CN112098157A - Sampling device and liquid-based cell pelleter - Google Patents
Sampling device and liquid-based cell pelleter Download PDFInfo
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- CN112098157A CN112098157A CN202011070674.0A CN202011070674A CN112098157A CN 112098157 A CN112098157 A CN 112098157A CN 202011070674 A CN202011070674 A CN 202011070674A CN 112098157 A CN112098157 A CN 112098157A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/34—Purifying; Cleaning
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Abstract
The utility model provides a sampling device and liquid-based cell pelleter, relate to cell pelleter technical field, including first rotary actuator, first support and set up respectively in first sampling needle and the second sampling needle of first support both sides, first sampling needle below corresponds the sample bottle that sets up and is used for holding sample liquid, second sampling needle below corresponds the washing tank that sets up and is used for holding the washing liquid, first rotary actuator's drive end is connected with the center transmission of first support, first rotary actuator drives first support and rotates so that the position of first sampling needle and the position of second sampling needle exchange. This sampling device and liquid-based cell pelleter carry out sampling operation and cleaning operation simultaneously, show improvement film-making efficiency.
Description
Technical Field
The invention relates to the technical field of cell slide, in particular to a sampling device and a liquid-based cell slide machine.
Background
The liquid-based cytology examination adopts a liquid-based thin-layer cell detection system to detect cervical cells and carry out cytological classification diagnosis, is a more advanced cervical cancer cytology examination technology internationally at present, obviously improves the satisfaction degree of specimens and the abnormal cell detection rate of the cervix compared with the traditional cervical smear examination by scraping and smearing, has the detection rate of the cervical cancer prevention cytology examination on the cervical cancer cells of 100 percent, and can discover partial precancerous lesions and microbial infections such as mould, trichomonas, virus and chlamydia at the same time.
Although the liquid-based thin-layer cell detection method obviously improves the detection quality of cervical cell samples, specimen liquid needs to be manually extracted through a sampling needle in the flaking process, the sampling needle needs to be manually cleaned through cleaning liquid after use, the workload is very huge, and the efficiency is very low.
Disclosure of Invention
The invention aims to provide a sampling device and a liquid-based cell pelleter, which can perform sampling operation and cleaning operation simultaneously and remarkably improve the pelleter efficiency.
The embodiment of the invention is realized by the following steps:
in one aspect of the embodiment of the invention, a sampling device is provided, which includes a first rotary driver, a first bracket, and a first sampling needle and a second sampling needle respectively disposed at two sides of the first bracket, wherein a sample bottle for containing a sample liquid is correspondingly disposed below the first sampling needle, a cleaning tank for containing a cleaning liquid is correspondingly disposed below the second sampling needle, a driving end of the first rotary driver is in transmission connection with a center of the first bracket, and the first rotary driver drives the first bracket to rotate so as to interchange positions of the first sampling needle and the second sampling needle. This sampling device carries out sampling operation and washing operation simultaneously, is showing improvement film-making efficiency.
Optionally, in a preferred embodiment of the present invention, the first support includes a first main support drivingly connected to the driving end of the first rotary driver, and a first arm and a second arm symmetrically disposed at a top end of the first main support, the first sampling needle is connected to the first arm, the second sampling needle is connected to the second arm, and the first sampling needle and the second sampling needle are symmetrically disposed with respect to the first main support.
Optionally, in a preferred embodiment of the present invention, the apparatus further includes a first linear driver in transmission connection with the first support, and the first linear driver drives the first support and the first sampling needle and the second sampling needle respectively disposed at two sides of the first support to move linearly in a vertical direction, so that a sampling end of the first sampling needle and a sampling end of the second sampling needle respectively extend into the sample bottle and the washing tank.
Optionally, in a preferred embodiment of the present invention, the first rotary driver is in transmission connection with the first bracket through the first linear driver, and the first rotary driver drives the first linear driver and the first bracket to rotate.
Optionally, in a preferred embodiment of the present invention, the sample analyzer further includes a second rotary driver, a second support, and a first sample injection needle and a second sample injection needle respectively disposed at two sides of the second support, a sedimentation bin for injecting a sample liquid is correspondingly disposed below the first sample injection needle, a recovery tank for recovering a cleaning liquid is correspondingly disposed below the second sample injection needle, a tail end of the first sample injection needle is communicated with a tail end of the first sampling needle through a pipeline, a tail end of the second sample injection needle is communicated with a tail end of the second sampling needle through a pipeline, a driving end of the second rotary driver is in transmission connection with a center of the second support, and the second rotary driver drives the second support to rotate so as to interchange a position of the first sample injection needle and a position of the second sample injection needle.
