CN112315892A - Sheep placenta anti-wrinkle whitening freeze-dried powder and method - Google Patents
Sheep placenta anti-wrinkle whitening freeze-dried powder and method Download PDFInfo
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- 210000002826 placenta Anatomy 0.000 title claims abstract description 70
- 241001494479 Pecora Species 0.000 title claims abstract description 64
- 239000000843 powder Substances 0.000 title claims abstract description 42
- 230000002087 whitening effect Effects 0.000 title claims abstract description 32
- 230000001153 anti-wrinkle effect Effects 0.000 title claims abstract description 27
- 238000000034 method Methods 0.000 title claims abstract description 9
- ZGSCRDSBTNQPMS-UJURSFKZSA-N 3-O-Ethylascorbic acid Chemical group CCOC1=C(O)C(=O)O[C@@H]1[C@@H](O)CO ZGSCRDSBTNQPMS-UJURSFKZSA-N 0.000 claims abstract description 25
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Natural products CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims abstract description 25
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 23
- 229930195725 Mannitol Natural products 0.000 claims abstract description 23
- 235000010355 mannitol Nutrition 0.000 claims abstract description 23
- 239000000594 mannitol Substances 0.000 claims abstract description 23
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims abstract description 19
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims abstract description 19
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims abstract description 19
- 239000000243 solution Substances 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 238000000108 ultra-filtration Methods 0.000 claims description 8
- 238000004108 freeze drying Methods 0.000 claims description 7
- 239000008176 lyophilized powder Substances 0.000 claims description 7
- 239000011259 mixed solution Substances 0.000 claims description 7
- 230000001815 facial effect Effects 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 238000011049 filling Methods 0.000 claims description 4
- 239000008213 purified water Substances 0.000 claims description 4
- 241000283898 Ovis Species 0.000 claims description 3
- 108091005804 Peptidases Proteins 0.000 claims description 3
- 239000004365 Protease Substances 0.000 claims description 3
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims description 3
- 239000011230 binding agent Substances 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- 239000000706 filtrate Substances 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 239000012530 fluid Substances 0.000 claims description 3
- 238000000227 grinding Methods 0.000 claims description 3
- 230000000415 inactivating effect Effects 0.000 claims description 3
- 239000002994 raw material Substances 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 13
- 230000037303 wrinkles Effects 0.000 abstract description 3
- 210000003491 skin Anatomy 0.000 description 28
- 102000004196 processed proteins & peptides Human genes 0.000 description 8
- 108090000765 processed proteins & peptides Proteins 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- 229920001184 polypeptide Polymers 0.000 description 7
- 102000008186 Collagen Human genes 0.000 description 4
- 108010035532 Collagen Proteins 0.000 description 4
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 229920001436 collagen Polymers 0.000 description 4
- 210000004927 skin cell Anatomy 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- 229930182555 Penicillin Natural products 0.000 description 2
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 2
- 102000003425 Tyrosinase Human genes 0.000 description 2
- 108060008724 Tyrosinase Proteins 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 230000003796 beauty Effects 0.000 description 2
- 238000005282 brightening Methods 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 229940049954 penicillin Drugs 0.000 description 2
- 230000008439 repair process Effects 0.000 description 2
- 230000037394 skin elasticity Effects 0.000 description 2
- 230000036548 skin texture Effects 0.000 description 2
- 230000037339 smooth wrinkles Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 201000010251 cutis laxa Diseases 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
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- 238000004904 shortening Methods 0.000 description 1
- 230000037384 skin absorption Effects 0.000 description 1
- 231100000274 skin absorption Toxicity 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
- A61K8/982—Reproductive organs; Embryos, Eggs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
- A61K8/022—Powders; Compacted Powders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Reproductive Health (AREA)
- Zoology (AREA)
- Emergency Medicine (AREA)
- Developmental Biology & Embryology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention belongs to the technical field of skin care products, and particularly relates to sheep placenta anti-wrinkle whitening freeze-dried powder and a method. The anti-wrinkle whitening freeze-dried powder of the sheep placenta extract comprises the following components in parts by weight: sheep placenta extract: 89-94 parts; mannitol: 3-5 parts; trehalose: 1-2 parts; vitamin C ethyl ether: 2-4 parts. The sheep placenta anti-wrinkle whitening freeze-dried powder has a good effect of improving skin looseness and wrinkles.
Description
Technical Field
The invention relates to the technical field of skin care products, and in particular relates to sheep placenta anti-wrinkle whitening freeze-dried powder and a method.
