CN112402635A - Water bath sterilization equipment capable of remarkably improving medicine sterilization effect - Google Patents
Water bath sterilization equipment capable of remarkably improving medicine sterilization effect Download PDFInfo
- Publication number
- CN112402635A CN112402635A CN202011374907.6A CN202011374907A CN112402635A CN 112402635 A CN112402635 A CN 112402635A CN 202011374907 A CN202011374907 A CN 202011374907A CN 112402635 A CN112402635 A CN 112402635A
- Authority
- CN
- China
- Prior art keywords
- sterilization
- water
- cavity
- pipe
- water bath
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 219
- 230000001954 sterilising effect Effects 0.000 title claims abstract description 143
- 238000004659 sterilization and disinfection Methods 0.000 title claims abstract description 130
- 239000003814 drug Substances 0.000 title claims abstract description 55
- 230000000694 effects Effects 0.000 title claims abstract description 24
- 238000009826 distribution Methods 0.000 claims abstract description 52
- 229940079593 drug Drugs 0.000 claims abstract description 29
- 238000003860 storage Methods 0.000 claims abstract description 13
- 239000011229 interlayer Substances 0.000 claims description 10
- 239000000126 substance Substances 0.000 abstract description 4
- 230000000704 physical effect Effects 0.000 abstract description 3
- 230000036512 infertility Effects 0.000 abstract description 2
- 238000010438 heat treatment Methods 0.000 description 23
- 239000010410 layer Substances 0.000 description 14
- 238000001816 cooling Methods 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- 238000010586 diagram Methods 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 238000005057 refrigeration Methods 0.000 description 6
- 239000000498 cooling water Substances 0.000 description 5
- 230000008901 benefit Effects 0.000 description 3
- 238000001802 infusion Methods 0.000 description 3
- 238000007731 hot pressing Methods 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 230000000630 rising effect Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 239000008236 heating water Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0023—Heat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/26—Accessories or devices or components used for biocidal treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/10—Apparatus features
- A61L2202/15—Biocide distribution means, e.g. nozzles, pumps, manifolds, fans, baffles, sprayers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/20—Targets to be treated
- A61L2202/21—Pharmaceuticals, e.g. medicaments, artificial body parts
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
The invention discloses a water bath sterilization device capable of remarkably improving the sterilization effect of a medicine, and belongs to the technical field of medicine sterilization. The water bath sterilization equipment capable of remarkably improving the sterilization effect of the medicines comprises: the sterilizer is internally provided with a sterilization cavity; the water distribution disc is arranged at the top of the sterilization cavity, a water storage cavity is arranged in the water distribution disc, and a plurality of first water leakage holes are formed in the bottom of the water storage cavity; the check ring is arranged at the bottom of the water storage cavity, and the shunt pipe of the sterilization cavity extends into the check ring; the sterilization frame is arranged in the sterilization cavity below the water distribution plate. By applying the water bath sterilization equipment for remarkably improving the sterilization effect of the medicines, the medicines of one batch can be heated (cooled) more uniformly in the same time period, and the sterility level, the physical property and the chemical property of the product are consistent.
Description
Technical Field
The invention relates to the technical field of medicine sterilization, in particular to a water bath sterilization device capable of remarkably improving the medicine sterilization effect.
Background
The infusion is the most widely used in clinic and one of the most important treatment means, the liquid medicine directly enters the blood through the veins of the human body, and the aseptic level of the liquid medicine is of great importance to the medication safety of the human body. The sterility guarantee of the large infusion is usually realized by killing microorganisms, and the sterilization method mainly adopted in the large infusion industry is a hot-pressing sterilization method.
The method of heating water by steam or other media and killing the drug microorganisms by the superheated water under a certain pressure is the most common hot-pressing sterilization method, and has been widely adopted by the pharmaceutical industry due to the factors of the temperature uniformity, the temperature controllability, the economy of the media and the like of the water. The method of killing microbes using "superheated water" is known as a water bath sterilization method.
The water bath sterilization method has advantages over other sterilization methods due to the uniformity of temperature, the uniformity of temperature is relative in the actual drug sterilization process, drugs sterilized by using 'superheated water' in the same sterilizer also have different physical and chemical properties due to the difference of temperature, and the root causes of the different properties are mainly non-uniformity of water quantity of the drug shower and non-uniformity of water temperature.