Optionally, in a preferred embodiment of the present invention, the second support includes a second main support in transmission connection with a driving end of the second rotary driver, and a third arm and a fourth arm symmetrically disposed at a top end of the second main support, the first sample injection needle is connected to the third arm, the second sample injection needle is connected to the fourth arm, and the first sample injection needle and the second sample injection needle are symmetrically disposed with respect to the second main support.
Optionally, in a preferred embodiment of the present invention, the sample collection device further includes a second linear driver in transmission connection with the second support, and the second linear driver drives the second support and the first sample injection needle and the second sample injection needle respectively disposed at two sides of the second support to move linearly in a vertical direction, so that the sample injection end of the first sample injection needle and the sample injection end of the second sample injection needle respectively extend into the settling bin and the recovery tank.
Optionally, in a preferred embodiment of the present invention, the second linear driver is in transmission connection with the second bracket through the second rotary driver, and the second linear driver drives the second rotary driver and the second bracket to move.
Optionally, in a preferred embodiment of the present invention, the apparatus further includes a controller, and the controller is electrically connected to the first rotary driver and the second rotary driver respectively, and is configured to control the first rotary driver and the second rotary driver to rotate.
According to another aspect of the embodiments of the present invention, there is provided a liquid-based cell pelleter, comprising the above-mentioned sampling device. This sampling device carries out sampling operation and washing operation simultaneously, is showing improvement film-making efficiency.
The embodiment of the invention has the beneficial effects that:
the sampling device comprises a first rotary driver and a first bracket, wherein the driving end of the first rotary driver is in transmission connection with the center of the first bracket, so that the sampling device can drive the first bracket to rotate around the center of the first bracket through the first rotary driver. The sampling device further comprises a first sampling needle and a second sampling needle, wherein the first sampling needle and the second sampling needle are respectively arranged on two sides of the first support, so that the position of the first sampling needle and the position of the second sampling needle can be interchanged along with the rotation of the first support. In the first case, the position of the first sampling needle is correspondingly located above the sample bottle so as to extract the sample liquid in the sample bottle through the first sampling needle and perform the sampling operation on the first sampling needle, and the position of the second sampling needle is correspondingly located above the cleaning tank so as to extract the cleaning liquid in the cleaning tank through the second sampling needle and perform the cleaning operation on the second sampling needle. Subsequently, the first sampling needle is polluted, a cleaning operation is required, the second sampling needle is cleaned, and the sampling operation can be carried out, at the moment, the first bracket is driven to rotate through the first rotary driver, so that the position of the first sampling needle and the position of the second sampling needle are interchanged. In the second case, the position correspondence of first sampling needle is located the top of washing tank to thereby extract the washing liquid in the washing tank through first sampling needle and carry out the cleaning operation to first sampling needle, the position correspondence of second sampling needle is located the top of sample bottle, thereby extracts the sample liquid in the sample bottle through second sampling needle and carry out the sampling operation to second sampling needle. Subsequently, the first sampling needle is cleaned to complete the sampling operation, the second sampling needle is polluted to be cleaned, at the moment, the first support is driven to rotate through the first rotary driver, so that the position of the first sampling needle and the position of the second sampling needle are exchanged again, and the steps can be repeated to realize circulation. In conclusion, this sampling device can carry out sampling operation and washing operation respectively to first sampling needle and second sampling needle to make this sampling device can carry out sampling operation and washing operation simultaneously, compare in prior art, carry out the sample operation back through the sampling needle, still need carry out the washing operation back with the sampling needle, just can put into use the film-making process, this sampling device can show improvement film-making efficiency.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained according to the drawings without inventive efforts.
Fig. 1 is a schematic structural diagram of a sampling device according to an embodiment of the present invention;
fig. 2 is a second schematic structural diagram of a sampling device according to an embodiment of the present invention;
fig. 3 is a third schematic structural diagram of a sampling device according to an embodiment of the present invention;
fig. 4 is a fourth schematic structural diagram of a sampling device according to an embodiment of the present invention.
Icon: 100-a sampling device; 10-a first scaffold; 11-a first main support; 12-a first arm; 13-a second arm; 20-a first sampling needle; 21-a second sampling needle; 30-a first rotary drive; 31-a first linear driver; 40-a second scaffold; 41-a second main support; 42-third arm; 43-a fourth arm; 50-a first injection needle; 51-a second injection needle; 60-a second rotary drive; 61-a second linear drive; 70-a controller; 80-peristaltic pump.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all, embodiments of the present invention. The components of embodiments of the present invention generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations.
