CN112268773A - Liquid-based cell full-automatic sheet making machine - Google Patents
Liquid-based cell full-automatic sheet making machine Download PDFInfo
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- CN112268773A CN112268773A CN202011253087.5A CN202011253087A CN112268773A CN 112268773 A CN112268773 A CN 112268773A CN 202011253087 A CN202011253087 A CN 202011253087A CN 112268773 A CN112268773 A CN 112268773A
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- axis moving
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/44—Sample treatment involving radiation, e.g. heat
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
- G01N2001/2846—Cytocentrifuge method
Abstract
A liquid-based cell full-automatic pelleter relates to the field of test instruments, and solves the problems that the existing pelleter is expensive in price and material consumption, and manual pelleter is low in efficiency and poor in pelleter quality. The invention comprises the following steps: a pipettor suction head box, a specimen collection bottle box and a slide glass box which are arranged on the base; two Y-axis motion mechanisms arranged on the left side and the right side of the upper surface of the machine base; two ends of the supporting frame are respectively fixed on the two Y-axis movement mechanisms; an X-axis movement mechanism mounted on the support frame; a Z-axis movement mechanism arranged on the X-axis movement mechanism; the test tube rack rotation driving mechanism is arranged in the base; the test tube rack is fixed at the upper end of the test tube rack rotation driving mechanism and is positioned in the through hole in the center of the base, and a plurality of clamping grooves which are uniformly distributed are respectively arranged on the outer ring and the inner ring of the test tube rack; a centrifugal tube arranged in the clamp groove on the outer ring of the test tube rack; and the test tube is arranged in the clamping groove of the inner ring of the test tube rack. The invention has the advantages of easy operation, safety, reliability, energy saving, environmental protection, low cost, high flaking quality and high flaking efficiency.
Description
Technical Field
The invention relates to the technical field of test instruments, in particular to a liquid-based cell full-automatic pelleter.
Background
The development of the advanced smear making technology not only improves the number of readable cells, but also removes red blood cells, mucus, cell debris and other impurities which are existed in the smear of the PAP method and hinder the observation and the diagnosis of the smear, so that the cells are uniformly distributed in a thin layer, the background is clear, and the cell nucleus is clear and visible, thereby the detected cell smear is easier to be read and diagnosed by a reader, the visual fatigue of the cell smear is effectively reduced, the smear reading effect is improved, and the diagnosis rate of cytological lesion is improved.
At present, the price and the consumable material of the existing full-automatic sheet making machine are expensive, so that a plurality of hospitals still adopt the traditional manual sheet making. However, the manual flaking method has many disadvantages and shortcomings, and due to inconsistent methods of operators and irregular operation procedures, high false positive and false negative rates are easily caused, and the manual flaking method has low efficiency and poor flaking quality, and cannot meet the increasing diagnosis requirements.
Disclosure of Invention
The invention provides a liquid-based cell full-automatic pelleter, which aims to solve the problems that the conventional full-automatic pelleter is high in price and material consumption, low in efficiency and poor in pelleting quality in manual pelleter production.
The technical scheme adopted by the invention for solving the technical problem is as follows:
the invention relates to a liquid-based cell full-automatic pelleter, which comprises: inside hollow frame, fix dustcoat on the frame, install the door in the spout of dustcoat front end, frame upper surface center is equipped with the through-hole, still includes:
the sample collecting device comprises a pipettor suction head box, a sample collecting bottle box and a glass slide box which are all arranged on the upper surface of a base, wherein a pipettor suction head is placed in the pipettor suction head box, a sample collecting bottle is placed in the sample collecting bottle box, and a glass slide is placed in the glass slide box;
the first Y-axis movement mechanism and the second Y-axis movement mechanism are respectively arranged on the left side and the right side of the upper surface of the machine base;
the two ends of the supporting frame are respectively fixed on the first Y-axis movement mechanism and the second Y-axis movement mechanism;
an X-axis movement mechanism mounted on the support frame;
a Z-axis movement mechanism arranged on the X-axis movement mechanism;
the test tube rack rotation driving mechanism is arranged in the base;
the test tube rack is fixed at the upper end of the test tube rack rotation driving mechanism, the test tube rack is positioned in a through hole in the center of the machine base, and a plurality of clamping grooves which are uniformly distributed are respectively arranged on the outer ring and the inner ring of the test tube rack;
a centrifugal tube arranged in the clamp groove on the outer ring of the test tube rack;
and the test tube is arranged in the clamping groove of the inner ring of the test tube rack.
Further, the method also comprises the following steps:
the switch, the USB interface and the video monitor are all arranged on the front surface of the base;
the waste liquid tank, the camera and the control system are all arranged in the base;
the X-axis motion mechanism, the Z-axis motion mechanism, the first Y-axis motion mechanism, the second Y-axis motion mechanism, the switch, the USB interface, the video monitor and the camera are all electrically connected with the control system.
Further, the method also comprises the following steps:
and the two ends of the transverse guide rail are respectively fixed on the supporting frame, and the lower end of the X-axis movement mechanism is arranged on the transverse guide rail.
