CN108685751A - A kind of the plant polypeptide skin protection cosmetics and preparation method of controlled absorbed - Google Patents
A kind of the plant polypeptide skin protection cosmetics and preparation method of controlled absorbed Download PDFInfo
- Publication number
- CN108685751A CN108685751A CN201810933715.0A CN201810933715A CN108685751A CN 108685751 A CN108685751 A CN 108685751A CN 201810933715 A CN201810933715 A CN 201810933715A CN 108685751 A CN108685751 A CN 108685751A
- Authority
- CN
- China
- Prior art keywords
- plant
- polypeptide
- skin protection
- plant polypeptide
- protection cosmetics
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
The present invention proposes a kind of the plant polypeptide skin protection cosmetics and preparation method of controlled absorbed, the skin protection cosmetics is after digesting plant polypeptide coarse fodder using alkali protease, it is filtered by animal cuticle, sterilizing obtains plant polypeptide, is then mixed with mannitol, vitamin, glycerine, Sodium Hyaluronate, myristyl alcohol, myristinate, C- leukotrienes, plant flavonoids and is uniformly dispersed and is made.Plant polypeptide skin protection cosmetics provided by the invention, sub-prime is uniform and small, and pass through C- leukotrienes of the addition with good percutaneous permeability, the absorption of plant polypeptide is effectively facilitated, the vegetable flavonoid of addition can be with aid in skin anti-aging, whitening, radioresistance, gained cosmetics have apparent antioxidant activity, can effectively facilitate growth and the proliferation of human skin fibroblasts, have apparent resisting age of skin effect.
Description
Technical field
The present invention relates to skin protection cosmetics technical fields, more particularly to a kind of plant polypeptide cosmetic skin-care of controlled absorbed
Product and preparation method.
Background technology
As people are to beautiful pursuit and the improvement of people's living standards, cosmetics are for many people, and especially one
A little daily skin care, hairdressing, cleaning supplies etc. have become the necessity of many Mies, there is an a large amount of people especially women, and one
The four seasons in year are all using different types of cosmetics.For the mankind skin the problem of carry out protection be the most basic category of cosmetics
Property.
Peptide is a kind of bioactive substance for being related to various kinds of cell function in organism, participates in the regulation and control various complexity of human body
Physiology course.The features such as peptide is active high, compatibility is strong, safe, and peptide molecule is Nano grade again, it is easy to
By the stomach of human body, oral mucosal absorption.Automatic nervous system is adjusted since polypeptide has, activating cell immunity function, is improved
The physiological activity such as cardiovascular function and anti-aging, this provides theoretical foundation for exploitation peptide cosmetics.
Research shows that free radical can cause Protein Damage, lipid peroxidation, nucleic acid damaging etc., and then induce various diseases
Disease.And antioxidation polypeptide has the effects that remove free radical, prevents lipid peroxidation, can be used in cosmetics playing anti-aging
Effect.Modern pharmacology research show some active peptides not only have antioxidant activity, can also effectively facilitate application on human skin at
The growth of fibrocyte and proliferation especially can effectively facilitate cellular matrix by the activity of increase skin fibroblasts
Significant resisting age of skin effect is played in the especially synthesis of the matrix such as collagen.Therefore, biologically active peptide is used for anti-skin
Skin aging cosmetics cause the highest attention of cosmetic field.
