CN103271031B - A kind of bactericidal composition containing 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M - Google Patents
A kind of bactericidal composition containing 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M Download PDFInfo
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Abstract
The present invention relates to a kind of bactericidal composition containing 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M, its active ingredient is 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M binary built.Wherein the mass ratio of 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M is 1~40: 40~1, the quality parts ratio 1%~80% of active ingredient 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M in preparation, remaining is the auxiliary element for allowing to use and receiving in agricultural chemicals, and the formulation of bactericidal composition of the present invention is missible oil, suspending agent, wettable powder, water dispersible granules, aqueous emulsion, microemulsion, granule, microcapsule formulations.Available for preventing and treating downy mildew, phytophthora root rot, rotten mildew, wheat scab, cotton wilt, banana Panama disease, bakanae disease of rice, watermelon blight etc..
Description
Technical field
The present invention relates to technical field of pesticide combination, more particularly to a kind of sterilization containing 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M
Composition.
Background technology
2-cyano-3-amino-3-phenylancryic acetate is the cyanoacrylate bactericide that a kind of structure is novel, the mode of action is unique, chemical name：2-
Cyano group -3- aminoacrylic acid ethyl esters, 2-cyano-3-amino-3-phenylancryic acetate effectively, is made to disease caused by reaping hook mushroom with protective effect and treatment
With.Available for preventing and treating wheat scab, cotton wilt, banana Panama disease, bakanae disease of rice, watermelon blight etc..
Metalaxyl-M is the R isomers of common metalaxyl, is a kind of efficient systemic fungicide.Metalaxyl-M have protection and
Therapeutic action, drug effect is high, it is low to remain, with good Environmental compatibility, is a kind of systematic, with prevention and treatment effect
Bactericide.This product is to Pseudoperonospora cubensis, phytophthora germ, the vegetables caused by rotten mildew fungus, fruit tree, tobacco, oil plant, cotton, grain
Have efficiently etc. crop disease.The chemical name of Metalaxyl-M is (R)-N- (2- Methoxyacetyls)-N- (2,6- dimethylbenzene
Base) -2- methyl lactamines, its chemical structural formula is
It is the maximally efficient means of controlling plant diseases using chemical agent.But apply single long-term continuous high dose
Chemical bactericide, the problems such as residual, environmental pollution and the resistance to resistance to the action of a drug fungi for easily causing medicament are developed.Rational chemistry
Bactericide compounded or mixture have expand fungicidal spectrum, improve prevention effect, extension the optimum period for applying fertilizer, reduce dosage, reduction poisoning,
Reduce residual, delay Antifungal resistance and drug-fast generation and the positive feature such as development, bactericide compounded is to solve above-mentioned ask
One of maximally efficient method of topic.Develop new product bactericide price constantly rises, and by contrast, exploitation with research efficiently,
Low toxicity, the compounding of low-residual and mixture has small investment, the lead time is short and is paid attention to both at home and abroad, numerous and confused increase develop
Dynamics.We screen and on the basis of field test, filter out 2-cyano-3-amino-3-phenylancryic acetate and compounded with Metalaxyl-M indoors, with bright
Aobvious synergistic effect.And there is no people to report at present on the bactericidal composition and application of 2-cyano-3-amino-3-phenylancryic acetate and the compounding of Metalaxyl-M
Cross.
The content of the invention
Based on case above, present invention aims at provide a kind of new and effective pesticide sterilizing composite.Available for preventing
Downy mildew, phytophthora root rot, rotten mildew, wheat scab, cotton wilt, banana Panama disease, bakanae disease of rice, watermelon is controlled to wither
Disease etc..
Technical scheme of the present invention is realized by following measures：
A kind of bactericidal composition containing 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M, the active ingredient 2-cyano-3-amino-3-phenylancryic acetate of the bactericidal composition
Compounded with Metalaxyl-M two-spot, remaining is auxiliary element.Active ingredient 2-cyano-3-amino-3-phenylancryic acetate and smart first in wherein described bactericidal composition
The mass ratio of white spirit is 1~40: 40~1, described bactericidal composition of the present invention through toxicity test experimental verification, 2-cyano-3-amino-3-phenylancryic acetate with
When the mass ratio of Metalaxyl-M is 1~40: 40~1, synergistic effect is preferable.