Further, the X-axis movement mechanism includes:
the supporting frame extends into the two mounting holes on the two sides of the upper end of the X-axis moving clamping seat; mounting holes are respectively formed in two sides of the lower end of the X-axis movable clamping seat, and the transverse guide rail extends into the mounting holes in the two sides of the lower end of the X-axis movable clamping seat;
z-axis synchronous toothed belts respectively arranged on the inner walls of the two sides of the opening at the front end of the X-axis movable clamping seat;
dovetail grooves respectively arranged on the outer walls of two sides of the opening at the front end of the X-axis movable clamping seat;
the X-axis moving servo motor is fixed in the X-axis moving clamping seat and is electrically connected with the control system;
the X-axis moving driving gear is fixedly connected with an output shaft of the X-axis moving servo motor through a flat key;
the X-axis synchronous toothed belt is arranged on the supporting frame and is meshed with the X-axis movable driving gear;
and starting the X-axis movement servo motor to drive the X-axis movement driving gear to rotate, and driving the whole X-axis movement clamping seat to move on the supporting frame along the X axis through the meshing action between the X-axis movement driving gear and the X-axis synchronous toothed belt.
Further, the Z-axis movement mechanism includes:
the Z-axis moves the clamping seat;
the Z-axis moving servo motor is fixed at the upper end of the front surface of the Z-axis moving clamping seat and is electrically connected with the control system;
the upper end of the manipulator absorber is fixedly connected with an output shaft of the Z-axis moving servo motor;
a suction pipe insertion opening is arranged at the lower end of the mechanical arm absorber, and a suction pipe is arranged in the suction pipe insertion opening;
dovetail structures respectively arranged on two sides of the rear surface of the Z-axis moving clamping seat, wherein the dovetail structures are correspondingly arranged with the dovetail grooves one by one;
the Z-axis moving driving gear is arranged at the upper end of the rear surface of the Z-axis moving clamping seat, the Z-axis moving driving gear is installed in an opening at the lower end of the X-axis moving clamping seat, and the Z-axis moving driving gear is meshed with the Z-axis synchronous toothed belt;
and starting the Z-axis movement servo motor to drive the Z-axis movement driving gear to rotate, and driving the whole Z-axis movement clamping seat and the manipulator absorber to move along the Z axis on the X-axis movement clamping seat through the meshing action between the Z-axis movement driving gear and the Z-axis synchronous toothed belt.
Further, the first Y-axis movement mechanism includes: the first Y-axis moving clamping seat, the first Y-axis moving servo motor, the first Y-axis moving driving gear, the first rack and the first linear guide rail are arranged on the first linear guide rail;
the first rack and the first linear guide rail are fixed on the left side of the upper surface of the machine base, and the first rack is positioned on the outer side of the first linear guide rail; the lower end of the left side of the supporting frame is fixed on the first Y-axis moving clamping seat; one side of the lower end of the first Y-axis moving clamping seat is installed on a first linear guide rail, the other side of the lower end of the first Y-axis moving clamping seat is arranged in an opening form, a first Y-axis moving servo motor is fixed inside the opening of the first Y-axis moving clamping seat and is electrically connected with a control system, a first Y-axis moving driving gear is fixedly connected with an output shaft of the first Y-axis moving servo motor through a flat key, and the first Y-axis moving driving gear is meshed with a first rack;
and starting the first Y-axis movement servo motor to drive the first Y-axis movement driving gear to rotate, and driving the whole first Y-axis movement clamping seat to move on the first linear guide rail along the Y-axis direction through the meshing action between the first Y-axis movement driving gear and the first rack.
Further, the second Y-axis movement mechanism includes: the second Y-axis moving clamping seat, a second Y-axis moving servo motor, a second Y-axis moving driving gear, a second rack and a second linear guide rail; the second rack and the second linear guide rail are fixed on the right side of the upper surface of the machine base, and the second rack is positioned on the outer side of the second linear guide rail; the lower end of the right side of the supporting frame is fixed on the second Y-axis moving clamping seat; one side of the lower end of the first Y-axis moving clamping seat is installed on the second linear guide rail, the other side of the lower end of the second Y-axis moving clamping seat is arranged in an opening form, a second Y-axis moving servo motor is fixed inside the opening of the second Y-axis moving clamping seat and electrically connected with a control system, a second Y-axis moving driving gear is fixedly connected with an output shaft of the second Y-axis moving servo motor, and the second Y-axis moving driving gear is meshed with the second rack;
and starting a second Y-axis movement servo motor to drive a second Y-axis movement driving gear to rotate, and driving the whole second Y-axis movement clamping seat to move on the second linear guide rail along the Y-axis direction through the meshing action between the second Y-axis movement driving gear and the second rack.
