CN112362620A - Multi-methodology combined optical path - Google Patents
Multi-methodology combined optical path Download PDFInfo
- Publication number
- CN112362620A CN112362620A CN202011110484.7A CN202011110484A CN112362620A CN 112362620 A CN112362620 A CN 112362620A CN 202011110484 A CN202011110484 A CN 202011110484A CN 112362620 A CN112362620 A CN 112362620A
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- China
- Prior art keywords
- light
- scattering
- light source
- fluorescence
- receiver
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- 230000003287 optical effect Effects 0.000 title claims abstract description 23
- 238000000034 method Methods 0.000 title claims abstract description 17
- 230000031700 light absorption Effects 0.000 claims abstract description 22
- 238000000149 argon plasma sintering Methods 0.000 claims 3
- 238000001514 detection method Methods 0.000 abstract description 14
- 239000003153 chemical reaction reagent Substances 0.000 description 10
- 238000006243 chemical reaction Methods 0.000 description 8
- 239000000126 substance Substances 0.000 description 6
- 210000001124 body fluid Anatomy 0.000 description 3
- 239000010839 body fluid Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 230000008033 biological extinction Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Images
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
- G01N21/51—Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N2021/0106—General arrangement of respective parts
- G01N2021/0112—Apparatus in one mechanical, optical or electronic block
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N2021/6463—Optics
Abstract
The invention relates to a multi-methodology optical combination light path, which comprises a bracket, a light absorption or fluorescence structure and a scattering turbidimetric structure, wherein the light absorption or fluorescence structure and the scattering turbidimetric structure are arranged on the bracket; the invention has light absorption or fluorescence structure and scattering turbidimetric structure, can complete various detection items at the same time, and greatly improves the detection efficiency.
Description
Technical Field
The invention relates to a multi-methodology optical combined optical path.
Background
In medical detection, a plurality of items of detection work are often required to be performed on collected body fluid, and the collected body fluid is required to be subjected to optical irradiation after being reacted with a reagent during detection, so that the concentration of a substance is measured. The applicant previously filed a patent related to a reagent disk, for example, patent No. 201820701609.5, and based on the description of the invention, one skilled in the art can design a plurality of reaction cells on a reagent disk to allow a body fluid to react with different reagents to perform different items of tests. After the reaction is finished, detection of various different methodologies is needed, and the detection efficiency can be greatly improved by designing a device capable of simultaneously carrying out various different detections on a plurality of reaction cells.
Disclosure of Invention
The invention aims to solve the technical problem of providing a multi-method optical combined optical path which can simultaneously carry out various different detections.
The technical scheme adopted by the invention is as follows: a multi-method optical combined light path is characterized by comprising a support, a light absorption or fluorescence structure and a scattering turbidimetric structure, wherein the light absorption or fluorescence structure and the scattering turbidimetric structure are arranged on the support, the light absorption or fluorescence structure comprises a light absorption or fluorescence light source and a light receiving device arranged below the light absorption or fluorescence light source, and the scattering turbidimetric structure comprises a scattering light source and a scattering light receiving device arranged below the scattering light source.
Further, a light source cover is arranged on the support, and the light absorption or fluorescence light source and the scattering light source are arranged in the light source cover.
Furthermore, the scattered light receiving device comprises a lens shell arranged below the scattered light source, and a first scattering biconvex lens, a flat mirror, a second scattering biconvex lens and a scattered light receiver which are sequentially arranged in the lens shell, wherein a plug is arranged on the flat mirror and at a position corresponding to the scattered light source.
Further, the scattering light source is laser.
Further, the light absorbing or fluorescent light source includes a lamp, a first plano-convex lens disposed under the lamp, and a first light receiver disposed at one side of the lamp.
Further, the light receiving device comprises a second plano-convex lens and a second light receiver arranged below the second plano-convex lens, and the second plano-convex lens is positioned below the first plano-convex lens.
Further, the light absorption or fluorescence light source comprises a third light receiver, a lamp arranged below the third light receiver and a light homogenizing sheet arranged below the lamp.
Further, the light receiving device comprises a fourth light receiver arranged below the light homogenizing sheet.
Further, the bracket comprises an upper bracket and a lower bracket, the light absorption or fluorescence light source and the scattering light source are arranged on the upper bracket, and the light receiving device and the scattering light receiving device are arranged on the lower bracket.
The invention has the positive effects that: the invention has light absorption or fluorescence structure and scattering turbidimetric structure, can complete various detection items at the same time, and greatly improves the detection efficiency.
Drawings
FIG. 1 is a schematic structural view of the present invention;
FIG. 2 is a schematic diagram of a scattering turbidimetric structure according to the present invention;
FIG. 3 is a schematic view of a light absorbing or fluorescent structure according to the present invention;
FIG. 4 is a schematic representation of another light absorbing or fluorescent structure according to the present invention.