The formulations of pesticide that described bactericidal composition of the present invention can be prepared are missible oil, suspending agent, wettable powder, moisture
Shot agent, aqueous emulsion, microemulsion, granule, microcapsule formulations.Wherein active ingredient 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M be in the formulation
Gross mass accounts for the 1%~80% of the whole quality of the pharmaceutical preparations, wherein when accounting for 5%~50%, toxicity and residual reach preferable balance, into
This is relatively low.
The specific embodiment for the formulations of pesticide that bactericidal composition of the present invention is configured to is as follows：
Described bactericidal composition is cream preparation, and the mass fraction of component is：1~40 part of 2-cyano-3-amino-3-phenylancryic acetate；Metalaxyl-M 1
~40 parts；10~30 parts of conventional emulsifier；20~50 parts of Conventional solvents；Conventional 1~5 part of synergist.The cream preparation it is specific
Production stage for first will active ingredient 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M add be completely dissolved in solvent after add emulsifying agent, synergy
Agent stir after into transparent and homogeneous oily liquids, it is filling, you can the cream preparation of the present composition is made.
Described bactericidal composition is suspending agent, and the mass fraction of component is：1~40 part of 2-cyano-3-amino-3-phenylancryic acetate；Metalaxyl-M 1~
40 parts；5~20 parts of dispersant；1~5 part of antifreezing agent；0.1~2 part of thickener；0.1~0.8 part of defoamer；Penetrating agent 0~10
Part；0.1~5 part of pH value regulator；Water, surplus.The specific production stage of the suspending agent is first mixes other auxiliary agents, through at a high speed
Shear-mixed is uniform, adds active ingredient 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M, abrading-ball 2~3 hours in ball crusher, makes a diameter equal
In below 5mm, you can the aqueous suspension formulations of the present composition are made.
Described bactericidal composition is wettable powder, and the mass fraction of component is：1~40 part of 2-cyano-3-amino-3-phenylancryic acetate；Smart first frost
1~40 part of spirit；3~10 parts of dispersant；1~5 part of wetting agent；Filler, surplus.The specific production stage of the wettable powder is：
Active ingredient 2-cyano-3-amino-3-phenylancryic acetate is mixed with Metalaxyl-M and dispersant, wetting agent and filler by above-mentioned formula, in stirred tank
Uniform stirring, well mixed after airslide disintegrating mill, you can the wettable powder of the present composition is made.
Described bactericidal composition is water dispersible granules, and the mass fraction of component is：1~40 part of 2-cyano-3-amino-3-phenylancryic acetate；Smart first frost
1~40 part of spirit；3~10 parts of dispersant；1~10 part of wetting agent；1~5 part of disintegrant；Filler, surplus.The tool of the water dispersible granules
Body production stage is：By above-mentioned formula by active ingredient 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M and dispersant, wetting agent, disintegrant and
Filler is well mixed, and is crushed with micro jet, through mediating, then granulated in addition fluidized-bed granulation dryer,
Through sampling analysis after dry, screening, you can the water dispersible granules of the present composition are made.
Described bactericidal composition is aqueous emulsion, and the mass fraction of component is：1~40 part of 2-cyano-3-amino-3-phenylancryic acetate；Metalaxyl-M 1~
40 parts；3~30 parts of emulsifying agent；5~15 parts of solvent；2~15 parts of stabilizer；1~5 part of antifreezing agent；0.1~8 part of defoamer；Thickening
0.2~2 part of agent；Water, surplus.The specific production stage of the aqueous emulsion is：First by 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M, solvent and breast
Agent, cosolvent are added together, and make to be dissolved into uniform oil phase；By part water, antifreeze, other agricultural chemicals such as antimicrobial
Auxiliary agent mixes into uniform aqueous phase；Oil phase is added into aqueous phase while high-speed stirred in a kettle., slowly added water straight
To phase inversion point is reached, open cutter and carry out high speed shear, and add remaining water, shearing about half an hour, form oil-in-water type
Aqueous emulsion, you can the aqueous emulsion of the present composition is made.
