CN112353927A - Granule for treating diarrhea and preparation method thereof - Google Patents

Granule for treating diarrhea and preparation method thereof Download PDF

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CN112353927A
CN112353927A CN202011343313.9A CN202011343313A CN112353927A CN 112353927 A CN112353927 A CN 112353927A CN 202011343313 A CN202011343313 A CN 202011343313A CN 112353927 A CN112353927 A CN 112353927A
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parts
boiling
diarrhea
pure water
treating
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李政槺
李桂文
苏玉英
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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Abstract

The invention relates to a granule for treating diarrhea and a preparation method thereof, which is prepared by scientifically mixing six traditional Chinese medicines of fiddlehead, motherwort, radix curcumae, dendrobium officinale, poria cocos and red dates and has the effects of relieving diarrhea during menstrual period, relieving dysmenorrheal and promoting blood circulation to restore menstrual flow. The dendrobium officinale, the poria cocos and the red dates are added to regulate the effects of prostaglandin secretion, the secretion amount of prostaglandin can be effectively reduced, menstrual diarrhea and abdominal pain can be fundamentally relieved, the drug effect can be greatly increased, the drug effect duration is about 24 hours, the drug administration frequency can be reduced to once a day, and the side effects are smaller; the auxiliary materials comprise stevioside, soluble starch, maltodextrin and ethanol, and the stevioside is used for regulating the sweetness of the diarrhea granules; when the weight ratio of the soluble starch to the maltodextrin is 2:1, the qualification rate of drying granulation can be greatly improved, the prepared diarrhea granules have more uniform granularity, are not easy to crush in the transportation process, and the product quality is higher.

Description

Granule for treating diarrhea and preparation method thereof
Technical Field
The invention relates to the technical field of diarrhea particles, and particularly relates to particles for treating diarrhea and a preparation method thereof.
Background
Diarrhea occurs during menstruation because gastrointestinal dysfunction due to excessive release of prostaglandins in the body causes diarrhea, even nausea and vomiting, and dysmenorrhea, which is involved and uncomfortable with gastrointestinal function, occurs due to uterine contraction during menstruation. Such a situation will end in 3-5 days without affecting the health. However, the diarrhea is more frequent, various functions of the body are affected to different degrees, and the menstrual diarrhea needs to be treated better earlier.
Spicy, pungent foods, including uncooked foods, are consumed as little as possible during menstruation to avoid conditions that aggravate dysmenorrhea and cause severe diarrhea.
The pathogenesis of menstrual diarrhea is greatly different from that of acute diarrhea caused by intestinal infection and the like, and the medicines for the menstrual diarrhea are studied, so that a plurality of medicines for the acute diarrhea caused by common intestinal infection and the like are available in the market at present, and the medicines for the menstrual diarrhea are not available. Due to different pathogenic mechanisms and more contraindications in menstrual periods, common acute diarrhea drugs have large side effects and even aggravate the occurrence of dysmenorrhea, and the development of antidiarrheal drugs for menstrual diarrhea is urgently needed.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide the particles for treating diarrhea, which are suitable for menstrual period, can improve diarrhea conditions, do not aggravate dysmenorrhea and have low side effect, and the preparation method thereof.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows: the particles for treating diarrhea comprise the following raw materials in parts by weight: 0.3-0.5 part of dendrobium officinale, 25-30 parts of motherwort, 3-5 parts of radix curcumae, 1.5-3.5 parts of bracken, 7-12 parts of poria cocos and 5-7 parts of red dates.
Further, the particles for treating diarrhea comprise the following raw materials in parts by weight: 0.35-0.5 part of dendrobium officinale, 27-30 parts of motherwort, 3.5-5 parts of radix curcumae, 2.5-3.5 parts of bracken, 9-12 parts of poria cocos and 6-7 parts of red dates.
Further, the particles for treating diarrhea comprise the following raw materials in parts by weight: 0.45 part of dendrobium officinale, 28 parts of motherwort, 4.5 parts of turmeric root-tuber, 2.8 parts of bracken, 10 parts of tuckahoe and 6.5 parts of red date.
Further, the red dates are counted by weight of dry red date pulp.
The invention also provides a preparation method of the granules for treating diarrhea, which comprises the following steps:
(1) weighing: weighing the raw materials according to the proportion;
(2) decocting a mixed solution of dendrobium officinale, motherwort and radix curcumae: decocting for four times repeatedly, mixing the decoctions to obtain mixed decoctions of herba Dendrobii, herba Leonuri and radix Curcumae;
(3) decocting mixed liquid of bracken, tuckahoe and red date: decocting for six times repeatedly, mixing the decoctions to obtain mixed decoctions of herba Fimbristylis Dichotomae, Poria and fructus Jujubae;
(4) mixing: mixing herba Dendrobii, herba Leonuri, and radix Curcumae, decocting to obtain decoction, mixing herba Fimbristylis Dichotomae, Poria, and fructus Jujubae, and decocting to obtain decoction;
(5) concentration: concentrating the mixed solution to obtain an extract with the relative density of 1.25g/ml at the temperature of 60 ℃;
(6) adding auxiliary materials: adding auxiliary materials into the extract, wherein the adding amount of the auxiliary materials is 3-5% of the weight of the extract;
(7) drying and granulating: drying and granulating the extract to obtain the diarrhea treating granules.
Further, the weight ratio of the raw materials to the pure water in the first boiling in the step (2) is 1: 30-35, wherein the boiling time is 125-135 min; the water consumption of the pure water for the second boiling is 90-100% of that of the pure water for the first boiling, and the second boiling time is 80-95 min; the water consumption of the pure water boiled for the third time is 70-90% of that of the pure water boiled for the first time, and the boiling time for the third time is 100-120 min; the water consumption of the pure water for the fourth boiling is 70-90% of that of the pure water for the first boiling, and the fourth boiling time is 30-40 min.
Further, the weight ratio of the raw materials to the pure water in the first boiling in the step (3) is 1: 35-45, wherein the boiling time is 35-45 min; the water consumption of the pure water for the second boiling-the sixth boiling is 80-110% of that of the pure water for the first boiling, and the time for the second boiling-the sixth boiling is 60-75 min.
Further, the auxiliary materials in the step (6) comprise the following raw materials in parts by weight: 0.035-0.050 parts of stevioside, 10-16 parts of soluble starch, 5-8 parts of maltodextrin and 25-35 parts of ethanol.
Further, the mass fraction of the ethanol in the step (6) is 55-65%.
Further, the soluble starch in the step (6) is soluble sweet potato starch or soluble potato starch.
