CN105409976A - Sterilization composition containing efficient metalaxyl-M and flumorph - Google Patents
Sterilization composition containing efficient metalaxyl-M and flumorph Download PDFInfo
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- CN105409976A CN105409976A CN201510964087.9A CN201510964087A CN105409976A CN 105409976 A CN105409976 A CN 105409976A CN 201510964087 A CN201510964087 A CN 201510964087A CN 105409976 A CN105409976 A CN 105409976A
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- flumorph
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/84—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms six-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,4
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
- A01N37/46—N-acyl derivatives
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Abstract
The invention relates to a sterilization composition containing efficient metalaxyl-M and flumorph. The sterilization composition comprises effective components including the efficient metalaxyl-M and the flumorph, which are compounded in a binary manner, wherein the mass ratio of the efficient metalaxyl-M to the flumorph is (1 to 50): (50 to 1); the mass percent of the effective components including the efficient metalaxyl-M and the flumorph in a preparation is 1 percent to 80 percent, and the balance is auxiliary components allowable and acceptable in pesticides. The sterilization composition provided by the invention has dosage forms including missible oil, a suspending agent, wettable powder, water dispersible granules, emulsion in water, micro-emulsion, granules and microcapsules. The sterilization composition can be used for effectively preventing and treating plant gray mold, peronospora and epidemic mildew bacteria.
Description
Technical field
The present invention relates to technical field of pesticide combination, particularly relate to a kind of bactericidal composition containing high-efficiency precision metalaxyl and flumorph.
Background technology
High-efficiency precision metalaxyl belongs to phenylamide; for efficient, low toxicity, low-residual, the lasting period is long, insecticide-applying way is diversified, the wide spectrum systemic fungicide of the equal excellence of protection and result for the treatment of; cauline leaf process, seed treatment and soil treatment can be made, have aobvious control efficiency of removing from office to the crop pest that downy mildew, phytophthora, pythium spp etc. cause.
Flumorph belongs to morpholine class disinfectant use in agriculture.Effective especially to Peronospora, epidemic disease mycin germ.To the Oomycete on grape, potato and tomato, especially Peronosporaceae and Phytophthora bacterium have fungicidal effectiveness, the chemical name of flumorph is 4-[3-(3,4-methoxyphenyl)-3-(4-fluorophenyl) acryloyl] morpholine, and its chemical structural formula is:
Use the most effective means that chemical agent is controlling plant diseases.But long-term use single chemical bactericide continuously high dose, easily cause the problems such as the remaining of medicament, environmental pollution and resistance to pesticide resistance fungi development.Composite or the mixture of rational chemical bactericide has expansion fungicidal spectrum, improve control efficiency, extend the optimum period for applying fertilizer, reduce dosage, reduce poisoning, minimizing remains, delay Antifungal resistance and the actively feature such as drug-fast generation and development, bactericide compounded is one of the effective method the most solved the problem.Develop new product bactericide price constantly rises, and by contrast, exploitation is efficient with research, low toxicity, low-residual composite and mixture has small investment, the lead time is short and be subject to domestic and international attention, numerous and confused increasing develops dynamics.We are on the basis of lab screening and field trial, filter out high-efficiency precision metalaxyl and flumorph carries out composite, have obvious synergistic effect.And about high-efficiency precision metalaxyl and flumorph composite bactericidal composition and apply and there is no people at present and reported.
Summary of the invention
Based on above situation, the object of the invention is to provide a kind of new and effective pesticide sterilizing composite.Be mainly used in the control of plant botrytis, Peronospora, epidemic disease mycin germ.
Technical scheme of the present invention is realized by following measures:
Contain a bactericidal composition for high-efficiency precision metalaxyl and flumorph, active ingredient high-efficiency precision metalaxyl and the flumorph two yuan of this bactericidal composition are composite, and all the other are auxiliary element.In wherein said bactericidal composition, the mass ratio of active ingredient high-efficiency precision metalaxyl and flumorph is 1 ~ 50: 50 ~ 1, described bactericidal composition of the present invention is through toxicity test experimental verification, when the mass ratio of high-efficiency precision metalaxyl and flumorph is 1 ~ 20: 20 ~ 1, synergistic effect is better.
