CN103271031A - Sterilization composition containing cyanoacrylate bactericide and metalaxyl-M - Google Patents
Sterilization composition containing cyanoacrylate bactericide and metalaxyl-M Download PDFInfo
- Publication number
- CN103271031A CN103271031A CN2013101812666A CN201310181266A CN103271031A CN 103271031 A CN103271031 A CN 103271031A CN 2013101812666 A CN2013101812666 A CN 2013101812666A CN 201310181266 A CN201310181266 A CN 201310181266A CN 103271031 A CN103271031 A CN 103271031A
- Authority
- CN
- China
- Prior art keywords
- metalaxyl
- cyano
- amino
- phenylancryic acetate
- bactericide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to a sterilization composition containing cyanoacrylate bactericide and metalaxyl-M. The sterilization composition is prepared by carrying out binary compounding on effective components, namely the cyanoacrylate bactericide and the metalaxyl-M. The mass ratio of the cyanoacrylate bactericide to penconazole is 1-40 to 40-1; the mass percentage of the effective components, namely the cyanoacrylate bactericide and the metalaxyl-M, in the preparation is 1-80 percent; and other components are pesticidally allowable and acceptable auxiliary components. The sterilization composition can be in the form of missible oil, suspension agent, wettable powder, water diffusion particle, water emulsion, microemulsion, granules and micro capsules and can be used for preventing and treating downy mildew, phytophthora root rot, pythium, wheat gibberellic disease, cotton fusarium wilt, banana panama disease, fusarium moniliforme sheld, watermelon fusarium wilt and the like.
Description
Technical field
The present invention relates to the agriculture chemical compounding technical field, particularly relate to a kind of bactericidal composition that contains 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M.
Background technology
2-cyano-3-amino-3-phenylancryic acetate is the cyanoacrylate bactericide of a kind of novel structure, mode of action uniqueness, chemical name: 2-cyano group-3-aminoacrylic acid ethyl ester, the disease that 2-cyano-3-amino-3-phenylancryic acetate causes the reaping hook mushroom is effective, has protective effect and therapeutic action.Can be used for preventing and treating wheat scab, cotton wilt, banana Panama disease, bakanae disease of rice, watermelon blight etc.
Metalaxyl-M is the R isomer of common metalaxyl, is a kind of efficient systemic fungicide.Metalaxyl-M has protection and therapeutic action, and drug effect is high, residual low, has good Environmental compatibility, is a kind of systematic, has the bactericide of prevention and therapeutic efficiency.This product is to Pseudoperonospora cubensis, the phytophthora root rot bacterium, and the vegetables due to rotten mildew fungus, fruit tree, tobacco, oil plant, cotton, the crop pests such as grain have efficiently.The chemical name of Metalaxyl-M is (R)-N-(2-methoxyl group acetyl group)-N-(2,6-xylyl)-2-methyl lactamine, and its chemical structural formula is
.
Using chemical agent is the most effectively means of controlling plant diseases.But long-term use single chemical bactericide continuously high dose, easily cause the problems such as residual, the environmental pollution of medicament and anti-pesticide resistance fungi development.Reasonably chemical bactericide is composite or be mixed and have the expansion fungicidal spectrum, improve control efficiency, extend the optimum period for applying fertilizer, reduce dosage, reduce poisoning, reduce residual, delay Antifungal resistance and the positive characteristics such as drug-fast generation and development, bactericide compounded is one of the effective method the most addressed the above problem.Exploitation new product bactericide price is constantly soaring, and by contrast, exploitation is efficient with research, low toxicity, low-residual composite be mixed there is small investment, the lead time is short and be subject to domestic and international attention, the numerous and confused dynamics that develops that strengthens.We filter out 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M and carry out compositely on the basis of lab screening and field trial, have obvious synergistic effect.And there is no at present the people about the composite bactericidal composition of 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M and application reported.
Summary of the invention
Based on above situation, the object of the invention is to provide a kind of new and effective pesticide sterilizing composite.Can be used for preventing and treating downy mildew, phytophthora root rot, rotten mildew, wheat scab, cotton wilt, banana Panama disease, bakanae disease of rice, watermelon blight etc.
