CN112451552A - Novel hydrocolloid acne patch for treating acne - Google Patents
Novel hydrocolloid acne patch for treating acne Download PDFInfo
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- CN112451552A CN112451552A CN202011512112.7A CN202011512112A CN112451552A CN 112451552 A CN112451552 A CN 112451552A CN 202011512112 A CN202011512112 A CN 202011512112A CN 112451552 A CN112451552 A CN 112451552A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/41—Crassulaceae (Stonecrop family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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Abstract
The invention discloses a novel hydrocolloid acne paste for treating acne, wherein a self-adhesive hydrocolloid matrix is attached to an outer substrate of the acne paste, a removable protective layer is covered on the hydrocolloid matrix, and the hydrocolloid acne paste contains revitalizing grass and quaternary ammonium salt 73, wherein the revitalizing grass is one or more of a tamariskoid spikemoss herb extract, a Barre dried chicory leaf extract and a Nanfei Fenghua extract. The hydrocolloid matrix further contains: 15-60% by weight of an adhesive base; 5 to 35 weight percent of a rubber elastomer; 5-60 wt% of a hydrophilic polymer; 0-40 wt% of a tackifying resin. The novel hydrocolloid acne patch for treating acne contains quaternary ammonium salt 73 and revival grass, can promote wound healing, has the effect of inhibiting acne bacillus, is remarkable in acne removing and inflammation diminishing, and has an obvious effect of improving the smoothness of skin.
Description
Technical Field
The invention belongs to the field of acne treatment, and particularly relates to a novel hydrocolloid acne patch for treating acne.
Background
The pox patch is a hydrocolloid patch with special hydrophilicity for treating the pox, can absorb secretion after being attached on the pox, and is beneficial to smoothening the pox. But also can reduce the chance of bacterial infection and is more suitable for inflammatory pox.
However, the existing acne plaster has an unsatisfactory antibacterial effect, skin at acne parts is easily inflamed, the recovery effect of the acne parts is poor, acne marks are obvious, the smoothness of the treated skin is low, and the attractiveness is affected.
Disclosure of Invention
The invention aims to provide a novel hydrocolloid acne patch for treating acne, which aims to solve the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme: a novel hydrocolloid pox patch for treating acne is characterized in that a self-adhesive hydrocolloid matrix is attached to an outer substrate of the pox patch, a removable protective layer is covered on the hydrocolloid matrix, and the hydrocolloid pox patch contains revival grass and quaternary ammonium salt 73.
Preferably, the content of the revival grass is 0.01-1 wt%; the content of quaternary ammonium salt 73 is 0.0002-0.2 wt%.
The quaternary ammonium salt-73 has bacteriostatic and antibacterial effects.
Preferably, the revival grass is one or more of selaginella tamariscina extract, Barbados chicory leaf extract and FenghuangCao extract.
Preferably, the hydrocolloid matrix further comprises: 15-60% by weight of an adhesive base; 5 to 35 weight percent of a rubber elastomer; 5-60 wt% of a hydrophilic polymer; 0-40 wt% of a tackifying resin.
Compared with the prior art, the invention has the beneficial effects that: the novel hydrocolloid acne patch for treating acne contains quaternary ammonium salt 73 and revival grass, so that acne treatment effect is better, antibacterial effect is better, acne removing and inflammation diminishing effects are obvious, and smoothness of skin is obviously improved.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Examples 1 to 7, as shown in Table 1
Table 1 examples 1-7
TABLE 2 COMPARATIVE EXAMPLES 1 to 3
The preparation method comprises the following steps: the adhesive base, rubber elastomer, tackifying resin, in the composition ratios of Table 1, were charged into a Mixer (Rheomix 3000Mixer from Thermofish Co.) and mixed for 20 minutes at 160 ℃ and 40 rpm. Then the revival grass, the quaternary ammonium salt 73 and the hydrophilic polymer are put into a mixer according to the composition proportion of the table 1 and mixed for 20 minutes at the temperature of 120 ℃ and the rotating speed of 30 rpm. The mixture was taken out and placed on release paper and cooled to room temperature.