The formulations of pesticide that described bactericidal composition of the present invention can be prepared are missible oil, suspending agent, wetting powder, water dispersible granules, aqueous emulsion, microemulsion, granule, microcapsule formulations.Wherein active ingredient high-efficiency precision metalaxyl and flumorph gross mass in the formulation accounts for 1% ~ 80% of the whole quality of the pharmaceutical preparations, and when wherein accounting for 5% ~ 60%, toxicity reaches good balance with residual, and cost is also lower.
The specific embodiments of the formulations of pesticide that bactericidal composition of the present invention is mixed with is as follows:
Described bactericidal composition is cream preparation, and the mass fraction of component is: high-efficiency precision metalaxyl 1 ~ 50 part; Flumorph 1 ~ 50 part; Conventional emulsifier 10 ~ 30 parts; Conventional solvents 20 ~ 50 parts; Conventional synergist 1 ~ 5 part.The concrete production stage of this cream preparation be first active ingredient high-efficiency precision metalaxyl and flumorph are added dissolve completely in solvent after add emulsifier again, synergist becomes transparent and homogeneous oily liquids after stirring, filling, namely can be made into the cream preparation of the present composition.
Described bactericidal composition is suspending agent, and the mass fraction of component is: high-efficiency precision metalaxyl 1 ~ 50 part; Flumorph 1 ~ 50 part; Dispersant 5 ~ 20 parts; Antifreezing agent 1 ~ 5 part; Thickener 0.1 ~ 2 part; Defoamer 0.1 ~ 0.8 part; Penetrating agent 0 ~ 10 part; PH value regulator 0.1 ~ 5 part; Water, surplus.The concrete production stage of this suspending agent is for first to mix other auxiliary agents, mix through high speed shear, add active ingredient high-efficiency precision metalaxyl and flumorph, abrading-ball 2 ~ 3 hours in ball crusher, make a diameter all at below 5mm, namely can be made into the aqueous suspension formulations of the present composition.
Described bactericidal composition is wetting powder, and the mass fraction of component is: high-efficiency precision metalaxyl 1 ~ 50 part; Flumorph 1 ~ 50 part; Dispersant 3 ~ 10 parts; Wetting agent 1 ~ 5 part; Filler, surplus.The concrete production stage of this wetting powder is: mixed with flumorph and dispersant, wetting agent and filler by active ingredient high-efficiency precision metalaxyl by above-mentioned formula, uniform stirring in stirred tank, mixing after airslide disintegrating mill, namely can be made into the wetting powder of the present composition.
Described bactericidal composition is water dispersible granules, and the mass fraction of component is: high-efficiency precision metalaxyl 1 ~ 50 part; Flumorph 1 ~ 50 part; Dispersant 3 ~ 10 parts; Wetting agent 1 ~ 10 part; Disintegrant 1 ~ 5 part; Filler, surplus.The concrete production stage of this water dispersible granules is: mixed with flumorph and dispersant, wetting agent, disintegrant and filler by active ingredient high-efficiency precision metalaxyl by above-mentioned formula, pulverize with micro jet, through mediating, then add in fluidized-bed granulation dryer and to carry out after granulation, drying, screening, through sample analysis, namely can be made into the water dispersible granules of the present composition.
Described bactericidal composition is aqueous emulsion, and the mass fraction of component is: high-efficiency precision metalaxyl 1 ~ 50 part; Flumorph 1 ~ 50 part; Emulsifier 3 ~ 30 parts; Solvent 5 ~ 15 parts; Stabilizing agent 2 ~ 15 parts; Antifreezing agent 1 ~ 5 part; Defoamer 0.1 ~ 8 part; Thickener 0.2 ~ 2 part; Water, surplus.The concrete production stage of this aqueous emulsion is: first high-efficiency precision metalaxyl and flumorph, solvent and emulsifier, cosolvent are added together, and makes to be dissolved into uniform oil phase; By part water, antifreeze, other the insecticides adjuvant such as antimicrobial mixes uniformly aqueous phase; While high-speed stirred, oil phase is added aqueous phase in a kettle., slowly add water until reach phase inversion point, open clipper and carry out high speed shear, and add remaining water, shear about half an hour, form the aqueous emulsion of oil-in-water type, namely can be made into the aqueous emulsion of the present composition.
