CN112426515A

CN112426515A - Medical mask for repairing burned skin

Info

Publication number: CN112426515A
Application number: CN202011374792.0A
Authority: CN
Inventors: 唐芳艳
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-11-30
Filing date: 2020-11-30
Publication date: 2021-03-02

Abstract

The invention discloses a medical mask for repairing burns and a preparation method thereof. The medical facial mask for repairing the burn comprises a facial mask base material and facial mask liquid. The mask base material is a medical mask for repairing burn, which is prepared by using coconut-based fibers after crosslinking modification, and the mask liquid consists of the following components: gelatin, collagen, hyaluronic acid, cephalosporin antibiotics, natural traditional Chinese medicine substances, 1,2 pentanediol, 1,2 hexanediol, p-hydroxyacetophenone, 3, 4-dibromo-2 (5H) -furanone, AIP compounds and deionized water. The coconut-based biological fiber with good biocompatibility is compounded with natural traditional Chinese medicine component substances and non-toxic antibacterial substances, so that the prepared facial mask has good air permeability and biocompatibility, has non-toxic and excellent antibacterial properties, can perform the functions of disinfection and bacteriostasis on an affected part, can effectively promote the growth and recovery of the skin of the affected part, effectively repairs skin injury and accelerates the healing of a wound surface. Meanwhile, the pain of the affected part can be effectively reduced, and the pain of the wounded can be relieved.

Description

Medical mask for repairing burned skin

Technical Field

The invention relates to the field of biomedical materials and burn repair, and particularly provides a medical mask for repairing burned skin and a preparation method thereof.

Background

Burn occurs in life or production, is a common accidental injury in life, harms human health and appearance, and has various types including firewood fumigation burn, charcoal fire burn, oil gas burn, electric burn and the like. Boiling water, gruel, hot oil, hot steam, and scalding are common occurrences. Burn is an injury caused by the action of factors such as flame, hot water, hot steam, hot oil, hot cement, electric current, chemical substances, radioactive substances and the like on the skin, mucous membranes, muscles and the like of a human body. For some burns, if treated in a timely manner, no adverse consequences result. However, serious burns endanger the lives of human beings and animals, and the superficial tissues and deep tissues of the skin are easily infected by epidermal bacteria, skin deformation and scars are easily left after the burns occur once, and even high fever, shock and the like are caused.

At present, the treatment aiming at the burn mainly comprises smearing ointment and oral antibiotic medicines, matching simple traditional Chinese medicine ointment, wrapping sterile gauze, and the like to treat and care the wound surface. In addition, the emerging burn mask can also play a role in burn care. The burn facial mask should have antibacterial property, but the antibacterial agent material of the existing burn facial mask adopts nano silver, the toxicity of the nano silver cannot be controlled, the skin infection is easily caused, and the healing of the skin is not facilitated. In addition, chitosan collagen and other materials are used as the mask base material, and the materials have poor air permeability, need to be replaced and washed, and are not beneficial to patients to use. The activity of the growth factor used in the prior art needs to be controlled, so that the service life of the medical mask is severely limited, the growth factor has high price and is difficult to use in large quantity, and the use of the medical mask is limited due to the slow regeneration speed of skin and the like. . Therefore, the existing burn repair mask has some defects and needs to be further improved.

Disclosure of Invention

In view of the above analysis, the present invention aims to provide a facial mask for burn repair and a preparation method thereof, which can promote the healing of skin wounds, shorten the healing days, prevent skin infection, relieve the pain of patients, and have high safety and simple use.

The invention improves the existing burn repairing mask. Firstly, the antibacterial material of the burn mask is improved, one or a plurality of natural traditional Chinese medicine substances and micromolecule antibacterial agents are mixed, so that the toxicity problem of the antibacterial material using the nano-silver antibacterial agent can be solved, the inflammation and the side effect of a patient in the using process are reduced, the skin infection is not easy to cause, the healing of skin wounds is promoted, and the pain of the patient is relieved. The use of the secretion of the skin stem cell growth factor is beneficial to accelerating the skin regeneration and reducing the cost of the mask. In addition, the invention improves the mask substrate material, the mask substrate of the burn mask is prepared by using the coconut-based fiber after crosslinking modification, and the burn mask has good biocompatibility, good air permeability and comfortable affinity.

The invention adopts the following technical scheme:

the medical mask for repairing the burn comprises the following components in percentage by mass: gelatin 3.8-5.2%; collagen 1.8-3.5%; hyaluronic acid 1.8-2.8%; 0.00-0.12% of cephalosporin antibiotics; the content of natural Chinese medicinal materials (herba Portulacae, herba Houttuyniae, ZIYUN paste, and Eucommiae cortex) is 0.00-0.12%; 0.00-0.12% of 1, 2-pentanediol; 0.00-0.12% of 1,2 hexanediol; 0.00-0.12% of p-hydroxyacetophenone; 0.00-0.12% of 3, 4-dibromo-2 (5H) -furanone; 0.00-0.12% of AIP compounds; the deionized water is 88-93%.