Dendrobium officinale, which is slightly cold in nature and sweet in taste. It enters stomach meridian and kidney meridian. Tonifying stomach and promoting fluid production, nourishing yin and clearing heat, which belong to yin tonics classified under deficiency tonics. Contains a large amount of dendrobii polysaccharide and dendrobine, and has effects of clearing away in vivo waste and toxin, purifying blood, regenerating cell, accelerating wound healing, inhibiting cell variation, and promoting metabolism.
Motherwort herb, herba leonuri, being pungent and bitter in taste and cool in nature, activating blood, removing blood stasis, regulating menstruation and eliminating water, treats irregular menstruation, vaginal bleeding, dystocia, retained afterbirth, postpartum anemic fainting, blood stasis and abdominal pain, metrorrhagia and metrostaxis, hematuria, bloody diarrhoea, carbuncle and pyocutaneous disease of women. Motherwort has the functions of inducing diuresis to reduce edema and contracting uterus, and is the essential medicine for treating gynecopathy in doctors of all generations. Herba Leonuri can be used as medicine, and contains leonurine as effective component, which contains various alkaloids such as leonurine, stachydrine, leonurine, benzoic acid, potassium chloride, etc.
The herba Leonuri preparation has the effect of exciting animal uterus, and similar to pituitary phyllanthoxanthin, herba Leonuri extract and decoction have strong and lasting exciting effect on uterus, and can not only enhance contractility, but also increase tensity and shrinkage.
Yu jin, pungent, bitter and cold in flavor, enters liver, heart and lung meridians; move qi and remove blood stasis, clear heart fire and relieve depression, promote bile flow and cure jaundice. Can be used for treating amenorrhea, dysmenorrhea, chest and abdomen distention and pain, pricking pain, fever unconsciousness, epilepsy, jaundice, and dark urine.
The bracken is sweet in taste and cold in nature, has the effects of detoxifying, clearing heat, lubricating intestines, reducing phlegm and the like when being used as a medicine, and can reduce blood pressure and relieve dizziness and insomnia when being eaten frequently. The herba Fimbristylis Dichotomae also has effects of relieving diarrhea and promoting diuresis, contains dietary fiber, and has effects of promoting gastrointestinal motility, descending qi, relaxing bowels, clearing intestine, removing toxic substance, treating rheumarthritis, dysentery, hemoptysis, etc., and preventing measles and influenza. The pteridium aquilinum has certain inhibiting effect on bacteria, can be used for treating persistent fever, intestinal wind heat toxin, eczema, pyocutaneous disease and other diseases, and has good effects of clearing heat and toxic materials, sterilizing and clearing inflammation. Meanwhile, the fiddlehead has the effects of tonifying spleen and qi, strengthening the body and enhancing the disease resistance.
Poria cocos, wherein the main component of Poria cocos is pachyman, has high content, and has inhibitory effect on various bacteria; can reduce gastric acid, and has prophylactic effect on digestive tract ulcer; has obvious protective effect on liver injury; has anti-tumor effect; the immune function can be adjusted in multiple ways; can accelerate the return of leucopenia caused by chemotherapy; and has tranquilizing effect. The traditional Chinese medicine is a traditional Chinese medicine capable of excreting dampness, strengthening spleen, harmonizing stomach and soothing nerves, can induce diuresis and excreting dampness, has mild drug property, induces diuresis without damaging vital qi, is a key herb for inducing diuresis and excreting dampness, and can be applied in combination for symptoms of dysuresia and retention of water-dampness, no matter whether the symptoms are cold-dampness or damp-heat or spleen deficiency and dampness accumulation.
The red dates have the effects of tonifying middle-jiao and Qi, nourishing blood and soothing nerves, can nourish heart blood and calm mind, and can be used for treating spleen deficiency, anorexia, weakness, loose stool, hysteria, insomnia and other diseases.
The invention relates to a granule for treating diarrhea and a preparation method thereof, wherein bracken is a monarch drug in the formula, has flat nature and slightly astringent taste, has the effects of detoxifying, clearing heat, relieving diarrhea and promoting urination when being used as a drug, and is used for relieving diarrhea during menstrual period. Motherwort and radix curcumae are taken as ministers to help bracken to relieve dysmenorrheal, promote blood circulation to regulate menstruation and increase menstrual blood volume; motherwort herb, which is pungent, bitter and cool in flavor, can promote blood circulation, regulate menstruation and treat irregular menstruation of women; yu jin, pungent, bitter and cold in flavor, enters liver, heart and lung meridians; promoting qi circulation, removing blood stasis, clearing heart fire, resolving stagnation, promoting bile flow, and eliminating jaundice, and can be used for treating amenorrhea and dysmenorrhea. The dendrobium officinale, the poria cocos and the red dates are used as adjuvants, so that the dendrobium officinale, the poria cocos and the red dates can be used for regulating the middle energizer and harmonizing the effects of the medicines and the spleen and stomach; dendrobium officinale, which is slightly cold in nature and sweet in taste, belongs to yin-tonifying medicines classified under deficiency-tonifying medicines, and enters stomach channels and kidney channels, and has the effects of tonifying stomach, promoting the production of body fluid, nourishing yin and clearing heat; the tuckahoe, a traditional Chinese medicine capable of excreting dampness, strengthening spleen, harmonizing stomach and soothing nerves, can promote diuresis and excreting dampness, has mild drug property and induces diuresis without damaging vital qi; the red dates have the effects of tonifying middle-jiao and Qi, nourishing blood and soothing nerves, and can nourish heart and blood and calm heart. The six traditional Chinese medicines are scientifically matched, and have the effects of relieving diarrhea during menstrual period, relieving dysmenorrheal and promoting blood circulation to restore menstrual flow.
The invention relates to a granule for treating diarrhea and a preparation method thereof, wherein the formula contains pteridium aquilinum which is used for relieving diarrhea during menstrual period, motherwort and curcuma aromatica have the functions of relieving dysmenorrheal, promoting blood circulation to restore menstrual flow and increasing menstrual blood volume, and the motherwort, curcuma aromatica and pteridium aquilinum are matched for use to relieve diarrhea during menstrual period, relieve dysmenorrheal, promote blood circulation to restore menstrual flow and regulate menstrual blood volume; the traditional Chinese medicine consisting of the pteridium aquilinum, the motherwort and the radix curcumae takes effect in the next hour after being taken, has the effects of relieving diarrhea in menstrual period, relieving dysmenorrheal and promoting blood circulation to regulate menstruation, and has the effect that the duration of the drug effect is about 3 hours, so the medicine taking frequency is required to be more than three times per day, but in the traditional Chinese medicine, the medicine is called three-way poison, and the body is damaged due to overlarge dosage in the menstrual period.
