CN114767609A - Cosmetic composition with skin activating and anti-aging effects - Google Patents
Cosmetic composition with skin activating and anti-aging effects Download PDFInfo
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- CN114767609A CN114767609A CN202210541618.3A CN202210541618A CN114767609A CN 114767609 A CN114767609 A CN 114767609A CN 202210541618 A CN202210541618 A CN 202210541618A CN 114767609 A CN114767609 A CN 114767609A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
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Abstract
The invention belongs to the field of cosmetics, and particularly relates to a cosmetic composition with skin-activating and anti-aging effects. The cosmetic composition comprises saffron fermentation extract. The saffron crocus fermentation extract obtained by the mixed bacterial liquid has better oxidation resistance and anti-inflammatory performance. Further, the applicant tests that the cosmetic composition has certain moisturizing capability and also has very excellent antibacterial performance. Provides reference significance for deeply developing the application research of saffron, digging and enriching characteristic plant raw materials and improving the cost performance and extraction effect of the saffron raw materials.
Description
Technical Field
The invention belongs to the field of cosmetics, and particularly relates to a cosmetic composition with skin-activating and anti-aging effects.
Background
Related researches show that the saffron extract has related activities of resisting inflammation, regulating immunity, inhibiting platelet aggregation, resisting aging and the like. However, based on the shortage of saffron crocus raw material resources, high price and irregular extraction process, the research and application of the product as a cosmetic raw material are relatively less, and the product has better market innovation prospect.
The total content of flavone, fatty acid, alkyl diol, polyphenol and polysaccharide in saffron is over 104 kinds of compounds separated successively from saffron, and these are also the main effective components of cosmetics. The traditional process is to extract active ingredients in plants by using an organic solvent or an aqueous solution, but the obtained active ingredients have low content and sometimes cannot meet the expected efficacy.
Disclosure of Invention
The saffron extract is an active product with definite efficacy, is widely applied in the field of medicines, has good research foundation, is less applied in cosmetics, and is used for deeply developing the application research of saffron, digging and enriching characteristic plant raw materials, and improving the cost performance and extraction effect of the saffron raw materials. Further, the applicant tests that the cosmetic composition has certain moisturizing capability and also has very excellent antibacterial performance.
In order to achieve the above purpose, the invention adopts the following technical scheme:
a cosmetic composition with skin-activating and anti-aging effects comprises saffron fermentation extract.
Preferably, the raw material formula of the cosmetic composition further comprises the following components: water, butanediol, squalane, hydrolyzed collagen, jojoba oil, sodium polyglutamate, distearyl dimethyl ammonium hectorite, p-hydroxyacetophenone, methylparaben and essence.
Preferably, the raw material formula of the cosmetic composition consists of the following components in percentage by weight: 10-15% of saffron fermentation extract, 5-9% of butanediol, 2-4% of squalane, 1-3% of hydrolyzed collagen, 2-4% of jojoba oil, 0.5-1.5% of sodium polyglutamate, 3-7% of disteardimonium hectorite, 0.3-0.5% of p-hydroxyacetophenone, 0.5-1% of methylparaben, 0.2-0.4% of essence and the balance of water.
Preferably, the raw material formula of the cosmetic composition consists of the following components in percentage by weight: 12% of saffron fermentation extract, 8% of butanediol, 4% of squalane, 1% of hydrolyzed collagen, 2% of jojoba oil, 0.6% of sodium polyglutamate, 5% of distearyl dimethyl ammonium hectorite, 0.3% of p-hydroxyacetophenone, 0.5% of methylparaben, 0.1% of essence and the balance of water.
Preferably, the saffron fermentation extract is a filtrate produced by microbial fermentation of saffron serving as a raw material.
Preferably, the preparation method of the saffron fermentation extract comprises the following steps: cleaning and air-drying saffron crocus, placing the saffron crocus into a 60-70 ℃ oven to be dried to constant weight, crushing and sieving the saffron crocus by a 40-60 mesh sieve, weighing quantitative powder and distilled water, mixing the powder and the distilled water in a conical flask, sealing the conical flask, sterilizing the conical flask, cooling the conical flask to room temperature, inoculating microbial strain liquid, culturing the conical flask in a constant temperature shaking table at 28-30 ℃ and 180-.