The hydrocolloid matrices prepared in examples 1 to 7 and comparative examples 1 to 3 were pressed into sheets of 0.3mm in thickness using a hand press, and then compounded with a polyurethane film of 25 μm in thickness to give hydrocolloid pox patch sheets, which were die cut into the desired 10mm pox patch discs.
Wherein the adhesive base is SDG-8650 polyisobutylene from Hangzhou Shundard plastics Co., Ltd (China), PB2400 polybutene from Korean Dalin Co., Ltd, and Ricon154 polybutadiene from Krevili (Guangzhou) chemical Co., Ltd;
the rubber elastomer is D1113 poly (styrene/isoprene/styrene) of Kraton company, IR2200 polyisoprene of Rueisen company, RSS5 natural rubber of Zhonghua International GmbH;
the tackifying resin is Escorez 1310 tackifying resin from Exxon Mobil, PICCOLYEA115 from Hercules, ZONATAC NG98 from Arizona Chemical;
the herba Polygoni Avicularis is herba Selaginellae extract, Barr dried folium Cichorii extract and herba Pteridis Multifidae extract of Umbelliferae industries, Ltd; quaternary ammonium salt 73 was purchased from Han Xiang Biotech Limited, Shanghai.
The hydrophilic polymer is carboxymethylcellulose sodium (CMC) of Shanghai Hercules chemical Co., Ltd. (China), medical pectin of Fuda pectin industries Co., Ltd., CARBOWAX 1450 polyethylene glycol of Dow chemical (China) Co., Ltd.
Example 8 evaluation of bacteriostatic Properties
The test strain is common strain acne bacillus causing acne. Lightly scratching a ring of acnes colony into 100mL of nutrient broth by using an inoculating ring, and culturing on a constant temperature shaker at 37 ℃ at 150rpm
Saline was formulated to dilute the bacterial suspension to 3.0X 106CFU/mL for antibacterial testing. The hydrocolloid pox patch prepared in the above example is leached by purified water for 24h, and the leaching ratio is water: sample 10: 1, taking the leaching liquor as a sample to be detected. The purified water is used as a blank experiment, and a commercially available Meifujing acne patch is used for a comparative experiment. Adding 1ML bacterial suspension into the sample solution to be detectedCulturing at 37 deg.C under 150rpm for lh, counting viable bacteria, placing on common nutrient agar plate, spreading, culturing at 37 deg.C for 24 hr, observing bacterial growth condition on each sample, and calculating average colony count. The results are shown in the following table.
TABLE 3 antibacterial Rate
Example 9 evaluation of acne-removing and anti-inflammatory effects
The age of the test population: 220 patients with acne had 110 men and 110 women as observation subjects.
Test protocol: 220 subjects were divided into 11 groups, and hydrocolloid pox patches prepared in examples 1 to 7 and comparative examples 1 to 3 and a commercially available similar product, Meifujing pox patch, were administered to the groups. The acne removing effect before and after the test was observed by naked eyes and the phenomenon was recorded. And respectively testing and recording each index and the use feeling of the volunteers, and comprehensively evaluating.
The using method comprises the following steps: according to the application method of the hydrocolloid adhesive patch, the package is removed, the hydrocolloid adhesive patch is taken out, the protective layer is removed, the patch with the proper size is selected, and the hydrocolloid adhesive patch is lightly attached to the designated part of a tester. The application time is one month, the patch is applied to the acne part after cleaning skin in the morning and evening every day, and the patch is removed and replaced with a new patch after absorbing the liquid and whitening the patch.