Background
The description of the background of the invention pertaining to the related art to which this invention pertains is given for the purpose of illustration and understanding only of the summary of the invention and is not to be construed as an admission that the applicant is explicitly or implicitly admitted to be prior art to the date of filing this application as first filed with this invention.
With the improvement of living standard and aesthetic standard of people, white and clean skin is more and more advocated by most women, and the demand of whitening products is continuously increased. People want to obtain white and smooth skin by using whitening care products.
The freeze-dried powder is a common skin care and beauty product, and is prepared by freezing a material solution to be dried into a solid in advance, and then directly subliming to remove water from the frozen state without passing through a liquid state under the conditions of low temperature and low pressure. The lyophilized powder well ensures the high activity of the original cosmetic components, achieves ultrahigh stability, is mixed with lysozyme, is quickly recovered and is convenient to use. High activity, ensures the nutrient components of the product, can be better absorbed by cells, thereby shortening and improving the skin cycle.
However, the existing whitening freeze-dried powder has not ideal effect on improving skin looseness and wrinkles.
Disclosure of Invention
The invention aims to provide sheep placenta anti-wrinkle whitening freeze-dried powder and a method thereof.
The purpose of the embodiment of the invention is realized by the following technical scheme:
in a first aspect, the invention provides anti-wrinkle whitening freeze-dried powder of sheep placenta, which comprises the following components in parts by weight:
sheep placenta extract: 89-94 parts; mannitol: 3-5 parts; trehalose: 1-2 parts; vitamin C ethyl ether: 2-4 parts.
Further, the coating comprises the following components in parts by weight:
sheep placenta extract: 94 parts of a binder; mannitol: 3 parts of a mixture; trehalose: 1 part; vitamin C ethyl ether: and 2 parts.
Further, the coating comprises the following components in parts by weight:
sheep placenta extract: 93 parts; mannitol: 4 parts of a mixture; trehalose: 1 part; vitamin C ethyl ether: and 2 parts.
Further, the coating comprises the following components in parts by weight:
sheep placenta extract: 92 parts of (1); mannitol: 5 parts of a mixture; trehalose: 1 part; vitamin C ethyl ether: and 2 parts.
In a second aspect, the invention provides a preparation method of the anti-wrinkle whitening lyophilized powder of sheep placenta, which comprises the following steps:
a. taking sheep placenta as a raw material, and grinding and crushing the sheep placenta to obtain sheep placenta powder;
b. adding water with the same mass as the sheep placenta powder into the sheep placenta powder, and uniformly stirring; inactivating at 120 deg.C to obtain placenta caprae seu ovis fluid;
c. and cooling the sheep placenta solution to 45 ℃, and adding protease for enzymolysis to obtain an enzymolysis solution.
d. Centrifuging and primarily filtering the enzymolysis solution, and performing ultrafiltration on the filtrate by using an ultrafiltration machine; collecting ultrafiltrate with molecular weight below 1500;
e. adding mannitol, trehalose and vitamin C ethyl ether into the ultrafiltrate, and uniformly stirring and dissolving to obtain a mixed solution;
f. and filling the mixed solution, and freeze-drying to obtain the sheep placenta anti-wrinkle whitening freeze-dried powder.
In a third aspect, the invention provides a using method of anti-wrinkle and whitening freeze-dried powder of sheep placenta, which is prepared by the preparation method, wherein the anti-wrinkle and whitening freeze-dried powder of sheep placenta and a solvent are mixed according to a mass ratio of 1: 10 dissolving the components, namely purified water or skin care water, uniformly applying a proper amount of the solution on the facial skin, and massaging the facial skin until the solution is completely absorbed.
The embodiment of the invention has the following beneficial effects:
the micromolecule polypeptide in the sheep placenta is obtained by adopting an ultrafiltration technology, and the activity of various nutrient substances in the sheep placenta can be retained to the maximum extent by utilizing a freeze-drying technology. The sheep placenta essence is rich in various polypeptides, can supplement skin cell nutrition, improve skin vitality, tighten skin, improve skin elasticity, comprehensively improve skin quality from outside to inside, smooth wrinkles, resist aging for a long time and improve skin quality; the vitamin C ethyl ether can inhibit the activity of tyrosinase and inhibit the formation of melanin, thereby whitening and brightening the skin, and simultaneously can participate in the synthesis of collagen to repair the activity of skin cells, so that the collagen is increased, thereby enabling the skin to become full and elastic and enabling the skin to be fine and smooth.
Detailed Description
The present application is further described below with reference to examples.