Because the medicine is placed and is disinfected in getting into the sterilization chamber of steriliser on a plurality of sterilization framves simultaneously, current sterilization frame is that a plurality of foraminiferous sterilization box are range upon range of to be placed mostly, and the sterilization frame of this kind of structure can not guarantee that the medicine of every layer of sterilization box is heated or cools off homogeneous in same time quantum.
Disclosure of Invention
The invention aims to provide water bath sterilization equipment which can obviously improve the sterilization effect of medicines so as to solve the technical problems in the background technology.
In order to achieve the purpose, the invention adopts the following technical scheme:
a water bath sterilization equipment capable of remarkably improving the sterilization effect of medicines comprises: the sterilizer is internally provided with a sterilization cavity; the water distribution disc is arranged at the top of the sterilization cavity, a water storage cavity is arranged in the water distribution disc, and a plurality of first water leakage holes are formed in the bottom of the water storage cavity; the check ring is arranged at the bottom of the water storage cavity, and the shunt pipe of the sterilization cavity extends into the check ring; the sterilization frame is arranged in the sterilization cavity below the water distribution plate.
Further, the sterilization frame includes the sterilization box of a plurality of range upon range of settings, be equipped with in the sterilization box and place the chamber, the bottom of sterilization box has the cavity intermediate layer, a plurality of second that run through holes that leak are seted up to the interbedded roof of cavity, a plurality of third that run through holes that leak are seted up to the interbedded diapire of cavity, the aperture in second hole that leaks is greater than the aperture in third hole that leaks.
Furthermore, the sterilization box is quadrilateral, supporting columns are arranged on all top corners of the sterilization box, positioning columns are arranged on a pair of supporting columns which are opposite to each other, and positioning grooves matched with the positioning columns are arranged at the bottoms of the supporting columns provided with the positioning columns.
Furthermore, the cross section of the positioning column is circular, trilateral, quadrilateral or pentagonal.
Further, the size of the retainer ring is as follows: the height is 15-20mm, the diameter is 25-30mm, and the distance for the shunt tube of the sterilization cavity to extend into the retainer ring is 5-10 mm.
Furthermore, a plurality of water distribution disks are arranged, each water distribution disk is provided with 2 retaining rings, each water distribution disk corresponds to a flow dividing pipe of the U-shaped sterilization cavity, and two ends of the flow dividing pipe of the U-shaped sterilization cavity correspondingly extend into the 2 retaining rings respectively; and a plurality of water distribution disks are arranged, and the area formed by the plurality of water distribution disks is equal to the area of the sterilization box.
Furthermore, the aperture of the first water leakage hole is 2-3mm, the aperture of the second water leakage hole is 6-8mm, the diameter of the third water leakage hole is 2-3mm, and the height of the hollow interlayer is 8-12 mm.
Compared with the prior art, the invention has the beneficial effects that:
the invention has novel structure, the sterilizer flows into the circulating water of the water distribution disc through the shunt pipe, and then carries out shower heating (cooling) on the medicines which are loaded in the sterilization box and are regularly arranged through the first water leakage holes with the same aperture and uniformly distributed on the water distribution disc, the circulating water flowing through the surface of the medicines flows through the second water leakage holes with larger upper layers of the sterilization box to form liquid levels such as water distribution and the like in the interlayer of the sterilization box, and carries out shower heating (cooling) on the medicines of the next layer through the third water leakage holes with smaller bottom layers of the sterilization box, thereby finally realizing more uniform heating (cooling) of the medicines of one batch in the same time period and realizing the consistency of the sterile level, the physical property and the chemical property of the product.
Drawings
Fig. 1 is a schematic view of a water bath sterilization apparatus for significantly improving the sterilization effect of a drug according to the present invention.
Fig. 2 is a schematic structural diagram of a sterilization cavity of the water bath sterilization equipment for remarkably improving the sterilization effect of the medicine.
Fig. 3 is a schematic connection diagram of a water distribution system and a circulating water constant pressure system of the water bath sterilization equipment for remarkably improving the sterilization effect of the medicine.
Fig. 4 is a schematic connection diagram of a water distribution disc and a retainer ring of the water bath sterilization equipment for remarkably improving the sterilization effect of the medicine.
Fig. 5 is a schematic connection diagram of a water distribution disc and a shunt pipe of the water bath sterilization equipment for remarkably improving the sterilization effect of the medicine.
