CN112384508A - 三并环类ask1抑制剂及其应用 - Google Patents

三并环类ask1抑制剂及其应用 Download PDF

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Publication number
CN112384508A
CN112384508A CN201980045016.5A CN201980045016A CN112384508A CN 112384508 A CN112384508 A CN 112384508A CN 201980045016 A CN201980045016 A CN 201980045016A CN 112384508 A CN112384508 A CN 112384508A
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radical
alkyl
membered
hydroxy
alkoxy
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CN112384508B (zh
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刘斌
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Shandong Xuanzhu Pharma Co Ltd
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Shandong Xuanzhu Pharma Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

本发明涉及通式(I)所示的化合物、其药学上可接受的盐、酯或其立体异构体。本发明还涉及该化合物的制备方法、包含该化合物的药物制剂及药物组合物。本发明的化合物能够有效抑制ASK1的氨基酸磷酸化，抑制ASK1的激活；因此能够治疗和/或预防ASK1介导的疾病及相关疾病。

Description

PCT国内申请，说明书已公开。

Claims (16)

  1. PCT国内申请，权利要求书已公开。
CN201980045016.5A 2018-09-30 2019-09-26 三并环类ask1抑制剂及其应用 Active CN112384508B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2018111557515 2018-09-30
CN201811155751 2018-09-30
PCT/CN2019/108068 WO2020063727A1 (zh) 2018-09-30 2019-09-26 三并环类ask1抑制剂及其应用

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CN112384508A true CN112384508A (zh) 2021-02-19
CN112384508B CN112384508B (zh) 2022-08-02

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WO (1) WO2020063727A1 (zh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114585616A (zh) * 2019-08-19 2022-06-03 广东东阳光药业有限公司 酰胺衍生物及其在药物中的应用
CN115554303A (zh) * 2021-09-18 2023-01-03 上海科技大学 一种三环类化合物、其制备方法及其应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101076332A (zh) * 2004-10-13 2007-11-21 Ptc医疗公司 吡唑或三唑化合物及其用于制备治疗体细胞突变相关疾病的药物的用途
CN102482257A (zh) * 2009-07-13 2012-05-30 吉利德科学股份有限公司 凋亡信号调节激酶抑制剂
CN106146525A (zh) * 2015-04-10 2016-11-23 山东轩竹医药科技有限公司 三并环类间变性淋巴瘤激酶抑制剂
CN107108519A (zh) * 2014-12-23 2017-08-29 吉利德科学公司 制备ask1抑制剂的方法
WO2019134680A1 (zh) * 2018-01-05 2019-07-11 广州市恒诺康医药科技有限公司 细胞凋亡信号调节激酶-1抑制剂及其应用
WO2019200267A1 (en) * 2018-04-12 2019-10-17 Terns, Inc. Tricyclic ask1 inhibitors

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101076332A (zh) * 2004-10-13 2007-11-21 Ptc医疗公司 吡唑或三唑化合物及其用于制备治疗体细胞突变相关疾病的药物的用途
CN102482257A (zh) * 2009-07-13 2012-05-30 吉利德科学股份有限公司 凋亡信号调节激酶抑制剂
CN107108519A (zh) * 2014-12-23 2017-08-29 吉利德科学公司 制备ask1抑制剂的方法
CN106146525A (zh) * 2015-04-10 2016-11-23 山东轩竹医药科技有限公司 三并环类间变性淋巴瘤激酶抑制剂
WO2019134680A1 (zh) * 2018-01-05 2019-07-11 广州市恒诺康医药科技有限公司 细胞凋亡信号调节激酶-1抑制剂及其应用
WO2019200267A1 (en) * 2018-04-12 2019-10-17 Terns, Inc. Tricyclic ask1 inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MONA A．HOSNY ET AL: "synthesis and anticancer activity of some new derivative of Coumarin and quinolinyl mercaptotriazoles", 《JOURNAL OF CHEMISTRY》 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114585616A (zh) * 2019-08-19 2022-06-03 广东东阳光药业有限公司 酰胺衍生物及其在药物中的应用
CN114585616B (zh) * 2019-08-19 2024-01-16 广东东阳光药业股份有限公司 酰胺衍生物及其在药物中的应用
CN115554303A (zh) * 2021-09-18 2023-01-03 上海科技大学 一种三环类化合物、其制备方法及其应用

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WO2020063727A1 (zh) 2020-04-02
CN112384508B (zh) 2022-08-02

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