CN114668697B - Essence water with antioxidant and anti-inflammatory effects - Google Patents
Essence water with antioxidant and anti-inflammatory effects Download PDFInfo
- Publication number
- CN114668697B CN114668697B CN202210478319.XA CN202210478319A CN114668697B CN 114668697 B CN114668697 B CN 114668697B CN 202210478319 A CN202210478319 A CN 202210478319A CN 114668697 B CN114668697 B CN 114668697B
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- Prior art keywords
- yang
- gouhua
- essence
- water
- extract
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 42
- 230000003110 anti-inflammatory effect Effects 0.000 title claims abstract description 17
- 230000003078 antioxidant effect Effects 0.000 title claims abstract description 9
- 239000003963 antioxidant agent Substances 0.000 title claims abstract description 7
- 239000000284 extract Substances 0.000 claims abstract description 45
- 238000000855 fermentation Methods 0.000 claims abstract description 18
- 230000004151 fermentation Effects 0.000 claims abstract description 18
- 244000005700 microbiome Species 0.000 claims abstract description 15
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 25
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims description 10
- 235000011187 glycerol Nutrition 0.000 claims description 10
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims description 9
- 229940101267 panthenol Drugs 0.000 claims description 9
- 235000020957 pantothenol Nutrition 0.000 claims description 9
- 239000011619 pantothenol Substances 0.000 claims description 9
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical class CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 8
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 8
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 claims description 8
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 8
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 8
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims description 8
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 8
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 8
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims description 8
- 229960003237 betaine Drugs 0.000 claims description 8
- SWQUTKGVXGTROS-UHFFFAOYSA-N bis(2-ethoxyethyl) butanedioate Chemical compound CCOCCOC(=O)CCC(=O)OCCOCC SWQUTKGVXGTROS-UHFFFAOYSA-N 0.000 claims description 8
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 8
- 239000004359 castor oil Substances 0.000 claims description 8
- 235000019438 castor oil Nutrition 0.000 claims description 8
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims description 8
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 8
- 229940119676 diethoxyethyl succinate Drugs 0.000 claims description 8
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 8
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 claims description 8
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 8
- 229960005323 phenoxyethanol Drugs 0.000 claims description 8
- 229940079889 pyrrolidonecarboxylic acid Drugs 0.000 claims description 8
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 8
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 8
- 229960001295 tocopherol Drugs 0.000 claims description 8
- 229930003799 tocopherol Natural products 0.000 claims description 8
- 235000010384 tocopherol Nutrition 0.000 claims description 8
- 239000011732 tocopherol Substances 0.000 claims description 8
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims description 8
- 229960000281 trometamol Drugs 0.000 claims description 8
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 8
- 240000006024 Lactobacillus plantarum Species 0.000 claims description 7
- 235000013965 Lactobacillus plantarum Nutrition 0.000 claims description 7
- 229940072205 lactobacillus plantarum Drugs 0.000 claims description 7
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 claims description 6
- 229940035437 1,3-propanediol Drugs 0.000 claims description 6
- 229920000166 polytrimethylene carbonate Polymers 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 5
- CRPCXAMJWCDHFM-UHFFFAOYSA-M sodium;5-oxopyrrolidine-2-carboxylate Chemical compound [Na+].[O-]C(=O)C1CCC(=O)N1 CRPCXAMJWCDHFM-UHFFFAOYSA-M 0.000 claims description 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
- 230000001580 bacterial effect Effects 0.000 claims description 3
- 230000000813 microbial effect Effects 0.000 claims description 3
- 229910052708 sodium Inorganic materials 0.000 claims description 3
- 239000011734 sodium Substances 0.000 claims description 3
- 241000235342 Saccharomycetes Species 0.000 claims description 2
- 239000012153 distilled water Substances 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims description 2
- 239000000706 filtrate Substances 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 238000005119 centrifugation Methods 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 11
- 239000002537 cosmetic Substances 0.000 abstract description 10
- 230000003020 moisturizing effect Effects 0.000 abstract description 8
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 5
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- 239000013543 active substance Substances 0.000 abstract description 4
- 239000006286 aqueous extract Substances 0.000 abstract description 4