Described bactericidal composition is microemulsion, and the mass fraction of component is：1~40 part of 2-cyano-3-amino-3-phenylancryic acetate；Metalaxyl-M 1~
40 parts；10~30 parts of emulsifying agent, 1~8 part of antifreezing agent, 0.5~10 part of stabilizer, 20~50 parts of Conventional solvents cosolvent.By cyanogen
Alkene bacterium ester is completely dissolved with Metalaxyl-M with cosolvent, adds the other compositions such as emulsifying agent, antifreezing agent stabilizer, uniform mixed
Close, be eventually adding water, microemulsion can be made into after being sufficiently stirred for.
Described bactericidal composition is granule, and the mass fraction of component is：1~40 part of 2-cyano-3-amino-3-phenylancryic acetate；Metalaxyl-M 1~
40 parts；1~10 part of wetting dispersing agent；0.1~5 part of thickener；0.1~5 part of defoamer；Castor oil, surplus is supplied.Will effectively into
Divide each component such as 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M, dispersant, stabilizer, defoamer and solvent to be mixed in the ratio of formula, be put into
After being ground in sand milling kettle, mix and get product in feeding mixer for well-distribution.
Described bactericidal composition is microcapsule formulations, and the mass fraction of component is：1~40 part of 2-cyano-3-amino-3-phenylancryic acetate；Metalaxyl-M 1
~40 parts；5~20 parts of urea；5~20 parts of formaldehyde；5~20 parts of emulsifying dispersant；1~5 part of antifreezing agent；0.1~2 part of thickener；
0.1~0.8 part of defoamer；Water, surplus.Urea and formaldehyde (the amount ratio of material are added in the three-necked flask equipped with agitating device
About l：1.5~2.0), the pH value for adjusting solution with sodium hydroxide solution then heats to 70~80 DEG C, instead to 8~9 or so
The urea resin prepolymer that should be stablized.The active compound of a certain amount of 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M is taken to be dissolved in hexamethylene, and
Emulsifying dispersant is added in the solution, and with being stirred vigorously, the O/W types being made into using the aqueous solution containing emulsifying dispersant as aqueous phase are steady
Determine emulsion.Above-mentioned urea resin prepolymer is added in emulsion, pH value is adjusted, occurs polymerisation under acid catalysed conditions,
Oil phase substance is wrapped, microcapsule granule is formed.Slow heating, solidification, temperature control is in 40~50 DEG C, hardening time
1h.Selection adds appropriate auxiliary agent, you can the microcapsule suspending agent that must stablize.
Wherein above-described emulsifying agent is selected from calcium dodecyl benzene sulfonate and aliphatic acid polyethenoxy ether, alkyl phenol polyoxy
Ethene ether sulfosuccinates, styrylphenol polyoxyethylene ether, NPE, castor oil polyoxyethylene ether,
Aliphatic acid polyethenoxy base ester, any one of polyoxyethylene aliphatic alcohol ether or more than one any mixtures than composition.
Described solvent is dimethylbenzene or biodiesel, toluene, diesel oil, methanol, ethanol, n-butanol, isopropanol, turpentine
Any mixing than composition of one or more in oil, solvent naphtha, dimethylformamide, dimethyl sulfoxide (DMSO), water equal solvent
Thing.
Described dispersant is selected from polycarboxylate, lignosulfonates, APES methyl ether condensation product sulfuric acid
Salt, alkylsulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, APES, polyoxyethylene carboxylate, fat
One or more of amine APEO, glycerine fatty acid ester APEO.
Described wetting agent is selected from lauryl sodium sulfate, and calcium dodecyl benzene sulfonate, Nekal BX moistens bleeding agent F,
One or more in alkylbenzenesulfonate polyoxyethylene triphen phosphenylic acid salt dimly, spaonin powder, silkworm excrement, spaonin powder.
Described disintegrant is selected from bentonite, urea, ammonium sulfate, aluminium chloride, citric acid, succinic acid, sodium acid carbonate
It is one or more.
Described thickener be selected from xanthans, carboxymethyl cellulose, carboxyethyl cellulose, methylcellulose, Magnesiumaluminumsilicate,
It is one or more in polyvinyl alcohol.
Described stabilizer is selected from one kind in sodium citrate, resorcinol.