Described bactericidal composition is microemulsion, and the mass fraction of component is: high-efficiency precision metalaxyl 1 ~ 50 part; Flumorph 1 ~ 50 part; Emulsifier 10 ~ 30 parts, antifreezing agent 1 ~ 8 part, stabilizing agent 0.5 ~ 10 part, Conventional solvents cosolvent 20 ~ 50 parts.High-efficiency precision metalaxyl and flumorph cosolvent are dissolved completely, then add other compositions such as emulsifier, antifreezing agent stabilizing agent, Homogeneous phase mixing, finally adds water, can be made into microemulsion after fully stirring.
Described bactericidal composition is granule, and the mass fraction of component is: high-efficiency precision metalaxyl 1 ~ 50 part; Flumorph 1 ~ 50 part; Wetting dispersing agent 1 ~ 10 part; Thickener 0.1 ~ 5 part; Defoamer 0.1 ~ 5 part; Castor oil, surplus is supplied.Each components such as active ingredient high-efficiency precision metalaxyl and flumorph, dispersant, stabilizing agent, defoamer and solvent are mixed in the ratio of filling a prescription, after putting into the grinding of sand milling still, sends into mixing in mixer for well-distribution and get product.
Described bactericidal composition is microcapsule formulations, and the mass fraction of component is: high-efficiency precision metalaxyl 1 ~ 50 part; Flumorph 1 ~ 50 part; 5 ~ 20 parts, urea; 5 ~ 20 parts, formaldehyde; Emulsifying dispersant 5 ~ 20 parts; Antifreezing agent 1 ~ 5 part; Thickener 0.1 ~ 2 part; Defoamer 0.1 ~ 0.8 part; Water, surplus.Urea and formaldehyde (amount of substance ratio is about l:1.5 ~ 2.0) is added in the there-necked flask that agitating device is housed, regulate the pH value of solution to about 8 ~ 9 with sodium hydroxide solution, then be warming up to 70 ~ 80 DEG C, be obtained by reacting stable urea resin prepolymer.Get a certain amount of high-efficiency precision metalaxyl and flumorph is dissolved in cyclohexane, and add emulsifying dispersant in the solution, with vigorous stirring, the O/W type stable emulsion that to be made into the aqueous solution containing emulsifying dispersant be aqueous phase.Above-mentioned urea resin prepolymer is added in emulsion, adjust ph, polymerization reaction take place under acid catalysed conditions, oil phase substance is wrapped, form microcapsule granule.Slow intensification, solidification, temperature controls at 40 ~ 50 DEG C, hardening time 1h.Select to add appropriate auxiliary agent, stable microcapsule suspending agent.
Wherein above-described emulsifier is selected from calcium dodecyl benzene sulfonate and aliphatic acid polyethenoxy ether, alkylphenol polyoxyethylene sulfosuccinate, styrylphenol polyoxyethylene ether, polyoxyethylene nonylphenol ether, castor oil polyoxyethylene ether, aliphatic acid polyethenoxy base ester, any one in polyoxyethylene aliphatic alcohol ether or more than one any mixtures than composition.
Described solvent is dimethylbenzene or biodiesel, toluene, diesel oil, methyl alcohol, ethanol, n-butanol, isopropyl alcohol, turpentine-based vegetable oil code name is ND-45, solvent naphtha, dimethyl formamide, dimethyl sulfoxide (DMSO), one or more in water equal solvent are arbitrarily than the mixture of composition.
It is LG-3, GY-D1252, GY-D1256, SNWGF-01 that described dispersant is selected from polycarboxylate code name, lignosulfonates code name is 201107,21108, alkylphenol polyoxyethylene methyl ether condensate sulfate, alkylsulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol polyoxyethylene, polyoxyethylene carboxylate, aliphatic amine polyoxyethylene ether, one or more in fatty acid glyceride APEO.
Described wetting agent is selected from lauryl sodium sulfate, calcium dodecyl benzene sulfonate, Nekal BX, moistening bleeding agent F, alkylbenzenesulfonate polyoxyethylene triphen phosphenylic acid salt dimly, spaonin powder, silkworm excrement, one or more in soapberry powder.
Described disintegrant is selected from bentonite, urea, ammonium sulfate, aluminium chloride, citric acid, succinic acid, one or more in sodium bicarbonate.
Described thickener is selected from xanthans, carboxymethyl cellulose, carboxyethyl cellulose, methylcellulose, Magnesiumaluminumsilicate, in polyvinyl alcohol one or more.
