CN114668697A - Essence water with antioxidant and anti-inflammatory effects - Google Patents
Essence water with antioxidant and anti-inflammatory effects Download PDFInfo
- Publication number
- CN114668697A CN114668697A CN202210478319.XA CN202210478319A CN114668697A CN 114668697 A CN114668697 A CN 114668697A CN 202210478319 A CN202210478319 A CN 202210478319A CN 114668697 A CN114668697 A CN 114668697A
- Authority
- CN
- China
- Prior art keywords
- essence
- populus
- trifoliata
- extract
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 230000003110 anti-inflammatory effect Effects 0.000 title claims abstract description 17
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Classifications
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- A61K8/9783—Angiosperms [Magnoliophyta]
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
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- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61Q19/00—Preparations for care of the skin
-
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Abstract
The invention belongs to the field of cosmetics, and particularly relates to essence water with antioxidant and anti-inflammatory effects. The formula of the essence water comprises a Populus trifoliata flower fermentation extract. According to the invention, the Populus trifoliata flower is fermented by microorganisms to extract active substances, and compared with a common Populus trifoliata flower aqueous extract or alcohol extract, the obtained fermentation liquid has higher clearance rate on free radicals and better anti-inflammatory effect, and a certain antibacterial property is kept. The applicant also finds out through experiments that the essence water of the invention can further improve the moisture retention capacity of the skin, greatly reduce the sensitization of the skin and has the advantages of mildness and no stimulation.
Description
Technical Field
The invention belongs to the field of cosmetics, and particularly relates to essence water with antioxidant and anti-inflammatory effects.
Background
There are a variety of active substances in natural plants, such as: polysaccharides, polypeptides, flavones, polyphenols, amino acids, and the like. The traditional process is to extract active ingredients in plants by using an organic solvent or an aqueous solution, but the obtained active ingredients have low content and sometimes cannot meet the expected efficacy. Research shows that the active ingredients can be enriched after the plant raw materials are fermented. For example, when the lactobacillus acidophilus is used for fermenting tricholoma matsutake, more or stronger whitening substances can be extracted from the tricholoma matsutake, and the whitening effect of the tricholoma matsutake fermentation liquid is better than that of the aqueous extract and the alcohol extract of the tricholoma matsutake.
Chinese plant resources are rich, the difference of planting environments in different regions is large, active substances in plants are complex, a few plant components may have certain toxic and side effects, and effective utilization of a part of plant resources is limited. In addition, the content of toxic components such as alkaloid, lactone substances, glycoside compounds, toxic protein, aristolochic acid, anthraquinone, tannin, heavy metal and the like in plants can be reduced by utilizing a microbial fermentation technology.
Populus tomentosa is a plant of Populus genus of Populicaceae family, also called Populus trifoliata, and is distributed in Liaoning, North China, northwest China, east China, etc. Generally, the cultivation is carried out, the collection can be carried out all the year round, and the resources are extremely rich. Poncirus trifoliata is an important traditional Chinese medicinal material, has wide source, low price and high medicinal value, contains abundant flavonoid compounds, has better free radical scavenging effect and anti-inflammatory effect, and has obvious inhibition effect on bacteria. The active ingredients of the Poncirus trifoliata flower are applied to cosmetics, so that a new choice is brought to the formula design, and meanwhile, the method has certain reference significance for the expansion of the utilization direction of Poncirus trifoliata flower resources.
Disclosure of Invention
In order to make up the blank of the prior art and enrich the types of functional cosmetics and bring more raw material selection ideas for plant fermentation cosmetics, the invention provides the essence water with antioxidant and anti-inflammatory effects. According to the invention, the Populus trifoliata flower is fermented by microorganisms to extract active substances, and compared with a common Populus trifoliata flower aqueous extract or alcohol extract, the obtained fermentation liquid has higher clearance rate on free radicals and better anti-inflammatory effect, and a certain antibacterial property is kept. The applicant also finds out through experiments that the essence water of the invention can further improve the moisture retention capacity of the skin, greatly reduce the sensitization of the skin and has the advantages of mildness and no stimulation.
In order to achieve the above object, the present invention adopts the following technical solutions:
an essence water with antioxidant and anti-inflammatory effects comprises a formula component of a Populus trifoliata flower fermentation extract.