Chinese invention patent application number 201610402400.4 discloses a kind of containing plant cell active matter and polypeptide
The active component of anti-aging cosmetics composition, the anti-aging cosmetics composition includes Desert Rose cell activity object, palm
Acyl tripeptides -5 and dipeptides diaminobutyryl benzyl amide diacetin, the active component of the cosmetic composition includes Desert Rose
Cell activity object, small-molecule peptide active additive, it is old to reach delaying skin using various composition reasonable combination, collective effect
The effect of change.Chinese invention patent application number 201410235938.1 discloses a kind of compound plant extraction rich in plant polypeptide
Compositions and its in cosmetic applications, the plant polypeptide of the high-content is respectively plant polypeptide growth factor and dehydration
Element compounds with high mountain rose Folium Rhododendri Simsii extract, Chinese Hibiscu flower extract, Chinese herbaceous peony flower extract, peony extract, can promote face
Portion's skin blood cycle, activates the epidermal cell of aging, and full face skin repairs microgroove, while can also alleviate skin and lack
Water improves red swelling of the skin symptom, bright color, moistening skin beautifying;The compound plant extract composition includes the plant of 0.1-5%
Object growth factor, the Dehydrins of 0.1-5%, high mountain rose Folium Rhododendri Simsii extract, the 0.1-5% Chinese herbaceous peony flower extracts of 0.1-3%
With 0.1-5% peony extracts.
In order to improve infiltration of the skin surface to polypeptide, promoting polypeptide epidermal absorption and control the rational size of polypeptide, have
Necessity proposes a kind of novel polypeptide cosmetics, and then improves the using effect of polypeptide cosmetic.
Invention content
For current active peptides, the low defect of absorbability, the present invention propose a kind of controlled absorbed in skin protection cosmetics
Plant polypeptide skin protection cosmetics and preparation method, to improve plant polypeptide for cosmetics assimilation effect, gained
Cosmetic has apparent resisting age of skin effect.
To solve the above problems, the present invention uses following technical scheme:
A kind of plant polypeptide skin protection cosmetics of controlled absorbed, the skin protection cosmetics are that plant polypeptide coarse fodder is utilized alkaline egg
After white enzyme enzymolysis, filtered by animal cuticle, sterilizing obtains plant polypeptide, then with mannitol, vitamin, glycerine, hyalomitome
Sour sodium, myristyl alcohol, myristinate, C- leukotrienes, plant flavonoids mixing are uniformly dispersed and are made.
Preferably, the plant polypeptide coarse fodder be corn, rice, muskmelon, soybean, wild jujube, matrimony vine, one kind in muskmelon or
The polypeptide coarse fodder that combination extraction more than the two obtains.
Preferably, the alkali protease is one kind in Novo protease, Carsberg protease.
Preferably, the animal cuticle is little white rabbit epidermis, the sheep epidermis obtained by high-temperature sterilization, freeze-drying
One kind, thickness are 50-100 μm.
Preferably, the vitamin is vitamin C.
Preferably, the plant flavonoids are celery aglycon, scutellaria flavine, hesperetin, Quercetin, myricetin, catechu
The combination of one or more of element, genistein, daidzein, anthocyanidin.
The present invention also provides the plant polypeptide skin protection cosmetics and preparation method of a kind of controlled absorbed, specific preparation methods
It is as follows:
(1)Plant polypeptide coarse fodder is dissolved in deionized water, is subsequently added into enzymolysis reactor, alkali protease is added and is heated
It is digested, obtains enzymolysis liquid;
(2)Enzymolysis liquid is filtered by the animal cuticle for the thin layer processing that sterilizes, the molecular weight of polypeptide is controlled in 600-
800, it obtains molecular size range uniformly and is suitble to the polypeptide through animal cuticle;
(3)Polypeptide is heated to 100 DEG C of progress enzyme deactivations, is then centrifuged for, takes supernatant, it is more to obtain the uniform plant of molecular size range
Peptide;
(4)By the uniform plant polypeptide of molecular size range and mannitol, vitamin, glycerine, Sodium Hyaluronate, myristyl alcohol, meat
Myristic acid fat, C- leukotrienes, plant flavonoids mixing, are uniformly dispersed to get the plant polypeptide skin protection cosmetics of controlled absorbed.
Preferably, step(1)Described in heat enzymolysis temperature be 30-50 DEG C, digest 4-6h.
Preferably, step(1)Described in enzymolysis liquid, deionized water, plant polypeptide coarse fodder, alkali protease mass ratio
Example is 100:30-50:2-4.