In the following description, different "one embodiment" or "an embodiment" may not necessarily refer to the same embodiment, in order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art. Various embodiments may be replaced or combined, and other embodiments may be obtained according to the embodiments without creative efforts for those skilled in the art.
The anti-wrinkle whitening freeze-dried sheep placenta powder comprises the following components in parts by weight:
sheep placenta extract: 89-94 parts; mannitol: 3-5 parts; trehalose: 1-2 parts; vitamin C ethyl ether: 2-4 parts.
In some embodiments of the present invention, the composition comprises the following components in parts by weight:
sheep placenta extract: 94 parts of a binder; mannitol: 3 parts of a mixture; trehalose: 1 part; vitamin C ethyl ether: and 2 parts.
In some embodiments of the present invention, the composition comprises the following components in parts by weight:
sheep placenta extract: 93 parts; mannitol: 4 parts of a mixture; trehalose: 1 part; vitamin C ethyl ether: and 2 parts.
In some embodiments of the present invention, the composition comprises the following components in parts by weight:
sheep placenta extract: 92 parts of (1); mannitol: 5 parts of a mixture; trehalose: 1 part; vitamin C ethyl ether: and 2 parts.
The preparation method of the anti-wrinkle whitening lyophilized powder of sheep placenta comprises the following steps:
a. taking sheep placenta as a raw material, and grinding and crushing the sheep placenta to obtain sheep placenta powder;
b. adding water with the same mass as the sheep placenta powder into the sheep placenta powder, and uniformly stirring; inactivating at 120 deg.C to obtain placenta caprae seu ovis fluid;
c. and cooling the sheep placenta solution to 45 ℃, and adding protease for enzymolysis to obtain an enzymolysis solution.
d. Centrifuging and primarily filtering the enzymolysis solution, and performing ultrafiltration on the filtrate by using an ultrafiltration machine; collecting ultrafiltrate with molecular weight below 1500;
e. adding mannitol, trehalose and vitamin C ethyl ether into the ultrafiltrate, and uniformly stirring and dissolving to obtain a mixed solution;
f. and filling the mixed solution, and freeze-drying to obtain the sheep placenta anti-wrinkle whitening freeze-dried powder.
Subpackaging the mixed solution into penicillin bottles by using a filling machine, and putting the penicillin bottles into a freeze dryer; and setting the pressure and the freeze-drying curve of the freeze dryer, starting the freeze dryer to carry out freeze-drying operation, and obtaining freeze-dried powder according to the program.
The application method of the anti-wrinkle and whitening freeze-dried powder of the sheep placenta is characterized in that the anti-wrinkle and whitening freeze-dried powder of the sheep placenta is prepared by the preparation method, and the anti-wrinkle and whitening freeze-dried powder of the sheep placenta and a solvent are mixed according to the mass ratio of 1: 10 dissolving the components, namely purified water or skin care water, uniformly applying a proper amount of the solution on the facial skin, and massaging the facial skin until the solution is completely absorbed.
The polypeptide in the sheep placenta is of biological origin, has complex polypeptide components, is not modified, and has weaker directionality and effect compared with synthetic polypeptides used by other products in the market. The method adopts ultrafiltration technology to obtain the small molecular polypeptide in the sheep placenta, and adopts freeze-drying technology to furthest retain the activity of various nutrient substances in the sheep placenta. The sheep placenta essence is rich in various polypeptides, can supplement skin cell nutrition, improve skin vitality, tighten skin, improve skin elasticity, comprehensively improve skin quality from outside to inside, smooth wrinkles, resist aging for a long time and improve skin quality; the vitamin C ethyl ether can inhibit the activity of tyrosinase and inhibit the formation of melanin, thereby whitening and brightening the skin, and simultaneously can participate in the synthesis of collagen to repair the activity of skin cells, so that the collagen is increased, thereby enabling the skin to become full and elastic and enabling the skin to be fine and smooth.
Compared with mannitol, trehalose and vitamin C ethyl ether with different concentrations in the freeze-dried powder, the influence on the appearance and redissolution property of the freeze-dried powder is avoided. The examples were designed according to the weight ratios shown in table 1:
TABLE 1
The total content of mannitol, trehalose and vitamin C ethyl ether is not higher than 8%, and when the content of vitamin C ethyl ether is not higher than mannitol, the redissolution and the appearance forming are good.