Detailed Description
As shown in fig. 1, the present invention includes a bracket, and a light-absorbing or fluorescent structure and a scattering turbidimetric structure which are arranged on the bracket, wherein the light-absorbing or fluorescent structure includes a light-absorbing or fluorescent light source and a light-receiving device arranged below the light-absorbing or fluorescent light source, and the scattering turbidimetric structure includes a scattering light source 6 and a scattering light-receiving device arranged below the scattering light source. The support includes upper bracket 1 and fixes lower carriage 2 in upper bracket 1 below, and extinction or fluorescence light source and scattered light source all install on upper bracket 1, and light receiver and scattered light receiver install on lower carriage 2, and the reagent dish 5 that awaits measuring is located between the upper and lower carriage.
A light source cover 3 is installed on the bottom surface of the upper bracket 1, a light absorption or fluorescence light source and a scattering light source are both installed in the light source cover 3, and a through hole is formed in the bottom of the light source cover 3 so that light can pass through.
As shown in fig. 2, the scattering light source 6 uses laser light and is fixed in the light source housing 3. The scattered light receiving device comprises a scattering first biconvex lens 7, a flat mirror 8, a scattering second biconvex lens 19 and a scattered light receiver 9 which are sequentially arranged on the lower bracket 1 from top to bottom. Preferably, the scattering light source 6, the scattering first biconvex lens 7, the flat mirror 8 and the scattering second biconvex lens 19 are positioned on the same axis, and the scattering light receiver 9 is positioned at the lowest part and receives the light signal. The scattering light source 6 irradiates on the reaction cell of the reagent disk 5, the reaction cell substance is scattered, and is condensed by the lens below, because the scattering light is needed, the direct light of the scattering light source is shielded by the plug on the flat mirror 8 corresponding to the position of the scattering light source 6, and finally the direct light is irradiated on the scattering light receiver 9, and the substance concentration is measured.
As shown in figure 3, the light source for light absorption or fluorescence comprises a 340 lamp 10 fixed in a light source cover 3, a first plano-convex lens 12 arranged below the 340 lamp and a first light receiver 11 arranged at one side of the 340 lamp 10, the light receiving device comprises a second plano-convex lens 13 and a second light receiver 14 which are sequentially arranged on a lower bracket 2 from top to bottom, the 340 lamp 10 emits light waves of 340nm, the first light receiver 11 at the side calibrates the light source according to the received light intensity, the light waves irradiate on a reagent disk reaction cell through the first plano-convex lens 12, and due to the light absorption effect of the mixture, the light is condensed through the second plano-convex lens 13 and irradiates on the second light receiver 14, and the concentration of a substance is measured. In this structure, since it is necessary to measure 340 the light intensity of the lamp 10 by using the first light receiver 11, a partition is provided in the light source housing 3 to form a single chamber in which the 340 lamp 10 and the first plano-convex lens 12 are provided, and the first light receiver 11 is located on the side wall of the chamber.
Referring to fig. 4, a schematic view of another light absorbing or fluorescent structure is shown, and one light absorbing or fluorescent structure may be selected to be mounted on the bracket, or both light absorbing and fluorescent structures may be mounted on the bracket. The light absorption or fluorescence light source comprises a third light receiver 15, a 405 lamp 16 and a light homogenizing sheet 17 which are sequentially fixed on the upper bracket 1 from top to bottom, and the light receiving device comprises a fourth light receiver 18 fixed on the lower bracket 2. The 405 lamp emits light wave with 405nm, the third light receiver 15 calibrates the light source according to the received light intensity, the light wave irradiates on the reagent disc reaction tank through the light homogenizing sheet (the structure has the light homogenizing and re-condensing effect), and the mixture has the light absorption effect, passes through less light intensity and irradiates on the fourth light receiver 18 through the light filtering sheet, and the substance concentration is measured.
In this embodiment, the light absorbing or fluorescent structure is specifically a light absorbing structure or a fluorescent structure, and is determined according to the type of the reagent in the detection area, but the structure is not changed regardless of the light absorbing structure or the fluorescent structure.
Preferably, an optical path sensor circuit board 4 is arranged below the lower bracket 2, the scattered light receiver 9, the second light receiver 14 and the fourth light receiver 18 are all mounted on the optical path sensor circuit board 4, corresponding through holes are formed in the lower bracket 2 for light irradiation to pass through, and the flat mirror 8, the scattered second biconvex lens 19 and the second biconvex lens 13 are all mounted in the through holes.
The scattered light receiver 9, the second light receiver 14, the fourth light receiver 18, the first light receiver 11, and the third light receiver 15 all employ silicon photocells.
The invention comprehensively uses various methodologies for detection, can simultaneously complete the detection of the concentration of substances in a plurality of reaction tanks on the reagent tray and detect various medical projects.
The above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.
Claims (9)
1. A multi-method optical combined light path is characterized by comprising a support, a light absorption or fluorescence structure and a scattering turbidimetric structure, wherein the light absorption or fluorescence structure and the scattering turbidimetric structure are arranged on the support, the light absorption or fluorescence structure comprises a light absorption or fluorescence light source and a light receiving device arranged below the light absorption or fluorescence light source, and the scattering turbidimetric structure comprises a scattering light source (6) and a scattering light receiving device arranged below the scattering light source (6).