Technical scheme of the present invention realizes by following measures:
A kind of bactericidal composition that contains 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M, two yuan of the active ingredient 2-cyano-3-amino-3-phenylancryic acetate of this bactericidal composition and Metalaxyl-Ms are composite, and all the other are auxiliary element.In wherein said bactericidal composition, the mass ratio of active ingredient 2-cyano-3-amino-3-phenylancryic acetate and penconazole is 1～40: 40～1, described bactericidal composition of the present invention is through the toxicity test experimental verification, the mass ratio of 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M is 1～40: 40～1 o'clock, and synergistic effect is better.
The formulations of pesticide that described bactericidal composition of the present invention can be prepared are missible oil, suspending agent, wetting powder, water dispersible granules, aqueous emulsion, microemulsion, granule, microcapsule formulations.Wherein active ingredient 2-cyano-3-amino-3-phenylancryic acetate and the Metalaxyl-M gross mass in preparation accounts for 1%～80% of the whole quality of the pharmaceutical preparations, while wherein accounting for 5%～50%, and toxicity and the residual balance preferably that reaches, cost is also lower.
The specific embodiments of the formulations of pesticide that bactericidal composition of the present invention is mixed with is as follows:
Described bactericidal composition is cream preparation, and the mass fraction of component is: 1～40 part of 2-cyano-3-amino-3-phenylancryic acetate; 1～40 part of Metalaxyl-M; 10～30 parts of conventional emulsifiers; 20～50 parts of conventional solvents; 1～5 part of conventional synergist.The concrete production stage of this cream preparation adds emulsifier, the synergist rear oily liquids that becomes transparent and homogeneous that stirs again for first active ingredient 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M being added in solvent after dissolving fully, filling, can be made into the cream preparation of the present composition.
Described bactericidal composition is suspending agent, and the mass fraction of component is: 1～40 part of 2-cyano-3-amino-3-phenylancryic acetate; 1～40 part of Metalaxyl-M; 5～20 parts of dispersants; 1～5 part of antifreezing agent; 0.1～2 part of thickener; 0.1～0.8 part of defoamer; 0～10 part of penetrating agent; 0.1～5 part of pH value conditioning agent; Water, surplus.The concrete production stage of this suspending agent is for first mixing other auxiliary agents, mix through high speed shear, add active ingredient 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M, in ball crusher, abrading-ball is 2～3 hours, make a diameter all below 5mm, can be made into the suspending agent preparation of the present composition.
Described bactericidal composition is wetting powder, and the mass fraction of component is: 1～40 part of 2-cyano-3-amino-3-phenylancryic acetate; 1～40 part of Metalaxyl-M; 3～10 parts of dispersants; 1～5 part of wetting agent; Filler, surplus.The concrete production stage of this wetting powder is: by above-mentioned formula, the active ingredient 2-cyano-3-amino-3-phenylancryic acetate is mixed with Metalaxyl-M and dispersant, wetting agent and filler, uniform stirring in stirred tank, mixing after airslide disintegrating mill, can be made into the wetting powder of the present composition.
Described bactericidal composition is water dispersible granules, and the mass fraction of component is: 1～40 part of 2-cyano-3-amino-3-phenylancryic acetate; 1～40 part of Metalaxyl-M; 3～10 parts of dispersants; 1～10 part of wetting agent; 1～5 part of disintegrant; Filler, surplus.The concrete production stage of this water dispersible granules is: by above-mentioned formula, the active ingredient 2-cyano-3-amino-3-phenylancryic acetate is mixed with Metalaxyl-M and dispersant, wetting agent, disintegrant and filler, with micro jet, pulverize, through mediating, then add in the fluidized bed prilling dryer and carry out granulation, drying, screening by sample analysis, can be made into the water dispersible granules of the present composition.
Described bactericidal composition is aqueous emulsion, and the mass fraction of component is: 1～40 part of 2-cyano-3-amino-3-phenylancryic acetate; 1～40 part of Metalaxyl-M; 3～30 parts of emulsifier; 5～15 parts of solvents; 2～15 parts of stabilizing agents; 1～5 part of antifreezing agent; 0.1～8 part of defoamer; 0.2～2 part of thickener; Water, surplus.The concrete production stage of this aqueous emulsion is: at first 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M, solvent and emulsifier, cosolvent are added together, make to be dissolved into uniform oil phase; By part water, antifreeze, other the insecticides adjuvant such as antimicrobial mixes into uniform water; When the reactor high speed stirs, oil phase is added to water, slowly add water until reach the phase inversion point, open clipper and carry out high speed shear, and add remaining water, shear about half an hour, form the aqueous emulsion of oil-in-water type, can be made into the aqueous emulsion of the present composition.
