CN112384514A - 作为janus激酶抑制剂的新的氨基-咪唑并嘧啶衍生物及其药物用途 - Google Patents

作为janus激酶抑制剂的新的氨基-咪唑并嘧啶衍生物及其药物用途 Download PDF

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Publication number
CN112384514A
CN112384514A CN201980045057.4A CN201980045057A CN112384514A CN 112384514 A CN112384514 A CN 112384514A CN 201980045057 A CN201980045057 A CN 201980045057A CN 112384514 A CN112384514 A CN 112384514A
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CN
China
Prior art keywords
alkyl
compounds
pharmaceutically acceptable
compound
diseases
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Pending
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CN201980045057.4A
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English (en)
Chinese (zh)
Inventor
J·C·H·拉森
M·拉森
A·里岑
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Leo Pharma AS
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Leo Pharma AS
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Application filed by Leo Pharma AS filed Critical Leo Pharma AS
Publication of CN112384514A publication Critical patent/CN112384514A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201980045057.4A 2018-07-06 2019-06-27 作为janus激酶抑制剂的新的氨基-咪唑并嘧啶衍生物及其药物用途 Pending CN112384514A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP18182186.9 2018-07-06
EP18182186 2018-07-06
PCT/EP2019/067127 WO2020007698A1 (en) 2018-07-06 2019-06-27 Novel amino-imidazopyrimidine derivatives as janus kinase inhibitors and pharmaceutical use thereof

Publications (1)

Publication Number Publication Date
CN112384514A true CN112384514A (zh) 2021-02-19

Family

ID=62874761

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980045057.4A Pending CN112384514A (zh) 2018-07-06 2019-06-27 作为janus激酶抑制剂的新的氨基-咪唑并嘧啶衍生物及其药物用途

Country Status (5)

Country Link
US (1) US20210269447A1 (https=)
EP (1) EP3818060B1 (https=)
JP (1) JP2021528479A (https=)
CN (1) CN112384514A (https=)
WO (1) WO2020007698A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022002210A1 (zh) * 2020-07-02 2022-01-06 南京明德新药研发有限公司 嘧啶并吡咯基类氘代化合物

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012146667A1 (en) * 2011-04-29 2012-11-01 Almirall, S.A. Imidazopyridine derivatives as pi3k inhibitors
CN103649089A (zh) * 2011-04-29 2014-03-19 阿尔米雷尔有限公司 作为pi3k抑制剂的吡咯并三嗪酮
CN104936959A (zh) * 2013-03-08 2015-09-23 中国人民解放军军事医学科学院放射与辐射医学研究所 2,6,9-三取代嘌呤衍生物及其制备方法与应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7723340B2 (en) * 2005-01-13 2010-05-25 Signal Pharmaceuticals, Llc Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith
TWI466885B (zh) * 2009-07-31 2015-01-01 Japan Tobacco Inc 含氮螺環化合物及其醫藥用途
EP2523957A1 (en) 2010-01-12 2012-11-21 F. Hoffmann-La Roche AG Tricyclic heterocyclic compounds, compositions and methods of use thereof
EP2527344A1 (en) * 2011-05-25 2012-11-28 Almirall, S.A. Pyridin-2(1H)-one derivatives useful as medicaments for the treatment of myeloproliferative disorders, transplant rejection, immune-mediated and inflammatory diseases
WO2013007765A1 (en) 2011-07-13 2013-01-17 F. Hoffmann-La Roche Ag Fused tricyclic compounds for use as inhibitors of janus kinases
WO2013007768A1 (en) * 2011-07-13 2013-01-17 F. Hoffmann-La Roche Ag Tricyclic heterocyclic compounds, compositions and methods of use thereof as jak inhibitors
CN104918945B (zh) 2012-11-01 2018-01-05 因赛特公司 作为jak抑制剂的三环稠合噻吩衍生物
PL3568396T3 (pl) * 2017-01-11 2021-05-31 Leo Pharma A/S Nowe pochodne aminoimidazopirydyny jako inhibitory kinaz janusowych i ich zastosowanie farmaceutyczne

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012146667A1 (en) * 2011-04-29 2012-11-01 Almirall, S.A. Imidazopyridine derivatives as pi3k inhibitors
CN103649089A (zh) * 2011-04-29 2014-03-19 阿尔米雷尔有限公司 作为pi3k抑制剂的吡咯并三嗪酮
CN104936959A (zh) * 2013-03-08 2015-09-23 中国人民解放军军事医学科学院放射与辐射医学研究所 2,6,9-三取代嘌呤衍生物及其制备方法与应用

Also Published As

Publication number Publication date
JP2021528479A (ja) 2021-10-21
EP3818060B1 (en) 2023-02-22
US20210269447A1 (en) 2021-09-02
WO2020007698A1 (en) 2020-01-09
EP3818060A1 (en) 2021-05-12

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