CN112263661A - Compound essential oil traditional Chinese medicine composition for improving cardiovascular problems as well as preparation method and application thereof - Google Patents

Compound essential oil traditional Chinese medicine composition for improving cardiovascular problems as well as preparation method and application thereof Download PDF

Info

Publication number
CN112263661A
CN112263661A CN202011179271.XA CN202011179271A CN112263661A CN 112263661 A CN112263661 A CN 112263661A CN 202011179271 A CN202011179271 A CN 202011179271A CN 112263661 A CN112263661 A CN 112263661A
Authority
CN
China
Prior art keywords
essential oil
parts
oil
chinese medicine
traditional chinese
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202011179271.XA
Other languages
Chinese (zh)
Inventor
罗晶
杜清
杨明
刘波
雷志强
李林
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiangxi University of Traditional Chinese Medicine
Original Assignee
Jiangxi University of Traditional Chinese Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangxi University of Traditional Chinese Medicine filed Critical Jiangxi University of Traditional Chinese Medicine
Priority to CN202011179271.XA priority Critical patent/CN112263661A/en
Publication of CN112263661A publication Critical patent/CN112263661A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/324—Boswellia, e.g. frankincense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/84—Valerianaceae (Valerian family), e.g. valerian
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/89—Cyperaceae (Sedge family)
    • A61K36/8905—Cyperus (flatsedge)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/009—Sachets, pouches characterised by the material or function of the envelope
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a compound essential oil traditional Chinese medicine composition for improving cardiovascular problems, a preparation method and application thereof, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 1-20 parts of ligusticum wallichii essential oil, 1-15 parts of angelica essential oil, 1-10 parts of storax essential oil, 5-15 parts of frankincense essential oil, 5-15 parts of myrrh essential oil, 1-10 parts of cinnamon essential oil, 2-20 parts of dalbergia wood essential oil, 3-20 parts of radix curcumae essential oil, 3-15 parts of rhizoma cyperi essential oil, 1-10 parts of sandalwood essential oil, 5-25 parts of benzoin essential oil, 3-10 parts of rhizoma acori graminei essential oil, 1-8 parts of valerian essential oil, 5-20 parts of lavender essential oil, 3-15 parts of borneol and 95-100 parts of base oil. The compound essential oil contains the following components in parts by weight: the heart rate can be effectively improved and the heart can be protected after the components such as the ligusticum wallichii essential oil, the angelica essential oil, the storax essential oil, the frankincense essential oil, the myrrh essential oil, the cinnamon essential oil, the dalbergia wood essential oil and the like are matched and used at a specific dosage.