The crystal form particles of the freeze-dried powder obtained after the vitamin C ethyl ether is freeze-dried are large, the appearance of the freeze-dried powder is rough, the crystal form particles of the freeze-dried powder obtained after the mannitol is freeze-dried are fine, and the appearance of the freeze-dried powder is smooth and flat, so when the vitamin C ethyl ether and the mannitol are mixed for use, the content of the vitamin C ethyl ether in the formula cannot be higher than the content of the mannitol in order to ensure that the appearance formability of the mixture freeze-dried powder is better.
The product reconstitution and appearance evaluations for examples 1-18 are shown in Table 2:
TABLE 2
Several representative example products were selected for testing: the sheep placenta extract with different concentrations has the effects: the examples were performed using purified water 10: 1, after dissolving, the solution is smeared on the canthus skin of a recipient, and is continuously used for 28 days, and a multifunctional skin analyzer of a beauty shop is adopted to analyze the skin texture. The analysis results are shown in Table 3
Skin texture change: it can be seen that the lyophilized powder has various degrees of improvement in skin laxity and wrinkles.
Among the components, mannitol directly determines the appearance of the freeze-dried powder, and the moisture-preserving effect of trehalose can promote skin absorption of small molecular peptides in vitamin C ethyl ether and sheep placenta extract.
It should be noted that the above embodiments can be freely combined as necessary. The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (6)
1. The anti-wrinkle whitening freeze-dried powder of sheep placenta is characterized by comprising the following components in parts by weight:
sheep placenta extract: 89-94 parts; mannitol: 3-5 parts; trehalose: 1-2 parts; vitamin C ethyl ether: 2-4 parts.
2. The anti-wrinkle whitening lyophilized powder of ovine placenta according to claim 1, which comprises the following components in parts by weight:
sheep placenta extract: 94 parts of a binder; mannitol: 3 parts of a mixture; trehalose: 1 part; vitamin C ethyl ether: and 2 parts.
3. The anti-wrinkle whitening lyophilized powder of ovine placenta according to claim 1, which comprises the following components in parts by weight:
sheep placenta extract: 93 parts; mannitol: 4 parts of a mixture; trehalose: 1 part; vitamin C ethyl ether: and 2 parts.
4. The anti-wrinkle whitening lyophilized powder of ovine placenta according to claim 1, which comprises the following components in parts by weight:
sheep placenta extract: 92 parts of (1); mannitol: 5 parts of a mixture; trehalose: 1 part; vitamin C ethyl ether: and 2 parts.
5. A preparation method of the sheep placenta anti-wrinkle whitening freeze-dried powder as claimed in any one of claims 1 to 3, characterized by comprising the following steps:
a. taking sheep placenta as a raw material, and grinding and crushing the sheep placenta to obtain sheep placenta powder;
b. adding water with the same mass as the sheep placenta powder into the sheep placenta powder, and uniformly stirring; inactivating at 120 deg.C to obtain placenta caprae seu ovis fluid;
c. cooling the sheep placenta solution to 45 ℃, and adding protease for enzymolysis to obtain an enzymolysis solution;
d. centrifuging and primarily filtering the enzymolysis solution, and performing ultrafiltration on the filtrate by using an ultrafiltration machine; collecting ultrafiltrate with molecular weight below 1500;
e. adding mannitol, trehalose and vitamin C ethyl ether into the ultrafiltrate, and uniformly stirring and dissolving to obtain a mixed solution;
f. and filling the mixed solution, and freeze-drying to obtain the sheep placenta anti-wrinkle whitening freeze-dried powder.
6. The application method of the lyophilized sheep placenta anti-wrinkle whitening powder is characterized in that the lyophilized sheep placenta anti-wrinkle whitening powder is prepared by the preparation method of claim 5, and the lyophilized sheep placenta anti-wrinkle whitening powder and a solvent are mixed according to a mass ratio of 1: 10 dissolving the components, namely purified water or skin care water, uniformly applying a proper amount of the solution on the facial skin, and massaging the facial skin until the solution is completely absorbed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011432746.1A CN112315892A (en) | 2020-12-10 | 2020-12-10 | Sheep placenta anti-wrinkle whitening freeze-dried powder and method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011432746.1A CN112315892A (en) | 2020-12-10 | 2020-12-10 | Sheep placenta anti-wrinkle whitening freeze-dried powder and method |
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| CN112315892A true CN112315892A (en) | 2021-02-05 |
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| CN202011432746.1A Pending CN112315892A (en) | 2020-12-10 | 2020-12-10 | Sheep placenta anti-wrinkle whitening freeze-dried powder and method |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1896268A (en) * | 2006-06-27 | 2007-01-17 | 扬州大学 | Extraction of activated micromolecular sheept germine from sheep embryo and its use |
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