Preferably, step(4)Described in skin protection cosmetics, plant polypeptide, mannitol, vitamin, glycerine, hyaluronic acid
Sodium, myristyl alcohol, myristic acid fat, C- leukotrienes, plant flavonoids mass ratio be 100:6-10:2-4:12-18:3-6:
8-12:5-8:4-7:6-10。
Existing active peptides absorbability in skin protection cosmetics is low, and cosmetic effect is bad, limits its application.Mirror
In this, the present invention proposes that a kind of preparation method of the plant polypeptide skin protection cosmetics of controlled absorbed, plant polypeptide coarse fodder are dissolved in
It in ionized water, is added in enzymolysis reactor, alkali protease is added under certain condition and is digested, then utilize sterilizing thin layer
Change the animal cuticle of processing as filtering membrane filtration enzymolysis liquid, obtains molecular size range uniformly and be suitble to the polypeptide through epidermis;
100 DEG C of enzyme deactivations are heated to, centrifuges, takes supernatant to get the uniform plant polypeptide of molecular size range;Then by molecular size range
Uniform plant polypeptide and mannitol, vitamin, glycerine, Sodium Hyaluronate, myristyl alcohol, myristic acid fat, C- leukotrienes,
Plant flavonoids are uniformly dispersed, and obtain a kind of plant polypeptide skin protection cosmetics of controlled absorbed.Plant polypeptide provided by the invention
Skin protection cosmetics, sub-prime is uniform and small, and by C- leukotrienes of the addition with good percutaneous permeability, effectively facilitates
The vegetable flavonoid of the absorption of plant polypeptide, addition can be with aid in skin anti-aging, whitening, radioresistance, gained
Cosmetic has apparent antioxidant activity, can effectively facilitate growth and the proliferation of human skin fibroblasts, has apparent anti-
Skin aging acts on.
The present invention proposes a kind of the plant polypeptide skin protection cosmetics and preparation method of controlled absorbed, compared with prior art,
Its feature protruded and excellent effect are:
1, the present invention remains the good micropore of epidermis by being freeze-dried animal cuticle as filter membrane, to which filtering obtains
It obtains molecular weight uniform and small plant polypeptide, improves assimilation effect of the plant polypeptide for cosmetics.
2, C- leukotrienes is added in the present invention, and there is good percutaneous permeability, can further promote the suction of plant polypeptide
It receives.
3, the vegetable flavonoid that adds of the present invention, have remove free radical in skin, promote skin metabolism,
The effects that reducing pigmentation and moist skin, further aid in skin anti-aging, whitening, radioresistance.
4, the plant polypeptide skin protection cosmetics of controlled absorbed prepared by the present invention has apparent antioxidant activity, can have
Effect promotes growth and the proliferation of human skin fibroblasts, has apparent resisting age of skin effect.
Specific implementation mode
In the following, the present invention will be further described in detail by way of specific embodiments, but this should not be interpreted as to the present invention
Range be only limitted to example below.Without departing from the idea of the above method of the present invention, according to ordinary skill
The various replacements or change that knowledge and customary means are made, should be included in the scope of the present invention.