Thus, the following detailed description of the embodiments of the present invention, presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, it need not be further defined and explained in subsequent figures.
In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings or the orientations or positional relationships that the products of the present invention are conventionally placed in use, and are only used for convenience in describing the present invention and simplifying the description, but do not indicate or imply that the devices or elements referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," "third," and the like are used solely to distinguish one from another and are not to be construed as indicating or implying relative importance.
Furthermore, the terms "horizontal", "vertical" and the like do not imply that the components are required to be absolutely horizontal or pendant, but rather may be slightly inclined. For example, "horizontal" merely means that the direction is more horizontal than "vertical" and does not mean that the structure must be perfectly horizontal, but may be slightly inclined.
In the description of the present invention, it should also be noted that, unless otherwise explicitly specified or limited, the terms "disposed," "mounted," "connected," and "connected" are to be construed broadly and may, for example, be fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; either directly or indirectly through intervening media, or may be internal to both elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
Referring to fig. 1, the present embodiment provides a sampling device 100, which includes a first rotary driver 30, a first support 10, and a first sampling needle 20 and a second sampling needle 21 respectively disposed at two sides of the first support 10, wherein a sample bottle (not shown) for containing a sample liquid is correspondingly disposed below the first sampling needle 20, a cleaning tank for containing a cleaning liquid is correspondingly disposed below the second sampling needle 21, a driving end of the first rotary driver 30 is in transmission connection with a center of the first support 10, and the first rotary driver 30 drives the first support 10 to rotate so as to interchange a position of the first sampling needle 20 with a position of the second sampling needle 21. This sampling device 100 carries out sampling operation and washing operation simultaneously, is showing improvement film-making efficiency.
It should be noted that, as shown in fig. 1, the sampling device 100 includes a first rotary driver 30 and a first support 10, and a driving end of the first rotary driver 30 is in transmission connection with a center of the first support 10, so that the sampling device 100 can drive the first support 10 to rotate around the center of the first support 10 through the first rotary driver 30. Since the sampling device 100 further includes the first sampling needle 20 and the second sampling needle 21, and the first sampling needle 20 and the second sampling needle 21 are both disposed on the first rack 10, both the first sampling needle 20 and the second sampling needle 21 can rotate along with the rotation of the first rack 10, that is, the position of the first sampling needle 20 and the position of the second sampling needle 21 are not completely fixed, but can change along with the rotation of the first rack 10. Since the first sampling needle 20 and the second sampling needle 21 are respectively disposed at both sides of the first holder 10, the positions of the first sampling needle 20 and the second sampling needle 21 can be interchanged with the rotation of the first holder 10.
It should be noted that, as shown in fig. 1, a sample bottle for containing a sample liquid is correspondingly disposed below the first sampling needle 20, and a cleaning tank for containing a cleaning liquid is correspondingly disposed below the second sampling needle 21, which means that in the first case, a sample bottle is correspondingly arranged below the first sampling needle 20, a cleaning groove is correspondingly arranged below the second sampling needle 21, in other words, in the first case, the first sampling needle 20 is located above the sample bottle, and the second sampling needle 21 is located above the washing bath, that is, reference is made here only to the position of the first sampling needle 20 and the position of the second sampling needle 21 in the first case, the description of the position of the sample bottle and the position of the washing tub does not mean that the sample bottle must be always located under the first sampling needle 20 and the washing tub must be always located under the second sampling needle 21.
In fact, it can be known from the foregoing that, in the second case (after the positions of the first sampling needle 20 and the second sampling needle 21 in the first case are interchanged), the position of the first sampling needle 20 corresponds to the position above the cleaning tank, and the position of the second sampling needle 21 corresponds to the position above the sample bottle. Just so, this sampling device 100 can carry out sampling operation and washing operation respectively to first sampling needle 20 and second sampling needle 21 to make this sampling device 100 can carry out sampling operation and washing operation simultaneously, compare in prior art, carry out the sample operation back through the sampling needle, still need carry out the washing operation back with the sampling needle, just can put into use the film-making process, this sampling device 100 can show improvement film-making efficiency.