Fig. 6 is a schematic connection diagram of a flow regulating flower disc and a shunt pipe of the water bath sterilization equipment for remarkably improving the sterilization effect of the medicines.
Fig. 7 is a schematic structural diagram of a sterilizing box of the water bath sterilizing apparatus for remarkably improving the sterilizing effect of the medicine.
Fig. 8 is a perspective view of the sterilizing case of the water bath sterilizing apparatus of the present invention, which significantly improves the sterilizing effect of the medicine.
Fig. 9 is a perspective view of a sterilization rack of the water bath sterilization device for remarkably improving the sterilization effect of the medicine.
Fig. 10 is a test chart of the temperature uniformity of the water bath sterilization equipment for remarkably improving the sterilization effect of the medicine by adopting the wireless verifier.
The labels in the figure are: 1-a sterilizer, 2-a heating heat exchanger, 3-a constant pressure tank, 4-a balance pipe, 5-an external constant pressure pipe, 6-a first water pump, 7-a refrigerating heat exchanger, 8-a water distribution disc, 9-a shunt pipe, 10-a temperature controller, 11-a temperature balancing device, 12-a water mixing pipe, 13-a flow adjusting flower disc, 14-a retainer ring, 15-a sterilization cavity, 16-a sterilization frame, 17-a medicine, 18-an internal constant pressure pipe, 19-an internal circulating water pipe, 20-a second water pump, 21-a first water leakage hole, 22-a sterilization box, 23-a second water leakage hole, 24-a third water leakage hole, 25-a hollow interlayer, 26-a support column and 27-a positioning column.
Detailed Description
The present invention will be further described with reference to the following examples, which are intended to illustrate only some, but not all, of the embodiments of the present invention. Based on the embodiments of the present invention, other embodiments used by those skilled in the art without any creative effort belong to the protection scope of the present invention.
Example 1:
as shown in fig. 1 and 2, a water bath sterilization device for significantly improving the sterilization effect of drugs is applied to a water bath sterilization temperature and pressure uniform water distribution system, and the water bath sterilization temperature and pressure uniform water distribution system comprises: the system comprises a water distribution system, a circulating water constant pressure system, a temperature equalizing device, a heating heat exchange device and a refrigerating heat exchange device; a sterilization cavity 15 is arranged in the sterilizer 1; the sterilizing rack 16 is slidably arranged in the sterilizing cavity 15, and the sterilizing rack 16 is used for placing medicines 17 to be sterilized. The water distribution system is arranged above the sterilization cavity 15 and is used for spraying and sterilizing products on the sterilization rack 16; the circulating water constant pressure system is arranged above the sterilizer 1 and is connected with the water distribution system; the temperature equalizing device is arranged on the circulating water constant pressure system; the heating heat exchange device and the refrigerating heat exchange device are respectively communicated with the temperature equalizing device.
As shown in fig. 1 to 3, in this embodiment, the water distribution system includes: the device comprises an in-cabinet constant pressure pipe 18, a shunt pipe 9, a water distribution disc 8 and a retainer ring 14, wherein the in-cabinet constant pressure pipe 18 is communicated with the water outlet end of a circulating water constant pressure system; a plurality of the shunt tubes 9 are connected to a constant pressure tube 18 in the cabinet at equal intervals; the water distribution disks 8 are arranged at the top of the sterilization cavity 15, a water storage cavity is arranged in each water distribution disk 8, a plurality of first water leakage holes 21 are arranged at the bottom of the water storage cavity, the diameter of each first water leakage hole 21 is about 2mm, and each water distribution disk 8 is arranged corresponding to one flow division pipe 9; the retainer ring 14 is arranged at the bottom of the water storage cavity, and the shunt pipe 9 is arranged in the retainer ring 14. The retainer ring 14 is used for preventing the circulating water from influencing the water level of the water distribution plate 8 and the like. Two retaining rings 14 with the height of 15-20mm and the diameter of 30mm are arranged at the geometric center of the water distribution plate 8, the retaining rings 14 are connected with the water distribution plate 8 through welding, the water distribution plate 8 is connected with the inner wall of the sterilization cavity 15 through a support, preferably, the flow dividing pipe 9 is U-shaped, the middle part of the flow dividing pipe 9 is connected to a constant pressure pipe 18 in the cabinet, two retaining rings 14 are arranged on each water distribution plate 8, two ends of the U-shaped flow dividing pipe 9 are respectively arranged in the retaining rings 14, and two end parts of the flow dividing pipe 9 are respectively provided with a flow adjusting flower disc 13.
