CN112342204B - 一种达比加群中间体的酶催化合成方法及脂肪酶 - Google Patents
一种达比加群中间体的酶催化合成方法及脂肪酶 Download PDFInfo
- Publication number
- CN112342204B CN112342204B CN202011360171.7A CN202011360171A CN112342204B CN 112342204 B CN112342204 B CN 112342204B CN 202011360171 A CN202011360171 A CN 202011360171A CN 112342204 B CN112342204 B CN 112342204B
- Authority
- CN
- China
- Prior art keywords
- compound
- lipase
- dabigatran
- calb
- ala
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C12N9/20—Triglyceride splitting, e.g. by means of lipase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
- C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/01—Carboxylic ester hydrolases (3.1.1)
- C12Y301/01003—Triacylglycerol lipase (3.1.1.3)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Description
Claims (5)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202011360171.7A CN112342204B (zh) | 2020-11-27 | 2020-11-27 | 一种达比加群中间体的酶催化合成方法及脂肪酶 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202011360171.7A CN112342204B (zh) | 2020-11-27 | 2020-11-27 | 一种达比加群中间体的酶催化合成方法及脂肪酶 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN112342204A CN112342204A (zh) | 2021-02-09 |
CN112342204B true CN112342204B (zh) | 2022-05-31 |
Family
ID=74366056
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202011360171.7A Active CN112342204B (zh) | 2020-11-27 | 2020-11-27 | 一种达比加群中间体的酶催化合成方法及脂肪酶 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN112342204B (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN117070496B (zh) * | 2023-10-16 | 2023-12-19 | 深圳昇瑞生物科技有限公司 | 一种南极假丝酵母脂肪酶b突变体及其制备方法和应用 |
-
2020
- 2020-11-27 CN CN202011360171.7A patent/CN112342204B/zh active Active
Also Published As
Publication number | Publication date |
---|---|
CN112342204A (zh) | 2021-02-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN108823179B (zh) | 一种源自放线菌的转氨酶、突变体、重组菌及应用 | |
CN109593805B (zh) | 一种利用l-氨基酸连接酶一步法合成l-肌肽的方法 | |
CN106929521B (zh) | 一种醛酮还原酶基因重组共表达载体、工程菌及其应用 | |
CN109851658B (zh) | 一种一步法合成l-肌肽的方法及截短的l-肌肽合成酶 | |
CN112342204B (zh) | 一种达比加群中间体的酶催化合成方法及脂肪酶 | |
CN111269870A (zh) | 一种高产胞苷酸的重组大肠杆菌及其应用 | |
CN111394289B (zh) | 一种基因工程菌及其应用,生产前列腺素e2的方法 | |
CN109679978B (zh) | 一种用于制备l-2-氨基丁酸的重组共表达体系及其应用 | |
CN111172128A (zh) | 一种蔗糖磷酸化酶在制备2-O-α-D-葡萄糖基-L-抗坏血酸中的应用 | |
CN107988131B (zh) | 一种高产α-酮-γ-甲硫基丁酸的方法 | |
CN112645952B (zh) | 一种(r)-(+)-9-(2-羟丙基)腺嘌呤的合成方法 | |
CN114703158B (zh) | 一种蔗糖磷酸化酶突变体、编码基因及其应用 | |
CN110577940A (zh) | 马克斯克鲁维酵母醛酮还原酶KmAKR突变体及其应用 | |
CN110343728B (zh) | 一种生物转化合成六氢哒嗪-3-羧酸的方法 | |
CN111172213A (zh) | 一种用双酶串联制备l-2-氨基丁酸的方法 | |
CN114574454B (zh) | 一种短链脱氢酶及其突变体和应用 | |
CN113881727B (zh) | 一种阿托伐他汀酸的合成方法 | |
CN114940985B (zh) | 兼具脱氧腺苷二磷酸激酶和乙酸激酶活性的蛋白及应用 | |
CN111254181A (zh) | 一种化学酶法制备(s)-1,2,3,4-四氢异喹啉-3-甲酸的方法 | |
CN114381412B (zh) | 一种合成3-羟基丙酸的重组菌及其构建方法与应用 | |
CN113528475B (zh) | 一种羰基还原酶突变体及其在制备甾体激素--睾酮中的应用 | |
CN112481229B (zh) | 一种ω转氨酶及其突变体、重组质粒、基因工程菌及其应用 | |
CN114854717B (zh) | 一种脂肪酶及其编码基因与应用 | |
CN113789293B (zh) | 一种高产天然水蛭素的大肠杆菌工程菌株及其应用 | |
CN116536279B (zh) | 一种基因工程菌及在制备去氢表雄酮上的应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
CB02 | Change of applicant information | ||
CB02 | Change of applicant information |
Address after: 223800 No.5 Yanshan Road, eco Chemical Technology Industrial Park, Suqian City, Jiangsu Province Applicant after: Jiangsu alpha Pharmaceutical Co.,Ltd. Address before: 223800 No.5 Yanshan Road, eco Chemical Technology Industrial Park, Suqian City, Jiangsu Province Applicant before: JIANGSU ALPHA PHARMACEUTICAL Co.,Ltd. |
|
GR01 | Patent grant | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20221207 Address after: 223800 No. 58 Yangzi Road, Eco-chemical Science and Technology Industrial Park, Suyu District, Suqian City, Jiangsu Province Patentee after: Suqian Shengji Pharmaceutical Technology Co.,Ltd. Address before: 223800 No.5 Yanshan Road, eco Chemical Technology Industrial Park, Suqian City, Jiangsu Province Patentee before: Jiangsu alpha Pharmaceutical Co.,Ltd. |