Further, the mask liquid of the medical mask for repairing burns comprises the following components in percentage by mass: gelatin 4.2-5.0%; collagen content of 2.0-3.1%; hyaluronic acid 1.6-2.4%; 0.02-0.10% of cephalosporin antibiotics; the content of natural Chinese medicinal materials (herba Portulacae, herba Houttuyniae, ZIYUN paste, and Eucommiae cortex) is 0.02-0.10%; 0.02-0.10% of 1, 2-pentanediol; 0.02-0.10% of 1,2 hexanediol; 0.02-0.10% of p-hydroxyacetophenone; 0.02-0.10% of 3, 4-dibromo-2 (5H) -furanone; 0.02-0.10% of AIP compounds; the deionized water is 89-92%.

Further, the mask liquid of the medical mask for repairing burns comprises the following components in percentage by mass: gelatin 4.4-4.8%; collagen content of 2.2-2.8%; hyaluronic acid 1.8-2.2%; the cephalosporin antibiotics are 0.04-0.08%; the content of natural Chinese medicinal materials (herba Portulacae, herba Houttuyniae, ZIYUN paste, and Eucommiae cortex) is 0.04-0.08%; 0.04-0.08% of 1, 2-pentanediol; 0.04-0.08% of 1,2 hexanediol; 0.04 to 0.08 percent of p-hydroxyacetophenone; 0.04-0.08% of 3, 4-dibromo-2 (5H) -furanone; 0.04-0.08% of AIP compound; the deionized water is 89-92%.

Further, the mask liquid of the medical mask for repairing burns comprises the following components in percentage by mass: gelatin content 4.6%; 2.8% of collagen; hyaluronic acid 2.2%; the cephalosporin antibiotics account for 0.06%; the content of natural Chinese medicinal materials (herba Portulacae, herba Houttuyniae, ZIYUN paste, and Eucommiae cortex) is 0.06%; 0.05% of 1, 2-pentanediol; 0.06% of 1, 2-hexanediol; 0.06 percent of p-hydroxyacetophenone; 0.05% of 3, 4-dibromo-2 (5H) -furanone; 0.06% of AIP compound; the deionized water content was 90%.

Further, the cephalosporin antibiotic is cefoperazone sodium. For special patients, other antibiotics can be selected according to the bacterial culture susceptibility experiment result.

A preparation method of a medical mask for repairing burns is characterized by comprising the following steps:

(1) freeze-drying or air-drying coconut-based fibers, pulverizing, curing, and sterilizing to obtain non-woven fabric as mask base material;

(2) weighing appropriate amount of gelatin, collagen, hyaluronic acid, cephalosporin antibiotics, natural traditional Chinese medicine substances, 1,2 pentanediol, 1,2 hexanediol, p-hydroxyacetophenone, 3, 4-dibromo-2 (5H) -furanone, AIP compounds and deionized water, and mixing to prepare facial mask liquid;

(3) soaking the coconut-based fiber non-woven fabric in a mask liquid, and performing crosslinking modification through a crosslinking agent;

(4) aseptically packaging the burn repairing mask in a medical packaging bag, and performing irradiation sterilization by adopting cobalt-60, wherein the dose is 25-50 kGy;

the coconut-based fiber in the step (1) is prepared by crushing and extracting biological fermentation coconut shells.

In the step (3), the cross-linking agent is any one of glutaraldehyde, 1-ethyl-3- (3-dimethylaminopropyl) -carbodiimide, genipin and dialdehyde starch.

The crosslinking time of the crosslinking agent in the step (3) is 0.5 to 4 hours.

The cephalosporin antibiotics in the mask liquid are cefoperazone sodium, are cephalosporin third-generation broad-spectrum antibiotics, can treat bacterial infection, have a good effect on sensitive bacteria, can effectively kill residual or reproduced bacteria in damaged skin tissues, and eliminate acute infection.

The natural traditional Chinese medicine substances in the mask liquid comprise purslane, houttuynia cordata, Ziyun paste and eucommia ulmoides. These components have the following properties.

Purslane: herba Portulacae (dry aerial parts of Portulaca oleracea L.) belonging to Portulacaceae is used as medicine. Sour and cold in nature. The chemical components of the compound comprise norepinephrine, potassium salt, dopa, dopamine, betanin, isobetanin, beet type, isobetanin, oxalic acid, malic acid, citric acid, glutamic acid, aspartic acid, alanine, glucose, fructose, sucrose and the like. Can be used for treating heat toxin and bloody dysentery, carbuncle, furuncle, eczema, erysipelas, snake and insect bite, hematochezia, hemorrhoidal bleeding, metrorrhagia, metrostaxis, etc. Has effects of clearing away heat and toxic materials, relieving swelling, stopping bleeding, and cooling blood.