The flux of a flow dividing pipe 9 can be adjusted by the relative rotation of the two flow adjusting faceplates 13, the water outlet of the flow dividing pipe 9 extends into the retainer ring 14 by 5mm, and the upper end of the flow dividing pipe 9 is connected with a constant pressure pipe 18 in the cabinet; the shunt tubes 9 are uniformly distributed on the constant-pressure tubes 18 in the cabinet, and the diameter of the constant-pressure tubes 18 in the cabinet is more than 2 times of that of the shunt tubes 9; the upper end of the constant-pressure pipe 18 in the cabinet is connected with the constant-pressure pipe 5 outside the cabinet through the sterilization cavity 15, the diameter of the constant-pressure pipe 5 outside the cabinet is about 2 times of the diameter of the constant-pressure pipe 18 in the cabinet, and the length of the constant-pressure pipe is equivalent to that of the constant-pressure pipe 18 in the cabinet; the joint of the constant pressure pipe 18 in the cabinet and the constant pressure pipe 5 outside the cabinet is the geometric center of the constant pressure pipe 5 outside the cabinet.
As shown in fig. 7 to 9, in the present embodiment, the sterilization rack 16 includes: the sterilization box 22 of a plurality of range upon range of settings, be equipped with in the sterilization box 22 and place the chamber, the bottom of sterilization box 22 is for having cavity intermediate layer 25, a plurality of second that run through holes 23 that leak are seted up to the roof of cavity intermediate layer 25, a plurality of third that run through holes 24 that leak are seted up to the diapire of cavity intermediate layer 25, the aperture that the second leaked holes 23 is greater than the aperture that the third leaked holes 24. The height of the hollow interlayer 25 is about 8-12mm, the diameter of the third water leakage hole 24 is about 2mm, and the diameter of the second water leakage hole 23 is about 6-8 mm.
The sterilization box 22 is quadrilateral, supporting columns 26 are arranged on the top corners of the sterilization box 22, positioning columns 27 are arranged on a pair of supporting columns 26 which are diagonal to each other, and positioning grooves matched with the positioning columns 27 are arranged at the bottoms of the supporting columns 26 provided with the positioning columns 27. The cross section of the positioning column 27 is circular, triangular, quadrangular or pentagonal. Facilitating stacked positioning of multiple sterilization cases 22.
As shown in fig. 4 to 6, in the present embodiment, the circulating water constant pressure system includes: the inlet of the balance pipe 4 is communicated with the water outlet of the temperature equalizing device; the water inlet of the constant pressure tank 3 is communicated with the outlet of the balance pipe 4; the constant voltage tube 5 outside the cabinet, the delivery port of constant voltage jar 3 is connected with the constant voltage tube 5 outside the cabinet, the constant voltage tube 5 outside the cabinet is connected with the constant voltage tube 18 in the cabinet through the connecting pipe, the connecting pipe is sealed to set firmly on the lateral wall of sterilizer 1. The diameter of the pipeline of the connecting pipe is equivalent to the diameter of the constant pressure pipe 5 outside the cabinet. The balance pipe 4 and the constant pressure tank 3 are respectively provided with two parts which are respectively and symmetrically arranged at two sides of the temperature equalizing device; the pipe diameter of the balance pipe 4 is arranged from big to small from one end far away from the constant pressure tank 3 to one end close to the constant pressure tank 3.
The diameter of the constant pressure tank 3 is 3-6 times of that of the constant pressure pipe 5 outside the cabinet, and the height of the constant pressure tank is 4-5 times of that of the constant pressure pipe 5 outside the cabinet; the constant pressure tank 3 is provided with a temperature controller 10; the upper end of the constant pressure tank 3 is connected with a balance pipe 4, the balance pipe 4 consists of three sections of pipes with diameters gradually reduced, and the constant pressure tank 3 is connected with the end with the smallest diameter of the balance pipe 4; the three-stage design has the advantages that: gas in the circulating water is collected at the large pipe and then buffered by the medium pipe, the possibility of gas generation of the circulating water flowing into the small pipe is reduced, and meanwhile, according to a fluid flow formula, the flow Q in the pipe is S V; q (flow in the pipe, in cubic meters per second); s (effective cross-sectional area of the pipe, in square meters); v (flow velocity through the medium in the pipe in meters per second); known from the formula, the pipe diameter diminishes gradually, and under the certain condition of total circulating water yield, the circulating line pipe diameter diminishes, and the flow increase of unit cross-sectional area, its benefit lies in: the water pressure is certain (the circulating pump outputs stably), and the flow passing through the small pipe diameter of the balance pipe 4 in a unit time is relatively consistent under the condition that the flow of the water mixing pipe 12 flowing to the balance pipes 4 on the two sides is inconsistent.