Described antifreezing agent is selected from the one or more in ethylene glycol, propane diols, glycerine.
Described defoamer is selected from silicone oil, silicone compound, C10-20Saturated fat acids compound, C8-10Fatty alcohol
It is one or more.
Described filler is selected from kaolin, diatomite, bentonite, attapulgite, white carbon, starch, precipitated calcium carbonate
One or more.
The present invention has obvious synergistic effect using 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M as the composite bactericide of active ingredient, prolongs
The generation of slow disease drug resistance, and reduce into production cost and use cost, the improvement available for resistance disease.Available for preventing and treating
Downy mildew, phytophthora root rot, rotten mildew, wheat scab, cotton wilt, banana Panama disease, bakanae disease of rice, watermelon blight
Deng.
Embodiment
To make technical scheme, purpose and advantage are more clearly understood, present invention specific examples below
Illustrate, but the present invention is not limited to these examples.The effect experiment of the present invention uses indoor biometricses and field test phase
With reference to mode, unless otherwise instructed, ratio mentioned below is all quality parts ratio.
Embodiment：2-cyano-3-amino-3-phenylancryic acetate is tested with Metalaxyl-M different ratio co-toxicity.
1.1 reagent agent
95% 2-cyano-3-amino-3-phenylancryic acetate active compound, 95% Metalaxyl-M active compound, above-mentioned active compound is by extra large rel medicine company limited company
Research and development department provides.
1.2 experiment targets
From Shandong Shouguang never applied 2-cyano-3-amino-3-phenylancryic acetate and the cucumber of Metalaxyl-M and same type it is potted plant gather and separate, supply
Try cucumber variety：Chang Chun Mi Ci.
1.3 test method
1.3.1 medicament is prepared
Acetone solution active compound is first used, two appropriate active compounds are made into by different ratio according to the result of preliminary experiment, then with third
It is stand-by that each processing is diluted to some concentration gradients by ketone respectively.
By the cultivation of susceptible cucumber variety Chang Chun Mi Ci in pot for growing seedlings, it is placed in greenhouse and cultivates, plant grows to three to four leaves
After phase, the blade of identical leaf age, culture and measure for cucumber downy mildew germ are gathered.
1.3.2 the culture of bacterium of downy mildew of cucumber and the preparation of spore suspension
Bacterium of downy mildew of cucumber is cultivated using plants method under conditions of 20 DEG C, 12h alternation of light and darkness, turns to be commissioned to train per 30d
Support 1 time.With the conidium on sterile water elution incidence of leaf during inoculation, spore concentration is configured to for l × 106Individual/mL's is outstanding
Supernatant liquid.
1.3.3 strains tested sensitivity testing
Toxicity test is carried out using leaf dish moisturizing method.The blade of collection is first prepared into a diameter of 1.5cm leaf dish, at random
Mix, be respectively placed in the series concentration decoction configured and soak lh, each 50 leaf dishes of concentration are tested with the place of not adding medicine
Manage as blank control, after immersion terminates, leaf is face-up placed on the blotting paper of identical liquor strength wetting, in leaf dish
Decoction blot, by the spore suspension l0L prepared be inoculated in leaf dish center, room temperature place 5min after, be placed in 20 DEG C, 12h
Cultivated under conditions of alternation of light and darkness, the onset area after 10d in measurement leaf dish calculates EC50。
On the basis of pilot study, virulence survey is carried out to single dose 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M respectively with above method
It is fixed, the two EC50Value is respectively 4.25 ㎎/l and 1.97 ㎎/l.
The percentage for accounting for leaf dish area according to lesion area divides sick level
0 grade：It is disease-free；
1 grade：Sorus area accounts for less than the 5% of whole leaf area；
3 grades：Sorus area accounts for below the 6%-10% of whole leaf area；
5 grades：Sorus area accounts for below the 11%-20% of whole leaf area；
7 grades：Sorus area accounts for below the 21%-50% of whole leaf area；
9 grades：Sorus area accounts for more than the 50% of whole leaf area.
1.3.4 mixture toxicity test and interpretation of result
The toxicity test of mixture is carried out according to mixed ratio with single dose toxicity test method.