Preferably, the microorganism is one or a mixture of two bacterial liquids of aspergillus niger and wine yeast.
Preferably, the microorganism is a mixed bacterial liquid of aspergillus niger and wine yeast.
Preferably, the strain ratio of the saccharomyces cerevisiae to the wine yeast is 1: 2.
further, the application provides the application of the saffron fermentation extract in the production of anti-aging cosmetics.
The beneficial effects of adopting the technical scheme are that: the applicant adopts plant microorganism fermentation technology, obtains the mixed bacteria liquid provided by the invention and the proportion thereof by screening different mass microorganisms for fermentation, thereby further improving the extraction efficiency of active ingredients in saffron crocus. The cosmetic composition of the invention has comparable moisturizing capability and slightly improved durability of moisturizing effect by adding the saffron fermentation extract compared with the saffron extract obtained by the conventional alcohol extraction method in the prior art. Meanwhile, the cosmetic composition disclosed by the invention is wide in application and can be applied to different formulations such as water emulsion, cream, essence, facial masks and the like. In addition, other performance test data show that the cosmetic composition has an obvious bacteriostatic action, and the saffron subjected to fermentation treatment is applied to the cosmetic composition, so that the antibacterial capability is greatly improved.
Detailed Description
The technical solutions in the embodiments of the present invention will be reviewed and completely described below with reference to the embodiments of the present invention, so as to further explain the present invention. It should be apparent that the described embodiments are only some embodiments of the present invention, and not all embodiments. Given the embodiments of the present invention, all other embodiments that can be obtained by a person of ordinary skill in the art without any inventive step are within the scope of the present invention.
Main experimental reagents and materials:
saffron is purchased from the producing area of Shanghai Chongming island, and aspergillus niger and wine yeast are purchased from China agricultural microorganism culture collection management center.
Butylene glycol, squalane, hydrolyzed collagen, jojoba oil, sodium polyglutamate, disteardimonium hectorite, p-hydroxyacetophenone, methylparaben and perfume were all purchased from commercially available products.
Example 1 preparation of saffron fermented extract and cosmetic composition
| Sample (I) | Microbial liquid (viable count 2.0X 10)10CFU·L-1） |
| Saffron fermentation extract 1 | Aspergillus niger |
| Saffron fermentation extract 2 | Wine yeast |
| Saffron fermentation extract 3 | Aspergillus niger and wine yeast (1: 1) |
| Saffron fermentation extract 4 | Aspergillus niger and wine yeast (1: 2) |
| Saffron fermentation extract 5 | Aspergillus niger and wine yeast (2: 1) |
The preparation method of the saffron crocus fermentation extract comprises the following steps: cleaning and air-drying saffron crocus, putting the saffron crocus into a 60-70 ℃ oven to be dried to constant weight, crushing and sieving the saffron crocus with a 40-60 mesh sieve, weighing quantitative powder and distilled water, mixing the powder and the distilled water in a conical flask, sealing the conical flask, sterilizing the conical flask, cooling the conical flask to room temperature, inoculating microbial liquid, culturing the conical flask in a shaking table at the constant temperature of 28-30 ℃ and 180 DEG for 200 r/min, centrifuging the conical flask, taking supernatant, and filtering the supernatant to obtain the saffron crocus fermentation extract.
The formula of the cosmetic composition comprises: 12% of saffron fermentation extract, 8% of butanediol, 4% of squalane, 1% of hydrolyzed collagen, 2% of jojoba oil, 0.6% of sodium polyglutamate, 5% of disteardimonium hectorite, 0.3% of p-hydroxyacetophenone, 0.5% of methylparaben, 0.1% of essence and the balance of water.