Described bactericidal composition is microemulsion, and the mass fraction of component is: 1～40 part of 2-cyano-3-amino-3-phenylancryic acetate; 1～40 part of Metalaxyl-M; 10～30 parts of emulsifier, 1～8 part of antifreezing agent, 0.5～10 part of stabilizing agent, 20～50 parts of conventional solvent cosolvents.2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M are dissolved fully with cosolvent, then add other compositions such as emulsifier, antifreezing agent stabilizing agent, evenly mix, finally add water, after fully stirring, can be made into microemulsion.
Described bactericidal composition is granule, and the mass fraction of component is: 1～40 part of 2-cyano-3-amino-3-phenylancryic acetate; 1～40 part of Metalaxyl-M; 1～10 part of wetting dispersing agent; 0.1～5 part of thickener; 0.1～5 part of defoamer; Castor oil, surplus is supplied.The active ingredient 2-cyano-3-amino-3-phenylancryic acetate is mixed in the ratio of formula with each components such as Metalaxyl-M, dispersant, stabilizing agent, defoamer and solvents, after putting into the grinding of sand milling still, send in mixer for well-distribution and mix and get product.
Described bactericidal composition is microcapsule formulations, and the mass fraction of component is: 1～40 part of 2-cyano-3-amino-3-phenylancryic acetate; 1～40 part of Metalaxyl-M; 5～20 parts, urea; 5～20 parts, formaldehyde; 5～20 parts of emulsifying dispersants; 1～5 part of antifreezing agent; 0.1～2 part of thickener; 0.1～0.8 part of defoamer; Water, surplus.In being housed, the there-necked flask of agitating device adds urea and formaldehyde (the amount of substance ratio is about l:1.5～2.0), with the pH value to 8 of sodium hydroxide solution regulator solution～9 left and right, then be warming up to 70～80 ℃, reaction obtains stable urea resin prepolymer.The former medicine of getting a certain amount of 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M is dissolved in cyclohexane, and adds emulsifying dispersant in solution, follows vigorous stirring, the O/W type stable emulsion that to be made into the aqueous solution of take containing emulsifying dispersant be water.Above-mentioned urea resin prepolymer is added in emulsion, regulate the pH value, polymerization reaction take place under the acid catalysis condition, be wrapped oil phase substance, forms microcapsule granule.Slowly heat up, solidify, temperature is controlled at 40～50 ℃, hardening time 1h.Selection adds appropriate auxiliary agent, the microcapsule suspending agent that gets final product stablely.
Wherein above-described emulsifier is selected from calcium dodecyl benzene sulfonate and aliphatic acid polyethenoxy ether, the alkylphenol polyoxyethylene sulfosuccinate, styrylphenol polyoxyethylene ether, polyoxyethylene nonylphenol ether, castor oil polyoxyethylene ether, aliphatic acid polyethenoxy base ester, any or more than one any mixtures than forming in polyoxyethylene aliphatic alcohol ether.
Described solvent is dimethylbenzene or biodiesel, toluene, and diesel oil, methyl alcohol, ethanol, n-butanol, isopropyl alcohol, turpentine oil, solvent naphtha, dimethyl formamide, dimethyl sulfoxide (DMSO), one or more in the water equal solvent are arbitrarily than the mixture formed.
Described dispersant is selected from polycarboxylate, lignosulfonates, alkylphenol polyoxyethylene methyl ether condensate sulfate, the alkylsulfonate calcium salt, the naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol polyoxyethylene, polyoxyethylene carboxylate, aliphatic amine polyoxyethylene ether, one or more in the fatty acid glyceride APEO.
Described wetting agent is selected from lauryl sodium sulfate, calcium dodecyl benzene sulfonate, and Nekal BX, moistening bleeding agent F, alkylbenzenesulfonate polyoxyethylene triphen is phosphenylic acid salt dimly, spaonin powder, silkworm excrement, one or more in the soapberry powder.
Described disintegrant is selected from bentonite, urea, ammonium sulfate, aluminium chloride, citric acid, succinic acid, one or more in sodium bicarbonate.
Described thickener is selected from xanthans, carboxymethyl cellulose, carboxyethyl cellulose, methylcellulose, Magnesiumaluminumsilicate, in polyvinyl alcohol one or more.
Described stabilizing agent is selected from sodium citrate, a kind of in resorcinol.
Described antifreezing agent is selected from ethylene glycol, propane diols, one or more in glycerine.