Houttuynia cordata: dried aerial parts of houttuynia cordata of Saururaceae are used as medicine. The property of the medicine is pungent, cold and cool. The chemical components of the compound comprise decanoyl acetaldehyde, lauraldehyde, alpha-pinene and linalool, methyl n-nonyl ketone, camphene, myrcene, limonene, bornyl acetate, caryophyllene, avocadin, hyperin, rutin, chlorogenic acid, beta-sitosterol, stearic acid, oleic acid, linoleic acid, quercitrin, isoquercitrin and the like. Can be used for treating lung abscess, empyema, phlegm heat, asthma, cough, dysentery, carbuncle, suppurative sore, and heat stranguria. Has effects in clearing away heat and toxic materials, relieving swelling, treating sore, promoting urination, removing dampness, clearing away heat, relieving dysentery, and invigorating stomach.

Ziyun ointment: the medicinal material source is root of Lithospermum erythrorhizon, Lithospermum erythrorhizon or Lithospermum erythrorhizon of Boraginaceae. Cold in nature, sweet and salty in flavor. The chemical components of the compound comprise deoxyshikonin, beta-dimethylacrylshikonin, acetylshikonin, shikonin, beta-sitosterol, beta-acetoxyvalerylshikonin and the like. Has effects in clearing away heat and toxic materials, removing necrotic tissue, and promoting granulation. Can be used for treating mild scald caused by water or fire. Can be used for treating mild scald caused by water or fire. . It has antibacterial and antiinflammatory effects.

Eucommia ulmoides: is a plant of genus eucommia of family Eucommiaceae, which is sweet in taste and warm in nature. The chemical components comprise gutta-percha, glucoside, alkaloid, pectin, fat, resin, organic acid, ketose, vitamin C, vitamin E, vitamin B, beta-carotene, etc. Has effects in promoting cell metabolism, inhibiting bacteria, and relieving inflammation, and can be used for inhibiting Staphylococcus aureus, Shigella flexneri, Escherichia coli, Pseudomonas aeruginosa, Bacillus anthracis, pneumococcus, pneumonia bacillus, diphtheria bacillus, and beta hemolytic streptococcus.

Effective components of natural traditional Chinese medicine substances in the mask liquid interact to generate substances for promoting skin tissue regeneration and substances for sterilization and bacteriostasis, the substances are stable in performance and structure, can be stored for a long time at normal temperature, are common raw materials in the traditional Chinese herbal medicines, are easy to obtain and low in price, and therefore, the mask liquid is beneficial to reducing the cost of burn medicines.

The invention has the beneficial effects that: the active ingredients in the components in the mask liquid are reasonably matched, so that the raw materials are fully mixed, the medicine effect is synergistically enhanced by the active ingredients of the components, the mask liquid can play a role in disinfecting and inhibiting bacteria on an affected part, reduce inflammation and side effects, prevent skin infection easily, effectively promote the growth and recovery of the skin of the affected part, effectively repair skin injury without leaving scars, and simultaneously effectively reduce pain of the affected part and relieve pain of patients. Thereby achieving the purpose of treating the symptoms of the trauma patients and having good treatment effect. The preparation method is simple, the preparation cost is low, and the method has great practicability and strong market popularization value.

The burn repairing mask liquid can be made into a mask with coconut-based fibers, and can also be prepared into emulsion, liquid, cream, ointment and the like according to a proportion for use.

Additional features and advantages of the invention will be set forth in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention. The objectives and other advantages of the invention will be realized and attained by the structure particularly pointed out in the written description and claims thereof.

Drawings

The invention is described in further detail below with reference to the following figures and embodiments:

FIG. 1 shows the chemical structural formula of cephalothin;

FIG. 2 is a chemical structural formula of cefazolin;

FIG. 3 shows the chemical structure of cefuroxime axetil;

fig. 4 is a schematic view of a medical mask according to example 1;

fig. 5 is a schematic view of the medical facial mask solution of example 2.

Detailed Description

Example 1

The mask liquid of the medical mask for repairing the burn comprises the following components in percentage by mass: gelatin 3.8-5.2%; collagen 1.8-3.5%; hyaluronic acid 1.8-2.8%; 0.00-0.12% of cephalosporin antibiotics; the content of natural Chinese medicinal materials (herba Portulacae, herba Houttuyniae, ZIYUN paste, and Eucommiae cortex) is 0.00-0.12%; 0.00-0.12% of 1, 2-pentanediol; 0.00-0.12% of 1,2 hexanediol; 0.00-0.12% of p-hydroxyacetophenone; 0.00-0.12% of 3, 4-dibromo-2 (5H) -furanone; 0.00-0.12% of AIP compounds; the deionized water is 88-93%.