- 238000002474 experimental method Methods 0.000 abstract description 4
- 206010070834 Sensitisation Diseases 0.000 abstract description 3
- 230000008313 sensitization Effects 0.000 abstract description 3
- 230000000638 stimulation Effects 0.000 abstract description 2
- 239000000686 essence Substances 0.000 description 31
- 238000012360 testing method Methods 0.000 description 21
- 241000196324 Embryophyta Species 0.000 description 13
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- 238000006243 chemical reaction Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
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- 239000000047 product Substances 0.000 description 5
- 241000121220 Tricholoma matsutake Species 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- 235000006708 antioxidants Nutrition 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 3
- 238000002835 absorbance Methods 0.000 description 3
- 239000008272 agar Substances 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
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- 239000000126 substance Substances 0.000 description 3
- 231100000331 toxic Toxicity 0.000 description 3
- 230000002588 toxic effect Effects 0.000 description 3
- OCZVHBZNPVABKX-UHFFFAOYSA-N 1,1-diphenyl-2-(2,4,6-trinitrophenyl)hydrazine;ethanol Chemical compound CCO.[O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1NN(C=1C=CC=CC=1)C1=CC=CC=C1 OCZVHBZNPVABKX-UHFFFAOYSA-N 0.000 description 2
- 244000063299 Bacillus subtilis Species 0.000 description 2
- 235000014469 Bacillus subtilis Nutrition 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 2
- 206010040880 Skin irritation Diseases 0.000 description 2
- 206010040914 Skin reaction Diseases 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000007760 free radical scavenging Effects 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000013641 positive control Substances 0.000 description 2
- 230000036556 skin irritation Effects 0.000 description 2
- 231100000475 skin irritation Toxicity 0.000 description 2
- 230000035483 skin reaction Effects 0.000 description 2
- 231100000430 skin reaction Toxicity 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 238000003809 water extraction Methods 0.000 description 2
- 230000002087 whitening effect Effects 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 241000228245 Aspergillus niger Species 0.000 description 1
- 240000001624 Espostoa lanata Species 0.000 description 1
- 235000009161 Espostoa lanata Nutrition 0.000 description 1
- 240000001046 Lactobacillus acidophilus Species 0.000 description 1
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- 241000219000 Populus Species 0.000 description 1
- 241000249899 Populus tomentosa Species 0.000 description 1
- 230000002292 Radical scavenging effect Effects 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
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- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- PYKYMHQGRFAEBM-UHFFFAOYSA-N anthraquinone Natural products CCC(=O)c1c(O)c2C(=O)C3C(C=CC=C3O)C(=O)c2cc1CC(=O)OC PYKYMHQGRFAEBM-UHFFFAOYSA-N 0.000 description 1
- 150000004056 anthraquinones Chemical class 0.000 description 1
- 238000010633 antibacterial capability test Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- BBFQZRXNYIEMAW-UHFFFAOYSA-N aristolochic acid I Chemical compound C1=C([N+]([O-])=O)C2=C(C(O)=O)C=C3OCOC3=C2C2=C1C(OC)=CC=C2 BBFQZRXNYIEMAW-UHFFFAOYSA-N 0.000 description 1
- 238000003287 bathing Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 239000007933 dermal patch Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- HHEAADYXPMHMCT-UHFFFAOYSA-N dpph Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1[N]N(C=1C=CC=CC=1)C1=CC=CC=C1 HHEAADYXPMHMCT-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000005069 ears Anatomy 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002213 flavones Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229960005150 glycerol Drugs 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 229940039695 lactobacillus acidophilus Drugs 0.000 description 1
- 150000002596 lactones Chemical class 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 238000000643 oven drying Methods 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
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- 238000011160 research Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 230000037384 skin absorption Effects 0.000 description 1
- 231100000274 skin absorption Toxicity 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Dermatology (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
Abstract
The invention belongs to the field of cosmetics, and particularly relates to essence water with antioxidant and anti-inflammatory effects. The formula components of the essence water comprise Yang Gouhua fermented extract. According to the invention, yang Gouhua is fermented by microorganisms to extract active substances, and compared with a common Yang Gou flower aqueous extract or alcohol extract, the obtained fermentation broth has higher free radical removal rate, better anti-inflammatory effect and certain antibacterial property. The applicant also discovers through experiments that the essence of the invention can further improve the moisturizing capability of skin, greatly reduce the sensitization of skin and has the advantages of mildness and no stimulation.