Described defoamer is selected from silicone oil, silicone compound, C
10-20the saturated fat acid compounds, C
8-10one or more of fatty alcohol.
Described filler is selected from kaolin, diatomite, bentonite, attapulgite, white carbon, starch, one or more in precipitated calcium carbonate.
The present invention be take the composite bactericide that 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M be active ingredient and is had obvious synergistic effect, delays the drug-fast generation in key, and has reduced to become to produce cost and use cost, can be used for the improvement of resistance disease.Can be used for preventing and treating downy mildew, phytophthora root rot, rotten mildew, wheat scab, cotton wilt, banana Panama disease, bakanae disease of rice, watermelon blight etc.
Embodiment
For making technical scheme of the present invention, purpose and advantage are clearer, and the present invention describes with following specific embodiment, but the present invention is not limited to these examples.The mode that effect experiment of the present invention adopts indoor biometrics and field trial to combine, if no special instructions, the ratio of below mentioning is all ratio of quality and the number of copies.
Embodiment: 2-cyano-3-amino-3-phenylancryic acetate proportioning co-toxicity experiments different from Metalaxyl-M.
1.1 reagent agent
The former medicine of 95% 2-cyano-3-amino-3-phenylancryic acetate, the former medicine of 95% Metalaxyl-M, above-mentioned former medicine provides by research and development department of extra large rel medicine company limited company.
1.2 test target
Never executed 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M from Shouguang, Shandong and cucumber of the same type gathers and separates potted plantly, for the examination cucumber variety: Chang Chun Mi Ci.
1.3 test method
1.3.1 medicament preparation
First use the former medicine of acetone solution, according to the result of preliminary experiment, two appropriate former medicines are made into to different proportionings, then it is stand-by with acetone, each processing to be diluted to respectively to some concentration gradients.
Susceptible cucumber variety Chang Chun Mi Ci cultivation, in pot for growing seedlings, is placed in to greenhouse and cultivates, and plant grows to three to four leaf after dates, gathers the blade of identical leaf age, for cultivation and the mensuration of cucumber downy mildew germ.
1.3.2 the cultivation of bacterium of downy mildew of cucumber and the preparation of spore suspension
Bacterium of downy mildew of cucumber adopts the plants method to cultivate under 20 ℃, the condition of 12h alternation of light and darkness, and every 30 d turn culture 1 time.During inoculation, with the conidium on sterile water wash-out incidence of leaf, being mixed with spore concentration is l * 10
6the suspension of individual/mL.
1.3.3 strains tested sensitivity testing
Adopt leaf dish moisturizing method to carry out toxicity test.First the blade of collection is prepared into to the leaf dish that diameter is 1.5cm, mix at random, be placed in respectively the series concentration liquid configured and soak lh, 50 leaf dishes of each concentration, test is with the blank that is treated to of adding medicine not, after soaking end, leaf faces up and puts on the blotting paper wetting in identical liquor strength, liquid on the leaf dish is blotted, the spore suspension l0L prepared is inoculated in to leaf dish central authorities, after room temperature is placed 5 min, is placed under 20 ℃, the condition of 1 2h alternation of light and darkness and cultivates, measure the onset area on the leaf dish after 10d, calculate EC
50.
On the basis of preliminary experiment, respectively single dose 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M are carried out to toxicity test in order to upper method, the two EC
50value is respectively 4.25 ㎎/l and 1.97 ㎎/l.
The percentage that accounts for the leaf disc area according to lesion area is divided sick level
0 grade: anosis;
1 grade: the sorus area accounts for below 5% of whole leaf area;
3 grades: the sorus area accounts for below the 6%-10% of whole leaf area;
5 grades: the sorus area accounts for below the 11%-20% of whole leaf area;
7 grades: the sorus area accounts for below the 21%-50% of whole leaf area;
9 grades: the sorus area accounts for more than 50% of whole leaf area.
1.3.4 mixture toxicity test and interpretation of result
Carry out the toxicity test of mixture according to mixed ratio by single dose toxicity test method.
If contrast lethality<5%, do not proofread and correct, the contrast lethality, between 5%-20%, is proofreaied and correct by formula 2, the contrast lethality > 20%, test need be reformed.