Description

Compound essential oil traditional Chinese medicine composition for improving cardiovascular problems as well as preparation method and application thereof
Technical Field
The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a compound essential oil traditional Chinese medicine composition for improving cardiovascular problems, and a preparation method and application thereof.
Background
With the change of the dietary structure, the travel mode and the living habits of modern people, the morbidity and the mortality of cardiovascular diseases are increased year by year, and the results of global disease burden research are reported: cardiovascular diseases have become the most deadly of the non-infectious diseases at present, and the diseases are more frequently encountered in human beings and are closely related to the high incidence of disability and death. Modern medicine has adopted primary or secondary prevention in prevention and treatment to control blood pressure, blood lipid and thrombosis, slow down the development of Atherosclerosis (AS), and control the development of cardiovascular diseases. However, in the current clinical application of traditional hypotensive drugs, hypolipidemic drugs, antiplatelet drugs and the like, a series of side effects such as cough, flushing, headache, shortness of breath and the like often appear after patients take the traditional hypotensive drugs, hypolipidemic drugs, antiplatelet drugs and the like. Therefore, the clinical problem is to find drugs that can reduce cardiovascular risk and have low side effects.
Modern researches have shown that the aromatic Chinese medicine has definite and reliable curative effect on cardiovascular diseases, especially ischemic heart diseases. Aromatic Chinese medicines have a special aromatic odor in which essential oil components are widely present, and essential oil is a volatile aromatic substance extracted from flowers, leaves, stems, roots or fruits of aromatic plants, and is used in national, traditional and folk medicine worldwide for treating various health problems.
Aromatic Chinese medicines for treating ischemic cardiomyopathy and the like belong to modern cardiovascular diseases for a long time, and with continuous research and development of essential oil at home and abroad in recent years, more plant essential oil can be used for treating the cardiovascular diseases of ischemic cardiomyopathy.
A large number of animal experiments show that the essential oil has the beneficial cardiovascular characteristics of resisting thrombus and platelet, protecting vascular endothelium, resisting oxidation, improving vascular elasticity, reducing blood pressure and the like, and some essential oil components can obviously improve cardiovascular diseases by removing oxygen free radicals, relaxing blood vessels, improving lipid metabolism, reducing heart rate, resisting platelet aggregation and the like.
In the prior art, no actual compound essential oil composition is used for improving the cardiovascular problem, and the research on treating the cardiovascular disease by aromatic traditional Chinese medicines is very little.
Disclosure of Invention
The invention provides a compound essential oil traditional Chinese medicine composition for improving cardiovascular problems, a preparation method and application thereof, wherein the compound essential oil comprises the following components in parts by weight: the heart rate can be effectively improved and the heart can be protected after the components such as ligusticum wallichii essential oil, angelica essential oil, storax essential oil, frankincense essential oil, myrrh essential oil, cinnamon essential oil, dalbergia wood essential oil, radix curcumae essential oil, rhizoma cyperi essential oil, sandalwood essential oil, benzoin essential oil, rhizoma acori graminei essential oil, valerian essential oil, lavender essential oil, borneol and the like are matched and used at a specific dosage.
The technical scheme adopted by the invention is as follows:
the compound essential oil traditional Chinese medicine composition for improving the cardiovascular problem comprises the following components in parts by weight: 1-20 parts of ligusticum wallichii essential oil, 1-15 parts of angelica essential oil, 1-10 parts of storax essential oil, 5-15 parts of frankincense essential oil, 5-15 parts of myrrh essential oil, 1-10 parts of cinnamon essential oil, 2-20 parts of dalbergia wood essential oil, 3-20 parts of radix curcumae essential oil, 3-15 parts of rhizoma cyperi essential oil, 1-10 parts of sandalwood essential oil, 5-25 parts of benzoin essential oil, 3-10 parts of rhizoma acori graminei essential oil, 1-8 parts of valerian essential oil, 5-20 parts of lavender essential oil and 3-15 parts of borneol.