The granules for treating diarrhea and the preparation method thereof, disclosed by the invention, comprise auxiliary materials of stevioside, soluble starch, maltodextrin and ethanol, wherein the stevioside is used for regulating the sweetness of the granules for treating diarrhea; when the weight ratio of the soluble starch to the maltodextrin is 2:1, the qualification rate of drying granulation can be greatly improved, the prepared diarrhea granules have more uniform granularity, are not easy to crush in the transportation process, and the product quality is higher.
Detailed Description
The following examples may help one skilled in the art to more fully understand the present invention, but are not intended to limit the invention in any way.
Preparation of example 1
The particles for treating diarrhea comprise the following raw materials in parts by weight: 0.3 part of dendrobium officinale, 25 parts of motherwort, 3 parts of radix curcumae, 1.5 parts of bracken, 7 parts of poria cocos and 5 parts of red dates; the red dates are counted by weight of dry red date pulp.
A preparation method of granules for treating diarrhea comprises the following steps:
(1) weighing: weighing the raw materials according to the proportion;
(2) decocting a mixed solution of dendrobium officinale, motherwort and radix curcumae: decocting for four times repeatedly, mixing the decoctions to obtain mixed decoctions of herba Dendrobii, herba Leonuri and radix Curcumae; the weight ratio of the raw materials to the pure water is 1: 30, the boiling time is 125 min; the water consumption of the pure water for the second boiling is 90% of that of the pure water for the first boiling, and the second boiling time is 80 min; the water consumption of the pure water boiled for the third time is 70% of that of the pure water boiled for the first time, and the boiling time for the third time is 100 min; the water consumption of the pure water for the fourth boiling is 70% of that of the pure water for the first boiling, and the fourth boiling time is 30 min;
(3) decocting mixed liquid of bracken, tuckahoe and red date: decocting for six times repeatedly, mixing the decoctions to obtain mixed decoctions of herba Fimbristylis Dichotomae, Poria and fructus Jujubae; the weight ratio of the raw materials to the pure water is 1: 35, the boiling time is 35 min; the water consumption of the pure water for the second boiling-the sixth boiling is 80% of that of the pure water for the first boiling, and the time for the second boiling-the sixth boiling is 60 min;
(4) mixing: mixing herba Dendrobii, herba Leonuri, and radix Curcumae, decocting to obtain decoction, mixing herba Fimbristylis Dichotomae, Poria, and fructus Jujubae, and decocting to obtain decoction;
(5) concentration: concentrating the mixed solution to obtain an extract with the relative density of 1.25g/ml at the temperature of 60 ℃;
(6) adding auxiliary materials: adding auxiliary materials into the extract, wherein the auxiliary materials comprise the following raw materials in parts by weight: 0.035 parts of stevioside, 10 parts of soluble sweet potato starch, 5 parts of maltodextrin and 25 parts of ethanol with the mass fraction of 55 percent, wherein the adding amount of auxiliary materials is 3 percent of the weight of the extract;
(7) drying and granulating: drying and granulating the extract to obtain the diarrhea treating granules.
When the particles for treating diarrhea are prepared, the weight ratio of the soluble starch to the maltodextrin is 2:1, the raw material viscosity, the compactness and the porosity are optimal, the particle forming is facilitated, the particle size of the prepared diarrhea particles is more uniform, the particles are less broken and have gaps when being dried and granulated, the raw materials adhered to a machine are less, the granulation qualification rate reaches more than 98.5 percent, the particles are not easy to crush in the transportation process, and the product quality is higher.
Preparation of example 2
The particles for treating diarrhea comprise the following raw materials in parts by weight: 0.5 part of dendrobium officinale, 30 parts of motherwort, 5 parts of radix curcumae, 3.5 parts of bracken, 12 parts of poria cocos and 7 parts of red dates; the red dates are counted by weight of dry red date pulp.
A preparation method of granules for treating diarrhea comprises the following steps:
(1) weighing: weighing the raw materials according to the proportion;
(2) decocting a mixed solution of dendrobium officinale, motherwort and radix curcumae: decocting for four times repeatedly, mixing the decoctions to obtain mixed decoctions of herba Dendrobii, herba Leonuri and radix Curcumae; the weight ratio of the raw materials to the pure water is 1: 35, decocting for 135 min; the water consumption of the pure water for the second boiling is 100% of that of the pure water for the first boiling, and the second boiling time is 95 min; the water consumption of the pure water boiled for the third time is 90 percent of that of the pure water boiled for the first time, and the boiling time for the third time is 120 min; the water consumption of the pure water for the fourth boiling is 90% of that of the pure water for the first boiling, and the fourth boiling time is 40 min;
(3) decocting mixed liquid of bracken, tuckahoe and red date: decocting for six times repeatedly, mixing the decoctions to obtain mixed decoctions of herba Fimbristylis Dichotomae, Poria and fructus Jujubae; the weight ratio of the raw materials to the pure water is 1: 45, the boiling time is 45 min; the water consumption of the pure water for the second boiling-the sixth boiling is 110% of that of the pure water for the first boiling, and the time for the second boiling-the sixth boiling is 75 min;
(4) mixing: mixing herba Dendrobii, herba Leonuri, and radix Curcumae, decocting to obtain decoction, mixing herba Fimbristylis Dichotomae, Poria, and fructus Jujubae, and decocting to obtain decoction;
(5) concentration: concentrating the mixed solution to obtain an extract with the relative density of 1.25g/ml at the temperature of 60 ℃;
(6) adding auxiliary materials: adding auxiliary materials into the extract, wherein the auxiliary materials comprise the following raw materials in parts by weight: 0.050 part of stevioside, 16 parts of soluble potato starch, 8 parts of maltodextrin and 35 parts of ethanol with the mass fraction of 65 percent, wherein the adding amount of auxiliary materials is 5 percent of the weight of the extract;
(7) drying and granulating: drying and granulating the extract to obtain the diarrhea treating granules.
When the particles for treating diarrhea are prepared, the weight ratio of the soluble starch to the maltodextrin is 2:1, the raw material viscosity, the compactness and the porosity are optimal, the particle forming is facilitated, the particle size of the prepared diarrhea particles is more uniform, the particles are less broken and have gaps when being dried and granulated, the raw materials adhered to a machine are less, the granulation qualification rate reaches more than 98.5 percent, the particles are not easy to crush in the transportation process, and the product quality is higher.