The logarithm value of drug concentration (mg/L) of take is independent variable x, and the probability value of corrected mortality of take is dependent variable y, sets up respectively the virulence regression equation formula, adopts DPS software to calculate the EC of single dose and each proportioning mixture
50calculate co-toxicity coefficient (CTC) according to the abundant method of Sun Yun.Co-toxicity coefficient CTC, computing formula is as follows: (take 2-cyano-3-amino-3-phenylancryic acetate as the standard medicament, its toxicity index is 100):
The EC of the toxicity index of Metalaxyl-M (TI)=2-cyano-3-amino-3-phenylancryic acetate
50the EC of/Metalaxyl-M
50* 100
The EC of the true toxicity index (ATI) of M=2-cyano-3-amino-3-phenylancryic acetate
50the EC of/M
50* 100
The TI of the TI of the theoretical toxicity index (TTI) of M=2-cyano-3-amino-3-phenylancryic acetate * P 2-cyano-3-amino-3-phenylancryic acetate+Metalaxyl-M * P Metalaxyl-M
The TTI of the ATI/M of the co-toxicity coefficient of M (CTC)=M * 100
In formula:
M is 2-cyano-3-amino-3-phenylancryic acetate and the mixture of the different proportionings of Metalaxyl-M
The P 2-cyano-3-amino-3-phenylancryic acetate is 2-cyano-3-amino-3-phenylancryic acetate shared ratio in mixture
The P Metalaxyl-M is Metalaxyl-M shared ratio in mixture.
2.1 toxicity test result
Table 1 2-cyano-3-amino-3-phenylancryic acetate and the Metalaxyl-M toxicity test to cucumber downy mildew
As can be seen from the table, the result of the test of different proportion proportioning shows, dilute respectively and all show stronger synergistic effect in the active ingredient ratio, wherein take 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M as 1:10～10:1 the time the good suggestion of synergistic effect suitable proportion 1:10～10:1 left and right mixture preparation is carried out to further field control effectiveness test, to estimate its field practical application effect.
The experimental result of 3 field trial control cucumber downy mildews, wheat scab
3.1 field trial control cucumber downy mildew
3.1.1 test method
Test is at 4 points of Pingdu City cucumber Di，Mei community, Shandong investigation, and every some investigation 2 strains, put down in writing occurring degree by staging, and grade scale is as follows:
0 grade: anosis;
1 grade: the sorus area accounts for below 5% of whole leaf area;
3 grades: the sorus area accounts for below the 6%-10% of whole leaf area;
5 grades: the sorus area accounts for below the 11%-20% of whole leaf area;
7 grades: the sorus area accounts for below the 21%-50% of whole leaf area;
9 grades: the sorus area accounts for more than 50% of whole leaf area.
3.1.2 control time and number of times
Test is investigated 4 times altogether, and radix investigation before medicine is investigated after 10 days, 10 days for the second time and medicine after medicine for the first time in 21 days.
3.1.3 drug effect computational methods
Sick leaf rate (%)=sick number of sheets/investigate total number of sheets * 100
Disease index=∑ (the sick numbers of sheets at different levels * relative level numerical value)/(investigating total number of sheets * 9) * 100
Control efficiency (%)=(disease index after disease index before 1-(blank district medicine * treatment region medicine)/(disease index before disease index after blank district medicine * treatment region medicine)) * 100.
3.1.4 poisoning investigation method
After dispenser, whether continuous 10d range estimation medicament has poisoning to crop.
3.1.5 result of the test and analysis
Each processes the effect of control cucumber downy mildew.(table 2)
Each processes the effect of control cucumber downy mildew table 2
As shown in Table 2 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M with 1:6 ratio composite bactericide for cucumber downy mildew control successful higher than 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M single dose, bactericidal effect increases progressively with the increase of dosage.According to the field range estimation, in the test dose scope, plant growth is normal, and the poisoning phenomenon to cucumber does not all appear in each treatment agent, illustrates that it is safe to cucumber.Advise that the bactericide different from the mechanism of action mixes use to delay the drug-fast generation of germ.
4.1 field trial is prevented and treated wheat scab
4.1.1 test method
Test, at Shandong Pingdu City wheat paddock, adopts 5 points of diagonal sampling ，Mei community investigation, the sick spike number in 100～200 wheat heads of every some casual inspection, and severity extent is divided into 5 grades by ocular estimate:
0 grade anosis;
The sick spikelet number of I level accounts for below 1/4 of whole small ears;
The sick spikelet number of II level accounts for 1/4～1/2 of whole small ears;
The sick spikelet number of III level accounts for 1/2～3/4 of whole small ears;
The sick spikelet number of IV level accounts for more than 3/4 of whole small ears.