Further, the test tube rack rotation driving mechanism includes: the device comprises a vertical shaft, a first ball bearing, a driving gear, a driven gear, a rotary servo motor, a second ball bearing, a thrust bearing, a rotary servo motor fixing seat and a bearing seat;
the rotary servo motor fixing seat and the bearing seat are both fixed inside the machine seat; the test tube rack is fixed at the upper end of the vertical shaft; the thrust bearing, the second ball bearing, the driving gear and the first ball bearing are sequentially arranged at the lower end of the vertical shaft from bottom to top; the outer diameter of the lower end of the vertical shaft is in transition fit with the inner hole of the thrust bearing, the lower end surface of the thrust bearing is in contact with a bearing seat in the base, the thrust bearing mainly bears axial force, the upper end surface of the thrust bearing is in contact with the inner ring of a second ball bearing, the inner hole of the second ball bearing and the inner hole of a first ball bearing are in transition fit with the outer diameter of the vertical shaft, the second ball bearing and the first ball bearing rotate together with the vertical shaft, and the outer diameter of the second ball bearing and the outer diameter of; the driving gear is arranged between the second ball bearing and the first ball bearing, and the inner diameter of the driving gear is in movable fit with the outer diameter of the vertical shaft; the rotary servo motor is fixed on a rotary servo motor fixing seat in the base and is electrically connected with the control system; the driving gear is meshed with the driven gear, and an inner hole of the rotary driving gear is tightly matched with a shaft of the rotary servo motor; when the rotary servo motor rotates, the driven gear drives the driving gear to rotate together, the driven gear is meshed with the driving gear to rotate, the vertical shaft is driven to rotate, and meanwhile, the test tube rack on the vertical shaft is driven to rotate together.
Furthermore, a resistance wire is arranged in the slide glass box.
Furthermore, the device also comprises a circular ring arranged on the outer ring of the central through hole of the machine seat.
The invention has the beneficial effects that: the liquid-based cell full-automatic slide making machine is a full-automatic machine for processing and making conventional in vitro cytological specimens, and is widely applicable to slide making of various cytological specimens of human bodies.
The invention adopts the design of centrifugation and slide-making, greatly improves the efficiency and quality of slide-making, and only needs to put the cell specimen collecting bottle into the machine, the slide-making machine can automatically complete a series of full-automatic slide-making processes of cell blending, sampling, centrifugation and the like, so that the cytological sample is more accurately processed, the error generated by manual operation is reduced, the working efficiency is improved, and the test verifies that the effect is good.
The invention integrates mechanical, electrical and pneumatic functions, has a plurality of innovation points on structures and parts such as liquid-based centrifugation, cell analysis, slide glass heating, liquid-based transfer, manipulator positioning control, cell adhesion and the like, overcomes the defects of unstable quality and poor effect of manual sheet production, and realizes sheet production automation.
The invention is easy to operate, safe and reliable, energy-saving and environment-friendly, has low cost, obviously improves the tabletting quality, improves the tabletting efficiency by more than 10 times compared with manual tabletting, and is suitable for middle and small hospitals in China.
Drawings
FIG. 1 is a schematic structural diagram of a liquid-based cell full-automatic pelleter according to the present invention.
FIG. 2 is a schematic diagram of the internal structure of the liquid-based cell full-automatic pelleter of the present invention.
Fig. 3 is a schematic structural view of the test tube rack rotation driving mechanism.
Fig. 4 is a schematic structural view of the X-axis movement mechanism.
Fig. 5 is a schematic structural view of the X-axis movement mechanism.
Fig. 6 is a schematic structural view of the Z-axis movement mechanism.
Fig. 7 is a schematic structural view of the Z-axis movement mechanism.
Fig. 8 is a schematic structural view of the Y-axis movement mechanism.
Fig. 9 is a schematic view of the installation of the test tube rack, centrifuge tube and test tube.
FIG. 10 is a schematic structural diagram of a liquid-based cell full-automatic pelleter according to the present invention.
In the figure, 1, an X-axis motion mechanism, 2, a Z-axis motion mechanism, 3, a first Y-axis motion mechanism, 4, a second Y-axis motion mechanism, 5, a support frame, 6, a transverse guide rail, 7, a base, 8, a first rack, 9, a second rack, 10, a first linear guide rail, 11, a second linear guide rail, 12, a circular ring, 13, a test tube rack, 14, a centrifuge tube, 15, a pipette tip box, 16, a specimen collection bottle box, 17, a slide glass box, 18, a switch, 19, a USB interface, 20, a video monitor, 21, a housing, 22, a door, 23, a vertical shaft, 24, a first ball bearing, 25, a driving gear, 26, a driven gear, 27, a rotary servo motor, 28, a second ball bearing, 29, a thrust bearing, 30 and a test tube.
Detailed Description
The present invention will be described in further detail with reference to the accompanying drawings.
As shown in fig. 1, fig. 2 and fig. 3, the liquid-based cell full-automatic pelleter of the present invention mainly comprises: the device comprises an X-axis motion mechanism 1, a Z-axis motion mechanism 2, a first Y-axis motion mechanism 3, a second Y-axis motion mechanism 4, a supporting frame 5, a transverse guide rail 6, a machine base 7, a circular ring 12, a test tube rack 13, a centrifuge tube 14, a pipette tip box 15, a sample collection bottle box 16, a slide glass box 17, a switch 18, a USB interface 19, a video monitor 20, an outer cover 21, a door 22, a test tube rack rotation driving mechanism, a test tube 30, a waste liquid box, a camera and a control system.