Specifically, in the first case, the first sampling needle 20 is located above the sample bottle to extract the sample liquid in the sample bottle through the first sampling needle 20 so as to perform the sampling operation on the first sampling needle 20, and the second sampling needle 21 is located above the cleaning tank to extract the cleaning liquid in the cleaning tank through the second sampling needle 21 so as to perform the cleaning operation on the second sampling needle 21. Subsequently, the first sampling needle 20 is contaminated to perform a cleaning operation, and the second sampling needle 21 is cleaned to perform a sampling operation, at which time the first support 10 is driven to rotate by the first rotary driver 30 so that the positions of the first sampling needle 20 and the second sampling needle 21 are interchanged.
Specifically, in the second case, the first sampling needle 20 is located above the cleaning tank to extract the cleaning solution in the cleaning tank through the first sampling needle 20 so as to perform the cleaning operation on the first sampling needle 20, and the second sampling needle 21 is located above the sample bottle to extract the sample solution in the sample bottle through the second sampling needle 21 so as to perform the sampling operation on the second sampling needle 21. Subsequently, the first sampling needle 20 is cleaned to perform the sampling operation, and the second sampling needle 21 is contaminated to perform the cleaning operation, at this time, the first support 10 is driven to rotate by the first rotary driver 30, so that the positions of the first sampling needle 20 and the second sampling needle 21 are exchanged again, and the above steps can be repeated to realize the cycle.
As described above, the sampling device 100 includes the first rotary driver 30 and the first support 10, and the driving end of the first rotary driver 30 is drivingly connected to the center of the first support 10, so that the sampling device 100 can drive the first support 10 to rotate around the center of the first support 10 through the first rotary driver 30. The sampling device 100 further comprises a first sampling needle 20 and a second sampling needle 21, wherein the first sampling needle 20 and the second sampling needle 21 are respectively arranged at two sides of the first bracket 10, so that the position of the first sampling needle 20 and the position of the second sampling needle 21 can be interchanged along with the rotation of the first bracket 10. In the first case, the first sampling needle 20 is located above the sample bottle to extract the sample liquid in the sample bottle through the first sampling needle 20 so as to perform the sampling operation on the first sampling needle 20, and the second sampling needle 21 is located above the cleaning tank to extract the cleaning liquid in the cleaning tank through the second sampling needle 21 so as to perform the cleaning operation on the second sampling needle 21. Subsequently, the first sampling needle 20 is contaminated to perform a cleaning operation, and the second sampling needle 21 is cleaned to perform a sampling operation, at which time the first support 10 is driven to rotate by the first rotary driver 30 so that the positions of the first sampling needle 20 and the second sampling needle 21 are interchanged. In the second case, the first sampling needle 20 is located above the cleaning tank to extract the cleaning solution in the cleaning tank through the first sampling needle 20 so as to perform the cleaning operation on the first sampling needle 20, and the second sampling needle 21 is located above the sample bottle to extract the sample solution in the sample bottle through the second sampling needle 21 so as to perform the sampling operation on the second sampling needle 21. Subsequently, the first sampling needle 20 is cleaned to perform the sampling operation, and the second sampling needle 21 is contaminated to perform the cleaning operation, at this time, the first support 10 is driven to rotate by the first rotary driver 30, so that the positions of the first sampling needle 20 and the second sampling needle 21 are exchanged again, and the above steps can be repeated to realize the cycle. In conclusion, this sampling device 100 can carry out sampling operation and washing operation respectively to first sampling needle 20 and second sampling needle 21 to make this sampling device 100 can carry out sampling operation and washing operation simultaneously, compare in prior art, carry out the sample operation back through the sampling needle, still need carry out the washing operation back with the sampling needle, just can put into use the film-making process, this sampling device 100 can show improvement film-making efficiency.
As shown in fig. 1, in the present embodiment, the first support 10 includes a first main support 11 drivingly connected to a driving end of the first rotary driver 30, and a first arm 12 and a second arm 13 symmetrically disposed on a top end of the first main support 11, the first sampling needle 20 is connected to the first arm 12, the second sampling needle 21 is connected to the second arm 13, and the first sampling needle 20 and the second sampling needle 21 are symmetrically disposed with respect to the first main support 11.
First, in the present embodiment, in order to facilitate the control of the rotation angle of the first rotary driver 30, the first arm 12 and the second arm 13 are symmetrically disposed with respect to the first main supporter 11, and the first sampling needle 20 and the second sampling needle 21 are symmetrically disposed with respect to the first main supporter 11, so that the first rotary driver 30 drives the first supporter 10 to rotate 180 ° to interchange the positions of the first sampling needle 20 and the second sampling needle 21.