As the best mode: comprises the following components in parts by weight: 5.5 parts of ligusticum wallichii essential oil, 5.5 parts of angelica sinensis essential oil, 8 parts of storax essential oil, 7.5 parts of frankincense essential oil, 7.5 parts of myrrh essential oil, 3.5 parts of cinnamon essential oil, 9 parts of dalbergia wood essential oil, 8 parts of radix curcumae essential oil, 8 parts of rhizoma cyperi essential oil, 7 parts of sandalwood essential oil, 15 parts of benzoin essential oil, 7.5 parts of rhizoma acori graminei essential oil, 5 parts of valerian essential oil, 15 parts of lavender essential oil and 10 parts of borneol.
The rhizoma ligustici wallichii essential oil, angelica essential oil, storax essential oil, frankincense essential oil, myrrh essential oil, cinnamon essential oil, rosewood essential oil, radix curcumae essential oil, rhizoma cyperi essential oil, sandalwood essential oil, benzoin essential oil, rhizoma acori graminei essential oil, valerian essential oil and lavender essential oil are respectively prepared by taking rhizoma ligustici wallichii, angelica sinensis, storax, frankincense, myrrh, cinnamon, rosewood heart wood, radix curcumae, rhizoma cyperi, sandalwood, benzoin, rhizoma acori graminei, valerian and lavender as raw materials and adopting a steam distillation method, a low-polarity organic solvent extraction method and a carbon dioxide fluid extraction method.
Wherein the purity of the ligusticum wallichii essential oil, the angelica essential oil, the storax essential oil, the frankincense essential oil, the myrrh essential oil, the cinnamon essential oil, the dalbergia wood essential oil, the curcuma aromatica essential oil, the cyperus rotundus essential oil, the sandalwood essential oil, the benzoin essential oil, the acorus gramineus essential oil, the valerian essential oil and the lavender essential oil is more than 99 percent.
Wherein, the oil also comprises 95 to 100 parts of base oil.
Preferably, the base oil comprises 95-98 parts, and the base oil comprises at least one of sweet almond oil, grape seed oil, jojoba oil and wheat germ oil.
The invention also provides a preparation method of the compound essential oil traditional Chinese medicine composition for improving cardiovascular problems, which comprises the following steps:
the method comprises the following steps: cleaning rhizoma Ligustici Chuanxiong, radix Angelicae sinensis, storax, Olibanum, Myrrha, cortex Cinnamomi, lignum Dalbergiae Odoriferae, radix Curcumae, rhizoma Cyperi, lignum Santali albi, Benzonum, rhizoma Acori Graminei, rhizoma et radix Valerianae, and Lavender, crushing, placing into a steam extraction tank, introducing steam, extracting until the oil amount is not increased, collecting the obtained essential oil, drying with anhydrous sodium sulfate, filtering, and refining to obtain the essential oil of each raw material.
Step two: mixing rhizoma Ligustici Chuanxiong essential oil, radix Angelicae sinensis essential oil, storax essential oil, Olibanum essential oil, Myrrha essential oil, cortex Cinnamomi essential oil, lignum Dalbergiae Odoriferae essential oil, radix Curcumae essential oil, rhizoma Cyperi essential oil, lignum Santali albi essential oil, Benzonum essential oil, rhizoma Acori Graminei essential oil, rhizoma et radix Valerianae essential oil, and Lavender essential oil according to weight.
The invention also provides application of the compound essential oil traditional Chinese medicine composition for improving the cardiovascular problems in preparation of dosage forms and daily chemical products for improving the cardiovascular problems.
The compound essential oil composition comprises the following components:
and (3) ligusticum wallichii essential oil: has pungent taste and warm nature, and has effects of promoting blood circulation, activating qi-flowing, and relieving pain due to arthralgia;
angelica essential oil: has effects in promoting blood circulation and relieving pain;
storax essential oil: has effects in dredging orifice, regulating qi-flowing, promoting blood circulation, and relieving pain, and can be used for treating coronary heart disease and angina pectoris;
frankincense essential oil: can promote blood circulation and remove meridian obstruction;
myrrh essential oil: can relax muscles and tendons, promote blood circulation, remove blood stasis, and relieve pain;
cinnamon essential oil: can promote blood circulation and relieve pain;
and (3) dalbergia wood essential oil: has effects in regulating qi, relieving pain, dispelling blood stasis, and stopping bleeding;
turmeric root-tuber essential oil: has effects in promoting blood circulation, dredging channels, and relieving pain;
and (2) nutgrass galingale rhizome essential oil: can regulate qi and relieve depression;
sandalwood essential oil: can be used for treating chest pain, abdominal pain, coronary heart disease, and chest pain;
benzoin essential oil: has effects in refreshing mind, promoting qi circulation, promoting blood circulation, and relieving pain, and can be used for treating sudden cardialgia;
grass-leaved sweetflag essential oil: can induce resuscitation and dispel phlegm;
valerian essential oil: can dispel wind and relieve spasm;
lavender essential oil: can be used for treating cardiovascular disorder;
