifreezing agent is selected from ethylene glycol, and propylene glycol is one or more in glycerine.
The antifoaming agent is selected from silicone oil, silicone compound, C10-20Saturated fat acids compound, C8-10Fatty alcohol It is one or more.
The filler is selected from kaolin, diatomite, bentonite, attapulgite, white carbon, starch, in precipitated calcium carbonate It is one or more.
The present invention has apparent synergy using fluorine thiazole pyrrole ethyl ketone and amisulbrom as the composite bactericide of active ingredient Effect, delays the generation of key drug resistance, and reduce production and application costs, can be used for the improvement of resistance disease.It is main It is used to prevent downy mildew of garpe, late blight and all kinds of powdery mildews.
Specific implementation mode
To make technical scheme of the present invention, purpose and advantage be more clearly understood, present invention following specific examples It illustrates, but the present invention is not limited to these examples.The effect experiment of the present invention uses indoor biometrics and field trial phase In conjunction with mode, unless otherwise instructed, ratio mentioned below all be quality parts ratio.
Embodiment：Fluorine thiazole pyrrole ethyl ketone and amisulbrom virulence experiment with different proportions.
1.1 reagent agent
96% fluorine thiazole pyrrole ethyl ketone active compound, 95% amisulbrom active compound, above-mentioned active compound are had by extra large Lear medicine company share Research and development department of limit company provides.
1.2 experiment targets
Fluorine thiazole pyrrole ethyl ketone was never applied from Shandong Shouguang to acquire with the cucumber potting of amisulbrom and same type Separation, for trying cucumber variety：Chang Chun Mi Ci.
1.3 test method
1.3.1 medicament is prepared
Acetone solution active compound is first used, suitable two active compound is made by different ratio according to the result of preliminary experiment, then with third To be diluted to several concentration gradients respectively for use by each processing for ketone.
By the cultivation of susceptible cucumber variety Chang Chun Mi Ci in pot for growing seedlings, it is placed in a greenhouse culture, plant grows to three to four leaves After phase, the blade of identical leaf age is acquired, the culture for cucumber powdery mildew's pathogen and measurement.
1.3.2 the culture of cucumber powdery mildew's pathogen and the preparation of spore suspension
Cucumber powdery mildew's pathogen is cultivated using plants method under conditions of 20 DEG C, 12h alternation of light and darkness, turns to be commissioned to train per 30d It supports 1 time.With the conidium on sterile water elution incidence of leaf when inoculation, it is l × 10 to be configured to spore concentration6A/mL's is outstanding Supernatant liquid.
1.3.3 strains tested sensitivity testing
Toxicity test is carried out using leaf dish moisturizing method.The blade of acquisition is first prepared into the leaf dish of a diameter of 1.5cm, at random Mixing is respectively placed in the series concentration liquid configured and impregnates lh, 50 leaf dishes of each concentration, tests with the place of not adding medicine Reason is blank control, and after immersion, leaf is face-up placed on the blotting paper of identical liquor strength wetting, in leaf dish Liquid blot, by prepared spore suspension l0L be inoculated in leaf dish center, after being placed at room temperature for 5min, be placed in 20 DEG C, 1 2h It is cultivated under conditions of alternation of light and darkness, the onset area in leaf dish is measured after 10d, calculates EC50。
On the basis of pilot study, poison is carried out to single dose fluorine thiazole pyrrole ethyl ketone and amisulbrom respectively with above method Power measures, the two EC50Value is respectively 8.69 ㎎/l and 8.26 ㎎/l.
The percentage that leaf dish area is accounted for according to lesion area divides sick grade
0 grade：It is disease-free；
1 grade：Sorus area accounts for 5% or less whole leaf area；
3 grades：Sorus area accounts for the 6%-10% or less of whole leaf area；
5 grades：Sorus area accounts for the 11%-20% or less of whole leaf area；
7 grades：Sorus area accounts for the 21%-50% or less of whole leaf area；
9 grades：Sorus area accounts for 50% or more of whole leaf area.
1.3.4 mixture toxicity test and interpretation of result
The toxicity test of mixture is carried out according to mixed ratio with single agent virulence determination method.