Described stabilizing agent is selected from sodium citrate, the one in resorcinol.
Described antifreezing agent is selected from ethylene glycol, propane diols, one or more in glycerine.
Described defoamer is selected from silicone oil, silicone compound, C
10-20saturated fat acid compounds, C
8-10one or more of fatty alcohol.
Described filler is selected from kaolin, diatomite, bentonite, attapulgite, white carbon, starch, one or more in precipitated calcium carbonate.
The composite bactericide that the present invention is active ingredient with high-efficiency precision metalaxyl and flumorph has obvious synergistic effect, delay the drug-fast generation in key, and reduce into product cost and use cost, be mainly used in the control of plant botrytis, Peronospora, epidemic disease mycin germ.
Embodiment
For making technical scheme of the present invention, object and advantage are clearly understood, the following specific embodiment of the present invention is described, but the present invention is not limited to these examples.The mode that effect experimental of the present invention adopts indoor biometrics and field trial to combine, if no special instructions, the ratio below mentioned is all ratio of quality and the number of copies.
Embodiment: high-efficiency precision metalaxyl and flumorph different ratio co-toxicity are tested.
1.1 reagent agent
The former medicine of 96% high-efficiency precision metalaxyl, the former medicine of 95% flumorph, above-mentioned former medicine provides by research and development department of extra large rel medicine company limited company.
1.2 test targets
Never executed efficient Metalaxyl-M and flumorph and cucumber of the same type to gather potted plantly be separated, for examination cucumber variety: Chang Chun Mi Ci from Shouguang, Shandong.
1.3 test method
1.3.1 medicament preparation
First use the former medicine of acetone solution, appropriate two former medicines are made into several different ratio by the result according to preliminary experiment, then it is stand-by with acetone, each process to be diluted to several concentration gradients respectively.
By susceptible cucumber variety Chang Chun Mi Ci cultivation in pot for growing seedlings, be placed in greenhouse and cultivate, plant grows to three to four leaf after dates, gathers the blade of identical leaf age, for cultivation and the mensuration of botrytis cinerea pers.
1.3.2 the cultivation of botrytis cinerea pers and the preparation of spore suspension
Botrytis cinerea pers adopt plants method 20 DEG C, cultivate under the condition of 12h alternation of light and darkness, every 30d turns culture 1 time.With the conidium on sterile water wash-out incidence of leaf during inoculation, being mixed with spore concentration is l × 10
6the suspension of individual/mL.
1.3.3 strains tested sensitivity testing
Leaf dish moisturizing method is adopted to carry out toxicity test.First the blade of collection is prepared into the leaf dish that diameter is 1.5cm, random mixing, be placed in the series concentration liquid configured respectively and soak lh, each concentration 50 leaf dishes, test with the process of not adding medicine as blank, after immersion terminates, leaf faces up and puts on the blotting paper that identical liquor strength is wetting, liquid on leaf dish is blotted, the spore suspension l0L prepared is inoculated in leaf dish central authorities, room temperature is placed after 5min, is placed in 20 DEG C, cultivates under the condition of 12h alternation of light and darkness, measure the onset area on leaf dish after 10d, calculate EC
50.
On the basis of preliminary experiment, respectively toxicity test is carried out to single dose high-efficiency precision metalaxyl and flumorph in order to upper method, the two EC
50value is respectively 5.3651 ㎎/l and 7.1973 ㎎/l.
The percentage accounting for leaf disc area according to lesion area divides disease level
0 grade: anosis;
1 grade: sorus area accounts for less than 5% of whole leaf area;
3 grades: sorus area accounts for below the 6%-10% of whole leaf area;
5 grades: sorus area accounts for below the 11%-20% of whole leaf area;
7 grades: sorus area accounts for below the 21%-50% of whole leaf area;
9 grades: sorus area accounts for more than 50% of whole leaf area;
1.3.4 mixture toxicity test and interpretation of result
Carry out the toxicity test of mixture according to mixed ratio by single dose toxicity test method.
If contrast lethality <5%, does not correct, contrast lethality, between 5%-20%, corrects by formula 2, and contrast lethality >20%, test need be reformed.