Preparation of example 3
The particles for treating diarrhea comprise the following raw materials in parts by weight: 0.35 part of dendrobium officinale, 27 parts of motherwort, 3.5 parts of radix curcumae, 2.5 parts of bracken, 9 parts of poria cocos and 6 parts of red dates; the red dates are counted by weight of dry red date pulp.
A preparation method of granules for treating diarrhea comprises the following steps:
(1) weighing: weighing the raw materials according to the proportion;
(2) decocting a mixed solution of dendrobium officinale, motherwort and radix curcumae: decocting for four times repeatedly, mixing the decoctions to obtain mixed decoctions of herba Dendrobii, herba Leonuri and radix Curcumae; the weight ratio of the raw materials to the pure water is 1: 32, the boiling time is 130 min; the water consumption of the pure water for the second boiling is 95% of that of the pure water for the first boiling, and the second boiling time is 85 min; the water consumption of the pure water boiled for the third time is 80% of that of the pure water boiled for the first time, and the boiling time for the third time is 110 min; the water consumption of the pure water for the fourth boiling is 80% of that of the pure water for the first boiling, and the fourth boiling time is 35 min;
(3) decocting mixed liquid of bracken, tuckahoe and red date: decocting for six times repeatedly, mixing the decoctions to obtain mixed decoctions of herba Fimbristylis Dichotomae, Poria and fructus Jujubae; the weight ratio of the raw materials to the pure water is 1: 40, decocting for 40 min; the water consumption of the pure water for the second boiling-the sixth boiling is 90% of that of the pure water for the first boiling, and the time for the second boiling-the sixth boiling is 65 min;
(4) mixing: mixing herba Dendrobii, herba Leonuri, and radix Curcumae, decocting to obtain decoction, mixing herba Fimbristylis Dichotomae, Poria, and fructus Jujubae, and decocting to obtain decoction;
(5) concentration: concentrating the mixed solution to obtain an extract with the relative density of 1.25g/ml at the temperature of 60 ℃;
(6) adding auxiliary materials: adding auxiliary materials into the extract, wherein the auxiliary materials comprise the following raw materials in parts by weight: 0.045 part of stevioside, 14 parts of soluble sweet potato starch, 7 parts of maltodextrin and 30 parts of ethanol with the mass fraction of 60%, wherein the adding amount of auxiliary materials is 4% of the weight of the extract;
(7) drying and granulating: drying and granulating the extract to obtain the diarrhea treating granules.
When the particles for treating diarrhea are prepared, the weight ratio of the soluble starch to the maltodextrin is 2:1, the raw material viscosity, the compactness and the porosity are optimal, the particle forming is facilitated, the particle size of the prepared diarrhea particles is more uniform, the particles are less broken and have gaps when being dried and granulated, the raw materials adhered to a machine are less, the granulation qualification rate reaches more than 98.5 percent, the particles are not easy to crush in the transportation process, and the product quality is higher.
Preparation of example 4
The particles for treating diarrhea comprise the following raw materials in parts by weight: 0.45 part of dendrobium officinale, 28 parts of motherwort, 4.5 parts of turmeric root-tuber, 2.8 parts of bracken, 10 parts of tuckahoe and 6.5 parts of red date; the red dates are counted by weight of dry red date pulp.
A preparation method of granules for treating diarrhea comprises the following steps:
(1) weighing: weighing the raw materials according to the proportion;
(2) decocting a mixed solution of dendrobium officinale, motherwort and radix curcumae: decocting for four times repeatedly, mixing the decoctions to obtain mixed decoctions of herba Dendrobii, herba Leonuri and radix Curcumae; the weight ratio of the raw materials to the pure water is 1: 33, the boiling time is 128 min; the water consumption of the pure water for the second boiling is 97 percent of that of the pure water for the first boiling, and the second boiling time is 90 min; the water consumption of the pure water boiled for the third time is 85% of that of the pure water boiled for the first time, and the boiling time for the third time is 110 min; the water consumption of the pure water for the fourth boiling is 85% of that of the pure water for the first boiling, and the fourth boiling time is 37 min;
(3) decocting mixed liquid of bracken, tuckahoe and red date: decocting for six times repeatedly, mixing the decoctions to obtain mixed decoctions of herba Fimbristylis Dichotomae, Poria and fructus Jujubae; the weight ratio of the raw materials to the pure water is 1: 42, decocting for 39 min; the water consumption of the pure water for the second boiling-the sixth boiling is 105% of that of the pure water for the first boiling, and the time for the second boiling-the sixth boiling is 72 min;
(4) mixing: mixing herba Dendrobii, herba Leonuri, and radix Curcumae, decocting to obtain decoction, mixing herba Fimbristylis Dichotomae, Poria, and fructus Jujubae, and decocting to obtain decoction;
(5) concentration: concentrating the mixed solution to obtain an extract with the relative density of 1.25g/ml at the temperature of 60 ℃;
(6) adding auxiliary materials: adding auxiliary materials into the extract, wherein the auxiliary materials comprise the following raw materials in parts by weight: 0.047 part of stevioside, 15 parts of soluble potato starch, 6 parts of maltodextrin and 28 parts of ethanol with the mass fraction of 62 percent, wherein the adding amount of auxiliary materials is 3.5 percent of the weight of the extract;
(7) drying and granulating: drying and granulating the extract to obtain the diarrhea treating granules.
In the preparation of the particles for treating diarrhea, the weight ratio of the soluble starch to the maltodextrin is 15:6, the raw material viscosity, the compactness and the porosity are better, the particle forming is better, the particle size of the prepared diarrhea particles is uniform, when the particles are dried and granulated, the particles are rarely broken and notched, the raw materials adhered to a machine are few, and the granulation qualification rate reaches 95.5-96.5%.
Preparation of example 5
The particles for treating diarrhea comprise the following raw materials in parts by weight: 0.45 part of dendrobium officinale, 28 parts of motherwort, 4.5 parts of turmeric root-tuber, 2.8 parts of bracken, 10 parts of tuckahoe and 6.5 parts of red date; the red dates are counted by weight of dry red date pulp.