Preferably, the formula components of the essence water further comprise water, glycerin, nicotinamide, 1, 3-propylene glycol, butylene glycol, glyceryl polyether-26, hydrogenated lecithin, betaine, tocopherol, diethoxyethyl succinate, phenoxyethanol, tocopherol acetate, PEG-60 hydrogenated castor oil, tromethamine, glycerol glucoside, sodium acetylated hyaluronate, sodium PCA, serine, pyrrolidone carboxylic acid, disodium hydrogen phosphate, panthenol and essence.
Preferably, the formula of the essence water consists of the following components in percentage by weight: 6-9% Populus tomentosa fermented extract, 1-2% of glycerin, 0.3-0.5% of nicotinamide, 0.2-0.4% of 1, 3-propylene glycol, 0.2-0.4% of butylene glycol, 0.2-0.4% of glyceryl polyether, 0.5-1% of hydrogenated lecithin, 0.4-0.6% of betaine, 0.5-1% of tocopherol, 0.3-0.5% of diethoxyethyl succinate, 0.1-0.3% of phenoxyethanol, 0.4-0.8% of tocopherol acetate, 0.2-0.4% of PEG-60 hydrogenated castor oil, 0.2-0.5% of tromethamine, 0.5-1% of glyceryl glucoside, 1-2% of sodium acetylide, 0.1-0.3% of sodium PCA, 0.5-1% of serine, 0.3-0.5% of pyrrolidone carboxylic acid, 0.2-0.5% of disodium hydrogen phosphate, 0.3-0.5% of panthenol and 0.1-0.2% of essence, the balance being water.
Preferably, the formula of the essence water consists of the following components in percentage by weight: 8% of a Populus flower fermentation extract, 2% of glycerol, 0.3% of nicotinamide, 0.2% of 1, 3-propanediol, 0.2% of butanediol, 0.2% of glyceryl polyether-260.2%, 0.8% of hydrogenated lecithin, 0.6% of betaine, 1% of tocopherol, 0.3% of diethoxyethyl succinate, 0.1% of phenoxyethanol, 0.5% of tocopherol acetate, 0.2% of PEG-60 hydrogenated castor oil, 0.3% of tromethamine, 1% of glyceryl glucoside, 1.5% of sodium hyaluronate acylate, 0.1% of sodium PCA, 0.6% of serine, 0.3% of pyrrolidone carboxylic acid, 0.3% of disodium hydrogen phosphate, 0.5% of panthenol and 0.1% of a flavor, and the balance of water.
Preferably, the Poncirus trifoliata flower fermentation extract is a filtrate produced by microbial fermentation of Poncirus trifoliata flowers serving as raw materials.
Preferably, the microorganism is one or more of yeast, lactobacillus plantarum and bacillus subtilis.
Preferably, the microorganism is yeast and lactobacillus plantarum.
Preferably, the strain ratio of the yeast and the lactobacillus plantarum is 2: 3.
further, the invention provides application of the Populus deltoides fermented extract obtained by fermenting Populus deltoides with the microorganism in production of moisturizing and anti-inflammatory skin care products. Preferably, the microorganism is yeast and lactobacillus plantarum.
The beneficial effects of adopting the technical scheme are that: the applicant further obtains bioactive substances which are beneficial to skin absorption from plants, and simultaneously develops a new green natural cosmetic, so that the efficacy of the product is effectively improved, and the product variety is enriched. According to the invention, the Populus trifoliata flower is taken as a plant raw material, different types of microorganisms are adopted to ferment the Populus trifoliata flower through a large number of experiments, relevant biological activity indexes of the obtained fermentation liquor are detected, and the combination and the proportion of the fermentation microorganisms with good antioxidant and anti-inflammatory effects of the fermentation liquor are screened out. The applicant finds in the test and detection data of the product-related performance that the essence obtained by the invention improves the skin moisturizing capability, greatly reduces the irritation to the skin, is a cosmetic with strong efficacy, is mild and non-irritant, and has a very wide application prospect.
Detailed Description
The technical solutions in the embodiments of the present invention will be examined and completely described below with reference to the embodiments of the present invention, so as to further explain the invention. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Main experimental reagents and materials:
populus flower is purchased from Liaoning producing area, and microzyme, lactobacillus plantarum and bacillus subtilis are purchased from China agricultural microorganism strain preservation management center.
Glycerol, nicotinamide, 1, 3-propanediol, butylene glycol, glyceryl polyether-26, hydrogenated lecithin, betaine, tocopherol, diethoxyethyl succinate, phenoxyethanol, tocopherol acetate, PEG-60 hydrogenated castor oil, tromethamine, glycerol glucoside, sodium acetylated hyaluronate, sodium PCA, serine, pyrrolidone carboxylic acid, disodium hydrogen phosphate, panthenol and perfume are all purchased from commercially available products.