If compareing the death rate<5%, it does not correct, the control death rate is corrected between 5%-20% by formula 2, is compareed The death rate>20%, experiment need to reform.
Using the logarithm of drug concentration (mg/L) as independent variable x, using the niqueMin of corrected mortality as dependent variable y, respectively Virulence regression equation is established, the EC of single dose and each proportioning mixture is calculated using DPS softwares50Poison altogether is calculated according to the abundant methods of Sun Yun Coefficient (CTC).Co-toxicity coefficient CTC, calculation formula are as follows：(using fluorine thiazole pyrrole ethyl ketone as standard agent, toxicity index is 100)：
The EC of the toxicity index (TI) of amisulbrom=fluorine thiazole pyrrole ethyl ketone50The EC of/amisulbrom50×100
The EC of the true toxicity index (ATI) of M=fluorine thiazole pyrrole ethyl ketone50The EC of/M50×100
The TI of TI × P fluorine thiazole pyrroles ethyl ketone+amisulbrom of the theoretical toxicity index (TTI) of M=fluorine thiazole pyrrole ethyl ketone × P amisulbroms
TTI × 100 of the ATI/M of co-toxicity coefficient (CTC)=M of M
In formula：
M is the mixture of fluorine thiazole pyrrole ethyl ketone and amisulbrom different ratio
P fluorine thiazole pyrrole ethyl ketones are fluorine thiazole pyrrole ethyl ketone ratio shared in mixture
P amisulbroms are amisulbrom ratio shared in mixture.
2.1 toxicity test results
1 fluorine thiazole pyrrole ethyl ketone of table is with amisulbrom to the toxicity test of powdery mildew of cucumber
As can be seen from the table, the test result of different proportion proportioning shows to dilute equal table respectively in active ingredient ratio Reveal stronger synergistic effect, wherein with fluorine thiazole pyrrole ethyl ketone：Amisulbrom is 1:20~20:Synergistic effect is good when 1 It is recommended that suitable proportion 1:20~20:1 or so mixture preparation carries out further field control effectiveness test, to evaluate its field reality Application effect.
3 field trials prevent powdery mildew of cucumber, the experimental result of downy mildew of garpe
3.1 field trials prevent powdery mildew of cucumber
3.1.1 test method
Experiment in Shandong Pingdu City cucumber, 4 points is investigated per cell, and every is investigated 2 plants, and morbidity journey is recorded with staging Degree, grade scale are as follows：
0 grade：It is disease-free；
1 grade：Sorus area accounts for 5% or less whole leaf area；
3 grades：Sorus area accounts for the 6%-10% or less of whole leaf area；
5 grades：Sorus area accounts for the 11%-20% or less of whole leaf area；
7 grades：Sorus area accounts for the 21%-50% or less of whole leaf area；
9 grades：Sorus area accounts for 50% or more of whole leaf area.
3.1.2 control time and number
Experiment is investigated 4 times altogether, and radix is investigated before medicine, is investigated within 15 days 7 days after first time medicine, after second 7 days and medicine.
3.1.3 drug effect computational methods
Sick leaf rate (the %)=disease number of sheets/investigation total number of sheets × 100
Disease index=∑ (the disease numbers of sheets at different levels × opposite value of series)/(investigation total number of sheets × 9) × 100
Control effect (%)=(1- (disease index after disease index × treatment region medicine before blank district medicine)/(blank pair According to disease index before disease index after area's medicine × treatment region medicine)) × 100.
3.1.4 poisoning investigation method
Whether continuous 15d range estimations medicament has poisoning to crop after dispenser.
3.1.5 test result and analysis
The effect of each processing prevention powdery mildew of cucumber.(table 2)
Table 2 respectively handles the effect of prevention powdery mildew of cucumber
48% fluorine thiazole pyrrole ethyl ketone as shown in Table 2：Amisulbrom is with 24:24 ratio composite bactericides are for cucumber white powder Controlling for disease is with obvious effects higher than fluorine thiazole pyrrole ethyl ketone and amisulbrom single dose, and bactericidal effect is incremented by with the increase of dosage.Root It is estimated according to field, within the range of experimental dose, plant growth is normal, and each treatment agent does not occur the poisoning phenomenon to cucumber, Illustrate that it is safe to cucumber.It is recommended that the fungicide different from the mechanism of action is used in mixed way to delay the production of germ drug resistance It is raw.