The inside of the machine base 7 is hollow. A through hole is formed in the center of the upper surface of the base 7, a circular ring 12 is arranged on the outer ring of the central through hole, and the test tube rack 13 is located in the central through hole of the base 7. The lower end of the test tube rack 13 is arranged on the test tube rack rotation driving mechanism. The outer ring and the inner ring of the test tube rack 13 are respectively provided with a plurality of clamping grooves which are uniformly distributed, the centrifuge tube 14 is arranged in the clamping groove of the outer ring of the test tube rack 13, and the test tube 30 is arranged in the clamping groove of the inner ring of the test tube rack 13, as shown in fig. 9.
The outer cover 21 is fixed on the base 7, the outer cover 21 is a transparent glass shield, sliding grooves are formed in two sides of the front end of the outer cover 21, the door 22 is installed in the sliding grooves in the front end of the outer cover 21, the door 22 can move up and down, and when a specimen and a glass slide are placed, the door 22 moves upwards and is lifted. Door 22 moves downwardly closed when the pelletier is in operation.
The pipette tip box 15, the specimen collection bottle box 16 and the slide glass box 17 are all arranged on the upper surface of the base 7. A pipette tip is placed in the pipette tip box 15, a specimen collection bottle is placed in the specimen collection bottle box 16, and a slide glass is placed in the slide glass box 17. Resistance wires are arranged in the slide glass box 17 for heating, and the resistance wires are standard purchased parts.
The switch 18, the USB interface 19 and the video monitor 20 are all arranged on the front surface of the base 7.
The test tube rack rotation driving mechanism, the waste liquid box, the camera and the control system are all arranged inside the base 7.
In the invention, an X-axis movement mechanism 1, a Z-axis movement mechanism 2, a first Y-axis movement mechanism 3 and a second Y-axis movement mechanism 4 form a manipulator adsorber movement system, the manipulator adsorber movement system performs 3-direction spatial movement, namely can perform X-axis, Y-axis and Z-axis movement simultaneously, the left and right movement is along the X-axis, the front and back movement is along the Y-axis, and the up and down movement is along the Z-axis. The X-axis movement mechanism 1 transmits power by using a synchronous toothed belt, and the Z-axis movement mechanism 2, the first Y-axis movement mechanism 3 and the second Y-axis movement mechanism 4 all transmit power by using a gear rack. The suction pipe is installed in the suction pipe socket 203 of the manipulator suction device 204, and the manipulator suction device 204 is moved to a designated position by driving the X-axis movement mechanism 1, the Z-axis movement mechanism 2, the first Y-axis movement mechanism 3 and the second Y-axis movement mechanism 4 to perform suction and smear.
The X-axis movement mechanism 1, the Z-axis movement mechanism 2, the first Y-axis movement mechanism 3, the second Y-axis movement mechanism 4, the test tube rack rotation driving mechanism, the switch 18, the USB interface 19, the video monitor 20 and the camera are all electrically connected with the control system.
The first Y-axis movement mechanism 3 is installed on the left side of the upper surface of the machine base 7, the second Y-axis movement mechanism 4 is installed on the right side of the upper surface of the machine base 7, and the first Y-axis movement mechanism 3 and the second Y-axis movement mechanism 4 can slide on the machine base 7 along the Y-axis direction.
Two ends of a supporting frame 5 are respectively fixed on the first Y-axis movement mechanism 3 and the second Y-axis movement mechanism 4, and two ends of a transverse guide rail 6 are respectively fixed on the supporting frame 5.
The upper end of the X-axis movement mechanism 1 is arranged on the supporting frame 5, the lower end of the X-axis movement mechanism 1 is arranged on the transverse guide rail 6, and the X-axis movement mechanism 1 can slide on the supporting frame 5 and the transverse guide rail 6 along the X-axis direction.
The Z-axis movement mechanism 2 is installed on the X-axis movement mechanism 1, and the Z-axis movement mechanism 2 can slide on the X-axis movement mechanism 1 along the Z-axis direction.
As shown in fig. 4, the X-axis movement mechanism 1 mainly includes: the X-axis moving clamping seat 101, the X-axis moving servo motor 102, the X-axis moving driving gear 103, the X-axis synchronous toothed belt 104, the Z-axis synchronous toothed belt 105, the dovetail groove 106 and the mounting hole 107. The X-axis movement servo motor 102 is connected to the control system. The X-axis moving servo motor 102 is fixed inside the X-axis moving clamping seat 101, and the X-axis moving driving gear 103 is fixedly connected with an output shaft 108 of the X-axis moving servo motor 102 through a flat key 109. Two sides of the upper end of the X-axis movable clamping seat 101 are respectively provided with a mounting hole 107, the supporting frame 5 extends into the two mounting holes 107 on the two sides of the upper end of the X-axis movable clamping seat 101, and then an X-axis synchronous toothed belt 104 arranged on the supporting frame 5 is meshed with the X-axis movable driving gear 103. Two sides of the lower end of the X-axis movable clamping seat 101 are also respectively provided with a mounting hole, and the transverse guide rail 6 extends into the mounting holes on two sides of the lower end of the X-axis movable clamping seat 101.
