CN112438898A - Cosmetic composition for moisturizing skin and improving skin barrier comprising electrolyte material - Google Patents
Cosmetic composition for moisturizing skin and improving skin barrier comprising electrolyte material Download PDFInfo
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- CN112438898A CN112438898A CN201911154372.9A CN201911154372A CN112438898A CN 112438898 A CN112438898 A CN 112438898A CN 201911154372 A CN201911154372 A CN 201911154372A CN 112438898 A CN112438898 A CN 112438898A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The present invention belongs to the field of cosmetics, and more particularly, to a cosmetic composition for moisturizing skin and improving skin barrier comprising an electrolyte material, which comprises sodium chloride, potassium chloride, sodium bicarbonate and calcium chloride. The technical problem of how to provide a cosmetic composition for moisturizing skin or improving skin barrier, which increases the synthesis of ceramide, thereby not only improving skin barrier but also having excellent effects on skin moisturizing, is solved by the technical scheme of the present invention.
Description
Technical Field
The present invention relates to a cosmetic composition comprising an electrolyte material.
Background
The skin acts as an organ, which is constantly in contact with the environment outside the body, and mainly acts as a physical barrier. The skin is roughly divided into three layers: epidermis, dermis and subcutaneous fat, wherein the stratum corneum of the epidermis inhibits the loss of moisture and electrolytes to the exterior, thereby preventing the skin from drying out and providing an environment for the normal biochemical metabolism of the skin. And, it can also protect the human body from humidity and temperature changes, ultraviolet rays, other physical or chemical external stimuli.
When the moisture content is maintained at about 10% to 30%, the layer of keratinocytes that constitutes the normal skin barrier appears to be smooth, moist and healthy skin. However, when the moisture content of the keratinocyte layer is equal to or less than 10%, the skin becomes dry, cracked and rough, and looks older. Thus, if certain moisture and electrolytes of the skin are not maintained, the acidity and osmotic pressure of the skin are reduced, the skin becomes dry and thus is sensitive to even a small stimulus, thereby possibly causing itching, stinging, inflammation, and the like. To improve this impaired skin barrier, lost oil and moisture may be provided to the skin by a cosmetic composition. So far, research into cosmetics for providing oil and moisture to the skin has been actively conducted, but research into cosmetics including electrolytes contributing to immediate and rapid recovery upon application to the skin and compositions thereof is still required.
When the electrolyte balance of the skin is disrupted, drying may continue even after the cosmetic is used. When the osmotic pressure of the cosmetic is higher than that of the skin, the skin becomes dry because moisture in skin cells escapes to the outside due to the osmotic pressure. In contrast, when the osmotic pressure of the cosmetic is lower than that of the skin, swelling and destruction of cells may be caused due to excessive entry of water into the cells. Therefore, there is a need to research and develop a cosmetic composition having similar osmotic pressure to that of electrolytes present in the human body to help promptly and rapidly restore the skin when it is applied to the skin, thereby maintaining skin homeostasis and improving skin barrier and moisture retention.
Disclosure of Invention
Technical problem
One aspect of the present invention provides a cosmetic composition for moisturizing skin or improving skin barrier, comprising sodium chloride, potassium chloride, sodium bicarbonate, and calcium chloride.
Technical scheme
One aspect of the present invention provides a cosmetic composition for moisturizing skin or improving skin barrier, comprising sodium chloride, potassium chloride, sodium bicarbonate, and calcium chloride. In one example, it was confirmed that the expression level of the CerS3 gene was significantly higher in the composition prepared by containing all of sodium chloride, potassium chloride, sodium bicarbonate, and calcium chloride, compared to the composition prepared by containing sodium chloride, potassium chloride, sodium bicarbonate, or calcium chloride. In addition, according to one aspect, it was confirmed that the skin moisture level of the composition comprising sodium chloride, potassium chloride, sodium bicarbonate and calcium chloride in a certain content ratio was significantly improved immediately as compared with the comparative example. Therefore, since the composition according to an aspect entirely contains sodium chloride, potassium chloride, sodium bicarbonate, and calcium chloride, the effects of effectively promoting the synthesis of ceramide, improving skin barrier weakened by aging or external stimuli, and instantly enhancing skin moisturizing power and moisturizing duration power are excellent, and thus may be used to improve skin barrier or skin moisturizing. In this case, the "skin moisturizing" may refer to any action of maintaining skin moisture or preventing moisture loss.