A preparation method of granules for treating diarrhea comprises the following steps:
(1) weighing: weighing the raw materials according to the proportion;
(2) decocting a mixed solution of dendrobium officinale, motherwort and radix curcumae: decocting for four times repeatedly, mixing the decoctions to obtain mixed decoctions of herba Dendrobii, herba Leonuri and radix Curcumae; the weight ratio of the raw materials to the pure water is 1: 31, the boiling time is 129 min; the water consumption of the pure water for the second boiling is 98 percent of that of the pure water for the first boiling, and the second boiling time is 92 min; the water consumption of the pure water boiled for the third time is 86% of that of the pure water boiled for the first time, and the boiling time for the third time is 110 min; the water consumption of the pure water for the fourth boiling is 82% of that of the pure water for the first boiling, and the fourth boiling time is 37 min;
(3) decocting mixed liquid of bracken, tuckahoe and red date: decocting for six times repeatedly, mixing the decoctions to obtain mixed decoctions of herba Fimbristylis Dichotomae, Poria and fructus Jujubae; the weight ratio of the raw materials to the pure water is 1: 38, the boiling time is 43 min; the water consumption of the pure water for the second boiling-the sixth boiling is 95 percent of that of the pure water for the first boiling, and the time for the second boiling-the sixth boiling is 67 min;
(4) mixing: mixing herba Dendrobii, herba Leonuri, and radix Curcumae, decocting to obtain decoction, mixing herba Fimbristylis Dichotomae, Poria, and fructus Jujubae, and decocting to obtain decoction;
(5) concentration: concentrating the mixed solution to obtain an extract with the relative density of 1.25g/ml at the temperature of 60 ℃;
(6) adding auxiliary materials: adding auxiliary materials into the extract, wherein the auxiliary materials comprise the following raw materials in parts by weight: 0.046 part of stevioside, 14 parts of soluble sweet potato starch, 6 parts of maltodextrin and 28 parts of ethanol with the mass fraction of 63 percent, wherein the adding amount of auxiliary materials is 4.7 percent of the weight of the extract;
(7) drying and granulating: drying and granulating the extract to obtain the diarrhea treating granules.
In the preparation of the particles for treating diarrhea, the weight ratio of the soluble starch to the maltodextrin is 14:6, the raw material viscosity, the compactness and the porosity are better, the particle forming is better, the particle size of the prepared diarrhea particles is uniform, the particles are rarely broken and notched during drying and granulating, the raw materials adhered to a machine are few, and the granulating qualification rate reaches 95.5-96.5%.
Preparation of comparative example 1
The particles for treating diarrhea comprise the following raw materials in parts by weight: 28 parts of motherwort, 4.5 parts of curcuma aromatica, 2.8 parts of fiddlehead, 10 parts of tuckahoe and 6.5 parts of red date; the red dates are counted by weight of dry red date pulp.
A preparation method of granules for treating diarrhea comprises the following steps:
(1) weighing: weighing the raw materials according to the proportion;
(2) decocting a mixed solution of motherwort and curcuma aromatica: decocting for four times repeatedly, mixing the decoctions to obtain mixed decoctions of herba Leonuri and radix Curcumae; the weight ratio of the raw materials to the pure water is 1: 31, the boiling time is 129 min; the water consumption of the pure water for the second boiling is 98 percent of that of the pure water for the first boiling, and the second boiling time is 92 min; the water consumption of the pure water boiled for the third time is 86% of that of the pure water boiled for the first time, and the boiling time for the third time is 110 min; the water consumption of the pure water for the fourth boiling is 82% of that of the pure water for the first boiling, and the fourth boiling time is 37 min;
(3) decocting mixed liquid of bracken, tuckahoe and red date: decocting for six times repeatedly, mixing the decoctions to obtain mixed decoctions of herba Fimbristylis Dichotomae, Poria and fructus Jujubae; the weight ratio of the raw materials to the pure water is 1: 38, the boiling time is 43 min; the water consumption of the pure water for the second boiling-the sixth boiling is 95 percent of that of the pure water for the first boiling, and the time for the second boiling-the sixth boiling is 67 min;
(4) mixing: mixing herba Leonuri and radix Curcumae, decocting to obtain decoction, mixing herba Fimbristylis Dichotomae, Poria and fructus Jujubae, and mixing to obtain mixed solution;
(5) concentration: concentrating the mixed solution to obtain an extract with the relative density of 1.25g/ml at the temperature of 60 ℃;
(6) adding auxiliary materials: adding auxiliary materials into the extract, wherein the auxiliary materials comprise the following raw materials in parts by weight: 0.046 part of stevioside, 14 parts of soluble sweet potato starch, 6 parts of maltodextrin and 28 parts of ethanol with the mass fraction of 63 percent, wherein the adding amount of auxiliary materials is 4.7 percent of the weight of the extract;
(7) drying and granulating: drying and granulating the extract to obtain the diarrhea treating granules.
In the preparation of the particles for treating diarrhea, the weight ratio of the soluble starch to the maltodextrin is 14:6, the raw material viscosity, the compactness and the porosity are better, the particle forming is better, the particle size of the prepared diarrhea particles is uniform, the particles are rarely broken and notched during drying and granulating, the raw materials adhered to a machine are few, and the granulating qualification rate reaches 95.5-96.5%.
Preparation of comparative example 2
The particles for treating diarrhea comprise the following raw materials in parts by weight: 0.45 part of dendrobium officinale, 28 parts of motherwort, 4.5 parts of radix curcumae, 2.8 parts of bracken and 6.5 parts of red dates; the red dates are counted by weight of dry red date pulp.
A preparation method of granules for treating diarrhea comprises the following steps:
(1) weighing: weighing the raw materials according to the proportion;
(2) decocting a mixed solution of dendrobium officinale, motherwort and radix curcumae: decocting for four times repeatedly, mixing the decoctions to obtain mixed decoctions of herba Dendrobii, herba Leonuri and radix Curcumae; the weight ratio of the raw materials to the pure water is 1: 31, the boiling time is 129 min; the water consumption of the pure water for the second boiling is 98 percent of that of the pure water for the first boiling, and the second boiling time is 92 min; the water consumption of the pure water boiled for the third time is 86% of that of the pure water boiled for the first time, and the boiling time for the third time is 110 min; the water consumption of the pure water for the fourth boiling is 82% of that of the pure water for the first boiling, and the fourth boiling time is 37 min;
(3) boiling the mixed solution of the bracken and the red dates: decocting for six times repeatedly, mixing the decoctions to obtain mixed decoctions of herba Fimbristylis Dichotomae, Poria and fructus Jujubae; the weight ratio of the raw materials to the pure water is 1: 38, the boiling time is 43 min; the water consumption of the pure water for the second boiling-the sixth boiling is 95 percent of that of the pure water for the first boiling, and the time for the second boiling-the sixth boiling is 67 min;
(4) mixing: mixing herba Dendrobii, herba Leonuri, and radix Curcumae, decocting to obtain decoction, mixing herba Fimbristylis Dichotomae and fructus Jujubae, and mixing to obtain mixture;
(5) concentration: concentrating the mixed solution to obtain an extract with the relative density of 1.25g/ml at the temperature of 60 ℃;
(6) adding auxiliary materials: adding auxiliary materials into the extract, wherein the auxiliary materials comprise the following raw materials in parts by weight: 0.046 part of stevioside, 14 parts of soluble sweet potato starch, 6 parts of maltodextrin and 28 parts of ethanol with the mass fraction of 63 percent, wherein the adding amount of auxiliary materials is 4.7 percent of the weight of the extract;
(7) drying and granulating: drying and granulating the extract to obtain the diarrhea treating granules.