borneol: has effects in inducing resuscitation, dispelling stagnated fire, relieving swelling and pain, and improving heart rate.
The invention has the following advantages:
1. the invention is a preparation obtained by a large number of preparation process tests and pharmacological and pharmacodynamic tests under the guidance of the theory of traditional Chinese medicine;
2. the compound essential oil contains the following components in parts by weight: after the ligusticum wallichii essential oil, the angelica essential oil, the storax essential oil, the frankincense essential oil, the myrrh essential oil, the cinnamon essential oil, the dalbergia wood essential oil, the radix curcumae essential oil, the rhizoma cyperi essential oil, the sandalwood essential oil, the benzoin essential oil, the rhizoma acori graminei essential oil, the valerian essential oil, the lavender essential oil, the borneol and other components are used in a matched mode under a specific dosage, the heart rate can be effectively improved, and the heart protection effect is achieved;
3. the sachet and the sachet are prepared by spraying the compound essential oil into the aromatic medicinal materials, and when the volatile liquid of the sachet is in contact with the air, the volatile components in the traditional Chinese medicine essential oil and the aromatic medicinal materials are released into the air, so that the aromatic smell is emitted, and the effects of calming, heart rate improving and the like are exerted.
Detailed Description
The present invention will be further described below, but the present invention is not limited to these.
Examples
The compound essential oil traditional Chinese medicine composition for improving the cardiovascular problem comprises the following components in parts by weight: 5.5 parts of ligusticum wallichii essential oil, 5.5 parts of angelica sinensis essential oil, 8 parts of storax essential oil, 7.5 parts of frankincense essential oil, 7.5 parts of myrrh essential oil, 3.5 parts of cinnamon essential oil, 9 parts of dalbergia wood essential oil, 8 parts of radix curcumae essential oil, 8 parts of rhizoma cyperi essential oil, 7 parts of sandalwood essential oil, 15 parts of benzoin essential oil, 7.5 parts of rhizoma acori graminei essential oil, 5 parts of valerian essential oil, 15 parts of lavender essential oil and 10 parts of borneol.
The rhizoma ligustici wallichii essential oil, angelica essential oil, storax essential oil, frankincense essential oil, myrrh essential oil, cinnamon essential oil, rosewood essential oil, radix curcumae essential oil, rhizoma cyperi essential oil, sandalwood essential oil, benzoin essential oil, rhizoma acori graminei essential oil, valerian essential oil and lavender essential oil are respectively prepared by taking rhizoma ligustici wallichii, angelica sinensis, storax, frankincense, myrrh, cinnamon, rosewood heart wood, radix curcumae, rhizoma cyperi, sandalwood, benzoin, rhizoma acori graminei, valerian and lavender as raw materials and adopting a steam distillation method, a low-polarity organic solvent extraction method and a carbon dioxide fluid extraction method.
Wherein the purity of the ligusticum wallichii essential oil, the angelica essential oil, the storax essential oil, the frankincense essential oil, the myrrh essential oil, the cinnamon essential oil, the dalbergia wood essential oil, the curcuma aromatica essential oil, the cyperus rotundus essential oil, the sandalwood essential oil, the benzoin essential oil, the acorus gramineus essential oil, the valerian essential oil and the lavender essential oil is more than 99 percent.
Wherein the base oil comprises at least one of sweet almond oil, grape seed oil, jojoba oil and wheat germ oil.
The invention also provides a preparation method of the compound essential oil traditional Chinese medicine composition for improving cardiovascular problems, which comprises the following steps:
the method comprises the following steps: cleaning rhizoma Ligustici Chuanxiong, radix Angelicae sinensis, storax, Olibanum, Myrrha, cortex Cinnamomi, lignum Dalbergiae Odoriferae, radix Curcumae, rhizoma Cyperi, lignum Santali albi, Benzonum, rhizoma Acori Graminei, rhizoma et radix Valerianae, and Lavender, crushing, placing into a steam extraction tank, introducing steam, extracting until the oil amount is not increased, collecting the obtained essential oil, drying with anhydrous sodium sulfate, filtering, and refining to obtain the essential oil of each raw material.
Step two: taking 5.5 parts of ligusticum wallichii essential oil, 5.5 parts of angelica sinensis essential oil, 8 parts of storax essential oil, 7.5 parts of frankincense essential oil, 7.5 parts of myrrh essential oil, 3.5 parts of cinnamon essential oil, 9 parts of dalbergia wood essential oil, 8 parts of radix curcumae essential oil, 8 parts of rhizoma cyperi essential oil, 7 parts of sandalwood essential oil, 15 parts of benzoin essential oil, 7.5 parts of rhizoma acori graminei essential oil, 5 parts of valerian essential oil, 15 parts of lavender essential oil and 10 parts of borneol, composing according to weight, and mixing.