The preparation method of the medical mask for repairing the burn is characterized by comprising the following steps:

(3) soaking the coconut-based fiber non-woven fabric in a mask liquid for crosslinking modification, wherein a crosslinking agent is glutaraldehyde;

example 2

The mask liquid of the medical mask for repairing the burn comprises the following components in percentage by mass: gelatin 4.4-4.8%; collagen content of 2.2-2.8%; hyaluronic acid 1.8-2.2%; the cephalosporin antibiotics are 0.04-0.08%; the content of natural Chinese medicinal materials (herba Portulacae, herba Houttuyniae, ZIYUN paste, and Eucommiae cortex) is 0.04-0.08%; 0.04-0.08% of 1, 2-pentanediol; 0.04-0.08% of 1,2 hexanediol; 0.04 to 0.08 percent of p-hydroxyacetophenone; 0.04-0.08% of 3, 4-dibromo-2 (5H) -furanone; 0.04-0.08% of AIP compound; the deionized water is 89-92%.

example 3

example 4

example 5

The mask liquid of the medical mask for repairing the burn comprises the following components in percentage by mass: gelatin content 4.6%; 2.8% of collagen; hyaluronic acid 2.2%; the cephalosporin antibiotics account for 0.06%; the content of natural Chinese medicinal materials (herba Portulacae, herba Houttuyniae, ZIYUN paste, and Eucommiae cortex) is 0.06%; 0.05% of 1, 2-pentanediol; 0.06% of 1, 2-hexanediol; 0.06 percent of p-hydroxyacetophenone; 0.05% of 3, 4-dibromo-2 (5H) -furanone; 0.06% of AIP compound; the deionized water content was 90%.

comparative example 1

This comparative example is different from example 5 only in that the crosslinking agent is 1-ethyl-3- (3-dimethylaminopropyl) -carbodiimide in the method of preparing the mask of this comparative example. The rest was the same as in example 5.

Comparative example 2

The comparative example is different from example 5 only in that the crosslinking agent is genipin in the preparation method of the mask of the comparative example. The rest was the same as in example 5.

Comparative example 3

The comparative example is different from example 5 only in that the cross-linking agent is dialdehyde starch in the preparation method of the facial mask of the comparative example. The rest was the same as in example 5.

The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention, and various modifications and changes will occur to those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. The mask liquid of the medical mask for repairing the burn is characterized by comprising the following components in percentage by mass: gelatin 3.8-5.2%; collagen 1.8-3.5%; hyaluronic acid 1.8-2.8%; 0.00-0.12% of cephalosporin antibiotics; the content of natural Chinese medicinal materials (herba Portulacae, herba Houttuyniae, ZIYUN paste, and Eucommiae cortex) is 0.00-0.12%; 0.00-0.12% of 1, 2-pentanediol; 0.00-0.12% of 1,2 hexanediol; 0.00-0.12% of p-hydroxyacetophenone; 0.00-0.12% of 3, 4-dibromo-2 (5H) -furanone; 0.00-0.12% of AIP compounds; the deionized water is 88-93%.

2. The mask liquid of the medical mask for repairing the burn according to the claim 1, which is characterized by comprising the following components in percentage by mass: gelatin content 4.6%; 2.8% of collagen; hyaluronic acid 2.2%; the cephalosporin antibiotics account for 0.06%; the content of natural Chinese medicinal materials (herba Portulacae, herba Houttuyniae, ZIYUN paste, and Eucommiae cortex) is 0.06%; 0.05% of 1, 2-pentanediol; 0.06% of 1, 2-hexanediol; 0.06 percent of p-hydroxyacetophenone; 0.05% of 3, 4-dibromo-2 (5H) -furanone; 0.06% of AIP compound; the deionized water content was 90%.

3. A preparation method of a medical mask for repairing burns is characterized by comprising the following steps:

(3) soaking the coconut-based fiber non-woven fabric in the mask liquid for crosslinking modification;

(4) the burn repairing mask is aseptically packaged in a medical packaging bag, and is subjected to radiation sterilization by adopting cobalt-60, wherein the dose is 25-50 kGy.

4. The method for preparing a medical mask for repairing burn according to claim 3, wherein: the coconut-based fiber in the step (1) is prepared by crushing and extracting biologically fermented coconut shells.

5. The method for preparing a medical mask for repairing burn according to claim 3, wherein: in the step (3), the cross-linking agent is any one of glutaraldehyde, 1-ethyl-3- (3-dimethylaminopropyl) -carbodiimide, genipin and dialdehyde starch.

6. The method for preparing a medical mask for repairing burn according to claim 3, wherein: and (3) the crosslinking time of the crosslinking agent in the step (3) is 0.5-4 hours.