2. A multi-method optical combined light path according to claim 1, characterized in that a light source housing (3) is provided on the support, the light-absorbing or fluorescent and light-scattering source (6) being arranged in the light source housing (3).
3. A multi-method optical combined light path according to claim 1, characterized in that the scattered light receiving device comprises a lens shell arranged below the scattered light source (6), and a scattering first biconvex lens (7), a flat mirror (8), a scattering second biconvex lens (19) and a scattered light receiver (9) which are arranged in the lens shell in sequence, and a plug is arranged on the flat mirror (8) and at a position corresponding to the scattered light source (6).
4. The multi-method optical combined optical path of claim 1, wherein the scattering light source is a laser.
5. A multi-method optical combined light path according to claim 1, characterized in that the light-absorbing or fluorescent light source comprises a 340 lamp (10), a first plano-convex lens (12) arranged below the 340 lamp (10) and a first light receiver (11) arranged at one side of the 340 lamp (10).
6. A multi-method optical combined optical path according to claim 5, characterized in that the light receiving means comprises a second plano-convex lens (13) and a second light receiver (14) arranged below the second plano-convex lens (13), the second plano-convex lens (13) being located below the first plano-convex lens (12).
7. A multi-method optical combining beam path according to claim 1, characterized in that the light absorbing or fluorescent light source comprises a third light receiver (15), a 405 lamp (16) arranged below the third light receiver (15) and a light homogenizing sheet (17) arranged below the 405 lamp (16).
8. A multi-method optical combining optical path according to claim 7, characterized in that said light receiving means comprises a fourth light receiver (18) disposed below the light homogenizer (17).
9. A multi-method optical combined light path according to claim 1, characterized in that the holder comprises an upper holder (1) and a lower holder (2), the light-absorbing or fluorescent light source and the light-scattering light source being mounted on the upper holder (1), and the light-receiving means and the light-scattering light receiving means being mounted on the lower holder (2).
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011110484.7A CN112362620A (en) | 2020-10-16 | 2020-10-16 | Multi-methodology combined optical path |
| PCT/CN2021/117672 WO2022078132A1 (en) | 2020-10-16 | 2021-09-10 | Multi-methodology combined optical path |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011110484.7A CN112362620A (en) | 2020-10-16 | 2020-10-16 | Multi-methodology combined optical path |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112362620A true CN112362620A (en) | 2021-02-12 |
Family
ID=74507264
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011110484.7A Pending CN112362620A (en) | 2020-10-16 | 2020-10-16 | Multi-methodology combined optical path |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN112362620A (en) |
| WO (1) | WO2022078132A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022078132A1 (en) * | 2020-10-16 | 2022-04-21 | 石家庄禾柏生物技术股份有限公司 | Multi-methodology combined optical path |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE380099B (en) * | 1974-02-07 | 1975-10-27 | Monega Anstalt | |
| RU1805347C (en) * | 1990-01-31 | 1993-03-30 | Ленинградское научно-производственное объединение "Буревестник" | Photometer-fluorimeter-nephelometer |
| CN201322721Y (en) * | 2008-10-24 | 2009-10-07 | 吉林欧伊尔环保科技发展有限公司 | Symmetrical conjugate optical system for infrared oil measuring instrument |
| CN201364309Y (en) * | 2009-03-20 | 2009-12-16 | 郝书顺 | Four-channel nephelometry testing device |
| CN104678115B (en) * | 2015-02-15 | 2018-04-27 | 石家庄禾柏生物技术股份有限公司 | Multi-pass agent detection devices in integrated quantitative sampling reagent adding device detector |
| CN104964927B (en) * | 2015-06-08 | 2018-09-21 | 上海蓝怡科技股份有限公司 | A kind of multisample detection device |
| CN113281284A (en) * | 2016-07-19 | 2021-08-20 | 株式会社日立高新技术 | Automatic analysis device and automatic analysis method |
| CN208547572U (en) * | 2018-05-15 | 2019-02-26 | 三诺生物传感股份有限公司 | A kind of compatible colorimetric, than turbid and fluorescence detection optical system |
| CN109269998A (en) * | 2018-11-16 | 2019-01-25 | 宁波普瑞柏生物技术股份有限公司 | A kind of light path system and detection device of specific protein analyzer |
| CN211061419U (en) * | 2019-10-16 | 2020-07-21 | 三诺生物传感股份有限公司 | Optical system and detector |
| CN214097154U (en) * | 2020-10-16 | 2021-08-31 | 石家庄禾柏生物技术股份有限公司 | Multi-methodology combined optical path |
| CN112362620A (en) * | 2020-10-16 | 2021-02-12 | 石家庄禾柏生物技术股份有限公司 | Multi-methodology combined optical path |
-
2020
- 2020-10-16 CN CN202011110484.7A patent/CN112362620A/en active Pending
-
2021
- 2021-09-10 WO PCT/CN2021/117672 patent/WO2022078132A1/en active Application Filing
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022078132A1 (en) * | 2020-10-16 | 2022-04-21 | 石家庄禾柏生物技术股份有限公司 | Multi-methodology combined optical path |
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| Publication number | Publication date |
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| WO2022078132A1 (en) | 2022-04-21 |
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