Description
Technical Field
The invention belongs to the field of cosmetics, and particularly relates to essence water with antioxidant and anti-inflammatory effects.
Background
A variety of active substances exist in natural plants, such as: polysaccharides, polypeptides, flavones, polyphenols, amino acids, and the like. The traditional process utilizes organic solvents or aqueous solutions to extract active ingredients from plants, but the obtained active ingredients are low in content and sometimes difficult to meet the expected efficacy. Research shows that the plant material can be enriched with active ingredients after fermentation. For example, by fermenting matsutake with lactobacillus acidophilus, more or stronger whitening substances can be extracted from matsutake, and the whitening effect of matsutake fermentation liquid is better than that of matsutake aqueous extract and alcohol extract.
The plant resources in China are rich, the planting environments in different regions are greatly different, active substances in the plants are complex, few plant components possibly have certain toxic and side effects, and effective utilization of a part of plant resources can be limited. In addition, by utilizing the microbial fermentation technology, the content of toxic components such as alkaloid, lactone substances, glycoside compounds, toxic proteins, aristolochic acid, anthraquinone, tannins, heavy metals and the like in plants can be reduced.
Populus tomentosa is a plant of Populus of Populaceae, also known as Yang Gouhua, and is distributed in Liaoning, north China, northwest, east China, etc. Generally, the cultivation is realized, the collection can be realized all the year round, and the resources are very rich. Yang Gouhua is an important Chinese medicinal material, has wide sources, low price and high medicinal value, contains abundant flavonoid compounds, has better free radical scavenging effect and anti-inflammatory effect, and has obvious inhibition effect on bacteria. The application of the active ingredients of the Yang Gou flowers to cosmetics brings new choices for the formulation design, and has certain reference significance for the expansion of the Yang Gou flower resource utilization direction.
Disclosure of Invention
In order to make up the blank of the prior art and enrich the variety of the functional cosmetics and bring more raw material selection ideas for the plant fermentation type cosmetics, the invention provides the essence water with the antioxidant and anti-inflammatory effects. According to the invention, yang Gouhua is fermented by microorganisms to extract active substances, and compared with a common Yang Gou flower aqueous extract or alcohol extract, the obtained fermentation broth has higher free radical removal rate, better anti-inflammatory effect and certain antibacterial property. The applicant also discovers through experiments that the essence of the invention can further improve the moisturizing capability of skin, greatly reduce the sensitization of skin and has the advantages of mildness and no stimulation.
In order to achieve the above object, the present invention adopts the following technical scheme:
an essence with antioxidant and anti-inflammatory effects comprises Yang Gouhua fermented extract.
Preferably, the formula components of the essence water further comprise water, glycerol, nicotinamide, 1, 3-propylene glycol, butanediol, glycerol polyether-26, hydrogenated lecithin, betaine, tocopherol, diethoxyethyl succinate, phenoxyethanol, tocopheryl acetate, PEG-60 hydrogenated castor oil, tromethamine, glyceroglycosides, acetylated sodium hyaluronate, sodium PCA, serine, pyrrolidone carboxylic acid, disodium hydrogen phosphate, panthenol and essence.