Embodiment 1
(1)Plant polypeptide coarse fodder is dissolved in deionized water, is subsequently added into enzymolysis reactor, alkali protease is added and is heated
It is digested, obtains enzymolysis liquid;Plant polypeptide coarse fodder is the polypeptide coarse fodder that corn extracts;Alkali protease is Novo albumen
Enzyme;The temperature of heating enzymolysis is 43 DEG C, digests 5h;In enzymolysis liquid, deionized water, the matter of plant polypeptide coarse fodder, alkali protease
Amount ratio is 100:38:3;
(2)Enzymolysis liquid is filtered by the animal cuticle for the thin layer processing that sterilizes, the molecular weight of polypeptide is controlled in 600-
800, it obtains molecular size range uniformly and is suitble to the polypeptide through animal cuticle;Animal cuticle is dry by high-temperature sterilization, freezing
Dry obtained little white rabbit epidermis, average thickness are 70 μm;
(3)Polypeptide is heated to 100 DEG C of progress enzyme deactivations, is then centrifuged for, takes supernatant, it is more to obtain the uniform plant of molecular size range
Peptide;
(4)By the uniform plant polypeptide of molecular size range and mannitol, vitamin, glycerine, Sodium Hyaluronate, myristyl alcohol, meat
Myristic acid fat, C- leukotrienes, plant flavonoids mixing, are uniformly dispersed to get the plant polypeptide skin protection cosmetics of controlled absorbed;
Vitamin is vitamin C;Plant flavonoids are celery aglycon;It is plant polypeptide, mannitol, vitamin, sweet in skin protection cosmetics
Oil, Sodium Hyaluronate, myristyl alcohol, myristic acid fat, C- leukotrienes, plant flavonoids mass ratio be 100:7:3:15:
3-6:11:7:5:9。
Test method:
The polypeptide skin protection cosmetics progress transdermal test in vitro permeance property test that the present embodiment is prepared, 25 DEG C of test temperature,
Relative humidity is 55%, is tested using HPIRI diffusion cells, and each half pond volume is 5mL, effective expanding area
0.64m2, magnetic agitation, rotating speed 500rpm is installed on diffusion cell after taking male rat skin of abdomen to handle, by present invention system
Makeup application in epidermis side, using polypeptide detector test 2h, 6h, 12h and for 24 hours when accumulative skin permeation amount, obtain
To the results are shown in Table 1.
Comparative example 1
Comparative example 1 compared with Example 1, is not filtered using animal cuticle, and polypeptide skin protection cosmetics obtained is using implementation
The method of example 1 is tested, and test result is as shown in table 1.
Embodiment 2
(1)Plant polypeptide coarse fodder is dissolved in deionized water, is subsequently added into enzymolysis reactor, alkali protease is added and is heated
It is digested, obtains enzymolysis liquid;Plant polypeptide coarse fodder is the polypeptide coarse fodder that rice extracts;Alkali protease is Carsberg
Protease;The temperature of heating enzymolysis is 30 DEG C, digests 6h;In enzymolysis liquid, deionized water, plant polypeptide coarse fodder, alkali protease
Mass ratio be 100:30:2;
(2)Enzymolysis liquid is filtered by the animal cuticle for the thin layer processing that sterilizes, the molecular weight of polypeptide is controlled in 600-
800, it obtains molecular size range uniformly and is suitble to the polypeptide through animal cuticle;Animal cuticle is dry by high-temperature sterilization, freezing
Dry obtained sheep epidermis, average thickness are 50 μm;
(3)Polypeptide is heated to 100 DEG C of progress enzyme deactivations, is then centrifuged for, takes supernatant, it is more to obtain the uniform plant of molecular size range
Peptide;
(4)By the uniform plant polypeptide of molecular size range and mannitol, vitamin, glycerine, Sodium Hyaluronate, myristyl alcohol, meat
Myristic acid fat, C- leukotrienes, plant flavonoids mixing, are uniformly dispersed to get the plant polypeptide skin protection cosmetics of controlled absorbed;
Vitamin is vitamin C;Plant flavonoids are scutellaria flavine;It is plant polypeptide, mannitol, vitamin, sweet in skin protection cosmetics
Oil, Sodium Hyaluronate, myristyl alcohol, myristic acid fat, C- leukotrienes, plant flavonoids mass ratio be 100:6:2:12:
3:8:5:4:6。
It is tested using the method for embodiment 1, test result is as shown in table 1.
Comparative example 2
Comparative example 2 compared with Example 2, is not added with C- leukotrienes, the method that polypeptide skin protection cosmetics obtained uses embodiment 1
It is tested, test result is as shown in table 1.