The preparation method of the cosmetic composition comprises the following steps: weighing the raw materials according to the mass percentage of the formula, mixing squalane, jojoba oil, distearic dimethyl ammonium hectorite, p-hydroxyacetophenone and methylparaben, heating to 65-70 ℃, stirring and dissolving to obtain an oil phase, then mixing water, butanediol, hydrolyzed collagen and sodium polyglutamate, heating to 65-70 ℃, stirring and dissolving to obtain a water phase, slowly adding the water phase into the oil phase, quickly stirring, cooling to 40-45 ℃, adding the saffron fermentation extract and the essence, continuously stirring and uniformly mixing, and cooling to room temperature to obtain the cosmetic composition.
Example 2 antioxidant and anti-inflammatory Properties of saffron fermentation extract
Determination of DPPH organic radical scavenging Capacity: adding 2.0 mL of different stigma croci Sativi fermented extract into 4.0mL of 2 x 10-4Uniformly mixing mol/L DPPH ethanol solution, standing for 30min, taking a solvent as a control sample, and recording the absorbance at the wavelength of 517nm as A1; a2 is the absorbance value of 2.0 mL sample and 4.0mL ethanol water solution mixed uniformly at wavelength of 517 nm; then 4.0mL of DPPH ethanol solution is mixed with 4.0mL of ethanol solution, the absorbance measured at the wavelength of 517nm is recorded as A3,Kcalculation of% clearance of organic free radicals:K（DPPH·）=
x 100%. The results of the experiment are shown in table 1.
TABLE 1 free radical scavenging rates of different saffron extracts
| Sample (I) | Saffron fermentation extract 1 | Saffron fermentation extract 2 | Saffron fermentation extract 3 | Saffron fermentation extract 4 | Saffron fermentation extract 5 |
| Radical scavenging ratio (%) | 76.0 | 77.1 | 85.9 | 87.1 | 82.2 |
From the experimental data in table 1, it can be found that the free radical clearance of the extract obtained by the fermentation of the saffron crocus by the microorganism is higher, and is more than 75%, wherein, when the adopted microorganism is aspergillus niger and wine yeast (the viable count ratio is 1: 2), the free radical clearance reaches 87.1%, which indicates that the saffron crocus extract prepared by the fermentation of the microorganism has excellent antioxidant activity.
Anti-inflammatory experiments: 60 mice were randomly divided into 12 groups. Physiological saline for blank control group, hydrocortisone 0.02 g/kg for positive control group-1The remaining groups were treated with saffron fermentation extract as in the formula table of example 1. Each group was administered by gavage 1 time every morning for 7 days, and positive control group was administered by intraperitoneal injection. 30min after the last administration, 0.2 mL of xylene was evenly smeared on both sides of the mouse right auricle with a cotton ball to cause inflammation, and the left auricle was not smeared as a control. After 1h, the mice were sacrificed by decapitation and the ears were cut off. Round lugs are respectively punched at the same position by a puncher with the diameter of 7 mm, the round lugs are weighed, the difference value of the weights of the left and right lugs is used as swelling degree, and the swelling inhibition percentage is calculated. The experimental results are shown in table 2, compared with other fermentation products, the saffron fermentation extract 4 has good anti-inflammatory effect and stronger anti-inflammatory effect on inflammation.
TABLE 2 anti-inflammatory Capacity of different saffron extracts
| Sample (I) | Saffron fermentation extract 1 | Saffron fermentation extract 2 | Saffron fermentation extract 3 | Saffron fermentation extract 4 | Saffron fermentation extract 5 |
| Swelling inhibition ratio (%) | 53.9 | 55.3 | 60.2 | 62.7 | 57.4 |
Example 3 moisturizing and antibacterial Capacity testing of cosmetic compositions
The experimental conditions are as follows: the test environment temperature is 22 ℃, the relative humidity is 40-50%, the same indoor light condition is kept, and real-time dynamic monitoring is carried out.