Secondly, the actual shape and extending direction of the first arm 12 and the second arm 13 are not particularly limited, and those skilled in the art should be able to design and select them appropriately according to the actual situation. Illustratively, the first bracket 10 may have a T-shaped configuration, a Y-shaped configuration, a U-shaped configuration, a convex-shaped configuration, a concave-shaped configuration, or the like. In order to facilitate the control of the first sampling needle 20 and the second sampling needle 21 to perform the sampling operation and the cleaning operation at the same time, in the present embodiment, the first sampling needle 20 and the second sampling needle 21 are both disposed along the vertical direction.
Third, the rotating direction of the first rotary driver 30 is not limited in particular, and those skilled in the art should be able to design and select the direction appropriately according to the actual situation. For example, the first rotary actuator 30 may always rotate clockwise along the horizontal direction, may always rotate counterclockwise along the horizontal direction, may always rotate in a "clockwise-counterclockwise" cycle along the horizontal direction, and may also rotate in a "counterclockwise-clockwise-counterclockwise" cycle along the horizontal direction.
As illustrated in the first case, since the sampling end of the first sampling needle 20 and the sampling end of the second sampling needle 21 need to respectively extend into the sample bottle to extract the sample solution and the cleaning tank to extract the cleaning solution, and interference between the rotation of the first sampling needle 20 and the rotation of the second sampling needle 21 by the sample bottle and the cleaning tank is avoided, the first sampling needle 20 and the second sampling needle 21 need to be capable of performing linear motion in the vertical direction. In this embodiment, the sampling device 100 further includes a first linear driver 31 in transmission connection with the first rack 10, the first linear driver 31 drives the first rack 10 and the first sampling needle 20 and the second sampling needle 21 respectively disposed at two sides of the first rack 10 to move linearly in a vertical direction, so that when the first sampling needle 20 and the second sampling needle 21 are required to be sampled and cleaned, the sampling end of the first sampling needle 20 and the sampling end of the second sampling needle 21 can respectively extend into the sample bottle and the cleaning tank, and when the position of the first sampling needle 20 and the position of the second sampling needle 21 are required to be driven by the first rotary driver 30 to be interchanged, the sampling end of the first sampling needle 20 and the sampling end of the second sampling needle 21 can be respectively far away from the tops of the sample bottle and the cleaning tank to avoid interference.
As shown in fig. 1, in the present embodiment, the first rotary driver 30 is in transmission connection with the first bracket 10 through the first linear driver 31, and the first rotary driver 30 drives the first linear driver 31 and the first bracket 10 to rotate in the horizontal direction. Of course, in other embodiments, it is also possible that the first linear driver 31 is in transmission connection with the first support 10 through the first rotary driver 30, and the first linear driver 31 drives the first rotary driver 30 and the first support 10 to move in the vertical direction.
Referring to fig. 2 again, in the present embodiment, the sampling device 100 further includes a second rotary driver 60, a second bracket 40, and a first sample injection needle 50 and a second sample injection needle 51 respectively disposed at two sides of the second bracket 40, a sedimentation chamber for injecting a sample liquid is correspondingly disposed below the first sample injection needle 50, a recovery tank for recovering a cleaning liquid is correspondingly disposed below the second sample injection needle 51, a tail end of the first sample injection needle 50 is communicated with a tail end of the first sampling needle 20 through a pipeline, a tail end of the second sample injection needle 51 is communicated with a tail end of the second sampling needle 21 through a pipeline, a driving end of the second rotary driver 60 is in transmission connection with a center of the second bracket 40, and the second rotary driver 60 drives the second bracket 40 to rotate so that a position of the first sample injection needle 50 and a position of the second sample injection needle 51 are interchanged.
Similar to the above, as shown in fig. 2, the sampling device 100 includes a second rotary driver 60 and a second bracket 40, and the driving end of the second rotary driver 60 is drivingly connected to the center of the second bracket 40, so that the sampling device 100 can drive the second bracket 40 to rotate around the center of the second bracket 40 through the second rotary driver 60. Since the sampling device 100 further includes the first and second sample injection needles 50 and 51, and the first and second sample injection needles 50 and 51 are both disposed on the second support 40, both the first and second sample injection needles 50 and 51 rotate with the rotation of the second support 40, that is, the positions of the first and second sample injection needles 50 and 51 are not completely fixed, but can change with the rotation of the second support 40. Since the first and second sampling needles 50 and 51 are respectively provided on both sides of the second holder 40, the positions of the first and second sampling needles 50 and 51 can be interchanged with the rotation of the second holder 40.