Be independent variable x with the logarithm value of drug concentration (mg/L), with the probability value of corrected mortality for dependent variable y, set up virulence regression equation formula respectively, adopt DPS software to calculate the LC of single dose and each proportioning mixture
50co-toxicity coefficient (CTC) is calculated according to the abundant method of Sun Yun.Co-toxicity coefficient CTC, computing formula is as follows: (with high-efficiency precision metalaxyl for standard agent, its toxicity index is 100):
The EC of toxicity index (the TI)=high-efficiency precision metalaxyl of flumorph
50the EC of/flumorph
50× 100
The EC of true toxicity index (the ATI)=high-efficiency precision metalaxyl of M
50the LC of/M
50× 100
TI × P flumorph of TI × P high-efficiency precision metalaxyl+flumorph of theoretical toxicity index (the TTI)=high-efficiency precision metalaxyl of M
TTI × 100 of the ATI/M of co-toxicity coefficient (the CTC)=M of M
In formula:
M is the mixture of high-efficiency precision metalaxyl and flumorph different ratio
P high-efficiency precision metalaxyl is the ratio of high-efficiency precision metalaxyl shared by mixture
P flumorph is the ratio of flumorph shared by mixture.
2.1 toxicity test results
Table 1 high-efficiency precision metalaxyl and flumorph are to the toxicity test of gray mold of cucumber
As can be seen from the table, the result of the test of different proportion proportioning shows, dilute respectively in active ingredient ratio and all show stronger synergistic effect, wherein with high-efficiency precision metalaxyl and flumorph for synergistic effect when 1:50 ~ 50:1 is good, suggestion carries out further field control effectiveness test to suitable proportion about 1:20 ~ 20:1 mixture preparation, to evaluate its field practical application effect.
3, field trial control cucumber downy mildew, the experimental result of gray mold of cucumber
3.1 field trial control cucumber downy mildews
3.1.1 test method
Test on Shandong Pingdu City cucumber ground, 4 points are investigated in every community, often some investigation 2 strains, and record occurring degree by staging, grade scale is as follows:
0 grade: anosis;
1 grade: sorus area accounts for less than 5% of whole leaf area;
3 grades: sorus area accounts for below the 6%-10% of whole leaf area;
5 grades: sorus area accounts for below the 11%-20% of whole leaf area;
7 grades: sorus area accounts for below the 21%-50% of whole leaf area;
9 grades: sorus area accounts for more than 50% of whole leaf area.
3.1.2 control time and number of times
Test is investigated 4 times altogether, after radix investigation before medicine, first time medicine 10 days, within 21 days, investigate after 10 days and medicine after second time medicine.
3.1.3 drug effect computational methods
Sick leaf rate (%)=sick number of sheets/investigate the total number of sheets × 100
Disease index=∑ (the sick number of sheets × relative level numerical value at different levels)/(investigating the total number of sheets × 9) × 100
Control efficiency (%)=(1-(before blank district medicine after disease index × treatment region medicine disease index)/(after blank district medicine before disease index × treatment region medicine disease index)) × 100.
3.1.4 poisoning investigation method
Whether after dispenser, continuous 7d estimates medicament has poisoning to crop.
3.1.5 result of the test and analysis
The effect (table 2) of each process control cucumber downy mildew
The effect of cucumber downy mildew prevented and treated by table 2 respectively process
The Mixed Pharmacy of different proportion as can be seen from Table 2, tests by different consumptions, and after medicine, it is all better than contrasting medicament to the control of cucumber downy mildew, and bactericidal effect increases progressively with the increase of dosage.According to field range estimation, within the scope of test dose, plant growth is normal, and the poisoning phenomenon to cucumber does not all appear in each treatment agent, illustrates that it is safe to cucumber.Advise that the bactericide different from the mechanism of action is used in combination to delay the drug-fast generation of germ.
3.2 field trial control gray molds of cucumber
3.2.1 test method
Test site is in the Pingdu herbary of Shandong, and be cucumber for examination vegetables, growing way is better, and test establishes every mu to establish contrast totally 10 process.Often process repetition 4 times, random district group arranges, plot area 14 square metres.
3.2.2 control time and number of times
Before dispenser, after the 1st medicine after 7 days and the 2nd dispenser 7 days, 14 days, every community adopted diagonal 5 sampling, often some investigation 2 strains, totally 10 strains, investigation complete stool blade, and by leaf classification investigation occurring degree, calculating disease refers to and control efficiency.