4.1.2 control time and number of times
Test is investigated 4 times altogether, radix investigation before medicine, for the first time after medicine 10 days, after 10 days and medicine, within 21 days, investigated after medicine for the second time.
4.1.3 drug effect computational methods
Disease tassel yield (%)=sick spike number/investigate total spike number * 100
Disease index=∑ (sick spike numbers at different levels * relative level numerical value)/(investigating total spike number * 4) * 100
Control efficiency (%)=(disease index after disease index before 1-(blank district medicine * treatment region medicine)/(disease index before disease index after blank district medicine * treatment region medicine)) * 100.
4.1.4 poisoning investigation method
After dispenser, whether continuous 7d range estimation medicament has poisoning to crop.
4.1.5 result of the test and analysis
Each processes the effect (table 3) of preventing and treating wheat scab
Each processes the effect of preventing and treating wheat scab table 3
The Mixed Pharmacy of different proportion, tested by different consumptions as can be seen from Table 3,2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M with 1:6 ratio compound medicine after its control to wheat scab all be better than contrasting medicament and bactericidal effect and increase progressively with the increase of dosage.According to the field range estimation, in the test dose scope, plant growth is normal, and the poisoning phenomenon to wheat does not all appear in each treatment agent, illustrates that it is safe to wheat.Advise that the bactericide different from the mechanism of action mixes use to delay the drug-fast generation of germ.
In sum, the Bactericidal composite that the present invention contains 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M, have good control efficiency to cucumber downy mildew, wheat scab, and it is to the target crop safety.Complex preparation has not only improved preventive effect, and has enlarged fungicidal spectrum, widens the scope of application, reduces costs, and multiple diseases is played to the double effect of controlling of a medicine, alleviates manpower and materials, improves productivity effect.So the invention of this complex preparation is of great significance social tool with popularization.
Claims (4)
1. a bactericidal composition that contains 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M, it is characterized in that: the active ingredient of this bactericidal composition is 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M binary built, all the other are auxiliary element, and wherein the mass ratio of active ingredient 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M is 1～40: 40～1.
2. bactericidal composition according to claim 1, it is characterized in that: 2-cyano-3-amino-3-phenylancryic acetate and the Metalaxyl-M gross weight in preparation accounts for 1%～80% of the whole quality of the pharmaceutical preparations.
3. bactericidal composition according to claim 2, it is characterized in that: 2-cyano-3-amino-3-phenylancryic acetate and the Metalaxyl-M gross weight in preparation accounts for 5%～50% of the whole quality of the pharmaceutical preparations.
4. according to claim 1 or 2 or 3 described bactericidal compositions, it is characterized in that: the formulation of this bactericidal composition is missible oil, suspending agent, wetting powder, water dispersible granules, aqueous emulsion, microemulsion, granule, microcapsule formulations
.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310181266.6A CN103271031B (en) | 2013-05-16 | 2013-05-16 | A kind of bactericidal composition containing 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310181266.6A CN103271031B (en) | 2013-05-16 | 2013-05-16 | A kind of bactericidal composition containing 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103271031A true CN103271031A (en) | 2013-09-04 |
| CN103271031B CN103271031B (en) | 2017-10-03 |
Family