Z-axis synchronous toothed belts 105 are respectively arranged on the inner walls of the two sides of the front opening of the X-axis movable clamping seat 101, and dovetail grooves 106 are respectively arranged on the outer walls of the two sides of the front opening of the X-axis movable clamping seat 101.
The X-axis movement servo motor 102 is started to drive the X-axis movement driving gear 103 to rotate, and the whole X-axis movement cassette 101 is driven to move along the X-axis on the support frame 5 by the meshing action between the X-axis movement driving gear 103 and the X-axis timing belt 104.
As shown in fig. 6 and 7, the Z-axis movement mechanism 2 mainly includes: a Z-axis moving cassette 201, a Z-axis moving servo motor 202, a suction pipe socket 203, a manipulator adsorber 204, a dovetail structure 205 and a Z-axis moving drive gear 206. The Z-axis movement servo motor 202 is connected to the control system. The Z-axis moving servo motor 202 is fixed at the upper end of the front surface of the Z-axis moving clamping seat 201, the manipulator absorber 204 is installed in an installation hole at the lower end of the front surface of the Z-axis moving clamping seat 201, meanwhile, the upper end of the manipulator absorber 204 is fixedly connected with an output shaft 207 of the Z-axis moving servo motor 202, and the suction pipe socket 203 is arranged at the lower end of the manipulator absorber 204. A dovetail structure 205 is respectively provided at both sides of the rear surface of the Z-axis moving cassette 201. A Z-axis moving driving gear 206 is provided at an upper end of a rear surface of the Z-axis moving cassette 201. The Z-axis moving driving gear 206 is installed in the opening at the lower end of the X-axis moving clamping seat 101, the Z-axis moving driving gear 206 is meshed with the Z-axis synchronous toothed belt 105, and meanwhile, the dovetail structures 205 are installed in one-to-one correspondence with the dovetail grooves 106.
The Z-axis moving servo motor 202 is started to drive the Z-axis moving driving gear 206 to rotate, and the whole Z-axis moving cassette 201 and the robot adsorber 204 are driven to move along the Z-axis on the X-axis moving cassette 101 through the meshing action between the Z-axis moving driving gear 206 and the Z-axis timing belt 105.
The first Y-axis moving mechanism 3 and the second Y-axis moving mechanism 4 have the same structure and size.
As shown in fig. 2 and 8, the first Y-axis moving mechanism 3 mainly includes: a first Y-axis moving cassette 301, a first Y-axis moving servo motor 303, a first Y-axis moving drive gear 302, a first rack 8, and a first linear guide 10. The first Y-axis movement servo motor 303 is connected to the control system. The lower left end of the support frame 5 is fixed to the first Y-axis moving cassette 301. One side of the lower end of the first Y-axis moving clamping seat 301 is mounted on the first linear guide rail 10, the other side of the lower end of the first Y-axis moving clamping seat 301 is provided with an opening, the first Y-axis moving servo motor 303 is fixed inside the opening of the first Y-axis moving clamping seat 301, the first Y-axis moving driving gear 302 is fixedly connected with an output shaft 305 of the first Y-axis moving servo motor 303 through a flat key 304, and the first Y-axis moving driving gear 302 is meshed with the first rack 8.
The first Y-axis movement servo motor 303 is started to drive the first Y-axis movement driving gear 302 to rotate, and the whole first Y-axis movement clamping seat 301 is driven to move on the first linear guide 10 along the Y-axis direction through the meshing action between the first Y-axis movement driving gear 302 and the first rack 8.
As shown in fig. 2 and 10, the second Y-axis movement mechanism 4 mainly includes: a second Y-axis moving cassette 401, a second Y-axis moving servo motor 403, a second Y-axis moving drive gear 402, a second rack 9, and a second linear guide 11. The second Y-axis moving servo motor is connected with the control system. The lower end of the right side of the support frame 5 is fixed to the second Y-axis moving block 401. One side of the lower end of the first Y-axis moving clamping seat 401 is installed on the second linear guide rail 11, the other side of the lower end of the second Y-axis moving clamping seat 401 is arranged in an opening form, a second Y-axis moving servo motor is fixed inside the opening of the second Y-axis moving clamping seat 401, a second Y-axis moving driving gear 402 is fixedly connected with an output shaft of the second Y-axis moving servo motor, and the second Y-axis moving driving gear 402 is meshed with the second rack 9.
And a second Y-axis movement servo motor is started to drive the second Y-axis movement driving gear 402 to rotate, and the whole second Y-axis movement clamping seat 401 is driven to move on the second linear guide rail 11 along the Y-axis direction through the meshing action between the second Y-axis movement driving gear 402 and the second rack 9.
The first rack 8 and the first linear guide rail 10 are fixed on the left side of the upper surface of the base 7 through screws, and the second rack 9 and the second linear guide rail 11 are fixed on the right side of the upper surface of the base 7 through screws. The first rack 8 is located outside the first linear guide 10, and the second rack 9 is located outside the second linear guide 11.