Example 1 preparation of Poncirus trifoliata fermented extract and essence water
The preparation method of the Populus trifoliata flower fermentation extract comprises the following steps: cleaning Poncirus trifoliata flower, drying in the shade, oven drying at 65 deg.C to constant weight, pulverizing, sieving with 20 mesh sieve, weighing quantitative powder, mixing with distilled water at a material-to-liquid ratio of (1: 100), sealing, sterilizing, cooling to room temperature, inoculating microbial liquid, culturing at 28 deg.C for 48 hr at 180r/min constant temperature, centrifuging, collecting supernatant, and filtering to obtain Poncirus trifoliata flower fermented extract.
The essence water formula comprises the following raw materials: 8% of a Populus flower fermentation extract, 2% of glycerol, 0.3% of nicotinamide, 0.2% of 1, 3-propanediol, 0.2% of butanediol, 0.2% of glyceryl polyether-260.2%, 0.8% of hydrogenated lecithin, 0.6% of betaine, 1% of tocopherol, 0.3% of diethoxyethyl succinate, 0.1% of phenoxyethanol, 0.5% of tocopherol acetate, 0.2% of PEG-60 hydrogenated castor oil, 0.3% of tromethamine, 1% of glyceryl glucoside, 1.5% of sodium hyaluronate acylate, 0.1% of sodium PCA, 0.6% of serine, 0.3% of pyrrolidone carboxylic acid, 0.3% of disodium hydrogen phosphate, 0.5% of panthenol and 0.1% of a flavor, and the balance of water.
The preparation method of the essence water comprises the following steps: placing the glyceryl polyether-26, the hydrogenated lecithin, diethoxyethyl succinate, tocopheryl acetate and PEG-60 hydrogenated castor oil in a water bath kettle at 65-70 ℃ and slowly stirring for 1h until all the materials are dissolved to obtain a mixture A; then placing water, glycerol, nicotinamide, 1, 3-propylene glycol, butanediol, betaine, tocopherol, phenoxyethanol, tromethamine, glycerol glucoside, acetylated sodium hyaluronate, sodium PCA, serine, pyrrolidone carboxylic acid, disodium hydrogen phosphate and panthenol in a 65-70 ℃ water bath kettle, and stirring at a constant speed for 30min until all the components are dissolved to obtain a mixture B; and slowly adding the mixture B into the mixture A for mixing, adding the Poncirus trifoliata fermented extract, the rest water and the essence, continuously stirring uniformly, cooling to 20-25 ℃, stopping stirring, discharging, and preparing to obtain an essence water sample.
Example 2 Populus trifoliata fermenting extract antioxidant, anti-inflammatory and antibacterial Effect test
Determination of DPPH organic radical scavenging Capacity: adding 2.0mL of fermented extract of different Poncirus trifoliata into 4.0mL of 2x10-4Uniformly mixing mol/L DPPH ethanol solution, standing for 30min, taking a solvent as a control sample, and recording the absorbance at the wavelength of 517nm as A1; a2 is the absorbance value of 2.0mL sample and 4.0mL ethanol water solution mixed uniformly at wavelength of 517 nm; and then 4.0mL of DPPH ethanol solution is mixed with 4.0mL of ethanol solution, the absorbance measured at the wavelength of 517nm is recorded as A3, and the clearance rate% of K organic free radicals is calculated as follows:
the results of the experiment are shown in table 1.
TABLE 1 free radical scavenging rates of different Populus trifoliata extracts
From the experimental data in table 1, it can be found that the free radical clearance of the extract obtained by fermenting the poplar flower with the microorganism is higher than that of the poplar flower extract obtained by the conventional water extraction method and alcohol extraction method, wherein when the microorganism adopted is saccharomycetes and lactobacillus plantarum (the ratio of viable bacteria is 2: 3), the free radical clearance is higher and reaches 86.8%, which indicates that the poplar flower extract prepared by fermenting with the microorganism has excellent antioxidant activity.