ID=49053278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310181266.6A Active CN103271031B (en) | 2013-05-16 | 2013-05-16 | A kind of bactericidal composition containing 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103271031B (en) |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103947640A (en) * | 2014-05-28 | 2014-07-30 | 陕西上格之路生物科学有限公司 | Bactericidal composition for controlling soil-borne diseases of crops |
| CN103975935A (en) * | 2014-05-28 | 2014-08-13 | 陕西上格之路生物科学有限公司 | Sterilization composition for preventing and treating soil-borne diseases of crops |
| CN104082309A (en) * | 2014-07-28 | 2014-10-08 | 江苏省绿盾植保农药实验有限公司 | Thiabendazole and 2-cyano-3-phenyl-3-amino ethyl acrylate compounded bactericidal composition and application thereof |
| CN104705307A (en) * | 2013-12-12 | 2015-06-17 | 南京华洲药业有限公司 | Sterilization composition containing penconazole and metalaxyl-M, and applications thereof |
| CN105340916A (en) * | 2015-12-19 | 2016-02-24 | 青岛奥迪斯生物科技有限公司 | Bactericidal composition containing efficient metalaxyl-M and dimethomorph |
| CN105660643A (en) * | 2016-04-01 | 2016-06-15 | 广西南宁益土生物科技有限责任公司 | Suspended seed coating agent capable of promoting germination and growth of seeds |
| CN105815333A (en) * | 2014-11-12 | 2016-08-03 | 陕西上格之路生物科学有限公司 | Bactericidal composition containing diacetonamine oxalate-copper |
| CN106538536A (en) * | 2015-09-18 | 2017-03-29 | 南京华洲药业有限公司 | The bactericidal composition and its application of a kind of 2-cyano-3-amino-3-phenylancryic acetate-containing and metalaxyl |
| CN106538535A (en) * | 2015-09-18 | 2017-03-29 | 南京华洲药业有限公司 | The bactericidal composition and its application of a kind of 2-cyano-3-amino-3-phenylancryic acetate-containing and Metalaxyl-M |
| CN106538537A (en) * | 2015-09-18 | 2017-03-29 | 南京华洲药业有限公司 | The bactericidal composition and its application of a kind of 2-cyano-3-amino-3-phenylancryic acetate-containing and M 9834 |
| CN107087605A (en) * | 2017-04-12 | 2017-08-25 | 江苏金凤凰农化有限公司 | A kind of composition and application process that cotton wilt is treated based on guaiacol |
| CN107960414A (en) * | 2017-12-26 | 2018-04-27 | 江苏省农药研究所股份有限公司 | A kind of bactericidal composition containing 2-cyano-3-amino-3-phenylancryic acetate and its application |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101984809A (en) * | 2010-07-22 | 2011-03-16 | 福建诺德生物科技有限责任公司 | Oil suspension preparation using resin-based vegetable oil as carrier and preparation method thereof |
-
2013
- 2013-05-16 CN CN201310181266.6A patent/CN103271031B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101984809A (en) * | 2010-07-22 | 2011-03-16 | 福建诺德生物科技有限责任公司 | Oil suspension preparation using resin-based vegetable oil as carrier and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 刁亚梅等: "创制杀菌剂氰烯菌酯的应用研究", 《植物保护》 * |
| 赵秀梅: "35%精甲霜灵种子处理乳剂防治花生根腐病田间药效试验", 《黑龙江农业科学》 * |
| 郎玉成等: "新型杀菌剂――氰烯菌酯(JS399-19)", 《世界农药》 * |
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104705307A (en) * | 2013-12-12 | 2015-06-17 | 南京华洲药业有限公司 | Sterilization composition containing penconazole and metalaxyl-M, and applications thereof |
| CN103975935B (en) * | 2014-05-28 | 2016-08-24 | 陕西上格之路生物科学有限公司 | A kind of bactericidal composition preventing and treating crops soil-borne disease |
| CN103975935A (en) * | 2014-05-28 | 2014-08-13 | 陕西上格之路生物科学有限公司 | Sterilization composition for preventing and treating soil-borne diseases of crops |
| CN103947640A (en) * | 2014-05-28 | 2014-07-30 | 陕西上格之路生物科学有限公司 | Bactericidal composition for controlling soil-borne diseases of crops |
| CN103947640B (en) * | 2014-05-28 | 2016-08-24 | 陕西上格之路生物科学有限公司 | A kind of bactericidal composition preventing and treating crops soil-borne disease |
| CN104082309A (en) * | 2014-07-28 | 2014-10-08 | 江苏省绿盾植保农药实验有限公司 | Thiabendazole and 2-cyano-3-phenyl-3-amino ethyl acrylate compounded bactericidal composition and application thereof |
| CN104082309B (en) * | 2014-07-28 | 2016-06-29 | 江苏丘陵地区镇江农业科学研究所 | A kind of bactericidal composition composite containing probenazole and 2-cyano-3-amino-3-phenylancryic acetate and application thereof |
| CN105815333B (en) * | 2014-11-12 | 2017-11-17 | 陕西上格之路生物科学有限公司 | A kind of bactericidal composition containing oxalic acid copper diacetonamine |
| CN105815333A (en) * | 2014-11-12 | 2016-08-03 | 陕西上格之路生物科学有限公司 | Bactericidal composition containing diacetonamine oxalate-copper |