It should be noted that, as shown in fig. 2, a corresponding settling bin (not shown in the figure) for injecting the sample liquid is arranged below the first sample injection needle 50, and a corresponding recovery tank (not shown in the figure) for recovering the cleaning liquid is arranged below the second sample injection needle 51, which means that in the first case, the settling bin is arranged below the first sample injection needle 50, and the recovery tank is arranged below the second sample injection needle 51, in other words, in the first case, the position of the first sample injection needle 50 is located above the settling bin, and the position of the second sample injection needle 51 is located above the recovery tank, that is, the description of the position of the settling bin and the position of the recovery tank is only made with reference to the position of the first sample injection needle 50 and the position of the second sample injection needle 51 in the first case, and does not mean that the settling bin must always be located below the first sample injection needle 50, the recovery groove must always be located below the second sampling needle 51.
In fact, it can be known from the foregoing that, in the second case (after the positions of the first sample injection needle 50 and the second sample injection needle 51 in the first case are interchanged), the position of the first sample injection needle 50 is correspondingly located above the recovery tank, and the position of the second sample injection needle 51 is correspondingly located above the settling bin. Just so, this sampling device 100 can annotate appearance needle 50 and second and annotate appearance needle 51 and carry out sampling operation and washing operation respectively to making this sampling device 100 can carry out sampling operation and washing operation simultaneously, compare in prior art, carry out the sample operation back through the sampling needle, still need pour into the sample liquid in the sampling needle into the subsider, after the rethread sampling needle carries out washing operation, still need let in the waste liquid in the sampling needle the accumulator, the film-making process that just can put into use, this sampling device 100 can show still further and improve film-making efficiency.
Specifically, in the first case, the first sample injection needle 50 is located above the settling bin to inject the sample liquid extracted by the first sampling needle 20 into the settling bin through the first sample injection needle 50 so as to perform a sampling operation on the first sample injection needle 50, and the second sample injection needle 51 is located above the recovery tank to inject the cleaning liquid extracted by the second sampling needle 21 into the recovery tank through the second sample injection needle 51 so as to perform a cleaning operation on the second sample injection needle 51. Subsequently, the first sample injection needle 50 is contaminated, which requires a cleaning operation, and the second sample injection needle 51 is cleaned to perform a sampling operation, at which time the second support 40 is driven to rotate by the second rotary driver 60, so that the positions of the first sample injection needle 50 and the second sample injection needle 51 are interchanged.
Specifically, in the second case, the first sample injection needle 50 is located above the recovery tank to inject the cleaning solution extracted by the first sampling needle 20 into the recovery tank through the first sample injection needle 50 so as to perform the cleaning operation on the first sample injection needle 50, and the second sample injection needle 51 is located above the settling bin to inject the sample solution extracted by the second sampling needle 21 into the settling bin through the second sample injection needle 51 so as to perform the sampling operation on the second sample injection needle 51. Subsequently, the first sample injection needle 50 is cleaned to perform a sampling operation, and the second sample injection needle 51 is contaminated to perform a cleaning operation, at this time, the second rotating driver 60 drives the second bracket 40 to rotate, so that the positions of the first sample injection needle 50 and the second sample injection needle 51 are exchanged again, and the above steps can be repeated to realize a cycle.
As shown in fig. 2, in the present embodiment, the second support 40 includes a second main support 41 drivingly connected to the driving end of the second rotary driver 60, and a third arm 42 and a fourth arm 43 symmetrically disposed on the top end of the second main support 41, the first sample injection needle 50 is connected to the third arm 42, the second sample injection needle 51 is connected to the fourth arm 43, and the first sample injection needle 50 and the second sample injection needle 51 are symmetrically disposed with respect to the second main support 41.
Similarly to the above, in the present embodiment, in order to facilitate the control of the rotation angle of the second rotary driver 60, the third arm 42 and the fourth arm 43 are symmetrically disposed with respect to the second main support 41, and the first sample injection needle 50 and the second sample injection needle 51 are symmetrically disposed with respect to the second main support 41, so that the second rotary driver 60 drives the second support 40 to rotate 180 ° to interchange the position of the first sample injection needle 50 and the position of the second sample injection needle 51.