Preferably, the essence water comprises the following components in percentage by weight: 6-9% Yang Gouhua fermented extract, 1-2% glycerin, 0.3-0.5% nicotinamide, 0.2-0.4% 1, 3-propanediol, 0.2-0.4% butanediol, 0.2-0.4% glycerolyether, 0.5-1% hydrogenated lecithin, 0.4-0.6% betaine, 0.5-1% tocopherol, 0.3-0.5% diethoxyethyl succinate, 0.1-0.3% phenoxyethanol, 0.4-0.8% tocopheryl acetate, 0.2-0.4% PEG-60 hydrogenated castor oil, 0.2-0.5% tromethamine, 0.5-1% glyceroglycoside, 1-2% acetylated sodium hyaluronate, 0.1-0.3% PCA sodium, 0.5-1% serine, 0.3-0.5% pyrrolidone carboxylic acid, 0.2-0.5% disodium hydrogen phosphate, 0.3-0.5% panthenol and 0.1-0.2% panthenol essence, and the balance water.
Preferably, the essence water comprises the following components in percentage by weight: 8% Yang Gouhua fermented extract, 2% glycerin, 0.3% nicotinamide, 0.2% 1, 3-propanediol, 0.2% butanediol, 0.2% glycerolyether-260.2% hydrogenated lecithin, 0.8% betaine, 1% tocopherol, 0.3% diethoxyethyl succinate, 0.1% phenoxyethanol, 0.5% tocopheryl acetate, 0.2% PEG-60 hydrogenated castor oil, 0.3% tromethamine, 1% glyceroglyceoside, 1.5% acetylated sodium hyaluronate, 0.1% sodium PCA, 0.6% serine, 0.3% pyrrolidone carboxylic acid, 0.3% disodium hydrogen phosphate, 0.5% panthenol and 0.1% essence, the balance being water.
Preferably, the Yang Gouhua fermented extract is a filtrate obtained by microbial fermentation using Yang Gouhua as a raw material.
Preferably, the microorganism is one or more of yeast, lactobacillus plantarum and bacillus subtilis.
Preferably, the microorganism is a yeast or lactobacillus plantarum.
Preferably, the ratio of the strains of the saccharomycetes to the lactobacillus plantarum is 2:3.
furthermore, the invention provides an application of Yang Gouhua fermentation extract obtained by fermenting Yang Gouhua by the microorganism in the production of moisturizing and anti-inflammatory skin care products. Preferably, the microorganisms are yeasts and lactobacillus plantarum.
The beneficial effects of adopting this technical scheme are: the applicant can further obtain bioactive substances which are favorable for skin absorption from plants, and develop new green natural cosmetics at the same time, so that the efficacy of the product is effectively improved, and the variety of the product is enriched. According to the invention, yang Gouhua is specifically taken as a plant raw material, a large number of experiments are carried out on the plant raw material, different types of microorganisms are adopted for fermentation, relevant biological activity indexes of the obtained fermentation broth are detected, and the combination and the proportion of the fermentation microorganisms with good oxidation resistance and anti-inflammatory effects of the fermentation broth are screened. In addition, the applicant finds that the essence water obtained by the invention improves the skin moisturizing capability in the test and detection data of the product related performance, and greatly reduces the skin irritation, so that the essence water is a cosmetic with strong efficacy, mild and no irritation, and has very broad application prospect.
Detailed Description
The technical scheme in the embodiment of the invention is checked and fully described in combination with the embodiment of the invention, and the invention is further explained. It will be apparent that the described embodiments are only some, but not all, embodiments of the invention. Given the embodiments of the present invention, all other embodiments that would be obvious to one of ordinary skill in the art without making any inventive effort are within the scope of the present invention.
Main experimental reagents and materials:
yang Gou flowers were purchased from Liaoning production, and yeasts, lactobacillus plantarum and Bacillus subtilis were all purchased from China center for type culture Collection of agricultural microorganisms.
Glycerol, nicotinamide, 1, 3-propanediol, butanediol, glycerol polyether-26, hydrogenated lecithin, betaine, tocopherol, diethoxyethyl succinate, phenoxyethanol, tocopheryl acetate, PEG-60 hydrogenated castor oil, tromethamine, glyceroglycosides, sodium hyaluronate, sodium PCA, serine, pyrrolidone carboxylic acid, disodium hydrogen phosphate, panthenol and fragrances are all available from commercial products.