Preparation before testing: four groups of volunteers were selected, aged 20-45 years, and tested for skin non-traumatic. The test site cannot use any cosmetics or external drugs 2-3 days before the test. Before the test, the tested part needs to be cleaned by the tested person, a plurality of areas can be marked simultaneously after the cleaning, the interval between every two test areas is at least 1cm, basic data is measured after the tested person sits statically in a constant-temperature and constant-humidity environment for 30min, water and beverage cannot be drunk in the period, the tested person is placed in a test state, and a relaxed state is kept.
The method comprises the following steps:
refer to QB/T4256-2011 evaluation method of cosmetic moisturizing efficacy evaluation guideline.
Firstly, a test sample is coated once according to a certain amount, a sample is uniformly coated in a test area by using a latex finger cot, and the actual sample coating amount is recorded.
The skin analysis tester measures the tested part, and each area is measured in parallel for at least 3 times. The initial value of each test area (before sample application) was measured and then the skin moisture content of the test area was measured after a set time.
Measuring the water content of the skin of the tested area after 1h, 2h and 4h after smearing respectively. The test of the same subject must be done by the same measuring person using the same instrument, and the measuring probe should be cleaned between the two measurements.
The results of the experiment are shown in table 4:
TABLE 3 Effect of cosmetic composition on skin moisture content
| Sample(s) | 30 min | 1 h | 2 h | 4 h |
| Cosmetic composition 1 | 66.1 | 59.5 | 49.3 | 43.6 |
| Cosmetic composition 2 | 60.3 | 56.0 | 51.7 | 40.4 |
Note: stigma croci Sativi fermented product 4 is added corresponding to cosmetic composition 1, and stigma croci Sativi alcoholic extract is added corresponding to cosmetic composition 2.
From the experimental data in table 3, it can be found that the moisture content of the skin can be better improved by using the saffron extract, and the skin has a certain moisturizing effect, and the moisturizing effect of the cosmetic composition 1 is better than that of the cosmetic composition 2 after the cosmetic composition is used for 4 hours, which indicates that the moisturizing capability of the saffron extract subjected to microbial fermentation treatment is longer in maintenance time. The difference between the moisture retention rate and the saffron alcohol extract is not large, which indicates that the original moisture retention components in the saffron extracted by microbial fermentation cannot be damaged.
The antibacterial ability test method comprises the following steps: coating a layer of diluted experimental bacteria on an agar plate, inversely placing the agar plate in a constant-temperature incubator at 37 ℃, vertically placing an Oxford cup on the surface of the agar plate by using a sterile forceps after the surface is dried, slightly pressing, adding a sample to be detected, and setting a blank bacteria growth control and a positive growth control. Culturing in a constant-temperature incubator at 37 ℃ for 24h, taking out the plate and measuring the diameter of the inhibition zone around each oxford cup. The experimental bacteria include various common strains such as escherichia coli, staphylococcus aureus, aspergillus niger and the like, and the data in the embodiment take the escherichia coli as an example.
The experiment shows that the diameter of the inhibition zone of the cosmetic composition 1 is 18.2 +/-1.3 mm, and the diameter of the inhibition zone of the cosmetic composition 2 is 13.0 +/-0.7 mm, which indicates that the diameter of the inhibition zone of the saffron fermentation extract is greatly increased and has good inhibition effect on experimental bacteria compared with the saffron extract obtained by the conventional alcohol extraction method through microbial fermentation, and the cosmetic composition obtained by the formula of the invention has strong inhibition effect and good antibacterial effect.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention, including any reference to the above-mentioned embodiments. Various modifications to these embodiments will be readily apparent to those skilled in the art. The general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (10)
1. A cosmetic composition with skin-activating and anti-aging effects is characterized by comprising a saffron fermentation extract.
2. The cosmetic composition of claim 1, wherein the raw material formulation of the cosmetic composition further comprises the following components: water, butanediol, squalane, hydrolyzed collagen, jojoba oil, sodium polyglutamate, disteardimonium hectorite, p-hydroxyacetophenone, methylparaben and essence.