Evaluation indexes are as follows:
the curative effect is expressed by four grades of obvious effect, effective effect, improvement and ineffective effect. The rating criteria are as follows:
the effect is shown: the acne red swelling on the skin is eliminated obviously, the acne is eliminated, no acne mark exists, and the sticking part is not different from the surrounding skin;
the method has the following advantages: the acne on the skin is removed after the acne red swelling subsides, and slight acne marks exist;
the improvement is as follows: the skin has reduced pox and inflammation, and has acne marks;
and (4) invalidation: acne and swelling on the skin are obvious and are not improved.
And (3) test results:
TABLE 4 evaluation of anti-acne and anti-inflammatory effects
In conclusion, after the hydrocolloid acne patch prepared in examples 1-7 is used, the acne removing and inflammation diminishing effects are obvious, the skin smoothness is obviously improved, disappearance of acnes at acne growing positions can be visually observed, few volunteers indicate that acne marks remain, and the skin smoothness is obviously improved.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (4)
1. The novel hydrocolloid acne patch is characterized in that the hydrocolloid acne patch contains revival grass and quaternary ammonium salt 73.
2. The novel hydrocolloid pox patch for the treatment of acne according to claim 1, wherein the revival grass is present in an amount of 0.01 to 1% by weight; the content of quaternary ammonium salt 73 is 0.0002-0.2 wt%.
3. The novel hydrocolloid pox patch for the treatment of acne according to claim 1, wherein said revival grass is one or more of tamariskoid spikemoss herb extract, Barr dried chicory leaf extract and Fenghuang grass extract.
4. The novel hydrocolloid pox patch for the treatment of acne according to claim 1 or 2, characterized in that said hydrocolloid matrix further comprises: 15-60% by weight of an adhesive base; 5 to 35 weight percent of a rubber elastomer; 5-60 wt% of a hydrophilic polymer; 0-40 wt% of a tackifying resin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011512112.7A CN112451552A (en) | 2020-12-19 | 2020-12-19 | Novel hydrocolloid acne patch for treating acne |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011512112.7A CN112451552A (en) | 2020-12-19 | 2020-12-19 | Novel hydrocolloid acne patch for treating acne |
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| Publication Number | Publication Date |
|---|---|
| CN112451552A true CN112451552A (en) | 2021-03-09 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011512112.7A Pending CN112451552A (en) | 2020-12-19 | 2020-12-19 | Novel hydrocolloid acne patch for treating acne |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115120576A (en) * | 2022-07-28 | 2022-09-30 | 德晟康(苏州)生物科技有限公司 | Phased slow-release pox patch and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106310353A (en) * | 2015-07-03 | 2017-01-11 | 江苏诺瓦立医疗用品有限公司 | Hydrocolloid adhesive, related application and hydrocolloid dressing |
| CN109364006A (en) * | 2018-12-03 | 2019-02-22 | 广州润虹医药科技股份有限公司 | A kind of acne-removing composition, Essence and preparation method thereof |
| CN208756322U (en) * | 2018-04-26 | 2019-04-19 | 上海华舟压敏胶制品有限公司 | Patch is used in visual small pox protection |
-
2020
- 2020-12-19 CN CN202011512112.7A patent/CN112451552A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106310353A (en) * | 2015-07-03 | 2017-01-11 | 江苏诺瓦立医疗用品有限公司 | Hydrocolloid adhesive, related application and hydrocolloid dressing |
| CN208756322U (en) * | 2018-04-26 | 2019-04-19 | 上海华舟压敏胶制品有限公司 | Patch is used in visual small pox protection |
| CN109364006A (en) * | 2018-12-03 | 2019-02-22 | 广州润虹医药科技股份有限公司 | A kind of acne-removing composition, Essence and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 腾讯网: "丝菲兰斯密罗木赋活肌肤自愈力", 《腾讯网,HTTPS://NEW.QQ.COM/CMSN/20190130/20190130005896.HTML?PC》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115120576A (en) * | 2022-07-28 | 2022-09-30 | 德晟康(苏州)生物科技有限公司 | Phased slow-release pox patch and preparation method thereof |
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