As shown in fig. 3, the test tube rack rotation driving mechanism mainly includes: vertical shaft 23, first ball bearing 24, driving gear 25, driven gear 26, rotary servo motor 27, second ball bearing 28, thrust bearing 29, rotary servo motor fixing seat and bearing seat.
The rotary servo motor fixing seat and the bearing seat are both fixed inside the machine base 7.
The test tube rack 13 is fixed on the upper end of the vertical shaft 23 through a screw.
The thrust bearing 29, the second ball bearing 28, the driving gear 25 and the first ball bearing 24 are sequentially arranged at the lower end of the vertical shaft 23 from bottom to top. The outer diameter of the lower end of the vertical shaft 23 is in transition fit with the inner hole of the thrust bearing 29, the lower end face of the thrust bearing 29 is in contact with a bearing seat in the base 7, the thrust bearing 29 mainly bears axial force, the upper end face of the thrust bearing 29 is in contact with the inner ring of the second ball bearing 28, the inner hole of the second ball bearing 28 and the inner hole of the first ball bearing 24 are in transition fit with the outer diameter of the vertical shaft 23, the second ball bearing 28 and the first ball bearing 24 rotate together with the vertical shaft 23, and the outer diameter of the second ball bearing 28 and the outer diameter of the first ball bearing. The second ball bearing 28 and the first ball bearing 24 function to fix the vertical shaft 23 and reduce the rotational resistance.
The driving gear 25 is arranged between the second ball bearing 28 and the first ball bearing 24, and the inner diameter of the driving gear 25 is in movable fit with the outer diameter of the vertical shaft 23.
The rotary servo motor 27 is fixed on a rotary servo motor fixing seat in the machine base 7 through a bolt, and the rotary servo motor 27 is electrically connected with a control system. The driving gear 25 is meshed with the driven gear 26, and an inner hole of the rotary driving gear 25 is tightly matched with a shaft of the rotary servo motor 27. When the rotary servo motor 27 rotates, the driven gear 26 rotates the driving gear 25, and the driven gear 26 rotates in mesh with the driving gear 25 to rotate the vertical shaft 23 and rotate the test tube rack 13 on the vertical shaft 23.
When the full-automatic pelleter for liquid-based cells is used, firstly, the work preparation is carried out, the cell specimen, the glass slide, the centrifuge tube 14, the test tube 30 and the like are put in, the labeling is started, the bar code scanner is used for scanning codes, the door 22 is closed, the switch 18 is opened, the processing mode is selected, the X-axis motion mechanism 1, the Z-axis motion mechanism 2, the first Y-axis motion mechanism 3 and the second Y-axis motion mechanism 4 jointly act to enable the manipulator adsorber 204 to move to the position above a pipette tip to extract the pipette tip, then the manipulator adsorber 204 is enabled to move to the position above a specimen collection bottle through the joint action of the X-axis motion mechanism 1, the Z-axis motion mechanism 2, the first Y-axis motion mechanism 3 and the second Y-axis motion mechanism 4, the sample in the specimen collection bottle is extracted by the pipette tip, the manipulator adsorber 204 is moved to the position above the corresponding centrifuge tube 14 to, and moving the manipulator absorber 204 to the upper part of the waste liquid tank to discard the suction pipe, picking up the corresponding suction pipe again, repeating the actions until all the samples are extracted, and driving the manipulator absorber 204 to stop working and return to the original position by the X-axis motion mechanism 1, the Z-axis motion mechanism 2, the first Y-axis motion mechanism 3 and the second Y-axis motion mechanism 4 together.
The test tube rack rotation driving mechanism drives the vertical shaft 23 and the test tube rack 13 to rotate, so that the centrifuge tube 14 inclines by 90 degrees, cells are attached to the bottom of the tube, the rotation of the test tube rack 13 stops, the manipulator adsorber 204 moves to the upper part of the pipette to pick up the 1ml pipette, the manipulator adsorber 204 moves to the upper part of the centrifuge tube 14 to adsorb the cell liquid in the centrifuge tube 14, the manipulator adsorber 204 rises, the manipulator adsorber 204 moves to the upper part of the test tube 30 to inject the cells into the corresponding test tube 30, the control system detects the cell liquid height to judge the cell quantity, the qualified test manipulator adsorber 204 transfers the cells to a glass slide (the bottom of the glass slide is heated through a resistance wire, so that the temperature of 40 degrees is kept), the operation from the centrifuge tube 14 to the test tube 30. During the slide preparation process, the number of cells on the slide is detected by a camera.
The switch 18 is turned on to select a processing mode, wherein the processing mode has three types:
mode 1: whole cell processing.
Mode 2: limited cytological procedures.
Mode 3: tube cytology processing.
In the invention, products are added in sampling and centrifugation, thereby forming a fully-automatic portable liquid cytology processing system, which is an in vitro universal cytology specimen processing instrument. Various cytological specimens are processed using cytological processing reagents and procedures to adhere cells to the slides, which are dried and then stained and read by trained professionals.