The invention also provides application of the compound essential oil traditional Chinese medicine composition for improving the cardiovascular problems in preparation of dosage forms and daily chemical products for improving the cardiovascular problems.
Example 1
The application of the compound essential oil traditional Chinese medicine composition for improving the cardiovascular problems in preparing coating essential oil for improving the cardiovascular problems comprises the following components in parts by weight: 10g of compound essential oil and 890g of jojoba oil, and uniformly mixing the compound essential oil and the jojoba oil to obtain the coating essential oil for improving cardiovascular problems.
Example 2
The application of the compound essential oil traditional Chinese medicine composition for improving the cardiovascular problems in preparing the sachet or sachet for improving the cardiovascular problems comprises the following components in parts by weight: 70-95 parts of aromatic medicinal materials and 5-30 parts of compound essential oil.
Preferably, the aromatic medicinal material comprises the following components in parts by weight:
Figure BDA0002749633100000061
Figure BDA0002749633100000071
pulverizing the above materials, spraying compound essential oil thereon to obtain sachet or sachet with effect in improving cardiovascular disease
Example 3
An application of a compound essential oil traditional Chinese medicine composition for improving cardiovascular problems in preparing a compound essential oil spray for improving cardiovascular problems is prepared by taking 3.5 parts of ligusticum wallichii essential oil, 3.5 parts of angelica sinensis essential oil, 5 parts of storax essential oil, 4.5 parts of frankincense essential oil, 4.5 parts of myrrh essential oil, 2.5 parts of cinnamon essential oil, 5.8 parts of dalbergia wood essential oil, 5 parts of radix curcumae essential oil, 5 parts of rhizoma cyperi essential oil, 4.5 parts of sandalwood essential oil, 10 parts of benzoin essential oil, 4.5 parts of rhizoma acori graminei essential oil, 3.25 parts of valerian essential oil, 9.75 parts of lavender essential oil, 6.5 parts of borneol, PEG-40055 parts, RH-40240 parts and water 4200 parts, adding the above essential oil raw materials into a beaker, mixing uniformly, adding a surfactant RH-40 and a cosurfactant PEG-400 into the beaker, mixing uniformly under the action of magnetic stirrer, and slowly adding water under the action of magnetic stirrer to directly add opalescence to obtain the final product.
Aromatherapy essential oil heart rate improvement test
56 rats were randomly divided into 7 groups of 8 rats each. Blank group (Sham group), Model group (Model group), nitroglycerin group (Ni group), compound Chinese medicinal essential oil group (RlwH group), coating essential oil group (RlwM group), compound Chinese medicinal essential oil perfume bag group (RlwS group), and compound essential oil spray group (Mo group). After the rats were weighed, the rats were intraperitoneally injected with isoproterenol hydrochloride injection at a dose of 20ml/kg (i.e., 10mg/kg) for 3 consecutive days in each group except the blank group, and the blank control group was intraperitoneally injected with physiological saline at the same administration dose. After injection and molding, each group is administered for 30min by aerosol inhalation, wherein the high, middle and low dose groups of rhizoma Ligustici Chuanxiong respectively smoke the corresponding dose of rhizoma Ligustici Chuanxiong aerosol, blank group smoke the blank aerosol, mixed group smoke the mixed perfume oil aerosol, and the positive medicine group is administered with 4 pressing of nitroglycerin spray, about 0.5 mg/time. On day 2 of molding, the ultrasonic electrocardiogram was monitored after each group administration, and ejection fraction (EF%) and left ventricular short axis shortening rate (FS%) were recorded for 1min, 5min, 15min, and 30 min.
After the rat is tested, immediately taking blood from femoral artery after ultrasonic heartbeat, and taking serum after centrifugation; then extracting heart and cerebral cortex, dividing the heart into two halves, soaking one half in formalin solution, placing the other half in a freezing storage tube, and storing at-80 ℃.
Researches show that after the ligusticum wallichii essential oil, the angelica essential oil, the storax essential oil, the frankincense essential oil, the myrrh essential oil, the cinnamon essential oil, the dalbergia wood essential oil, the radix curcumae essential oil, the rhizoma cyperi essential oil, the sandalwood essential oil, the benzoin essential oil, the rhizoma acori graminei essential oil, the valerian essential oil, the lavender essential oil and the borneol are matched for use at a specific dosage, the heart rate can be effectively improved, and the heart protection effect is achieved.
It is noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention.