Embodiment 3
(1)Plant polypeptide coarse fodder is dissolved in deionized water, is subsequently added into enzymolysis reactor, alkali protease is added and is heated
It is digested, obtains enzymolysis liquid;The polypeptide coarse fodder that plant polypeptide coarse fodder is muskmelon, soybean is extracted;Alkali protease is
Novo protease;The temperature of heating enzymolysis is 50 DEG C, digests 4h;In enzymolysis liquid, deionized water, plant polypeptide coarse fodder, alkaline egg
The mass ratio of white enzyme is 100: 50: 4;
(2)Enzymolysis liquid is filtered by the animal cuticle for the thin layer processing that sterilizes, the molecular weight of polypeptide is controlled in 600-
800, it obtains molecular size range uniformly and is suitble to the polypeptide through animal cuticle;Animal cuticle is dry by high-temperature sterilization, freezing
Dry obtained sheep epidermis, average thickness are 100 μm;
(3)Polypeptide is heated to 100 DEG C of progress enzyme deactivations, is then centrifuged for, takes supernatant, it is more to obtain the uniform plant of molecular size range
Peptide;
(4)By the uniform plant polypeptide of molecular size range and mannitol, vitamin, glycerine, Sodium Hyaluronate, myristyl alcohol, meat
Myristic acid fat, C- leukotrienes, plant flavonoids mixing, are uniformly dispersed to get the plant polypeptide skin protection cosmetics of controlled absorbed;
Vitamin is vitamin C, vitamin E;Plant flavonoids are Quercetin;In skin protection cosmetics, plant polypeptide, mannitol, dimension life
Element, glycerine, Sodium Hyaluronate, myristyl alcohol, myristic acid fat, C- leukotrienes, plant flavonoids mass ratio be 100:
10: 4: 18: 6: 2: 8: 7: 10。
It is tested using the method for embodiment 1, test result is as shown in table 1.
Comparative example 3
Comparative example 3 compared with Example 3, is not added with vegetable flavonoid, polypeptide skin protection cosmetics obtained is using implementation
The method of example 1 is tested, and test result is as shown in table 1.
Embodiment 4
(1)Plant polypeptide coarse fodder is dissolved in deionized water, is subsequently added into enzymolysis reactor, alkali protease is added and is heated
It is digested, obtains enzymolysis liquid;The polypeptide coarse fodder that plant polypeptide coarse fodder is matrimony vine, muskmelon extracts;Alkali protease is
Carsberg protease;The temperature of heating enzymolysis is 40 DEG C, digests 5h;In enzymolysis liquid, deionized water, plant polypeptide coarse fodder, alkali
Property protease mass ratio be 100:40:3;
(2)Enzymolysis liquid is filtered by the animal cuticle for the thin layer processing that sterilizes, the molecular weight of polypeptide is controlled in 600-
800, it obtains molecular size range uniformly and is suitble to the polypeptide through animal cuticle;Animal cuticle is dry by high-temperature sterilization, freezing
Dry obtained sheep epidermis, average thickness are 80 μm;
(3)Polypeptide is heated to 100 DEG C of progress enzyme deactivations, is then centrifuged for, takes supernatant, it is more to obtain the uniform plant of molecular size range
Peptide;
(4)By the uniform plant polypeptide of molecular size range and mannitol, vitamin, glycerine, Sodium Hyaluronate, myristyl alcohol, meat
Myristic acid fat, C- leukotrienes, plant flavonoids mixing, are uniformly dispersed to get the plant polypeptide skin protection cosmetics of controlled absorbed;
Vitamin is vitamin C, biotin, citrin;Plant flavonoids Quercetin;In skin protection cosmetics, plant polypeptide, sweet dew
Alcohol, vitamin, glycerine, Sodium Hyaluronate, myristyl alcohol, myristic acid fat, C- leukotrienes, plant flavonoids mass ratio be
100:9:315:4:10:6:6:8。
It is tested using the method for embodiment 1, test result is as shown in table 1.
Comparative example 4
Comparative example 4 compared with Example 4, is not digested, and polypeptide skin protection cosmetics obtained is carried out using the method for embodiment 1
Test, test result are as shown in table 1.