In the description of the present invention, it is to be understood that the terms "central", "longitudinal", "lateral", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate orientations or positional relationships based on those shown in the drawings, and are used only for convenience in describing the present invention and for simplicity in description, and do not indicate or imply that the referenced devices or elements must have a particular orientation, be constructed and operated in a particular orientation, and thus, are not to be considered as limiting the scope of the present invention.
Finally, it should be noted that: the above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: it is to be understood that modifications may be made to the technical solutions described in the foregoing embodiments, or equivalents may be substituted for some of the technical features thereof, but such modifications or substitutions do not depart from the spirit and scope of the technical solutions of the embodiments of the present invention.
Claims (10)
1. Full-automatic pelleter of liquid-based cell includes: inside hollow frame, fix dustcoat on the frame, install the door in the spout of dustcoat front end, frame upper surface center is equipped with the through-hole, its characterized in that still includes:
the sample collecting device comprises a pipettor suction head box, a sample collecting bottle box and a glass slide box which are all arranged on the upper surface of a base, wherein a pipettor suction head is placed in the pipettor suction head box, a sample collecting bottle is placed in the sample collecting bottle box, and a glass slide is placed in the glass slide box;
the first Y-axis movement mechanism and the second Y-axis movement mechanism are respectively arranged on the left side and the right side of the upper surface of the machine base;
the two ends of the supporting frame are respectively fixed on the first Y-axis movement mechanism and the second Y-axis movement mechanism;
an X-axis movement mechanism mounted on the support frame;
a Z-axis movement mechanism arranged on the X-axis movement mechanism;
the test tube rack rotation driving mechanism is arranged in the base;
the test tube rack is fixed at the upper end of the test tube rack rotation driving mechanism, the test tube rack is positioned in a through hole in the center of the machine base, and a plurality of clamping grooves which are uniformly distributed are respectively arranged on the outer ring and the inner ring of the test tube rack;
a centrifugal tube arranged in the clamp groove on the outer ring of the test tube rack;
and the test tube is arranged in the clamping groove of the inner ring of the test tube rack.
2. The machine according to claim 1, further comprising:
the switch, the USB interface and the video monitor are all arranged on the front surface of the base;
the waste liquid tank, the camera and the control system are all arranged in the base;
the X-axis motion mechanism, the Z-axis motion mechanism, the first Y-axis motion mechanism, the second Y-axis motion mechanism, the switch, the USB interface, the video monitor and the camera are all electrically connected with the control system.
3. The machine according to claim 2, further comprising:
and the two ends of the transverse guide rail are respectively fixed on the supporting frame, and the lower end of the X-axis movement mechanism is arranged on the transverse guide rail.
4. The machine according to claim 3, wherein the X-axis movement mechanism comprises:
the supporting frame extends into the two mounting holes on the two sides of the upper end of the X-axis moving clamping seat; mounting holes are respectively formed in two sides of the lower end of the X-axis movable clamping seat, and the transverse guide rail extends into the mounting holes in the two sides of the lower end of the X-axis movable clamping seat;
z-axis synchronous toothed belts respectively arranged on the inner walls of the two sides of the opening at the front end of the X-axis movable clamping seat;
dovetail grooves respectively arranged on the outer walls of two sides of the opening at the front end of the X-axis movable clamping seat;
the X-axis moving servo motor is fixed in the X-axis moving clamping seat and is electrically connected with the control system;
the X-axis moving driving gear is fixedly connected with an output shaft of the X-axis moving servo motor through a flat key;
the X-axis synchronous toothed belt is arranged on the supporting frame and is meshed with the X-axis movable driving gear;
and starting the X-axis movement servo motor to drive the X-axis movement driving gear to rotate, and driving the whole X-axis movement clamping seat to move on the supporting frame along the X axis through the meshing action between the X-axis movement driving gear and the X-axis synchronous toothed belt.
5. The machine according to claim 4, wherein the Z-axis motion mechanism comprises:
the Z-axis moves the clamping seat;
the Z-axis moving servo motor is fixed at the upper end of the front surface of the Z-axis moving clamping seat and is electrically connected with the control system;
the upper end of the manipulator absorber is fixedly connected with an output shaft of the Z-axis moving servo motor;
a suction pipe insertion opening is arranged at the lower end of the mechanical arm absorber, and a suction pipe is arranged in the suction pipe insertion opening;
dovetail structures respectively arranged on two sides of the rear surface of the Z-axis moving clamping seat, wherein the dovetail structures are correspondingly arranged with the dovetail grooves one by one;
the Z-axis moving driving gear is arranged at the upper end of the rear surface of the Z-axis moving clamping seat, the Z-axis moving driving gear is installed in an opening at the lower end of the X-axis moving clamping seat, and the Z-axis moving driving gear is meshed with the Z-axis synchronous toothed belt;
and starting the Z-axis movement servo motor to drive the Z-axis movement driving gear to rotate, and driving the whole Z-axis movement clamping seat and the manipulator absorber to move along the Z axis on the X-axis movement clamping seat through the meshing action between the Z-axis movement driving gear and the Z-axis synchronous toothed belt.