Example 1 preparation of Yang Gouhua fermentation extract and essence Water
Yang Gouhua fermented extract preparation method: washing Yang Gouhua, drying in the shade, oven drying at 65deg.C to constant weight, pulverizing, sieving with 20 mesh sieve, weighing quantitative powder and distilled water, mixing in a conical flask according to feed-liquid ratio (1:100), sealing, sterilizing, cooling to room temperature, inoculating microorganism bacterial liquid, culturing at 28deg.C with 180r/min constant temperature shaking table for 48 hr, centrifuging, collecting supernatant, and filtering to obtain Yang Gouhua fermented extract.
The essence water comprises the following raw materials: 8% Yang Gouhua fermented extract, 2% glycerin, 0.3% nicotinamide, 0.2% 1, 3-propanediol, 0.2% butanediol, 0.2% glycerolyether-26, 0.8% hydrogenated lecithin, 0.6% betaine, 1% tocopherol, 0.3% diethoxyethyl succinate, 0.1% phenoxyethanol, 0.5% tocopheryl acetate, 0.2% PEG-60 hydrogenated castor oil, 0.3% tromethamine, 1% glucosyl glycerate, 1.5% sodium hyaluronate, 0.1% sodium PCA, 0.6% serine, 0.3% pyrrolidone carboxylic acid, 0.3% disodium hydrogen phosphate, 0.5% panthenol and 0.1% essence, the balance being water.
The preparation method of the essence water comprises the following steps: the preparation method comprises the steps of (1) placing glycerolyether-26, hydrogenated lecithin, diethoxyethyl succinate, tocopheryl acetate and PEG-60 hydrogenated castor oil in a water bath kettle at 65-70 ℃ for slow stirring for 1h until all the components are dissolved to obtain a mixture A; then placing water, glycerol, nicotinamide, 1, 3-propylene glycol, butanediol, betaine, tocopherol, phenoxyethanol, tromethamine, glyceroglycosides, acetylated sodium hyaluronate, PCA sodium, serine, pyrrolidone carboxylic acid, disodium hydrogen phosphate and panthenol in a water bath kettle at 65-70 ℃ and stirring at constant speed for 30min until all the components are dissolved to obtain a mixture B; and slowly adding the mixture B into the mixture A for mixing, adding Yang Gouhua fermented extract, residual water and essence, continuously stirring uniformly, cooling to 20-25 ℃, stopping stirring, and discharging to prepare the essence water sample.
Example 2 test of antioxidant Properties, anti-inflammatory and antibacterial Effect of Yang Gouhua fermentation extracts
Measurement of DPPH organic radical scavenging ability: adding 2.0mL of different Yang Gouhua fermented extract into 4.0mL of 2×10 -4 mixing the DPPH ethanol solution with mol/L, standing for 30min, taking the solvent as a reference sample, and measuring absorbance at the wavelength of 517nm to obtain A1; a2 is absorbance value of the mixture of 2.0mL of sample and 4.0mL of ethanol water solution at 517 nm; and then 4.0mL of DPPH ethanol solution is taken and evenly mixed with 4.0mL of ethanol solution, absorbance is measured at the wavelength of 517nm and recorded as A3, and the clearance percent of K organic free radicals is calculated:the experimental results are shown in table 1.
TABLE 1 free radical scavenging rates of different Yang Gou flower extracts
From the experimental data in Table 1, it can be found that the extract obtained by fermenting Yang Gouhua with microorganism has higher free radical clearance than Yang Gou flower extract obtained by conventional water extraction and alcohol extraction, wherein when the microorganism is yeast and lactobacillus plantarum (the ratio of viable bacteria is 2:3), the free radical clearance is higher and reaches 86.8%, which indicates that Yang Gou flower extract prepared by fermenting the microorganism has excellent antioxidant activity.