Anti-inflammatory experiments: 60 mice were randomly divided into 12 groups. The blank control group is physiological saline, the positive control group is hydrocortisone 0.02 g/kg-1The remaining groups were treated with the Populus trifoliata fermentation extract, the aqueous extract and the alcoholic extract in the formulation table of example 1. The groups were administered by intragastric administration 1 time in the morning for 7 days, and the positive control group was administered by intraperitoneal injection. 30min after the last administration, 0.2mL of xylene was evenly smeared on both sides of the mouse right auricle with a cotton ball to cause inflammation, and the left auricle was not smeared with the cotton ball to serve as a control. After 1h, the mice were sacrificed by decapitation and both ears were cut off. Round lugs are respectively punched at the same position by a puncher with the diameter of 7mm, the round lugs are weighed, the difference value of the weights of the left and right lugs is used as swelling degree, and the swelling inhibition percentage is calculated. The experimental results are shown in table 2, which shows that the Populus deltoides fermented extract has good anti-inflammatory effect and stronger anti-inflammatory effect on inflammation compared with an aqueous extract and an alcohol extract.
TABLE 2 anti-inflammatory Capparis auriculata extract
The antibacterial ability test method comprises the following steps: coating a layer of diluted experimental bacteria on an agar plate, inversely placing the agar plate in a constant-temperature incubator at 37 ℃, vertically placing an oxford cup on the surface of the agar plate by using an aseptic forceps after the surface is dried, slightly pressing the oxford cup, adding a sample to be detected, and setting a blank bacterial growth control and a positive growth control. Culturing in a constant-temperature incubator at 37 ℃ for 24h, taking out the plate and measuring the diameter of the inhibition zone around each oxford cup. The experimental bacteria include various common strains such as escherichia coli, staphylococcus aureus and aspergillus niger, and the data in this embodiment take escherichia coli as an example.
TABLE 3 antibacterial Capacity of different Populus extracts
As can be seen from Table 3, compared with the Populus trifoliata extract obtained by the conventional water extraction method and the alcohol extraction method, the diameter of the inhibition zone of the Populus trifoliata fermented extract is slightly reduced, but the inhibition zone is basically kept in a higher range, and the inhibition effect on experimental bacteria is hardly influenced, wherein the data of the Populus trifoliata fermented extract 7 and the Populus trifoliata alcohol extract are relatively close, which indicates that the Populus trifoliata extract obtained by the formula has relatively strong inhibition effect and relatively good antibacterial effect.
Example 3 moisturizing ability test of Populus trifoliata fermenting extract-containing essence liquid
The experimental conditions are as follows: the test environment temperature is 20 ℃, the relative humidity is 45-55%, the same indoor light condition is kept, and real-time dynamic monitoring is carried out.
Preparation before testing: four groups of volunteers were selected, aged 20-45 years, and tested for skin non-traumatic. The test site cannot use any cosmetics or external drugs 2-3 days before the test. Before the test, a tested part needs to be cleaned by a tested subject, a plurality of areas can be marked simultaneously after the cleaning, the interval between every two testing areas is at least 1cm, basic data is tested after the tested subject sits statically for 30min in a constant-temperature and constant-humidity environment, water and beverage cannot be drunk in the period, the tested subject is placed in a testing state, and a relaxation state is kept.
The method comprises the following steps:
refer to QB/T4256-.
Firstly, a test sample is coated for one time according to a certain dosage, a latex finger sleeve is used for uniformly coating the sample in a test area, and the actual sample coating quantity is recorded.
Measuring the tested part with the skin analyzing and testing instrument for at least 3 times. The initial value of each test area (before sample application) was measured and then the skin moisture content of the test area was measured after a set time.
Measuring the skin water content of the tested area after 1h, 2h and 4h after smearing respectively. The test of the same subject must be done by the same measuring person using the same instrument, and the measuring probe should be cleaned between the two measurements.
The results of the experiment are shown in table 4:
TABLE 4 Effect of essential waters containing different Populus trifoliata fermentation extracts on skin Water content
Note: 1-9 parts of Populus trifoliata fermenting extract is correspondingly added, and 10 parts of essence water is essence water containing Populus trifoliata alcohol extract.
From the experimental data in table 4, it can be found that the essence containing the citric flower fermentation extract has a significant moisturizing effect after being used for 1 hour, can still achieve a significant moisturizing effect until 4 hours, is maintained for a long time, and has a significantly improved moisturizing rate compared with an essence sample containing no citric flower fermentation extract.
Example 4 skin irritation test with Populus trifoliata fermenting extract essence Water
20 qualified volunteers were selected according to the regulations of technical Specification for safety of cosmetics (2015 edition), 0.2mL of sample was added on a filter paper sheet, a blank control was deionized water, the filter paper sheet was placed in a spot tester, the spot tester was fixed on the forearm curvature side of the subject, the spot tester was lightly pressed with the palm to be uniformly applied on the skin, and vigorous exercise or bathing, etc. could not be performed during this period. The condition of the skin was observed 24h and 48h after removal of the plaque tester, and the skin reactions were recorded according to the standard in Table 5.