Claims (9)

1. The compound essential oil traditional Chinese medicine composition for improving the cardiovascular problem is characterized in that: comprises the following components in parts by weight: 1-20 parts of ligusticum wallichii essential oil, 1-15 parts of angelica essential oil, 1-10 parts of storax essential oil, 5-15 parts of frankincense essential oil, 5-15 parts of myrrh essential oil, 1-10 parts of cinnamon essential oil, 2-20 parts of dalbergia wood essential oil, 3-20 parts of radix curcumae essential oil, 3-15 parts of rhizoma cyperi essential oil, 1-10 parts of sandalwood essential oil, 5-25 parts of benzoin essential oil, 3-10 parts of rhizoma acori graminei essential oil, 1-8 parts of valerian essential oil, 5-20 parts of lavender essential oil and 3-15 parts of borneol.
2. The compound essential oil traditional Chinese medicine composition for improving cardiovascular problems as claimed in claim 1, wherein: comprises the following components in parts by weight: 5.5 parts of ligusticum wallichii essential oil, 5.5 parts of angelica sinensis essential oil, 8 parts of storax essential oil, 7.5 parts of frankincense essential oil, 7.5 parts of myrrh essential oil, 3.5 parts of cinnamon essential oil, 9 parts of dalbergia wood essential oil, 8 parts of radix curcumae essential oil, 8 parts of rhizoma cyperi essential oil, 7 parts of sandalwood essential oil, 15 parts of benzoin essential oil, 7.5 parts of rhizoma acori graminei essential oil, 5 parts of valerian essential oil, 15 parts of lavender essential oil and 10 parts of borneol.
3. The compound essential oil traditional Chinese medicine composition for improving cardiovascular problems as claimed in claim 1, wherein: the ligusticum wallichii essential oil, the angelica sinensis essential oil, the storax essential oil, the frankincense essential oil, the myrrh essential oil, the cinnamon essential oil, the rosewood essential oil, the radix curcumae essential oil, the rhizoma cyperi essential oil, the sandalwood essential oil, the benzoin essential oil, the rhizoma acori graminei essential oil, the valerian essential oil and the lavender essential oil are respectively prepared by adopting ligusticum wallichii, the angelica sinensis, the storax, the frankincense, the myrrh, the cinnamon, the rosewood heart wood, the radix curcumae, the rhizoma cyperi, the sandalwood, the benzoin, the rhizoma acori graminei, the valerian and the lavender as raw materials and adopting a steam distillation.
4. The compound essential oil traditional Chinese medicine composition for improving cardiovascular problems as claimed in claim 1, wherein: the purities of the ligusticum wallichii essential oil, the angelica essential oil, the storax essential oil, the frankincense essential oil, the myrrh essential oil, the cinnamon essential oil, the dalbergia wood essential oil, the radix curcumae essential oil, the rhizoma cyperi essential oil, the sandalwood essential oil, the benzoin essential oil, the rhizoma acori graminei essential oil, the valerian essential oil and the lavender essential oil are all more than 99%.
5. The compound essential oil traditional Chinese medicine composition for improving cardiovascular problems as claimed in claim 1, wherein: also comprises 95 to 100 parts of base oil.
6. The compound essential oil traditional Chinese medicine composition for improving cardiovascular problems as claimed in claim 5, wherein: the base oil comprises at least one of sweet almond oil, grape seed oil, jojoba oil and wheat germ oil.
7. The compound essential oil traditional Chinese medicine composition for improving cardiovascular problems as claimed in claim 5, wherein: 95-98 parts of the base oil.
8. The method for preparing a compound essential oil traditional Chinese medicine composition for improving cardiovascular problems according to claim 1, is characterized in that: the method comprises the following steps:
the method comprises the following steps: cleaning rhizoma Ligustici Chuanxiong, radix Angelicae sinensis, storax, Olibanum, Myrrha, cortex Cinnamomi, lignum Dalbergiae Odoriferae, radix Curcumae, rhizoma Cyperi, lignum Santali albi, Benzonum, rhizoma Acori Graminei, rhizoma et radix Valerianae, and Lavender, crushing, placing into a steam extraction tank, introducing steam, extracting until the oil amount is not increased, collecting the obtained essential oil, drying with anhydrous sodium sulfate, filtering, and refining to obtain the essential oil of each raw material.
Step two: mixing rhizoma Ligustici Chuanxiong essential oil, radix Angelicae sinensis essential oil, storax essential oil, Olibanum essential oil, Myrrha essential oil, cortex Cinnamomi essential oil, lignum Dalbergiae Odoriferae essential oil, radix Curcumae essential oil, rhizoma Cyperi essential oil, lignum Santali albi essential oil, Benzonum essential oil, rhizoma Acori Graminei essential oil, rhizoma et radix Valerianae essential oil, and Lavender essential oil according to weight.
9. The use of the compound essential oil traditional Chinese medicine composition for improving cardiovascular problems according to claim 1 in the preparation of dosage forms and daily chemical products for improving cardiovascular problems.
CN202011179271.XA 2020-10-29 2020-10-29 Compound essential oil traditional Chinese medicine composition for improving cardiovascular problems as well as preparation method and application thereof Pending CN112263661A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202011179271.XA CN112263661A (en) 2020-10-29 2020-10-29 Compound essential oil traditional Chinese medicine composition for improving cardiovascular problems as well as preparation method and application thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202011179271.XA CN112263661A (en) 2020-10-29 2020-10-29 Compound essential oil traditional Chinese medicine composition for improving cardiovascular problems as well as preparation method and application thereof