Grade scale is as follows:
0 grade: anosis;
1 grade: lesion area accounts for less than 5% of one-piece blade area;
3 grades: lesion area accounts for the 6%-15% of one-piece blade area;
5 grades: lesion area accounts for the 16%-25% of one-piece blade area;
7 grades: lesion area accounts for the 26%-50% of one-piece blade area;
9 grades: lesion area accounts for more than 50% of one-piece blade area.
3.2.3 drug effect computational methods
Sick leaf rate (%)=sick number of sheets/investigate the total number of sheets × 100
Disease index=∑ (the sick number of sheets × relative level numerical value at different levels)/(investigating the total number of sheets × 9) × 100
Control efficiency (%)=(1-(before blank district medicine after disease index × treatment region medicine disease index)/(after blank district medicine before disease index × treatment region medicine disease index)) × 100.
3.2.4 poisoning investigation method
Whether after dispenser, continuous 14d estimates medicament has poisoning to crop.
3.2.5 result of the test and analysis
The effect of gray mold of cucumber prevented and treated by table 3 respectively process
The Mixed Pharmacy of different proportion as can be seen from Table 3, tests by different consumptions, and high-efficiency precision metalaxyl flumorph is all better than contrast medicament with its right control after 1:3 ratio compound medicine and bactericidal effect increases progressively with the increase of dosage.According to field range estimation, within the scope of test dose, plant growth is normal, and the poisoning phenomenon to cucumber does not all appear in each treatment agent, illustrates that it is safe to cucumber.Advise that the bactericide different from the mechanism of action is used in combination to delay the drug-fast generation of germ.
In sum, the present invention contains the bactericidal composition of high-efficiency precision metalaxyl and flumorph, have good control efficiency, and it is to Target crops safety to cucumber downy mildew, gray mold.Complex preparation not only increases preventive effect, and expands fungicidal spectrum, widens the scope of application, reduces costs, and plays the double effect controlled of a medicine, alleviate manpower and materials to multiple diseases, improves productivity effect.So the invention of this complex preparation is of great significance social tool with popularization.
Claims (4)
1. one kind contains the bactericidal composition of high-efficiency precision metalaxyl and flumorph, it is characterized in that: the active ingredient of this bactericidal composition is high-efficiency precision metalaxyl and flumorph binary built, all the other are auxiliary element, and wherein the mass ratio of active ingredient high-efficiency precision metalaxyl and flumorph is 1 ~ 50: 50 ~ 1.
2. bactericidal composition according to claim 1, is characterized in that: high-efficiency precision metalaxyl and flumorph gross weight in the formulation accounts for 1% ~ 80% of the whole quality of the pharmaceutical preparations.
3. bactericidal composition according to claim 2, is characterized in that: high-efficiency precision metalaxyl and flumorph gross weight in the formulation accounts for 5% ~ 60% of the whole quality of the pharmaceutical preparations.
4. the bactericidal composition according to claim 1 or 2 or 3, is characterized in that: the formulation of this bactericidal composition is missible oil, suspending agent, wetting powder, water dispersible granules, aqueous emulsion, microemulsion, granule, microcapsule formulations.
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| CN114208842A (en) * | 2021-12-31 | 2022-03-22 | 海南大学 | Bactericidal composition for reducing drug resistance of late blight bacteria and application thereof |
| CN114711241A (en) * | 2022-05-05 | 2022-07-08 | 山东亿嘉农化有限公司 | Bactericidal composition containing flumorph and metalaxyl-M and application thereof |
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| CN107568224A (en) * | 2017-09-20 | 2018-01-12 | 湖南泽丰农化有限公司 | Bactericidal composition and application containing flumorph and Metalaxyl-M suspension emulsion |
| CN114208842A (en) * | 2021-12-31 | 2022-03-22 | 海南大学 | Bactericidal composition for reducing drug resistance of late blight bacteria and application thereof |
| CN114711241A (en) * | 2022-05-05 | 2022-07-08 | 山东亿嘉农化有限公司 | Bactericidal composition containing flumorph and metalaxyl-M and application thereof |
| CN114711241B (en) * | 2022-05-05 | 2023-10-20 | 山东亿嘉农化有限公司 | Sterilization composition containing flumorph and metalaxyl-M and application thereof |
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