In a specific embodiment, the sodium chloride is 0.5 to 1.5 weight% (w/v), the potassium chloride is 0.005 to 0.1 weight% (w/v), the sodium bicarbonate is 0.01 to 0.1 weight% (w/v), and the calcium chloride is 0.005 to 0.1 weight% (w/v), based on the total weight of the composition.
In one embodiment, the sodium chloride, potassium chloride, sodium bicarbonate, and calcium chloride may be mixed in a weight ratio of 85 to 97: 0.5 to 5: 1 to 5: 0.5 to 5. The sodium chloride, potassium chloride, sodium bicarbonate and calcium chloride may be mixed, for example, in a weight ratio of 90 to 97: 0.5 to 2: 1 to 5: 0.5 to 3, 90 to 97: 0.5 to 1.5: 1 to 5: 0.5 to 3.5, 90 to 97: 0.5 to 1.5, 2 to 5: 0.5 to 3, 90 to 97: 0.5 to 1.5: 2 to 4: 0.5 to 4, 90 to 97: 0.5 to 1.5: 0.5 to 3.5: 0.5 to 3, 90 to 97: 1 to 2: 1 to 5: 1 to 3, 90 to 97: 1 to 2: 1 to 4: 1 to 5, 90 to 97: 1 to 1.5: 1 to 5: 1.5 to 3, 92 to 96: 0.5: 2 to 4: 1 to 3, 93 to 97: 0.5 to 2: 2 to 3, 90 to 5: 1 to 5: 1.5: 1 to 3, 90 to 5: 1.5: 1 to 3, and 5: 0.5 to 5: 1 to 5: 1.5: 3, 95: 1 to 5: 1.5: 1 to 5: 3, 93 to 97: 0.5: 1 to 5: 1 to 5: 1.5: 1 to 5: 3, and. At this time, when the mixing ratio of sodium chloride, potassium chloride, sodium bicarbonate and calcium chloride is less than the range, there is a problem that the skin moisturizing and barrier improving effects are negligible; when it exceeds the range, there is a problem of affecting the stability of the dosage form or precipitating in the cosmetic composition, etc.
In one embodiment, the cosmetic composition may have an osmolality of 150 to 300 mOsm/L. For example, it may be 150 to 250mOsm/L, 150 to 200mOsm/L, 200 to 300mOsm/L, 200 to 250mOsm/L, or 250 to 300 mOsm/L. When the osmotic pressure of the cosmetic composition is less than 150mOsm/L, since the osmotic pressure concentration of the cosmetic composition is lower than that of the skin, moisture excessively enters into skin cells, thereby possibly causing cell swelling and destruction; when it exceeds 300mOsm/L, since the osmolality of the cosmetic composition is higher than that of the skin, moisture in the skin cells escapes to the outside, and thus there may occur a problem that the skin becomes dry. According to an aspect, since the cosmetic composition comprising 0.5 to 1.5 parts by weight of sodium chloride, 0.005 to 0.1 parts by weight of potassium chloride, 0.01 to 0.1 parts by weight of sodium bicarbonate, and 0.005 to 0.1 parts by weight of calcium chloride has an osmotic pressure similar to that of an electrolyte present in a human body, based on 100 parts by weight of the total composition, it may help to promptly recover skin upon its application to the skin, and improve skin barrier and moisturization.
The cosmetic composition according to an aspect may be prepared into a specific formulation by a method well known in the art of cosmetics, and may further comprise a cosmetically acceptable additive. Such additives include stabilizers, solubilizers, opacifiers, vitamins, pigments, nutrients or combinations thereof, and the like, and may vary depending on the formulation to be prepared.
The cosmetic composition may be prepared in any formulation conventionally prepared in the art. Examples include solutions, suspensions, emulsions, pastes, gels, creams, lotions, shampoos, surfactant-containing cleansers, foundation lotions, foundation creams, and the like, and more particularly, can be prepared in the form of pliable lotions, nourishing emulsions, nourishing creams, massage creams, essences, eye creams, cleansing foams, cleansing lotions, facial masks, and the like.
Another aspect of the present invention provides a composition for external preparation for skin comprising sodium chloride, potassium chloride, sodium bicarbonate and calcium chloride. The specific contents of the sodium chloride, potassium chloride, sodium bicarbonate and calcium chloride are as described above.