Table 1:
Claims (10)
1. a kind of plant polypeptide skin protection cosmetics of controlled absorbed, which is characterized in that the skin protection cosmetics is by plant polypeptide
It after coarse fodder is using alkali protease enzymolysis, is filtered by animal cuticle, sterilizing obtains plant polypeptide, is then given birth to mannitol, dimension
Element, glycerine, Sodium Hyaluronate, myristyl alcohol, myristinate, C- leukotrienes, plant flavonoids mixing are uniformly dispersed and are made.
2. a kind of plant polypeptide skin protection cosmetics of controlled absorbed according to claim 1, which is characterized in that the plant
Polypeptide coarse fodder is that the combination of one or both of corn, rice, muskmelon, soybean, wild jujube, matrimony vine, muskmelon or more extracts to obtain
Polypeptide coarse fodder.
3. a kind of plant polypeptide skin protection cosmetics of controlled absorbed according to claim 1, which is characterized in that the alkalinity
Protease is one kind in Novo protease, Carsberg protease.
4. a kind of plant polypeptide skin protection cosmetics of controlled absorbed according to claim 1, which is characterized in that the animal
Epidermis is by one kind of high-temperature sterilization, the little white rabbit epidermis that freeze-drying obtains, sheep epidermis, and thickness is 50-100 μm.
5. a kind of plant polypeptide skin protection cosmetics of controlled absorbed according to claim 1, which is characterized in that the dimension life
Element is vitamin C.
6. a kind of plant polypeptide skin protection cosmetics of controlled absorbed according to claim 1, which is characterized in that the plant
Flavonoids is celery aglycon, scutellaria flavine, hesperetin, Quercetin, myricetin, catechin, genistein, daidzein, cyanine
The combination of one or more of element.
7. a kind of preparation method of the plant polypeptide skin protection cosmetics of controlled absorbed as described in any claims of claim 1-6,
It is characterized in that, specific preparation method is as follows:
(1)Plant polypeptide coarse fodder is dissolved in deionized water, is subsequently added into enzymolysis reactor, alkali protease is added and is heated
It is digested, obtains enzymolysis liquid;
(2)Enzymolysis liquid is filtered by the animal cuticle for the thin layer processing that sterilizes, the molecular weight of polypeptide is controlled in 600-
800, it obtains molecular size range uniformly and is suitble to the polypeptide through animal cuticle;
(3)Polypeptide is heated to 100 DEG C of progress enzyme deactivations, is then centrifuged for, takes supernatant, it is more to obtain the uniform plant of molecular size range
Peptide;
(4)By the uniform plant polypeptide of molecular size range and mannitol, vitamin, glycerine, Sodium Hyaluronate, myristyl alcohol, meat
Myristic acid fat, C- leukotrienes, plant flavonoids mixing, are uniformly dispersed to get the plant polypeptide skin protection cosmetics of controlled absorbed.
8. a kind of preparation method of the plant polypeptide skin protection cosmetics of controlled absorbed according to claim 7, feature exist
In step(1)Described in heat enzymolysis temperature be 30-50 DEG C, digest 4-6h.