If compareing the death rate<5%, do not correct, the control death rate is corrected between 5%-20% by formula 2, is compareed
The death rate>20%, experiment need to be reformed.
Using the logarithm value of drug concentration (mg/L) as independent variable x, using the niqueMin of corrected mortality as dependent variable y, respectively
Virulence regression equation is set up, the EC of single dose and each proportioning mixture is calculated using DPS softwares50Poison altogether is calculated according to the abundant methods of Sun Yun
Coefficient (CTC).Co-toxicity coefficient CTC, calculation formula is as follows：(using 2-cyano-3-amino-3-phenylancryic acetate as standard agent, 100) its toxicity index is：
The EC of toxicity index (TI)=2-cyano-3-amino-3-phenylancryic acetate of Metalaxyl-M50The EC of/Metalaxyl-M50×100
The EC of M true toxicity index (ATI)=2-cyano-3-amino-3-phenylancryic acetate50/ M EC50×100
TI × P Metalaxyl-Ms of TI × P 2-cyano-3-amino-3-phenylancryic acetates+Metalaxyl-M of M theoretical toxicity index (TTI)=2-cyano-3-amino-3-phenylancryic acetate
M co-toxicity coefficient (CTC)=M ATI/M TTI × 100
In formula：
M is the mixture of 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M different ratio
P 2-cyano-3-amino-3-phenylancryic acetates are 2-cyano-3-amino-3-phenylancryic acetate ratio shared in mixture
P Metalaxyl-Ms are Metalaxyl-M ratio shared in mixture.
2.1 toxicity test results
The 2-cyano-3-amino-3-phenylancryic acetate of table 1 and toxicity test of the Metalaxyl-M to cucumber downy mildew
As can be seen from the table, the result of the test of different proportion proportioning shows, equal table is diluted respectively in active ingredient ratio
Reveal stronger synergistic effect, wherein using 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M as 1:10~10:Synergistic effect good suggestion pair when 1
Suitable proportion 1:10~10:1 or so mixture preparation carries out further field control effectiveness test, is imitated with evaluating its field practical application
Really.
3 field tests preventing and treating cucumber downy mildew, the experimental result of wheat scab
3.1 field tests prevent and treat cucumber downy mildew
3.1.1 test method
Experiment investigates 4 points per cell, investigate 2 plants at every, morbidity journey is recorded with staging in Shandong Pingdu City cucumber
Degree, grade scale is as follows：
0 grade：It is disease-free；
1 grade：Sorus area accounts for less than the 5% of whole leaf area；
3 grades：Sorus area accounts for below the 6%-10% of whole leaf area；
5 grades：Sorus area accounts for below the 11%-20% of whole leaf area；
7 grades：Sorus area accounts for below the 21%-50% of whole leaf area；
9 grades：Sorus area accounts for more than the 50% of whole leaf area.
3.1.2 control time and number of times
Experiment is investigated 4 times altogether, and radix is investigated before medicine, is adjusted within 21 days 10 days after first time medicine, after second 10 days and medicine
Look into.
3.1.3 drug effect computational methods
Sick leaf rate (the %)=disease number of sheets/investigation total number of sheets × 100
Disease index=∑ (the sick numbers of sheets at different levels × relative value of series)/(investigation total number of sheets × 9) × 100
Prevention effect (%)=(1- (disease index after disease index × treatment region medicine before blank district medicine)/(blank pair
According to disease index before disease index after area's medicine × treatment region medicine)) × 100.
3.1.4 poisoning investigation method
Whether continuous 10d range estimations medicament has poisoning to crop after dispenser.
3.1.5 result of the test and analysis
The effect of each processing preventing and treating cucumber downy mildew.(table 2)
Table 2 respectively handles the effect of preventing and treating cucumber downy mildew
2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M are with 1 as shown in Table 2:6 ratio composite bactericides control effect for cucumber downy mildew
Apparently higher than 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M single dose, bactericidal effect is incremented by with the increase of dosage.Estimated according to field, in experiment
In dosage range, plant growth is normal, and each treatment agent does not occur the poisoning phenomenon to cucumber, and it is safety to cucumber to illustrate it
's.It is recommended that the bactericide different from the mechanism of action is used in mixed way to delay the drug-fast generation of germ.