The external preparation composition according to one embodiment may be prepared in a formulation generally prepared in the art. For example, it can be prepared in the form of cream, gel, patch, spray, ointment, plaster, emulsion, liniment, paste, cataplasm, and the like.
The cosmetic composition and the skin external agent composition may further include various known additives according to the formulation, and according to a specific embodiment, may further include an additive selected from the group consisting of a carrier, an emulsifier, a humectant, a surfactant, a chelating agent, an antioxidant, a bactericide, a stabilizer, and any combination thereof.
The carrier may include animal fibers, vegetable fibers, waxes, paraffins, starches, tragacanth, cellulose derivatives, polyethylene glycols, silicones, bentonites, silica, talc, zinc oxide, lactose, aluminum hydroxide, calcium silicate, polyamide powder, water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1, 3-butylene glycol oil, glyceryl aliphatic esters, polyethylene glycols, liquid diluents, ethoxylated isostearyl alcohols, suspending agents such as polyoxyethylene sorbitol esters and polyoxyethylene sorbitan esters, microcrystalline cellulose, aluminum methylhydroxide, agar, fatty alcohol sulfates, fatty alcohol ether sulfates, sulfosuccinic acid monoesters, isethionates, imidazoline derivatives, methyl taurates, sarcosinates, fatty acid amide sulfates, sodium lauryl sulfate, sodium, Alkyl amide betaine, fatty alcohol, fatty glyceride, fatty diethanolamide, vegetable oil, lanolin derivative or fatty acid ethoxylated glycerol, etc.
The emulsifier may include fluid paraffin, cetyl octanoate, stearic acid, and the like.
The humectant may include a polyol selected from the group consisting of glycerin, butylene glycol, propylene glycol, dipropylene glycol, pentylene glycol, hexylene glycol, polyethylene glycol, sorbitol, and any combination thereof. Specifically, the above-mentioned polyol may be contained in an amount of 5 to 50 wt%, 5 to 30 wt%, 10 to 30 wt%, or 5 to 10 wt%, based on the total weight of the composition. At this time, when the content of the polyol is less than the range, there is a problem that the moisturizing durability is reduced; when it exceeds the above range, there is a problem that the feeling in use is lowered by increasing the stickiness and the moisture.
The chelating agent may include sodium Ethylenediaminetetraacetate (EDTA), alpha-hydroxy fatty acids, lactoferrin, alpha-hydroxy acids, citric acid, lactic acid, malic acid, bilirubin, biliverdin, and the like.
The antioxidant may include butylated hydroxyanisole, dibutyl hydroxytoluene, propyl gallate, or the like.
Further, examples of the ingredients that can be mixed into the cosmetic composition and the external preparation for skin include oil and fat ingredients, emollients, organic and inorganic pigments, organic powders, ultraviolet absorbers, pH adjusters, alcohols, pigments, perfumes, blood circulation promoters, cold feeling agents, antiperspirants, and the like.
The cosmetic composition for skin and the skin external agent composition may be applied by applying an appropriate amount to the skin according to the area of the skin to be applied, and may be repeatedly used one or more times per day as needed. Further, the amount and number of applications may be increased or decreased as needed in consideration of the individual's skin condition, age, and the like.
Advantageous effects
The cosmetic composition according to an aspect increases the synthesis of ceramide, thereby not only improving the skin barrier but also having an excellent effect on immediately improving skin moisturization.
Drawings
Fig. 1 is a graph showing the expression level of CerS3 in cells treated with human keratinocytes in example 1 and comparative examples 1 to 5.
Fig. 2 is a graph for confirming the improvement of moisturizing effect when example 1 is applied to the skin.
Detailed Description
Hereinafter, preferred embodiments of the present invention will be provided to facilitate understanding of the present invention. However, the following examples are provided only for easier understanding of the present invention, and the present invention is not limited by the following examples.
Example 1 and comparative examples 1 to 5 preparation of cosmetic compositions
Cosmetic compositions (unit: g) of example 1 and comparative examples 1 to 5 were prepared by dissolving the ingredients shown in table 1 below in 1L of pure distilled water, respectively.
[ Table 1]
| Composition (I) | Example 1 | Comparative example 1 | Comparative example 2 | Comparative example 3 | Comparative example 4 | Comparative example 5 |
| Sodium chloride | 7.8 | 7.8 | 7.8 | 7.8 | 7.8 | |
| Potassium chloride | 0.1 | 0.1 | 0.1 | 0.1 | ||
| Sodium bicarbonate | 0.23 | 0.23 | 0.23 | 0.23 | ||
| Calcium chloride | 0.14 | 0.14 | 0.14 | 0.14 |
The cosmetic compositions of example 1 and comparative examples 1 to 5 were prepared under conditions of maximum osmotic pressure of 246mOsm/L, conductivity of 14.27ms/cm, and pH of 8.02.