In the preparation of the particles for treating diarrhea, the weight ratio of the soluble starch to the maltodextrin is 14:6, the raw material viscosity, the compactness and the porosity are better, the particle forming is better, the particle size of the prepared diarrhea particles is uniform, the particles are rarely broken and notched during drying and granulating, the raw materials adhered to a machine are few, and the granulating qualification rate reaches 95.5-96.5%.
Preparation of comparative example 3
The particles for treating diarrhea comprise the following raw materials in parts by weight: 0.45 part of dendrobium officinale, 28 parts of motherwort, 4.5 parts of radix curcumae, 2.8 parts of fiddlehead and 10 parts of poria cocos.
A preparation method of granules for treating diarrhea comprises the following steps:
(1) weighing: weighing the raw materials according to the proportion;
(2) decocting a mixed solution of dendrobium officinale, motherwort and radix curcumae: decocting for four times repeatedly, mixing the decoctions to obtain mixed decoctions of herba Dendrobii, herba Leonuri and radix Curcumae; the weight ratio of the raw materials to the pure water is 1: 31, the boiling time is 129 min; the water consumption of the pure water for the second boiling is 98 percent of that of the pure water for the first boiling, and the second boiling time is 92 min; the water consumption of the pure water boiled for the third time is 86% of that of the pure water boiled for the first time, and the boiling time for the third time is 110 min; the water consumption of the pure water for the fourth boiling is 82% of that of the pure water for the first boiling, and the fourth boiling time is 37 min;
(3) boiling the mixed liquid of the bracken and the tuckahoe: decocting for six times repeatedly, mixing the decoctions to obtain mixed decoctions of herba Fimbristylis Dichotomae and Poria; the weight ratio of the raw materials to the pure water is 1: 38, the boiling time is 43 min; the water consumption of the pure water for the second boiling-the sixth boiling is 95 percent of that of the pure water for the first boiling, and the time for the second boiling-the sixth boiling is 67 min;
(4) mixing: mixing herba Dendrobii, herba Leonuri, and radix Curcumae, decocting to obtain decoction, mixing herba Fimbristylis Dichotomae and Poria, and mixing to obtain mixture;
(5) concentration: concentrating the mixed solution to obtain an extract with the relative density of 1.25g/ml at the temperature of 60 ℃;
(6) adding auxiliary materials: adding auxiliary materials into the extract, wherein the auxiliary materials comprise the following raw materials in parts by weight: 0.046 part of stevioside, 14 parts of soluble sweet potato starch, 6 parts of maltodextrin and 28 parts of ethanol with the mass fraction of 63 percent, wherein the adding amount of auxiliary materials is 4.7 percent of the weight of the extract;
(7) drying and granulating: drying and granulating the extract to obtain the diarrhea treating granules.
In the preparation of the particles for treating diarrhea, the weight ratio of the soluble starch to the maltodextrin is 14:6, the raw material viscosity, the compactness and the porosity are better, the particle forming is better, the particle size of the prepared diarrhea particles is uniform, the particles are rarely broken and notched during drying and granulating, the raw materials adhered to a machine are few, and the granulating qualification rate reaches 95.5-96.5%.
Effect verification example 1
This example was conducted to verify the effect of the diarrhea treating granules of example 1 and comparative examples 1 to 3, respectively.
Firstly, measuring the content of prostaglandin in ICR mice: animal grouping: 170 oestrus ICR mice purchased from Guangdong provincial medicine experimental animal center are divided into one to 17 groups, and each group comprises ten mice;
the first blank group directly detects the prostaglandin content of the cerebral cortex of an ICR mouse;
a second group of ICR mice takes the medicine of example 1 for 4 hours, and the prostaglandin content of cerebral cortex of the ICR mice is detected;
the third group of ICR mice took the medicine of example 1 for 8 hours, and the prostaglandin content of the cerebral cortex of the ICR mice is detected;
a fourth group of ICR mice takes the medicine of example 1 for 12 hours, and the prostaglandin content of cerebral cortex of the ICR mice is detected;
a fifth group of ICR mice takes the medicine of example 1 for 24 hours, and the prostaglandin content of cerebral cortex of the ICR mice is detected;
a sixth group of ICR mice takes the medicine of the comparative example 1 for 4 hours, and the prostaglandin content of the cerebral cortex of the ICR mice is detected;
a seventh group of ICR mice takes the medicine of the comparative example 1 for 8 hours, and the prostaglandin content of the cerebral cortex of the ICR mice is detected;
taking the medicine of the comparative example 1 for 12 hours by an ICR mouse in an eighth group, and detecting the prostaglandin content of the cerebral cortex of the ICR mouse;
a ninth group of ICR mice takes the medicine of the comparative example 1 for 24 hours, and the prostaglandin content of the cerebral cortex of the ICR mice is detected;
taking the medicine of the comparative example 2 for 4 hours by a tenth group of ICR mice, and detecting the prostaglandin content of the cerebral cortex of the ICR mice;
the tenth group of ICR mice take the medicine of the comparative example 2 for 8 hours, and the prostaglandin content of the cerebral cortex of the ICR mice is detected;
a twelfth group of ICR mice takes the medicine of the comparative example 2 for 12 hours, and the prostaglandin content of the cerebral cortex of the ICR mice is detected;
the tenth group of ICR mice takes the medicine of the comparative example 2 for 24 hours, and the prostaglandin content of the cerebral cortex of the ICR mice is detected;
taking the comparative example 3 medicine for 4 hours by a fourth group of ICR mice, and detecting the prostaglandin content of the cerebral cortex of the ICR mice;
taking the medicine of the comparative example 3 for 8 hours by a fifteenth group of ICR mice, and detecting the prostaglandin content of the cerebral cortex of the ICR mice;
sixteenth group ICR mice took the medicine of the comparative example 3 for 12 hours, and the prostaglandin content of the cerebral cortex of the ICR mice is detected;
seventeenth group of ICR mice took the medicine of comparative example 3 for 24 hours, and the prostaglandin content of cerebral cortex of the ICR mice was detected;
the determination method comprises the following steps: killing animals, quickly taking out cerebral cortex, homogenizing with anhydrous alcohol, and adjusting pH; extracting prostaglandin with solvent, eluting and separating PGA2、PGE1、PGF2α(ii) a The determination method refers to the authors in the No. 06 of 1991: fructus seu radix Linderae Caeruleae, fructus Pruni Salicinae;