4.1 field tests prevent and treat wheat scab
4.1.1 test method
Experiment is sampled in Shandong Pingdu City wheat paddock using diagonal, and 5 points, every casual inspection 100 are investigated per cell
Sick spike number in~200 wheat heads, severity extent is divided into 5 grades with ocular estimate：
0 grade disease-free；
I grade of sick spikelet number accounts for less than the 1/4 of whole small ears；
II grade of sick spikelet number accounts for the 1/4~1/2 of whole small ears；
III grade of sick spikelet number accounts for the 1/2~3/4 of whole small ears；
IV grade of sick spikelet number accounts for more than the 3/4 of whole small ears.
4.1.2 control time and number of times
Experiment is investigated 4 times altogether, radix investigation before medicine, is entered within 21 days after 10 days and medicine 10 days after first time medicine, after second of medicine
Row investigation.
4.1.3 drug effect computational methods
Disease tassel yield (%)=total spike number × 100 of disease spike number/investigation
Disease index=∑ (sick spike numbers at different levels × relative value of series)/(total spike number × 4 of investigation) × 100
Prevention effect (%)=(1- (disease index after disease index × treatment region medicine before blank district medicine)/(blank pair
According to disease index before disease index after area's medicine × treatment region medicine)) × 100.
4.1.4 poisoning investigation method
Whether continuous 7d range estimations medicament has poisoning to crop after dispenser.
4.1.5 result of the test and analysis
Each processing prevents and treats the effect (table 3) of wheat scab
Table 2 respectively handles the effect for preventing and treating wheat scab
The Mixed Pharmacy of different proportion, is tested by different consumptions as can be seen from Table 3,2-cyano-3-amino-3-phenylancryic acetate and smart first
White spirit is with 1:After 6 ratio compound medicines its preventing and treating to wheat scab be superior to comparison medicament and bactericidal effect with dosage increase
And be incremented by.Estimated according to field, in the range of test dose, plant growth is normal, and each treatment agent does not occur to wheat
Poisoning phenomenon, it is safe to wheat to illustrate it.It is recommended that the bactericide different from the mechanism of action is used in mixed way to delay germ to resist
The generation of the property of medicine.
In summary, the Bactericidal composite of the invention containing 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M, to cucumber downy mildew, gibberella saubinetii
Disease has good prevention effect, and it is to Target crops safety.Complex preparation not only increases preventive effect, and expands sterilization
Spectrum, is widened and uses scope, reduce cost, and multiple diseases are played a part of with a medicine is simultaneous to be controlled, and mitigates manpower and materials, improves production effect
Benefit.So, the invention of this complex preparation is of great significance with promoting to society's tool.
Claims (4)
1. a kind of bactericidal composition containing 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M, it is characterised in that：The bactericidal composition it is effective into
It is divided into 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M binary built, remaining is auxiliary element, wherein active ingredient 2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M
Mass ratio be 1~40: 40~1.
2. bactericidal composition according to claim 1, it is characterised in that：2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M in the formulation total
Weight accounts for the 1%~80% of the whole quality of the pharmaceutical preparations.
3. bactericidal composition according to claim 2, it is characterised in that：2-cyano-3-amino-3-phenylancryic acetate and Metalaxyl-M in the formulation total
Weight accounts for the 5%~50% of the whole quality of the pharmaceutical preparations.
4. the bactericidal composition according to claim 1 or 2 or 3, it is characterised in that：The formulation of the bactericidal composition is breast
Oil, suspending agent, wettable powder, water dispersible granules, aqueous emulsion, microemulsion, granule, microcapsule formulations.
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| CN103947640B (en) * | 2014-05-28 | 2016-08-24 | 陕西上格之路生物科学有限公司 | A kind of bactericidal composition preventing and treating crops soil-borne disease |
| CN103975935B (en) * | 2014-05-28 | 2016-08-24 | 陕西上格之路生物科学有限公司 | A kind of bactericidal composition preventing and treating crops soil-borne disease |
| CN104082309B (en) * | 2014-07-28 | 2016-06-29 | 江苏丘陵地区镇江农业科学研究所 | A kind of bactericidal composition composite containing probenazole and 2-cyano-3-amino-3-phenylancryic acetate and application thereof |
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