4.1 field trials prevent downy mildew of garpe
4.1.1 test method
Experiment in Shandong Pingdu City wine-growing, 4 points is investigated per cell, and every is investigated 2 plants, is recorded and is sent out with staging Course of disease degree, grade scale are as follows：
0 grade：It is disease-free；
1 grade：Sorus area accounts for 5% or less whole leaf area；
3 grades：Sorus area accounts for the 6%-10% or less of whole leaf area；
5 grades：Sorus area accounts for the 11%-20% or less of whole leaf area；
7 grades：Sorus area accounts for the 21%-50% or less of whole leaf area；
9 grades：Sorus area accounts for 50% or more of whole leaf area.
4.1.2 control time and number
Experiment is investigated 4 times altogether, radix investigation before medicine, 14 days after first time medicine, after second of medicine after 14 days and medicine 21 days into Row investigation.
4.1.3 drug effect computational methods
Sick leaf rate (the %)=disease number of sheets/investigation total number of sheets × 100
Disease index=∑ (the disease numbers of sheets at different levels × opposite value of series)/(investigation total number of sheets × 9) × 100
Control effect (%)=(1- (disease index after disease index × treatment region medicine before blank district medicine)/(blank pair According to disease index before disease index after area's medicine × treatment region medicine)) × 100.
4.1.4 poisoning investigation method
Whether continuous 14d range estimations medicament has poisoning to crop after dispenser.
4.1.5 test result and analysis
The effect (table 3) of each processing prevention cucumber downy mildew
Table 3 respectively handles the effect of prevention cucumber downy mildew
The Mixed Pharmacy of different proportion as can be seen from Table 3 is tested by different dosages, it is to oenin after medicine The prevention of mildew is superior to comparison medicament, and bactericidal effect is incremented by with the increase of dosage.It is estimated according to field, in test dose model In enclosing, plant growth is normal, and each treatment agent does not occur the poisoning phenomenon to grape, illustrates that it is safe to grape.It builds The view fungicide different from the mechanism of action is used in mixed way to delay the generation of germ drug resistance.
In conclusion the present invention contains the bactericidal composition of fluorine thiazole pyrrole ethyl ketone and amisulbrom, to powdery mildew of cucumber There is good control effect with downy mildew of garpe, and it is safe to Target crops.Complex preparation not only increases preventive effect, and Fungicidal spectrum is expanded, so this compounded combination has a very important significance in production practice.

Claims (4)

1. a kind of bactericidal composition containing fluorine thiazole pyrrole ethyl ketone and amisulbrom, it is characterised in that：The bactericidal composition Active ingredient is fluorine thiazole pyrrole ethyl ketone and amisulbrom binary built, remaining is auxiliary element, wherein active ingredient fluorine thiazole The mass ratio of pyrrole ethyl ketone and amisulbrom is 1~40: 40~1.
2. bactericidal composition according to claim 1, it is characterised in that：Fluorine thiazole pyrrole ethyl ketone is with amisulbrom in preparation In total weight account for the 1%~80% of the entire quality of the pharmaceutical preparations.
3. bactericidal composition according to claim 2, it is characterised in that：Fluorine thiazole pyrrole ethyl ketone is with amisulbrom in preparation In total weight account for the 5%~50% of the entire quality of the pharmaceutical preparations.
4. bactericidal composition according to claim 1 or 2 or 3, it is characterised in that：The dosage form of the bactericidal composition is breast Oil, suspending agent, wettable powder, water dispersible granules, aqueous emulsion, microemulsion.
CN201611133745.0A 2016-12-10 2016-12-10 A kind of bactericidal composition containing fluorine thiazole pyrrole ethyl ketone and amisulbrom Pending CN108605948A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109221163A (en) * 2017-07-10 2019-01-18 江苏龙灯化学有限公司 A kind of bactericidal composition

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109221163A (en) * 2017-07-10 2019-01-18 江苏龙灯化学有限公司 A kind of bactericidal composition

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Application publication date: 20181002