Anti-inflammatory experiments: 60 mice were randomly divided into 12 groups. The blank control group uses normal saline, the positive control group uses hydrocortisone 0.02 g.kg -1 The remaining groups were treated with Yang Gouhua fermentation extract, aqueous extract and alcoholic extract from the formulation table of example 1. Each group was given 1 time per day by gavage in the morning and 7 days in succession, and the positive control group was given by intraperitoneal injection. 30min after the last administration, 0.2mL of xylene was uniformly smeared on both sides of the right auricle of the mouse with cotton balls to cause inflammation, and the left ear was not smeared as a control. After 1h, the mice were sacrificed at break and the ears were cut off. Respectively rounding at the same position by using a puncher with the diameter of 7mmThe tabs were weighed and the percent inhibition of swelling calculated as the difference in weight of the left and right tabs as the swelling degree. The experimental results are shown in table 2, and show that the Yang Gouhua fermented extract has better anti-inflammatory effect and stronger anti-inflammatory effect on inflammation compared with the water extract and the alcohol extract.
TABLE 2 anti-inflammatory Capacity of different Yang Gou flower extracts
The antibacterial capability test method comprises the following steps: coating a layer of diluted experimental bacteria on an agar plate, pouring the agar plate into a constant temperature incubator at 37 ℃, standing an oxford cup on the surface of the agar plate by using sterile forceps after the surface is dried, adding a sample to be detected after light pressure, and setting a blank bacterial growth control and a positive growth control. Culturing in a constant temperature incubator at 37 ℃ for 24 hours, taking out the flat plate, and measuring the diameter of the bacteriostasis ring around each oxford cup. The experimental bacteria comprise various common strains such as escherichia coli, staphylococcus aureus, aspergillus niger and the like, and the data of the embodiment take the escherichia coli as an example.
TABLE 3 antibacterial Capacity of different Yang Gou flower extracts
As can be seen from Table 3, compared with Yang Gou flower extracts obtained by the conventional water extraction method and alcohol extraction method, the diameter of the inhibition zone of the Yang Gouhua fermented extract is slightly reduced, but basically kept in a higher range, and the inhibition effect on experimental bacteria is hardly affected, wherein the data of Yang Gouhua fermented extract 7 and Yang Gouhua alcohol extract are relatively similar, which indicates that Yang Gou flower extract obtained by the formula has relatively strong inhibition effect and relatively good antibacterial effect.
Example 3 moisture retention test of essence containing Yang Gouhua fermentation extract
Experimental conditions: the test environment temperature is 20 ℃, the relative humidity is 45-55%, and the same indoor lighting conditions are kept for real-time dynamic monitoring.
Preparation before testing: four groups of volunteers were selected, aged 20-45 years, and tested for skin non-invasive. The test site cannot use any cosmetics or external medicines until 2-3 days of testing. Before the test, the tested part of the subject needs to be cleaned, after the test, a plurality of areas can be marked at the same time, the interval between each test area is at least 1cm, basic data are measured after sitting still for 30min in a constant temperature and humidity environment, water and beverage cannot be drunk in the period, and the test area is placed in a test state, and a relaxation state is kept.
The method comprises the following steps:
reference is made to the evaluation method of QB/T4256-2011 cosmetic moisturizing efficacy evaluation guidelines.
(1) The test sample is coated for one time according to a certain dosage, the latex finger sleeve is used for uniformly coating the sample in a test area, and the actual sample coating amount is recorded.
(2) The skin analysis tester measures the test site, at least 3 times per area in parallel. The initial value of each test area (before the sample is used) is measured, and then the skin moisture content of the test area is tested after a set time.
(3) Skin moisture content of the test area after 1h, 2h and 4h after application was measured, respectively. Testing of the same subject must be performed by the same measurement person using the same instrument, and the measurement probe should be cleaned between measurements.
The experimental results are shown in table 4:
TABLE 4 effects of serum containing different Yang Gouhua fermented extracts on skin moisture
Note that: the essence water 1-9 is added with Yang Gou flower ferment 1-9, and the essence water 10 is an alcohol extract containing Yang Gouhua.
From the experimental data in table 4, it can be found that the essence water containing Yang Gouhua fermented extract has remarkable moisturizing effect after being used for 1h, can still achieve remarkable moisturizing effect after 4h, has longer maintenance time, and has remarkably improved moisturizing rate compared with the essence water sample without Yang Gouhua fermented extract.