[ Experimental example ]
Cellular assessment to improve the efficacy of moisturization and barrier
As skin ages, the amount of ceramide, an important component that accounts for 40% of the lipid constituting the skin barrier, is significantly reduced, and moisture retention and the skin barrier are changed. In this experiment, the expression level of CerS3, which is an enzyme that synthesizes ceramide, was measured at the mRNA level using Human keratinocytes (Human keratincyte) to measure the moisturizing and barrier-improving effects of skin.
(1) Preparation of sample
The samples prepared in example 1 and comparative examples 1 to 5 were filtered with a 0.2 μm Syringe filter (Syringe filter). This was added to the cell culture broth so that the final concentration was 10% (v/v). Pure distilled water was added as a control.
(2) Culture of human keratinocytes
HaCaT cells, which are keratinocytes, were cultured in Dulbecco Modified Eagle's Medium (DMEM), which is the most widely used medium for culturing skin cells. After mixing 10% Fetal Bovine Serum (FBS) and 1% penicillin in a 100mm culture dish, cells were cultured. Maintaining the culture solution containing the sample at 37 deg.C and 5% CO2The culture was carried out in an incubator at a concentration and humidity of 95% for 24 hours.
(3) Test of skin moisturizing Effect
The cells cultured in the medium of (1) were recovered, washed with cooled Phosphate Buffered Saline (PBS), and total RNA was extracted using PureLink RNA miniprep kit (seemer feishel technology). The specific RNA extraction procedure followed the manual attached to the product. The gene expression change was measured by quantitative real-time PCR (qRT-PCR) which binds a fluorescent substance to a DNA product amplified in Polymerase Chain Reaction (PCR) and continuously detects the fluorescent substance. To quantify the expression of ceramide synthase CerS3 gene, the fluorescence emitted by the PCR product was measured by sibogerin (SYBR green, siemer fly technologies). A reaction solution was prepared by mixing 0.2. mu.M of a primer, 50mM potassium chloride, 20mM Tris-HCl (pH8.4), 0.8mM deoxyribonucleoside triphosphate (dNTP), 0.5U Extaq DNA polymerase, 3mM magnesium chloride and 1 XSaibogelin in a PCR tube. A total of 40 cycles of denaturation (30 seconds), annealing (annealing) and polymerization (polymerization) were performed using a PCR instrument at 94 ℃ for 3 minutes, 30 seconds at 58 ℃ and 30 seconds at 72 ℃ for 30 seconds, and the fluorescence intensity was measured after the end of each cycle. The fluorescence intensity of the CerS3 gene was normalized to GAPDH value and 100% of the control group was converted to compare the difference. The primer sequences used in the experiments are shown in table 2 below.
[ Table 2]
FIG. 1 is a graph showing the results of measuring the expression level of CerS3 gene.
As shown in FIG. 1, it was confirmed that the expression level of CerS3 gene was significantly higher in example 1 than in comparative examples 1 to 5.
That is, the cosmetic composition according to an aspect may entirely contain sodium chloride, potassium chloride, sodium bicarbonate, and calcium chloride to effectively promote synthesis of ceramide, thereby improving skin moisturization and barrier.
Evaluation of efficacy in improving skin moisturization
In this experiment, in order to measure the effect of immediate improvement in moisturization of the skin, the composition of example 1 was applied to the skin and the skin moisture level was observed using Epsilon.
Specifically, the composition of example 1 was applied to the arms of five subjects to measure the moisture content of the skin. Pure distilled water was used as a control group instead of example 1.
Fig. 2 is a graph for confirming the improvement of moisturizing effect when example 1 is applied to the skin.
As shown in FIG. 2, it was confirmed that the skin moisture content increased about 1.8 times after the composition of example 1 was applied to the skin, and the amount of change in the increase in the skin moisture content was also significantly higher compared to the non-applied group or the control group.
That is, the cosmetic composition according to an aspect, which entirely includes sodium chloride, potassium chloride, sodium bicarbonate, and calcium chloride, may immediately improve skin moisturization, and thus may improve skin moisturization and barrier.
