CN112368271A - 二芳基吡啶衍生物的制造方法 - Google Patents

二芳基吡啶衍生物的制造方法 Download PDF

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Publication number
CN112368271A
CN112368271A CN201980043226.0A CN201980043226A CN112368271A CN 112368271 A CN112368271 A CN 112368271A CN 201980043226 A CN201980043226 A CN 201980043226A CN 112368271 A CN112368271 A CN 112368271A
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China
Prior art keywords
formula
added
salt
compound represented
compound
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CN201980043226.0A
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English (en)
Chinese (zh)
Inventor
安艺祐一
鸟山史彦
樱井夏树
龟田蓝
小仓友和
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Daiichi Sankyo Co Ltd
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Daiichi Sankyo Co Ltd
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Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of CN112368271A publication Critical patent/CN112368271A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/12—1,4-Dioxanes; Hydrogenated 1,4-dioxanes not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
    • B01J23/44—Palladium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B61/00—Other general methods
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201980043226.0A 2018-07-04 2019-07-03 二芳基吡啶衍生物的制造方法 Pending CN112368271A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2018-127197 2018-07-04
JP2018127197 2018-07-04
PCT/JP2019/026395 WO2020009132A1 (ja) 2018-07-04 2019-07-03 ジアリールピリジン誘導体の製造方法

Publications (1)

Publication Number Publication Date
CN112368271A true CN112368271A (zh) 2021-02-12

Family

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Family Applications (1)

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CN201980043226.0A Pending CN112368271A (zh) 2018-07-04 2019-07-03 二芳基吡啶衍生物的制造方法

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US (1) US11999724B2 (enExample)
EP (1) EP3819296B1 (enExample)
JP (2) JP7337058B2 (enExample)
CN (1) CN112368271A (enExample)
AU (1) AU2019299152A1 (enExample)
CA (1) CA3105328A1 (enExample)
ES (1) ES2925365T3 (enExample)
IL (1) IL279070B2 (enExample)
TW (1) TWI840378B (enExample)
WO (1) WO2020009132A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20250019362A1 (en) 2021-11-19 2025-01-16 Nippon Soda Co., Ltd. Method for producing 2-heteroarylpyridine compound

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104185627A (zh) * 2012-01-31 2014-12-03 第一三共株式会社 吡啶酮衍生物
CN106604920A (zh) * 2014-07-07 2017-04-26 第三共株式会社 具有四氢吡喃基甲基的吡啶酮衍生物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI796326B (zh) 2017-03-24 2023-03-21 日商第一三共股份有限公司 含有ａｘｌ抑制劑與ｅｇｆｒ酪胺酸激酶抑制藥的醫藥品及其用途

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104185627A (zh) * 2012-01-31 2014-12-03 第一三共株式会社 吡啶酮衍生物
CN106604920A (zh) * 2014-07-07 2017-04-26 第三共株式会社 具有四氢吡喃基甲基的吡啶酮衍生物

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DIDIER VILLEMIN等: "Solventless convenient synthesis of new cyano-2-aminopyridine derivatives from enaminonitriles", TETRAHEDRON LETTERS, vol. 54, pages 1664 - 1668, XP055357314, DOI: 10.1016/j.tetlet.2013.01.021 *
ROBERT CHURCH等: "New Synthetic Routes to 3-, 5-, and 6-Aryl-2-chloropyridines", J. ORG. CHEM., vol. 60, no. 12, pages 3750 - 3758, XP055357318, DOI: 10.1021/jo00117a029 *
TIBOR DOCSA等: "Synthesis and glycogen phosphorylase inhibitor activity of 2, 3-dihydrobenzo[1, 4]dioxin derivatives", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 15, pages 4048 - 4056, XP022062537, DOI: 10.1016/j.bmc.2007.03.084 *

Also Published As

Publication number Publication date
WO2020009132A1 (ja) 2020-01-09
EP3819296A4 (en) 2021-06-09
ES2925365T3 (es) 2022-10-17
AU2019299152A1 (en) 2021-03-04
EP3819296A1 (en) 2021-05-12
CA3105328A1 (en) 2020-01-09
JPWO2020009132A1 (ja) 2021-07-08
EP3819296B1 (en) 2022-06-29
IL279070B2 (en) 2024-05-01
TW202005962A (zh) 2020-02-01
US20210188823A1 (en) 2021-06-24
JP7337058B2 (ja) 2023-09-01
US11999724B2 (en) 2024-06-04
IL279070A (en) 2021-01-31
JP2023159297A (ja) 2023-10-31
IL279070B1 (en) 2024-01-01
TWI840378B (zh) 2024-05-01
AU2019299152A2 (en) 2021-03-11

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