CN112236433B - 新化合物 - Google Patents

新化合物 Download PDF

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Publication number
CN112236433B
CN112236433B CN201980037789.9A CN201980037789A CN112236433B CN 112236433 B CN112236433 B CN 112236433B CN 201980037789 A CN201980037789 A CN 201980037789A CN 112236433 B CN112236433 B CN 112236433B
Authority
CN
China
Prior art keywords
compound
benzo
dihydro
hydroxy
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201980037789.9A
Other languages
English (en)
Chinese (zh)
Other versions
CN112236433A (zh
Inventor
J·利德勒
A·L·沃克
G·V·怀特
A·德尼
N·多迪克
M-H·福歇
A·布里约
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut National de la Sante et de la Recherche Medicale INSERM
Original Assignee
Institut National de la Sante et de la Recherche Medicale INSERM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut National de la Sante et de la Recherche Medicale INSERM filed Critical Institut National de la Sante et de la Recherche Medicale INSERM
Priority to CN202310268678.7A priority Critical patent/CN116217603A/zh
Publication of CN112236433A publication Critical patent/CN112236433A/zh
Application granted granted Critical
Publication of CN112236433B publication Critical patent/CN112236433B/zh
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201980037789.9A 2018-06-07 2019-06-05 新化合物 Active CN112236433B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202310268678.7A CN116217603A (zh) 2018-06-07 2019-06-05 新化合物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1809378.1A GB201809378D0 (en) 2018-06-07 2018-06-07 Novel compounds
GB1809378.1 2018-06-07
PCT/EP2019/064599 WO2019234075A1 (en) 2018-06-07 2019-06-05 Novel benzimidamides compounds comprising an oxaborinin ring

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202310268678.7A Division CN116217603A (zh) 2018-06-07 2019-06-05 新化合物

Publications (2)

Publication Number Publication Date
CN112236433A CN112236433A (zh) 2021-01-15
CN112236433B true CN112236433B (zh) 2023-04-04

Family

ID=62975712

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201980037789.9A Active CN112236433B (zh) 2018-06-07 2019-06-05 新化合物
CN202310268678.7A Pending CN116217603A (zh) 2018-06-07 2019-06-05 新化合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202310268678.7A Pending CN116217603A (zh) 2018-06-07 2019-06-05 新化合物

Country Status (9)

Country Link
US (2) US11352372B2 (https=)
EP (1) EP3802550B1 (https=)
JP (1) JP7317866B2 (https=)
KR (1) KR102661802B1 (https=)
CN (2) CN112236433B (https=)
BR (1) BR112020024740A2 (https=)
ES (1) ES2973710T3 (https=)
GB (1) GB201809378D0 (https=)
WO (1) WO2019234075A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116217603A (zh) * 2018-06-07 2023-06-06 国家医疗保健研究所 新化合物

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20200040103A1 (en) 2018-03-14 2020-02-06 Genentech, Inc. Anti-klk5 antibodies and methods of use
PE20221906A1 (es) 2019-09-18 2022-12-23 Genentech Inc Anticuerpos anti-klk7, anticuerpos anti-klk5, anticuerpos multiespecificos anti-klk5/klk7 y metodos de uso

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101160124A (zh) * 2005-02-16 2008-04-09 安纳考尔医药公司 含硼的小分子
CN106132940A (zh) * 2014-01-23 2016-11-16 西可斯拉制药公司 新的激肽释放酶7 抑制剂

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2575131T3 (es) 2007-12-03 2016-06-24 Obe Therapy Biotechnology Inhibidores boropéptidos de enteropeptidasa y sus usos en tratamientos de obesidad, sobrepeso y/o enfermedades asociadas con un metabolismo anormal de la grasa
CN102014927A (zh) * 2008-03-06 2011-04-13 安纳考尔医药公司 作为抗炎药的含硼的小分子
DK3097085T3 (da) 2014-01-23 2020-10-26 Sixera Pharma Ab Benzoxazinonderivater til behandling af hudsygdomme
GB201809378D0 (en) * 2018-06-07 2018-07-25 Glaxosmithkline Ip Dev Ltd Novel compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101160124A (zh) * 2005-02-16 2008-04-09 安纳考尔医药公司 含硼的小分子
CN106132940A (zh) * 2014-01-23 2016-11-16 西可斯拉制药公司 新的激肽释放酶7 抑制剂

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Inhibitors of kallikrein-related peptidases: An overview;Nicolas Masurier，等;《Medicinal research reviews》;第38卷(第2期);第655-683页 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116217603A (zh) * 2018-06-07 2023-06-06 国家医疗保健研究所 新化合物

Also Published As

Publication number Publication date
BR112020024740A2 (pt) 2021-03-23
WO2019234075A1 (en) 2019-12-12
US20220267357A1 (en) 2022-08-25
JP7317866B2 (ja) 2023-07-31
US11767333B2 (en) 2023-09-26
EP3802550A1 (en) 2021-04-14
GB201809378D0 (en) 2018-07-25
US20210253604A1 (en) 2021-08-19
JP2021530440A (ja) 2021-11-11
CN116217603A (zh) 2023-06-06
US11352372B2 (en) 2022-06-07
KR20210018464A (ko) 2021-02-17
ES2973710T3 (es) 2024-06-24
EP3802550B1 (en) 2023-12-27
KR102661802B1 (ko) 2024-04-26
CN112236433A (zh) 2021-01-15

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Legal Events

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Inventor after: J. Lidler

Inventor after: A.L. Walker

Inventor after: G.V. White

Inventor after: A. Denis

Inventor after: N. dordick

Inventor after: M-h. foucher

Inventor after: A. Briyo

Inventor before: J. Lidler

Inventor before: A.L. Walker

Inventor before: G.V. White

CB03 Change of inventor or designer information
GR01 Patent grant
GR01 Patent grant