The foregoing description of the present invention has been provided for illustrative purposes only, and it will be readily understood by those skilled in the art that the present invention may be modified in other specific forms without changing the technical spirit or essential features of the present invention. It is therefore to be understood that the above described embodiments are illustrative and not restrictive in all respects.
Claims (6)
1. A cosmetic composition for moisturizing skin or improving skin barrier comprising sodium chloride, potassium chloride, sodium bicarbonate, and calcium chloride.
2. The cosmetic composition of claim 1, wherein,
the sodium chloride, potassium chloride, sodium bicarbonate and calcium chloride are mixed in a weight ratio of 85 to 97: 0.5 to 5: 1 to 5: 0.5 to 5.
3. The cosmetic composition of claim 1, wherein,
the sodium chloride is from 0.5 to 1.5 weight% (w/v), the potassium chloride is from 0.005 to 0.1 weight% (w/v), the sodium bicarbonate is from 0.01 to 0.1 weight% (w/v), and the calcium chloride is from 0.005 to 0.1 weight% (w/v), based on the total weight of the composition.
4. The cosmetic composition of claim 1, wherein the composition promotes ceramide synthesis.
5. The cosmetic composition of claim 1, wherein the composition has an osmolality of 150 to 300 mOsm/L.
6. A skin external composition for moisturizing skin or improving skin barrier comprises sodium chloride, potassium chloride, sodium bicarbonate and calcium chloride.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020190108300A KR102097265B1 (en) | 2019-09-02 | 2019-09-02 | A cosmetic composition comprising electrolytes for hydration and skin barrier |
| KR10-2019-0108300 | 2019-09-02 |
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| CN112438898A true CN112438898A (en) | 2021-03-05 |
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| CN114504526A (en) * | 2021-01-27 | 2022-05-17 | 江苏巴帝恩生物科技有限公司 | Preparation method of fermentation product filtrate composition containing glucose electrolyte |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1813663A (en) * | 2005-12-02 | 2006-08-09 | 何秋莎 | Skin care product |
| CN103126917A (en) * | 2013-02-27 | 2013-06-05 | 广州市科玮生物技术有限公司 | Bionic gynecologic care solution and its preparation method |
| CN106726686A (en) * | 2017-01-19 | 2017-05-31 | 弎西艾斯（苏州）生物科技有限公司 | A kind of human skin cell's growth-promoting media |
| CN107260639A (en) * | 2017-06-21 | 2017-10-20 | 广州军区广州总医院 | A kind of gel rich in autologous growth factor repairs facial mask and preparation method thereof |
| KR20180023827A (en) * | 2016-08-25 | 2018-03-07 | 문득곤 | Cosmetic composition and method supplying the useful components in skin |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10123771B4 (en) * | 2001-05-16 | 2019-01-10 | Beiersdorf Ag | Use of electrolytes to strengthen the barrier function of the skin |
| KR20100001244A (en) * | 2008-06-26 | 2010-01-06 | 김보라 | Aprocessing method of antibacterial moisturing liquid made by deep seaelectronic water and the antibacterial moisturing liquid made by deepseaelectronic water thereof |
| KR101611930B1 (en) * | 2015-07-14 | 2016-04-12 | 주식회사 비오코스 | Cosmetic Composition Containing Mixture Extracts of Marine Plants For Promoting Ceramide Biosynthesis and Enhancing Skin Barrier |
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- 2019-09-02 KR KR1020190108300A patent/KR102097265B1/en active IP Right Grant
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1813663A (en) * | 2005-12-02 | 2006-08-09 | 何秋莎 | Skin care product |
| CN103126917A (en) * | 2013-02-27 | 2013-06-05 | 广州市科玮生物技术有限公司 | Bionic gynecologic care solution and its preparation method |
| KR20180023827A (en) * | 2016-08-25 | 2018-03-07 | 문득곤 | Cosmetic composition and method supplying the useful components in skin |
| CN106726686A (en) * | 2017-01-19 | 2017-05-31 | 弎西艾斯（苏州）生物科技有限公司 | A kind of human skin cell's growth-promoting media |
| CN107260639A (en) * | 2017-06-21 | 2017-10-20 | 广州军区广州总医院 | A kind of gel rich in autologous growth factor repairs facial mask and preparation method thereof |
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| KR102097265B1 (en) | 2020-04-06 |
| CN112438898B (en) | 2023-07-11 |
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