In this embodiment, the temperature uniforming device includes: the temperature controllers 10, the temperature controllers 10 are respectively arranged on the constant pressure tanks 3; the temperature balancing device 11 is arranged on the balancing pipe 4; and the water outlet end of the water mixing pipe 12 is respectively communicated with the water inlets of the two balance pipes 4. The heating heat exchange device comprises a heating heat exchanger 2 and a first water pump 6, the water inlet end of the first water pump 6 is communicated with the bottom of the sterilizer 1, the water outlet end of the first water pump 6 is communicated with the water inlet of the heating heat exchanger 2, and the water outlet of the heating heat exchanger 2 is connected with the water inlet end of the water mixing pipe 12. The refrigeration heat exchange device comprises a refrigeration heat exchanger 7 and a second water pump 20, wherein the water inlet end of the second water pump 20 is communicated with the bottom of the sterilizer 1, preferably the lowest point of the bottom of the sterilizer 1, the water outlet end of the second water pump 20 is communicated with the water inlet of the refrigeration heat exchanger 7, and the water outlet of the refrigeration heat exchanger 7 is connected with the water inlet end of the water mixing pipe 12.
The temperature balancing device 11 is wound on the middle section of the balancing pipe 4, and the temperature balancing device 11 is a double-winding cold (heat) exchange device; the maximum pipe diameter end of the balance pipe 4 is connected with the water mixing pipe 12, the diameter of the water mixing pipe 12 is 2 times of the maximum pipe diameter of the balance pipe 4, and the connecting position of the maximum pipe diameter end of the balance pipe 4 and the water mixing pipe 12 is located at 1/2 of the geometric dimension inside the water mixing pipe 12; the other end of the water mixing pipe 12 is connected with a water circulation pipeline in the cabinet through a reducing pipe, and the other end of the water circulation pipeline in the cabinet is connected with a water heat exchanger in the cabinet. The water pipeline in the cabinet is respectively connected with the water inlet ends of the refrigerating heat exchanger 7 and the heating heat exchanger 2, the medium end of the refrigerating heat exchanger 7 is connected with cooling water, the medium end of the heating heat exchanger 2 is connected with steam, and the water outlet ends of the refrigerating heat exchanger 7 and the heating heat exchanger 2 are connected with the water inlet end of the water mixing pipe 12 through pipelines.
When the sterilizer 1 is in the temperature-raising stage: circulating water in the cabinet is pumped out along the arrow direction through the first water pump 6 and the second water pump 20 and respectively enters the refrigerating heat exchanger 7 and the heating heat exchanger 2 along a circulating water pipeline 19 in the cabinet, a steam valve at a medium end of the heating heat exchanger 2 is opened, and the circulating water in the cabinet is heated by steam; the cooling water valve at the medium end of the refrigeration heat exchanger 7 is in a closed state, the refrigeration heat exchanger 7 is used as a bypass of the heating heat exchanger 2 in the temperature rising stage to play a role in balancing water temperature, and deformation caused by imbalance of internal and external pressures of the medicine 17 due to the fact that the pressure of the sterilization cavity 15 rises rapidly and the pressure of the medicine 17 is too high due to rapid temperature rising of circulating water in the cabinet is avoided.