Secondly, the actual shape and extending direction of the third arm 42 and the fourth arm 43 are not limited in particular, and those skilled in the art should be able to design and select them appropriately according to the actual situation. Illustratively, the second bracket 40 may have a T-shaped configuration, a Y-shaped configuration, a U-shaped configuration, a male configuration, a female configuration, or the like. In order to facilitate control of the first and second sample injection needles 50 and 51 to perform the sampling operation and the cleaning operation at the same time, in the present embodiment, the first and second sample injection needles 50 and 51 are both disposed in the vertical direction.
Thirdly, the rotating direction of the second rotary driver 60 is not particularly limited, and those skilled in the art should be able to design and select the direction appropriately according to the actual situation. For example, the second rotary actuator 60 may always perform clockwise rotation along the horizontal direction, may always perform counterclockwise rotation along the horizontal direction, may perform "clockwise-counterclockwise-clockwise" cyclic rotation along the horizontal direction, and may perform "counterclockwise-clockwise-counterclockwise" cyclic rotation along the horizontal direction.
Here, as an example of the first case, since the sample injection end of the first sample injection needle 50 and the sample injection end of the second sample injection needle 51 need to respectively extend into the settling bin for injecting the sample liquid and the recovery tank for injecting the cleaning liquid, and interference of the settling bin and the recovery tank on rotation of the first sample injection needle 50 and rotation of the second sample injection needle 51 is also avoided, the first sample injection needle 50 and the second sample injection needle 51 need to be capable of performing linear motion in the vertical direction. In this embodiment, the sampling device 100 further includes a second linear driver 61 in transmission connection with the second support 40, the second linear driver 61 drives the second support 40 and the first sample injection needle 50 and the second sample injection needle 51 respectively disposed at two sides of the second support 40 to move linearly in the vertical direction, so that when the first sample injection needle 50 and the second sample injection needle 51 need to be sampled and cleaned, the sample injection end of the first sample injection needle 50 and the sample injection end of the second sample injection needle 51 can respectively extend into the settling chamber and the recovery tank, and when the position of the first sample injection needle 50 and the position of the second sample injection needle 51 need to be driven by the second rotary driver 60 to be interchanged, the sample injection end of the first sample injection needle 50 and the sample injection end of the second sample injection needle 51 can respectively be far away from the tops of the settling chamber and the recovery tank to avoid interference.
As shown in fig. 2, in the present embodiment, the second linear actuator 61 is in transmission connection with the second bracket 40 through the second rotary actuator 60, and the second linear actuator 61 drives the second rotary actuator 60 and the second bracket 40 to move. Of course, in other embodiments, the second rotary driver 60 may be in transmission connection with the second bracket 40 through the second linear driver 61, and the second rotary driver 60 drives the second linear driver 61 and the second bracket 40 to move.
In order to avoid the winding of the pipe connecting the first sampling needle 20 and the first injection needle 50 and the pipe connecting the second sampling needle 21 and the second injection needle 51, the first rotary driver 30 and the second rotary driver 60 should rotate at the same time, in the same direction, and at the same angle. To this end, referring to fig. 3 again, in the present embodiment, the sampling device 100 further includes a controller 70, and the controller 70 is electrically connected to the first rotary driver 30 and the second rotary driver 60 respectively, and is used for controlling the first rotary driver 30 and the second rotary driver 60 to rotate, so as to control the rotation of the first rotary driver 30 and the second rotary driver 60 through the controller 70, thereby significantly improving the automation degree of the sampling device 100.
In addition, referring to fig. 4, the tube connecting the first sampling needle 20 and the first sample injection needle 50 and the tube connecting the second sampling needle 21 and the second sample injection needle 51 are respectively provided with a peristaltic pump 80 for providing suction force, and the peristaltic pump 80 is electrically connected to the controller 70 to precisely control the dosage of the sampling operation and the cleaning operation.
It should be noted by those skilled in the art that the cleaning solution disposed in the cleaning tank and used in the cleaning operation as described above refers to a liquid that can be used for cleaning the sampling needle or the injection needle in a broad sense, and does not refer to only a cleaning solution in a narrow sense, but may actually include a buffer solution and the like.
The application also provides a liquid-based cell pelleter. The liquid-based cell pelleter provided by this embodiment includes the above-mentioned sampling device 100. Since the structure and the advantageous effects of the sampling device 100 have been described in detail in the foregoing embodiments, no further description is provided herein.