9. a kind of preparation method of the plant polypeptide skin protection cosmetics of controlled absorbed according to claim 7, feature exist
In step(1)Described in enzymolysis liquid, deionized water, plant polypeptide coarse fodder, alkali protease mass ratio be 100:30-
50:2-4。
10. a kind of preparation method of the plant polypeptide skin protection cosmetics of controlled absorbed according to claim 7, feature exist
In step(4)Described in skin protection cosmetics, plant polypeptide, mannitol, vitamin, glycerine, Sodium Hyaluronate, myristyl alcohol,
Myristic acid fat, C- leukotrienes, plant flavonoids mass ratio be 100:6-10:2-4:12-18:3-6:8-12:5-8:4-
7:6-10。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810933715.0A CN108685751A (en) | 2018-08-16 | 2018-08-16 | A kind of the plant polypeptide skin protection cosmetics and preparation method of controlled absorbed |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810933715.0A CN108685751A (en) | 2018-08-16 | 2018-08-16 | A kind of the plant polypeptide skin protection cosmetics and preparation method of controlled absorbed |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108685751A true CN108685751A (en) | 2018-10-23 |
Family
ID=63841592
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810933715.0A Withdrawn CN108685751A (en) | 2018-08-16 | 2018-08-16 | A kind of the plant polypeptide skin protection cosmetics and preparation method of controlled absorbed |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108685751A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114983852A (en) * | 2022-04-20 | 2022-09-02 | 赵宏强 | Anti-aging cosmetic with whitening and moisturizing effects and preparation method thereof |
| CN117598924A (en) * | 2023-11-30 | 2024-02-27 | 广州市仙迪生物科技有限公司 | Plant polypeptide composition and application thereof |
-
2018
- 2018-08-16 CN CN201810933715.0A patent/CN108685751A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114983852A (en) * | 2022-04-20 | 2022-09-02 | 赵宏强 | Anti-aging cosmetic with whitening and moisturizing effects and preparation method thereof |
| CN117598924A (en) * | 2023-11-30 | 2024-02-27 | 广州市仙迪生物科技有限公司 | Plant polypeptide composition and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103845272B (en) | Earth-worm extractive as raw material with resisting age of skin effect and its preparation method and application | |
| CN103599063B (en) | A kind of anti-aging face cream | |
| KR20080094457A (en) | Anti-wrinkle cosmetic composition | |
| CN103845273B (en) | A kind of earthworm peptide of resisting age of skin and its preparation method and application | |
| CN104940038A (en) | Application of lycium ruthenicum anthocyanin in preparation of cosmetic and cosmetic containing lycium ruthenicum anthocyanin | |
| CN110772454B (en) | Skin-brightening, moisturizing, soothing and anti-aging compound essential oil, and preparation method and application thereof | |
| CN106236689A (en) | A kind of whitening skin and preserving moisture frost and preparation method thereof | |
| CN106692023A (en) | Multifunctional bio-fiber traditional Chinese medicine mask and manufacturing method thereof | |
| CN101690709A (en) | Manufacturing method of honey lip balm | |
| CN108685751A (en) | A kind of the plant polypeptide skin protection cosmetics and preparation method of controlled absorbed | |
| CN114557927B (en) | Yeast essence water composition, yeast essence water, and preparation method and application thereof | |
| CN115137673A (en) | Fermented cosmetic composition and preparation method and application thereof | |
| KR20190071883A (en) | Cosmetic composition for prevention of skin-wrinkle containing low-molecular weight peptide through microbial fermentation of bilberry fruit | |
| CN108977488B (en) | Elastin for intensive skin repair and preparation method thereof | |
| CN114288221A (en) | A method for preparing essence containing polypeptide and plant extractive solution with hair growth promoting effect and its application | |
| CN112716855B (en) | Composition with barrier repairing and anti-aging effects and preparation method and application thereof | |
| CN109381390A (en) | A kind of sodium hyaluronate skin lightening Face-protecting mask and preparation method thereof | |
| CN105287332A (en) | Whitening and moisturizing composition containing floral essence polypeptide and preparation method and application of whitening and moisturizing composition | |
| CN111529468A (en) | Water-replenishing and moisture-preserving mask essence and preparation method thereof | |
| CN108309871B (en) | Anti-wrinkle moisturizing and water-locking essence and preparation method thereof | |
| CN116440035A (en) | Regulator of biological rhythm gene expression quantity, application thereof, skin care product and cosmetics | |
| CN107595753B (en) | A kind of ginseng compounding creme and preparation method thereof promoting the synthesis of human collagen albumen | |
| CN107496251A (en) | A kind of Skin whitening care cosmeticses containing Chinese herbaceous peony stem cell extract | |
| CN109288754A (en) | A kind of Essence and preparation method containing persimmon leaf extractive from fermentative | |
| KR102047442B1 (en) | Composite for mask pack |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20181023 |
|
| WW01 | Invention patent application withdrawn after publication |