TABLE 5 grading Standard of adverse skin reactions
TABLE 6 skin patch test results containing Populus deltoides fermented extract essence water
Table 7 shows that after the patches are removed for 24h and 48h, the skin reaction grades of the essence water 7 to the tested volunteers are negative reactions, while after the essence water 10 samples are used for 24h, 2 1-grade suspicious reactions appear, 1-grade 2 reactions appear, the 1-grade 2 reactions turn into 1-grade reactions after 48h, and the erythema elimination of the other volunteers turns into negative reactions, which indicates that the essence water containing the citric fermentation extract has no irritation to the skin, and the sensitization of the essence water containing the citric fermentation extract to the skin is greatly reduced compared with the sensitization of the essence water containing the citric alcohol extract to the skin.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention, including any reference to the above-mentioned embodiments. Various modifications to these embodiments will be readily apparent to those skilled in the art. The general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (10)
1. The essence water with the effects of oxidation resistance and inflammation resistance is characterized in that the formula components of the essence water comprise a Populus trifoliata flower fermentation extract.
2. The serum according to claim 1, characterized in that the formula components of the serum further comprise water, glycerin, niacinamide, 1, 3-propanediol, butylene glycol, glyceryl polyether-26, hydrogenated lecithin, betaine, tocopherol, diethoxyethyl succinate, phenoxyethanol, tocopheryl acetate, PEG-60 hydrogenated castor oil, tromethamine, glyceryl glucoside, sodium hyaluronate acetylated, sodium PCA, serine, pyrrolidone carboxylic acid, disodium hydrogen phosphate, panthenol and perfume.
3. The essence lotion according to claim 1, wherein the formula of the essence lotion comprises the following components in percentage by weight: 6-9% Populus tomentosa fermented extract, 1-2% of glycerin, 0.3-0.5% of nicotinamide, 0.2-0.4% of 1, 3-propylene glycol, 0.2-0.4% of butylene glycol, 0.2-0.4% of glyceryl polyether, 0.5-1% of hydrogenated lecithin, 0.4-0.6% of betaine, 0.5-1% of tocopherol, 0.3-0.5% of diethoxyethyl succinate, 0.1-0.3% of phenoxyethanol, 0.4-0.8% of tocopherol acetate, 0.2-0.4% of PEG-60 hydrogenated castor oil, 0.2-0.5% of tromethamine, 0.5-1% of glyceryl glucoside, 1-2% of sodium acetylide, 0.1-0.3% of sodium PCA, 0.5-1% of serine, 0.3-0.5% of pyrrolidone carboxylic acid, 0.2-0.5% of disodium hydrogen phosphate, 0.3-0.5% of panthenol and 0.1-0.2% of essence, the balance being water.
4. The essence lotion according to claim 1, wherein the formula of the essence lotion comprises the following components in percentage by weight: 8% of a Populus flower fermentation extract, 2% of glycerol, 0.3% of nicotinamide, 0.2% of 1, 3-propanediol, 0.2% of butanediol, 0.2% of glyceryl polyether-260.2%, 0.8% of hydrogenated lecithin, 0.6% of betaine, 1% of tocopherol, 0.3% of diethoxyethyl succinate, 0.1% of phenoxyethanol, 0.5% of tocopherol acetate, 0.2% of PEG-60 hydrogenated castor oil, 0.3% of tromethamine, 1% of glyceryl glucoside, 1.5% of sodium hyaluronate acylate, 0.1% of sodium PCA, 0.6% of serine, 0.3% of pyrrolidone carboxylic acid, 0.3% of disodium hydrogen phosphate, 0.5% of panthenol and 0.1% of a flavor, and the balance of water.
5. The essence according to any one of claims 1 to 4, wherein the Populus trifoliata fermentation extract is a filtrate produced by microbial fermentation of Populus trifoliata.
6. The essence water of claim 5, wherein the microorganism is one or more of yeast, Lactobacillus plantarum and Bacillus subtilis.
7. The essence of claim 6, wherein the microorganisms are yeasts and Lactobacillus plantarum.
8. The essence lotion of claim 7, wherein the ratio of yeast to lactobacillus plantarum strain is 2: 3.
9. use of the Poncirus trifoliata fermented extract obtained by fermenting Poncirus trifoliata with the microorganism of any one of claims 5-8 in the production of antioxidant and anti-inflammatory skin care products.
10. The use according to claim 9, wherein the microorganisms are yeasts and lactobacillus plantarum.
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