Example 4 skin irritation test with Yang Gouhua fermented extract essence
According to the specification of cosmetic safety technology (2015 edition), 20 qualified volunteers are selected, 0.2mL of sample is added on a filter paper sheet, a blank control is deionized water, the filter paper sheet is placed in a patch tester, the patch tester is fixed on the bent side of the forearm of a subject, and the patch tester is slightly pressed by a palm so that the patch tester is uniformly applied to the skin, and intense exercise or bathing can not be performed during the period. After the spot tester was removed for 24 hours and 48 hours, the skin conditions were observed, and skin reactions were recorded according to the criteria shown in Table 5.
TABLE 5 skin adverse reaction grading criteria
Table 6 skin patch test results with Yang Gouhua fermented extract essence
As can be seen from Table 7, after removing the patches for 24 hours and 48 hours, the grade of skin reaction of the essence water 7 on the tested volunteers is a negative reaction, 2 cases of 1-grade suspicious reactions appear after the sample of the essence water 10 is used for 24 hours, 1 case of 2-grade reactions are converted into 1-grade reactions after 48 hours, and the red spot elimination of the other volunteers is converted into a negative reaction, which indicates that the essence water containing the Yang Gouhua fermented extract of the invention has no irritation to skin, and compared with the essence water containing Yang Gouhua alcohol extract, the sensitization of the essence water on skin is greatly reduced.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art. The generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (2)
1. The essence water with the antioxidant and anti-inflammatory effects is characterized by comprising the following components in percentage by weight: 6-9% Yang Gouhua fermented extract, 1-2% glycerin, 0.3-0.5% nicotinamide, 0.2-0.4% 1, 3-propanediol, 0.2-0.4% butanediol, 0.2-0.4% glycerolyether, 0.5-1% hydrogenated lecithin, 0.4-0.6% betaine, 0.5-1% tocopherol, 0.3-0.5% diethoxyethyl succinate, 0.1-0.3% phenoxyethanol, 0.4-0.8% tocopheryl acetate, 0.2-0.4% PEG-60 hydrogenated castor oil, 0.2-0.5% tromethamine, 0.5-1% glyceroglycoside, 1-2% acetylated sodium hyaluronate, 0.1-0.3% PCA sodium, 0.5-1% serine, 0.3-0.5% pyrrolidone carboxylic acid, 0.2-0.5% disodium hydrogen phosphate, 0.3-0.5% panthenol and 0.1-0.2% essence, and the balance water;
the Yang Gouhua fermented extract is filtrate produced by microbial fermentation with Yang Gouhua as a raw material; the preparation method of the Yang Gouhua fermented extract comprises the following steps: yang Gouhua is cleaned, ventilated and dried in the shade, then is put into a 65 ℃ oven for drying to constant weight, is crushed and passes through a 20-mesh sieve, and quantitative powder and distilled water are weighed according to a feed-liquid ratio of 1:100 are mixed in a conical flask, sealed, sterilized, cooled to room temperature, inoculated with microorganism bacterial liquid, cultured for 48 hours by a constant temperature shaking table at 28 ℃ and 180r/min, and filtered after centrifugation to obtain Yang Gouhua fermentation extract; the microorganisms are saccharomycetes and lactobacillus plantarum, and the ratio of the viable count is 2:3.
2. The essence water according to claim 1, wherein the formula of the essence water consists of the following components in percentage by weight: 8% Yang Gouhua fermented extract, 2% glycerin, 0.3% nicotinamide, 0.2% 1, 3-propanediol, 0.2% butanediol, 0.2% glycerolyether-260.2% hydrogenated lecithin, 0.8% betaine, 1% tocopherol, 0.3% diethoxyethyl succinate, 0.1% phenoxyethanol, 0.5% tocopheryl acetate, 0.2% PEG-60 hydrogenated castor oil, 0.3% tromethamine, 1% glyceroglyceoside, 1.5% acetylated sodium hyaluronate, 0.1% sodium PCA, 0.6% serine, 0.3% pyrrolidone carboxylic acid, 0.3% disodium hydrogen phosphate, 0.5% panthenol and 0.1% essence, the balance being water.
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