Publications (1)

Publication Number Publication Date
CN112263661A true CN112263661A (en) 2021-01-26

Family

ID=74344862

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202011179271.XA Pending CN112263661A (en) 2020-10-29 2020-10-29 Compound essential oil traditional Chinese medicine composition for improving cardiovascular problems as well as preparation method and application thereof

Country Status (1)

Country Link
CN (1) CN112263661A (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1491683A (en) * 2002-10-21 2004-04-28 马德林 Chinese medicine adhesive film for preventing and treating coronary heart disease and angina pectoris and its preparing method

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1491683A (en) * 2002-10-21 2004-04-28 马德林 Chinese medicine adhesive film for preventing and treating coronary heart disease and angina pectoris and its preparing method

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
柏业军等: "张培影运用通络保心贴治疗不稳定性心绞痛的经验", 《中医药临床杂志》 *

Similar Documents

Publication Publication Date Title
Musthaba et al. Patented herbal formulations and their therapeutic applications
CN110339331A (en) A kind of plant is releived essential oil
CN110179694A (en) A kind of scar repairs compound essential oil and preparation method thereof
KR100319721B1 (en) a smoking material for medicinal uses and its preparing method
CN112891504A (en) Four-season skin-care epidemic-prevention ginger paste with ginger decoction dregs as base materials and preparation method
DE69912840T2 (en) METHOD FOR USE OF THE STEAM IRONING OF WOVEN MATERIALS AS CAUSE OF RESTRICTING PHYSIOLOGICAL AND / OR SUBJECTIVE REACTIVITY TO STRESS IN HUMANS
CN112263661A (en) Compound essential oil traditional Chinese medicine composition for improving cardiovascular problems as well as preparation method and application thereof
US5603935A (en) Composition for the treatment of snoring and methods of use thereof
Cushny A Textbook of pharmacology and therapeutics, or, the Action of drugs in health and disease
CN108379529A (en) A kind of waist kidney essential oil for maintaining and preparation method thereof
CN108096318A (en) Treat pharmaceutical composition of cardiovascular and cerebrovascular disease and its preparation method and application
CN100356937C (en) External use prepns. for wind-dispelling, removing-obstruction in channels to relieve pain
CN108404044B (en) Compound plant incense essential oil for treating depression
CN104739952A (en) Compound tea tree essential oil with effect of promoting wound healing
CN1321649C (en) Composition for treating female algomenorrhea and its preparing method
CN108853174A (en) A kind of Siberian cocklebur grass Pityrol ointment
CN117731712B (en) Production method of traditional Chinese medicine tincture for promoting blood circulation and relaxing tendons
CN101869668B (en) Film coating agent for treating empyrosis and preparation method thereof
CN107198689A (en) Tetraodotoxin pharmaceutical composition and externally applied drug for treating antalgesic
CN106729375A (en) One kind treats gout, traumatic injury, arthralgic Chinese medicine composition
US11654175B2 (en) Elsholtzia ciliata essential oil extract as antiarrhythmic drug
CN105797068A (en) Application of traditional Chinese medicine preparation in preparation of medicine for treating heel pains through external application
Nimje et al. PREVENTIVE ASPECT OF ARJUN KSHIRAPAK IN CARDIO VASCULAR DISEASES-A REVIEW
CN105287723B (en) A kind of hiding schizonepeta compound essential oil and preparation method thereof
CN114984121A (en) Aromatic brain-refreshing and anti-fatigue traditional Chinese medicine composition as well as preparation method and application thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20210126