3. The cosmetic composition as claimed in claim 1, wherein the raw material formulation of the cosmetic composition consists of the following components in amounts: 10-15% of saffron fermentation extract, 5-9% of butanediol, 2-4% of squalane, 1-3% of hydrolyzed collagen, 2-4% of jojoba oil, 0.5-1.5% of sodium polyglutamate, 3-7% of distearyl dimethyl ammonium hectorite, 0.3-0.5% of p-hydroxyacetophenone, 0.5-1% of methylparaben, 0.2-0.4% of essence and the balance of water.
4. The cosmetic composition as claimed in claim 1, wherein the raw material formulation of the cosmetic composition consists of the following components in amounts: 12% of saffron fermentation extract, 8% of butanediol, 4% of squalane, 1% of hydrolyzed collagen, 2% of jojoba oil, 0.6% of sodium polyglutamate, 5% of distearyl dimethyl ammonium hectorite, 0.3% of p-hydroxyacetophenone, 0.5% of methylparaben, 0.1% of essence and the balance of water.
5. The cosmetic composition according to any one of claims 1 to 4, wherein said saffron fermentation extract is a filtrate obtained by microbial fermentation of saffron as a raw material.
6. Cosmetic composition according to claim 5, characterized in that said saffron fermented extract is prepared as follows: cleaning and air-drying saffron crocus, placing the saffron crocus into a 60-70 ℃ oven to be dried to constant weight, crushing and sieving the saffron crocus by a 40-60 mesh sieve, weighing quantitative powder and distilled water, mixing the powder and the distilled water in a conical flask, sealing the conical flask, sterilizing the conical flask, cooling the conical flask to room temperature, inoculating microbial strain liquid, culturing the conical flask in a constant temperature shaking table at 28-30 ℃ and 180-.
7. The cosmetic composition according to claim 6, wherein the microorganism is one or a mixture of two bacterial liquids of Aspergillus niger and wine yeast.
8. The cosmetic composition according to claim 7, wherein the microorganism is a mixed bacterial solution of Aspergillus niger and wine yeast.
9. The cosmetic composition of claim 8, wherein the saccharomyces cerevisiae and saccharomyces cerevisiae are prepared in a ratio of 1: 2.
10. use of saffron fermentation extract according to any of claims 5 to 9 in the production of anti-aging cosmetic.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116270386A (en) * | 2023-03-20 | 2023-06-23 | 杨伊森(广州)生命科学技术有限公司 | Preparation method and application of saffron crocus fermentation filtrate |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105496901A (en) * | 2016-01-19 | 2016-04-20 | 佛山市芊茹化妆品有限公司 | Cosmetic composition with anti-aging effect as well as preparation method and application thereof |
| CN105943461A (en) * | 2016-06-23 | 2016-09-21 | 青岛浩大海洋保健食品有限公司 | Plateau pome health skincare lotion capable of resisting skin ageing, maintaining beauty and protecting and whitening skin |
| CN114146042A (en) * | 2021-09-18 | 2022-03-08 | 西行班达米尔(海南经济特区)生物科技有限公司 | Saffron crocus fermentation product and preparation method and application thereof |
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- 2022-05-19 CN CN202210541618.3A patent/CN114767609A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105496901A (en) * | 2016-01-19 | 2016-04-20 | 佛山市芊茹化妆品有限公司 | Cosmetic composition with anti-aging effect as well as preparation method and application thereof |
| CN105943461A (en) * | 2016-06-23 | 2016-09-21 | 青岛浩大海洋保健食品有限公司 | Plateau pome health skincare lotion capable of resisting skin ageing, maintaining beauty and protecting and whitening skin |
| CN114146042A (en) * | 2021-09-18 | 2022-03-08 | 西行班达米尔(海南经济特区)生物科技有限公司 | Saffron crocus fermentation product and preparation method and application thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116270386A (en) * | 2023-03-20 | 2023-06-23 | 杨伊森(广州)生命科学技术有限公司 | Preparation method and application of saffron crocus fermentation filtrate |
| CN116270386B (en) * | 2023-03-20 | 2023-09-22 | 广州杨森药业有限公司 | Preparation method and application of saffron crocus fermentation filtrate |
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