| CN106538537A (en) * | 2015-09-18 | 2017-03-29 | 南京华洲药业有限公司 | The bactericidal composition and its application of a kind of 2-cyano-3-amino-3-phenylancryic acetate-containing and M 9834 |
| CN106538536A (en) * | 2015-09-18 | 2017-03-29 | 南京华洲药业有限公司 | The bactericidal composition and its application of a kind of 2-cyano-3-amino-3-phenylancryic acetate-containing and metalaxyl |
| CN106538535A (en) * | 2015-09-18 | 2017-03-29 | 南京华洲药业有限公司 | The bactericidal composition and its application of a kind of 2-cyano-3-amino-3-phenylancryic acetate-containing and Metalaxyl-M |
| CN105340916A (en) * | 2015-12-19 | 2016-02-24 | 青岛奥迪斯生物科技有限公司 | Bactericidal composition containing efficient metalaxyl-M and dimethomorph |
| CN105660643A (en) * | 2016-04-01 | 2016-06-15 | 广西南宁益土生物科技有限责任公司 | Suspended seed coating agent capable of promoting germination and growth of seeds |
| CN107087605A (en) * | 2017-04-12 | 2017-08-25 | 江苏金凤凰农化有限公司 | A kind of composition and application process that cotton wilt is treated based on guaiacol |
| CN107960414A (en) * | 2017-12-26 | 2018-04-27 | 江苏省农药研究所股份有限公司 | A kind of bactericidal composition containing 2-cyano-3-amino-3-phenylancryic acetate and its application |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103271031B (en) | 2017-10-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103271031A (en) | Sterilization composition containing cyanoacrylate bactericide and metalaxyl-M | |
| CN103355333A (en) | Sterilization composition containing pyraclostrobin and boscalid | |
| CN105409990A (en) | Sterilization composition containing pyraclostrobin and efficient metalaxyl-M | |
| CN103168780A (en) | Bactericidal composition containing fluopicolide and metrafenone | |
| CN103719102A (en) | Sterilization composite containing fluopyram and prothioconazole | |
| CN103355308A (en) | Sterilization composition containing prothioconazole and boscalid | |
| CN103125508A (en) | Bactericidal composition containing fluopicolide and benthiavalicarb-isopropyl | |
| CN103081913A (en) | Sterilization composition containing boscalid and kresoxim-methyl | |
| CN103125494A (en) | Bactericidal composition containing (E,E,E)-N-methyl-2-[((((1-methyl-3-(2,6-dichlorophenyl)-2-propenyl)imino)oxy)methyl)phenyl]-2-methoxyiminoacetamide and penthiopyrad | |
| CN105409976A (en) | Sterilization composition containing efficient metalaxyl-M and flumorph | |
| CN105475317A (en) | Sterilization combination containing efficient metalaxyl-M and cymoxanil | |
| CN103229767A (en) | Trifloxystrobin and bupirimate-containing sterilization composition | |
| CN103141493A (en) | Bactericidal composition containing difenoconazole and benthiavalicarb-isopropyl | |
| CN103355334A (en) | Sterilization composition containing pyraclostrobin and famoxadone | |
| CN103355316A (en) | Bactericide composition containing N-methyl-3-(4-chloro)phenyl-5-methyl-5-pyridyl-3-methyl-oxazoline and methyl (E)-2-(2-((3-(4-chlorphenyl)-1-methyl-1H-pyrazolyl-5-oxy)methyl)phenyl-3-methoxyacrylate | |
| CN103931640A (en) | Bactericidal composition containing meptyldinocap and pyraclostrobin | |
| CN103688938A (en) | Bactericidal composition containing fluopyram and bupirimate | |
| CN104054708A (en) | Bactericidal composition containing meptyldinocap and spiroxamine | |
| CN103503879A (en) | Sterilization composition containing prothioconazole and bupirimate | |
| CN103975928A (en) | Bactericidal composition containing meptyldinocap and penconazole | |
| CN103688951A (en) | Bactericidal composition containing fluopyram and pyrisoxazole | |
| CN103688965A (en) | Bactericidal composition containing fluopyram and pyraclostrobin | |
| CN103355318A (en) | Sterilization composition containing pyrisoxazole and flumorph | |
| CN103688939A (en) | Bactericidal composition containing fluopyram and ethirimol | |
| CN104041494A (en) | Bactericidal composition containing meptyldinocap and bupirimate |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20191112 Address after: 262737 Lingang Industrial Park, Binhai Economic Development Zone, Weifang, Shandong Patentee after: Shandong Hailir Chemical Co.,Ltd. Address before: Changyang Industrial Park in Laixi city of Shandong Province, Qingdao City, 266603 Patentee before: Qingdao Audis Bio & Tech Co., Ltd. |