6. The machine of claim 2, wherein the first Y-axis motion mechanism comprises: the first Y-axis moving clamping seat, the first Y-axis moving servo motor, the first Y-axis moving driving gear, the first rack and the first linear guide rail are arranged on the first linear guide rail;
the first rack and the first linear guide rail are fixed on the left side of the upper surface of the machine base, and the first rack is positioned on the outer side of the first linear guide rail; the lower end of the left side of the supporting frame is fixed on the first Y-axis moving clamping seat; one side of the lower end of the first Y-axis moving clamping seat is installed on a first linear guide rail, the other side of the lower end of the first Y-axis moving clamping seat is arranged in an opening form, a first Y-axis moving servo motor is fixed inside the opening of the first Y-axis moving clamping seat and is electrically connected with a control system, a first Y-axis moving driving gear is fixedly connected with an output shaft of the first Y-axis moving servo motor through a flat key, and the first Y-axis moving driving gear is meshed with a first rack;
and starting the first Y-axis movement servo motor to drive the first Y-axis movement driving gear to rotate, and driving the whole first Y-axis movement clamping seat to move on the first linear guide rail along the Y-axis direction through the meshing action between the first Y-axis movement driving gear and the first rack.
7. The machine according to claim 2, wherein the second Y-axis motion mechanism comprises: the second Y-axis moving clamping seat, a second Y-axis moving servo motor, a second Y-axis moving driving gear, a second rack and a second linear guide rail; the second rack and the second linear guide rail are fixed on the right side of the upper surface of the machine base, and the second rack is positioned on the outer side of the second linear guide rail; the lower end of the right side of the supporting frame is fixed on the second Y-axis moving clamping seat; one side of the lower end of the first Y-axis moving clamping seat is installed on the second linear guide rail, the other side of the lower end of the second Y-axis moving clamping seat is arranged in an opening form, a second Y-axis moving servo motor is fixed inside the opening of the second Y-axis moving clamping seat and electrically connected with a control system, a second Y-axis moving driving gear is fixedly connected with an output shaft of the second Y-axis moving servo motor, and the second Y-axis moving driving gear is meshed with the second rack;
and starting a second Y-axis movement servo motor to drive a second Y-axis movement driving gear to rotate, and driving the whole second Y-axis movement clamping seat to move on the second linear guide rail along the Y-axis direction through the meshing action between the second Y-axis movement driving gear and the second rack.
8. The machine according to claim 2, wherein the rack rotation driving mechanism comprises: the device comprises a vertical shaft, a first ball bearing, a driving gear, a driven gear, a rotary servo motor, a second ball bearing, a thrust bearing, a rotary servo motor fixing seat and a bearing seat;
the rotary servo motor fixing seat and the bearing seat are both fixed inside the machine seat; the test tube rack is fixed at the upper end of the vertical shaft; the thrust bearing, the second ball bearing, the driving gear and the first ball bearing are sequentially arranged at the lower end of the vertical shaft from bottom to top; the outer diameter of the lower end of the vertical shaft is in transition fit with the inner hole of the thrust bearing, the lower end surface of the thrust bearing is in contact with a bearing seat in the base, the thrust bearing mainly bears axial force, the upper end surface of the thrust bearing is in contact with the inner ring of a second ball bearing, the inner hole of the second ball bearing and the inner hole of a first ball bearing are in transition fit with the outer diameter of the vertical shaft, the second ball bearing and the first ball bearing rotate together with the vertical shaft, and the outer diameter of the second ball bearing and the outer diameter of; the driving gear is arranged between the second ball bearing and the first ball bearing, and the inner diameter of the driving gear is in movable fit with the outer diameter of the vertical shaft; the rotary servo motor is fixed on a rotary servo motor fixing seat in the base and is electrically connected with the control system; the driving gear is meshed with the driven gear, and an inner hole of the rotary driving gear is tightly matched with a shaft of the rotary servo motor; when the rotary servo motor rotates, the driven gear drives the driving gear to rotate together, the driven gear is meshed with the driving gear to rotate, the vertical shaft is driven to rotate, and meanwhile, the test tube rack on the vertical shaft is driven to rotate together.
9. The machine of claim 1, wherein a resistance wire is disposed in the slide cassette.
10. The machine according to claim 1, further comprising a ring disposed around the central through hole of the base.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011253087.5A CN112268773A (en) | 2020-11-11 | 2020-11-11 | Liquid-based cell full-automatic sheet making machine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011253087.5A CN112268773A (en) | 2020-11-11 | 2020-11-11 | Liquid-based cell full-automatic sheet making machine |
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| CN112268773A true CN112268773A (en) | 2021-01-26 |
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| CN202011253087.5A Pending CN112268773A (en) | 2020-11-11 | 2020-11-11 | Liquid-based cell full-automatic sheet making machine |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113731650A (en) * | 2021-09-08 | 2021-12-03 | 深圳市森盈生物科技有限公司 | Integrated centrifugal system and method for full-automatic sheet making machine |
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2020
- 2020-11-11 CN CN202011253087.5A patent/CN112268773A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113731650A (en) * | 2021-09-08 | 2021-12-03 | 深圳市森盈生物科技有限公司 | Integrated centrifugal system and method for full-automatic sheet making machine |
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