the results of the estrous ICR mouse cerebral cortex prostaglandin assay are shown in table 1 below: (microgram/ml)
TABLE 1
PGA2(microgram/ml) PGE1(microgram/ml) PGF2α(microgram/ml)
First group 11.6±0.6 9.2±0.7 10.8±0.8
Second group 7.2±0.2 5.0±0.3 6.1±0.4
Third group 7.3±0.3 5.1±0.4 6.2±0.6
Fourth group 7.2±0.4 5.2±0.3 6.3±0.5
Fifth group 7.4±0.3 5.0±0.2 6.1±0.4
Sixth group 10.4±0.6 8.1±0.3 9.7±0.6
Seventh group 11.0±0.2 9.4±0.5 10.7±0.4
Eighth group 11.5±0.4 9.0±0.3 10.6±0.5
Ninth group 11.2±0.3 9.1±0.4 10.5±0.3
Tenth group 10.3±0.5 8.0±0.6 9.1±0.8
Eleventh group 11.1±0.3 9.5±0.4 10.2±0.5
Twelfth group 11.4±0.6 9.2±0.7 10.2±0.6
Group thirteen 11.6±0.7 9.3±0.4 10.3±0.5
Fourteenth group 10.7±1.0 8.5±0.5 9.9±0.5
Fifth group 10.6±0.6 9.7±0.9 10.5±0.5
Sixteenth group 10.9±0.7 9.2±0.6 10.4±0.4
Seventeenth group 10.8±0.4 9.5±0.7 10.9±0.6
II, treatment effect experiment: 1) preparation of a medicine: the granules for treating diarrhea prepared in examples 1-5 and comparative examples 1-3; 2) case selection: selecting 8 groups of patients with dysmenorrhea and diarrhea during menstrual period, wherein each group comprises ten patients, the total number of the patients is 80, and the age of the patients is 16-45 years old; 3) the treatment method comprises the following steps: the granule for treating diarrhea is taken by a patient on the same day at the beginning of menstrual period for 1 time, 3 g for each time, and the administration time is after meal; 4) observing and recording the physical condition of the patient; the therapeutic effects are shown in the following table 2,
TABLE 2
Whether or not to stop diarrhea Whether or not toRelieving dysmenorrhea Duration of drug effect The amount of menstrual blood is compared with that in the previous month
Example 1 Is that Is that 24h Normal without increase or decrease
Example 2 Is that Is that 24h Normal without increase or decrease
Example 3 Is that Is that 24h Normal without increase or decrease
Example 4 Is that Is that 24h Normal without increase or decrease
Example 5 Is that Is that 24h Normal without increase or decrease
Comparative example 1 Is that Is that 3h Normal without increase or decrease
Comparative example 2 Is that Is that 3h Normal without increase or decrease
Comparative example 3 Is that Is that 3h Normal without increase or decrease
Three, typical cases
Case one: when a woman is in 26 years old, the woman always feels defecated before and after menstruation, diarrhea can occur from the first day to the third day of the menstrual period, the diarrhea is accompanied by the conditions of abdominal pain, sweating due to debility, cold hands and feet, dizziness, vomiting and lumbago till the woman cannot get up, the duration of the lumbago till the woman cannot get up reaches 3 days, and the diarrhea is repeatedly attacked for many years and is difficult to radically cure. After the diarrhea particles are taken for 1 time in the same day in the menstrual period, the states of abdominal pain, sweating due to debility, cold hands and feet, dizziness and vomiting can be effectively relieved, and the diarrhea does not occur in the same day; the medicine can be taken for 2 days, once a day, to relieve lumbago; the medicine is continuously taken for 4 months, and no recurrence occurs in half a year.
Case two: when a woman is 16 years old, the woman always feels defecated around menstruation, diarrhea can appear from the first day to the second day of the menstrual period, the situation of abdominal pain, sweating due to debility, cold hands and feet and cold fear is also accompanied, the duration time of the sweating due to debility reaches 3 days, and the woman has recurrent attacks for many years and is difficult to radically cure. The diarrhea granule is taken for 1 time in the menstrual period on the day, and the diarrhea does not exist on the day of taking the medicine; the bellyache, the sweating due to debility and the cold state of hands and feet can be effectively relieved, and the discomfort in the menstrual period can be completely relieved by continuously taking the medicine for 2 days once a day; the medicine is taken continuously for five months without recurrence in half a year.
Case three: when a woman is in age of 45, sweating always occurs in the middle and at night before the menstrual period, watery diarrhea occurs in the first day of the menstrual period, the frequency of diarrhea reaches five times a day, and the watery diarrhea is accompanied with the conditions of abdominal pain, dizziness, vomiting and nausea, and the watery diarrhea attacks are repeated for many years, so that the watery diarrhea is difficult to cure radically. After the diarrhea granules are taken for 1 time in the same day in the menstrual period, the states of abdominal pain, dizziness, vomiting and nausea can be effectively relieved, and the diarrhea does not exist in the same day; the medicine is continuously taken for 3 months, and no recurrence occurs in half a year.
Case four: wuzhi, women, age 32, watery diarrhea in the first to third days of the menstrual period, with symptoms of abdominal pain, sweating due to debility, and cold hands and feet, repeatedly attacks for many years and is difficult to cure radically. When the diarrhea particles are taken for 1 time in the current day in the menstrual period, the diarrhea state in the current day is obviously relieved, and the diarrhea is reduced from the original diarrhea 5 times in the day to the diarrhea 2 times in the day; the medicine is taken for 2 days continuously, once a day, the condition of watery diarrhea can be relieved, and the conditions of abdominal pain, sweating due to debility and cold hands and feet can be effectively relieved; the medicine is continuously taken for 3 months, and no recurrence occurs in half a year.
Case five: when a woman ages 19 years old and has a sense of stool before and after menstruation, diarrhea occurs in the first day of the menstrual period, the symptoms of abdominal pain, sweating due to debility and cold hands and feet are also accompanied, the menstrual condition cannot be effectively improved by taking various Chinese and western medicines, and the Chinese and western medicines are repeatedly attacked for many years and are difficult to radically cure. After the diarrhea particles are taken for 1 time in the same day in the menstrual period, the states of abdominal pain, sweating due to debility and cold hands and feet can be effectively relieved, and the diarrhea does not occur in the same day; the medicine is taken continuously for 3 months, and is taken once every first day during the menstrual period, so that the bad conditions in the menstrual period can be relieved, and no relapse occurs in half a year.