The circulating water in the cabinet flowing through the refrigerating heat exchanger 7 and the heating heat exchanger 2 is mixed in the water mixing pipe 12, so that the water temperature is relatively uniform, the mixed circulating water respectively flows into the balance pipe 4 along the arrow direction and then flows into the constant pressure tank 3, and the pipe diameter of the balance pipe 4 is reduced from large to small, so that the water flow and the pressure flowing into the constant pressure tank 3 are relatively uniform; the temperature controller 10 is installed on the constant pressure tanks 3, the temperature controller 10 detects the temperature difference of the circulating water in the constant pressure tanks 3 and starts steam adding to finely adjust the temperature through a temperature balancing device 11 arranged at the middle section of the balancing pipe 4, so that the temperature of the circulating water in the constant pressure tanks 3 is similar; circulating water with similar temperature and pressure enters the constant pressure pipe 5 outside the cabinet through the constant pressure tank 3, flows into the constant pressure pipe 18 inside the cabinet after secondary constant pressure, flows into the water distribution discs 8 through the flow dividing pipe 9 after tertiary constant pressure, and the slight flow difference of the water distribution discs 8 is realized through the flow adjusting flower disc 13 arranged at the outlet ends of the water distribution pipes.
Circulating water flowing into the water distribution disc 8 is blocked by the retaining ring 14 and then flows into the water storage cavity of the water distribution disc 8 to form a constant water level, so that the circulating water is uniformly distributed in each first water leakage hole 21 of the water distribution disc 8, and the outflow water volume is consistent; the retainer ring 14 is used for preventing the circulating water from influencing the liquid level of the water distribution plate 8 and the like; the heated circulating water showers the medicines 17 stored in the sterilizing box 22 through the first water leakage holes 21 uniformly distributed on the water distribution plate 8, so that each medicine 17 is guaranteed to be showered by the circulating water with the same temperature and flow at the same time; the circulating water flowing through the surface of the first layer of medicine 17 passes through the second water leakage hole 23 at the upper end of the sterilizing box 22, forms a constant liquid level water surface on the hollow interlayer 25, and then passes through the third water leakage hole 24 at the lower layer of the sterilizing box 22 to shower the medicine container at the next layer.
The invention has novel structure, the sterilizer flows into the circulating water of the water distribution disc through the shunt pipe, and then carries out shower heating (cooling) on the medicines which are loaded in the sterilization box and are regularly arranged through the first water leakage holes with the same aperture and uniformly distributed on the water distribution disc, the circulating water flowing through the surface of the medicines flows through the second water leakage holes with larger upper layers of the sterilization box to form liquid levels such as water distribution and the like in the interlayer of the sterilization box, and carries out shower heating (cooling) on the medicines of the next layer through the third water leakage holes with smaller bottom layers of the sterilization box, thereby finally realizing more uniform heating (cooling) of the medicines of one batch in the same time period and realizing the consistency of the sterile level, the physical property and the chemical property of the product.
The sterilization and heat preservation stage has the same principle as the temperature rise stage;
in the sterilization and cooling stage, a cooling water valve at the medium end of the heating heat exchanger 2 is opened, and circulating water in the cabinet is cooled by cooling water; the steam valve at the medium end of the heating heat exchanger is in a closed state, and the heating heat exchanger 2 is used as a bypass of the refrigerating heat exchanger 7 in the cooling stage to play a role in balancing water temperature, so that deformation caused by unbalanced internal and external pressures of the medicine 17 due to rapid cooling of circulating water in the cabinet is avoided; meanwhile, the temperature controller 10 detects the temperature difference of the circulating water in the constant-pressure tanks 3 and starts cooling water to finely adjust the temperature through the temperature balancing device 11 arranged at the middle section of the balancing pipe 4, so that the temperature of the circulating water in the constant-pressure tanks 3 is close, the temperature balancing device 11 stops working when the temperature is lower than 100 ℃, and other working flows are the same as the temperature rise stage.
FIG. 10 is a graph showing the temperature uniformity in the sterilizer 1 using wireless validators, which are distributed one for each cube; it can be seen from the figure that the temperature difference at the same time point is only 0.16 ℃ after the system of the present invention is adopted, which is much less than the level of 1.5 ℃ in the industry and the level of +/-1 ℃ required by the regulations, and the overall temperature uniformity is 0.12 ℃.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included within the scope of the present invention.
Claims (7)
1. The utility model provides a show water bath sterilization equipment that improves medicine sterilization effect which characterized in that includes:
the sterilizer comprises a sterilizer (1), wherein a sterilization cavity (15) is arranged in the sterilizer (1);
the water distribution plate (8) is arranged at the top of the sterilization cavity (15), a water storage cavity is arranged in the water distribution plate (8), and a plurality of first water leakage holes (21) are formed in the bottom of the water storage cavity;
the check ring (14), the said check ring (14) is set up in the bottom of the water storage cavity, the shunt tube (9) of the sterilization cavity (15) stretches into the said check ring (14) and sets up;
the sterilization rack (16), the sterilization rack (16) is arranged in the sterilization cavity (15) below the water distribution plate (8).