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. The utility model provides a sampling device, its characterized in that, include first rotary actuator, first support and set up respectively in the first sampling needle and the second sampling needle of first support both sides, first sampling needle below corresponds the sample bottle that sets up and is used for holding sample liquid, second sampling needle below corresponds the setting and is used for holding the washing tank of washing liquid, first rotary actuator's drive end with the center transmission of first support is connected, first rotary actuator drive first support rotates so that the position of first sampling needle with the position interchange of second sampling needle.
2. The sampling device of claim 1, wherein the first support comprises a first main support in driving connection with a driving end of the first rotary driver, and a first arm and a second arm symmetrically arranged on a top end of the first main support, the first sampling needle is connected and arranged on the first arm, the second sampling needle is connected and arranged on the second arm, and the first sampling needle and the second sampling needle are symmetrically arranged relative to the first main support.
3. The sampling device according to claim 1 or 2, further comprising a first linear driver in transmission connection with the first support, wherein the first linear driver drives the first support and the first sampling needle and the second sampling needle respectively arranged at two sides of the first support to move linearly in a vertical direction, so that the sampling end of the first sampling needle and the sampling end of the second sampling needle respectively extend into the sample bottle and the washing tank.
4. The sampling device of claim 3, wherein the first rotary drive is in driving connection with the first rack via the first linear drive, the first rotary drive driving the first linear drive and the first rack to rotate.
5. The sampling device according to claim 1, further comprising a second rotary driver, a second support, and a first sample injection needle and a second sample injection needle respectively disposed on two sides of the second support, wherein a sedimentation bin for injecting a sample liquid is correspondingly disposed below the first sample injection needle, a recovery tank for recovering a cleaning liquid is correspondingly disposed below the second sample injection needle, a tail end of the first sample injection needle is communicated with a tail end of the first sampling needle through a pipeline, a tail end of the second sample injection needle is communicated with a tail end of the second sampling needle through a pipeline, a driving end of the second rotary driver is in transmission connection with a center of the second support, and the second rotary driver drives the second support to rotate so that a position of the first sample injection needle and a position of the second sample injection needle are interchanged.
6. The sampling device of claim 5, wherein the second support comprises a second main support in transmission connection with a driving end of the second rotary driver, and a third arm and a fourth arm symmetrically arranged at the top end of the second main support, the first sample injection needle is arranged on the third arm in connection, the second sample injection needle is arranged on the fourth arm in connection, and the first sample injection needle and the second sample injection needle are symmetrically arranged relative to the second main support.
7. The sampling device according to claim 5 or 6, further comprising a second linear driver in transmission connection with the second support, wherein the second linear driver drives the second support and the first sample injection needle and the second sample injection needle respectively arranged at two sides of the second support to move linearly in a vertical direction, so that the sample injection ends of the first sample injection needle and the second sample injection needle respectively extend into the settling bin and the recovery tank.
8. The sampling device of claim 7, wherein the second linear drive is in driving connection with the second support via the second rotary drive, the second linear drive driving the second rotary drive and the second support in motion.
9. The sampling device of claim 5, further comprising a controller electrically connected to the first and second rotary drivers, respectively, for controlling the rotation of the first and second rotary drivers.
10. A liquid-based cell pelleter comprising a sampling device according to any one of claims 1 to 9.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011070674.0A CN112098157A (en) | 2020-10-09 | 2020-10-09 | Sampling device and liquid-based cell pelleter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011070674.0A CN112098157A (en) | 2020-10-09 | 2020-10-09 | Sampling device and liquid-based cell pelleter |
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| CN112098157A true CN112098157A (en) | 2020-12-18 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011070674.0A Pending CN112098157A (en) | 2020-10-09 | 2020-10-09 | Sampling device and liquid-based cell pelleter |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116875439A (en) * | 2023-09-07 | 2023-10-13 | 微纳动力(北京)科技有限责任公司 | Cell sampling and cleaning device |
| CN117705542A (en) * | 2024-02-05 | 2024-03-15 | 珠海迪尔生物工程股份有限公司 | Specimen pretreatment system |
-
2020
- 2020-10-09 CN CN202011070674.0A patent/CN112098157A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116875439A (en) * | 2023-09-07 | 2023-10-13 | 微纳动力(北京)科技有限责任公司 | Cell sampling and cleaning device |
| CN117705542A (en) * | 2024-02-05 | 2024-03-15 | 珠海迪尔生物工程股份有限公司 | Specimen pretreatment system |
| CN117705542B (en) * | 2024-02-05 | 2024-05-31 | 珠海迪尔生物工程股份有限公司 | Specimen pretreatment system |
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