Six cases: when a certain Chua woman is in 34 years old, the woman always feels defecate before and after menstruation, watery diarrhea appears from the first day to the second day of the menstruation, the watery diarrhea is also accompanied with severe abdominal pain and excessive sweating due to debility, the upper garment can be wetted, and the watery diarrhea is repeatedly attacked for many years and is difficult to radically cure. After the diarrhea granules are taken for 1 time in the same day in the menstrual period, the states of abdominal pain and sweating due to debility can be effectively relieved, and the diarrhea does not occur in the same day; the medicine can be taken for 2 days, once a day, to relieve sweating due to debility; the medicine is taken continuously for 4 months, and is taken once every first day during the menstrual period, so that the bad conditions in the menstrual period can be relieved, and no relapse occurs in half a year.
According to the effect verification results, the particles for treating diarrhea and the preparation method thereof are scientifically combined by six traditional Chinese medicines, namely, the bracken, the motherwort, the turmeric root-tuber, the dendrobium officinale, the poria cocos and the red dates, and have the effects of relieving diarrhea during menstrual period, relieving dysmenorrheal and promoting blood circulation to regulate menstruation. The dendrobium officinale, the poria cocos and the red dates are added to regulate the effects of prostaglandin secretion, the secretion amount of prostaglandin can be effectively reduced, menstrual diarrhea and abdominal pain can be fundamentally relieved, the drug effect can be greatly increased, the drug effect duration is about 24 hours, the drug administration frequency can be reduced to once a day, and the side effects are smaller; the auxiliary materials comprise stevioside, soluble starch, maltodextrin and ethanol, and the stevioside is used for regulating the sweetness of the diarrhea granules; when the weight ratio of the soluble starch to the maltodextrin is 2:1, the qualification rate of drying granulation can be greatly improved, the prepared diarrhea granules have more uniform granularity, are not easy to crush in the transportation process, and the product quality is higher.
Although the invention has been described in detail hereinabove with respect to a general description and specific embodiments thereof, it will be apparent to those skilled in the art that modifications or improvements may be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.

Claims (10)

1. The granule for treating diarrhea is characterized by comprising the following raw materials in parts by weight: 0.3-0.5 part of dendrobium officinale, 25-30 parts of motherwort, 3-5 parts of radix curcumae, 1.5-3.5 parts of bracken, 7-12 parts of poria cocos and 5-7 parts of red dates.
2. The diarrhea treating granule according to claim 1, wherein the diarrhea treating granule is prepared from the following raw materials in parts by weight: 0.35-0.5 part of dendrobium officinale, 27-30 parts of motherwort, 3.5-5 parts of radix curcumae, 2.5-3.5 parts of bracken, 9-12 parts of poria cocos and 6-7 parts of red dates.
3. The diarrhea treating granule according to claim 1, wherein the diarrhea treating granule is prepared from the following raw materials in parts by weight: 0.45 part of dendrobium officinale, 28 parts of motherwort, 4.5 parts of turmeric root-tuber, 2.8 parts of bracken, 10 parts of tuckahoe and 6.5 parts of red date.
4. The granule for treating diarrhea according to claim 1, wherein the red dates are based on the weight of dry red date pulp.
5. A preparation method of granules for treating diarrhea is characterized by comprising the following steps:
(1) weighing: weighing the raw materials according to the proportion;
(2) decocting a mixed solution of dendrobium officinale, motherwort and radix curcumae: decocting for four times repeatedly, mixing the decoctions to obtain mixed decoctions of herba Dendrobii, herba Leonuri and radix Curcumae;
(3) decocting mixed liquid of bracken, tuckahoe and red date: decocting for six times repeatedly, mixing the decoctions to obtain mixed decoctions of herba Fimbristylis Dichotomae, Poria and fructus Jujubae;
(4) mixing: mixing herba Dendrobii, herba Leonuri, and radix Curcumae, decocting to obtain decoction, mixing herba Fimbristylis Dichotomae, Poria, and fructus Jujubae, and decocting to obtain decoction;
(5) concentration: concentrating the mixed solution to obtain an extract with the relative density of 1.25g/ml at the temperature of 60 ℃;
(6) adding auxiliary materials: adding auxiliary materials into the extract, wherein the adding amount of the auxiliary materials is 3-5% of the weight of the extract;
(7) drying and granulating: drying and granulating the extract to obtain the diarrhea treating granules.
6. The method for preparing granules for treating diarrhea according to claim 5, wherein the weight ratio of the raw materials to the pure water in the first decoction in the step (2) is 1: 30-35, wherein the boiling time is 125-135 min; the water consumption of the pure water for the second boiling is 90-100% of that of the pure water for the first boiling, and the second boiling time is 80-95 min; the water consumption of the pure water boiled for the third time is 70-90% of that of the pure water boiled for the first time, and the boiling time for the third time is 100-120 min; the water consumption of the pure water for the fourth boiling is 70-90% of that of the pure water for the first boiling, and the fourth boiling time is 30-40 min.
7. The method for preparing granules for treating diarrhea according to claim 5, wherein the weight ratio of the raw materials to the pure water in the first decoction in the step (3) is 1: 35-45, wherein the boiling time is 35-45 min; the water consumption of the pure water for the second boiling-the sixth boiling is 80-110% of that of the pure water for the first boiling, and the time for the second boiling-the sixth boiling is 60-75 min.
8. The method for preparing granules for treating diarrhea according to claim 5, wherein the auxiliary materials in the step (6) are composed of the following raw materials in parts by weight: 0.035-0.050 parts of stevioside, 10-16 parts of soluble starch, 5-8 parts of maltodextrin and 25-35 parts of ethanol.
9. The method for preparing granules for treating diarrhea according to claim 8, wherein the mass fraction of ethanol in the step (6) is 55-65%.
10. The method for preparing granules for treating diarrhea according to claim 8, wherein the soluble starch in the step (6) is soluble sweet potato starch or soluble potato starch.
CN202011343313.9A 2020-11-26 2020-11-26 Granule for treating diarrhea and preparation method thereof Pending CN112353927A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106729111A (en) * 2017-03-01 2017-05-31 李桂文 It is a kind of to treat particle of diarrhoea and preparation method thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106729111A (en) * 2017-03-01 2017-05-31 李桂文 It is a kind of to treat particle of diarrhoea and preparation method thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
柳书琴: "《杂粮野菜养生宝典》", 30 September 2016, 上海科学技术文献出版社 *
郑其国: "郑长松老中医治疗经行泄泻的经验", 《辽宁中医杂志》 *

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