2. The water bath sterilization equipment capable of remarkably improving the sterilization effect of the medicines according to claim 1, wherein the sterilization rack (16) comprises a plurality of sterilization boxes (22) which are arranged in a stacked manner, a placing cavity is arranged in each sterilization box (22), a hollow interlayer (25) is arranged at the bottom of each sterilization box (22), a plurality of second water leakage holes (23) which penetrate through the top wall of each hollow interlayer (25) are formed, a plurality of third water leakage holes (24) which penetrate through the bottom wall of each hollow interlayer (25) are formed, and the hole diameter of each second water leakage hole (23) is larger than that of each third water leakage hole (24).
3. The water bath sterilization equipment capable of obviously improving the sterilization effect of the medicines according to claim 2, wherein the sterilization box (22) is quadrilateral, supporting columns (26) are arranged at each top corner of the sterilization box (22), positioning columns are arranged on a pair of supporting columns (26) which are opposite to each other, and positioning grooves matched with the positioning columns are arranged at the bottoms of the supporting columns (26) provided with the positioning columns.
4. A water bath sterilization device capable of remarkably improving the sterilization effect of medicines as claimed in claim 3, wherein the cross section of the positioning column is circular, triangular, quadrangular or pentagonal.
5. A water bath sterilization apparatus for significantly improving the sterilization effect of drugs according to claim 2, wherein the size of the retainer ring (14) is: the height is 15-20mm, the diameter is 25-30mm, and the distance for the shunt tube (9) of the sterilization cavity (15) to extend into the retainer ring (14) is 5-10 mm.
6. The water bath sterilization equipment capable of obviously improving the sterilization effect of the medicines according to claim 5, wherein a plurality of water distribution disks (8) are provided, and each water distribution disk (8) is provided with 2 retaining rings (14), each water distribution disk (8) corresponds to one shunt pipe (9) of the U-shaped sterilization cavity (15), and two ends of the shunt pipe (9) of the U-shaped sterilization cavity (15) respectively correspondingly extend into the 2 retaining rings (14); and the water distribution disks (8) are arranged in an array way, and the area formed by the water distribution disks (8) is equal to the area of the sterilization box (22).
7. A water bath sterilization device capable of remarkably improving the sterilization effect of medicines according to claim 2, characterized in that the aperture of the first water leakage hole (21) is 2-3mm, the aperture of the second water leakage hole (23) is 6-8mm, the diameter of the third water leakage hole (24) is 2-3mm, and the height of the hollow interlayer (25) is 8-12 mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011374907.6A CN112402635A (en) | 2020-11-30 | 2020-11-30 | Water bath sterilization equipment capable of remarkably improving medicine sterilization effect |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011374907.6A CN112402635A (en) | 2020-11-30 | 2020-11-30 | Water bath sterilization equipment capable of remarkably improving medicine sterilization effect |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112402635A true CN112402635A (en) | 2021-02-26 |
Family
ID=74829002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011374907.6A Pending CN112402635A (en) | 2020-11-30 | 2020-11-30 | Water bath sterilization equipment capable of remarkably improving medicine sterilization effect |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112402635A (en) |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1094586A (en) * | 1996-09-20 | 1998-04-14 | Atamu Giken Kk | Washing steriization unit |
| CN102908640A (en) * | 2012-10-07 | 2013-02-06 | 贵州科伦药业有限公司 | Sterile box and sterile cabinet for improving sterile temperature uniformity of transfusion product |
| CN103055335A (en) * | 2012-11-28 | 2013-04-24 | 山东齐都药业有限公司 | Special water distributor for water bath sterilizer |
| CN206050380U (en) * | 2016-06-16 | 2017-03-29 | 楚天科技股份有限公司 | Bottle pedestal, pallet apparatus and water-bath sterilization cabinet |
| CN207688728U (en) * | 2017-11-22 | 2018-08-03 | 无锡三九制冷设备有限公司 | A kind of water inlet flow dividing structure and open cooling tower |
| CN109539524A (en) * | 2018-12-29 | 2019-03-29 | 深圳市海吉源科技有限公司 | Water distributor |
| CN211068162U (en) * | 2019-09-30 | 2020-07-24 | 海南紫杉园制药有限公司 | Disinfection vehicle for ampoule water bath sterilizer |
| CN111803657A (en) * | 2020-08-11 | 2020-10-23 | 山东新华医疗器械股份有限公司 | Dry type water bath sterilizer |
-
2020
- 2020-11-30 CN CN202011374907.6A patent/CN112402635A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1094586A (en) * | 1996-09-20 | 1998-04-14 | Atamu Giken Kk | Washing steriization unit |
| CN102908640A (en) * | 2012-10-07 | 2013-02-06 | 贵州科伦药业有限公司 | Sterile box and sterile cabinet for improving sterile temperature uniformity of transfusion product |
| CN103055335A (en) * | 2012-11-28 | 2013-04-24 | 山东齐都药业有限公司 | Special water distributor for water bath sterilizer |
| CN206050380U (en) * | 2016-06-16 | 2017-03-29 | 楚天科技股份有限公司 | Bottle pedestal, pallet apparatus and water-bath sterilization cabinet |
| CN207688728U (en) * | 2017-11-22 | 2018-08-03 | 无锡三九制冷设备有限公司 | A kind of water inlet flow dividing structure and open cooling tower |
| CN109539524A (en) * | 2018-12-29 | 2019-03-29 | 深圳市海吉源科技有限公司 | Water distributor |
| CN211068162U (en) * | 2019-09-30 | 2020-07-24 | 海南紫杉园制药有限公司 | Disinfection vehicle for ampoule water bath sterilizer |
| CN111803657A (en) * | 2020-08-11 | 2020-10-23 | 山东新华医疗器械股份有限公司 | Dry type water bath sterilizer |
Non-Patent Citations (2)
| Title |
|---|
| 天津大学等院校合编；余国琮主编: "《化工容器及设备》", 30 November 1980, 北京：化学工业出版社 * |
| 曹志超主编: "《常用机械电器实用手册 下》", 31 July 2000, 北京：化学工业出版社 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN209882970U (en) | Energy-saving sterilization pot for canned food | |
| CN207285080U (en) | A kind of sterilization machine for producing vegetable protein beverage | |
| CN112402635A (en) | Water bath sterilization equipment capable of remarkably improving medicine sterilization effect | |
| CN106399084A (en) | Probiotic culture system | |
| CN214511947U (en) | Water bath sterilization temperature pressure water distribution system that evenly distributes | |
| CN202892568U (en) | Heating device for infusion appliance | |
| CN208838630U (en) | A kind of Multifunctional sterilization device of Novel bunk temperature steam ozone combination | |
| CN106234911A (en) | A kind of pressure relief device for supertension sterilize device | |
| CN112402634A (en) | Water bath sterilization temperature pressure water distribution system that evenly distributes | |
| CN107596472B (en) | A kind of cold-heat exchange system stoping jumping operation for department of cardiac surgery | |
| CN103394150B (en) | Thermostatic controller for medical fluid | |
| CA1236960A (en) | Method for sterilizing artificial organs and apparatus used therefor | |
| CN218628437U (en) | Water-bath sterilization water distribution temperature and flow detection equipment for large infusion product | |
| KR960006803A (en) | Sterilizer and manufacturing equipment for liquid food | |
| CN112210494A (en) | Fermentation device for plant cell culture and use method thereof | |
| CN115790717A (en) | Water bath sterilization water distribution temperature and flow detection equipment for large infusion product | |
| CN207369997U (en) | A kind of energy-efficient board-like sterilization machine | |
| CN207400936U (en) | A kind of vertical pressure steam sterilizer with safety head | |
| CN115773785A (en) | Water distribution temperature and flow detection method for large infusion product water bath sterilization equipment | |
| CN206037581U (en) | A cold and hot exchange water tank for cardiac surgery stops jump and performs operation | |
| CN209984754U (en) | Water storage device of breathing machine | |
| CN201030065Y (en) | Water-bath type sterilizing device | |
| CN205653149U (en) | Thermal -insulated system of cooling of filling elemene liquid medicine | |
| CN214710075U (en) | Fluid high-temperature sterilization equipment | |
| CN219071416U (en) | Water bath sterilization water consumption collecting and temperature measuring device for large infusion product |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20210226 |