CN112236422A - 喹唑啉类化合物作为egfr三突变抑制剂及其应用 - Google Patents

喹唑啉类化合物作为egfr三突变抑制剂及其应用 Download PDF

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CN112236422A
CN112236422A CN201980025718.7A CN201980025718A CN112236422A CN 112236422 A CN112236422 A CN 112236422A CN 201980025718 A CN201980025718 A CN 201980025718A CN 112236422 A CN112236422 A CN 112236422A
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pharmaceutically acceptable
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alkyl
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CN112236422B (zh
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李洪林
丁健
徐玉芳
谢华
李倩男
张弢
赵振江
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East China University of Science and Technology
Shanghai Institute of Materia Medica of CAS
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Shanghai Institute of Materia Medica of CAS
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    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
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    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

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Abstract

涉及喹唑啉类化合物作为EGFR三突变抑制剂及其应用。具体而言，公开了下式(I)所示化合物、含有下式(I)化合物的药物组合物及所述化合物在治疗EGFR介导的相关疾病以及制备治疗EGFR介导的相关疾病的药物中的用途。

Description

PCT国内申请，说明书已公开。

Claims (12)

  1. PCT国内申请，权利要求书已公开。
CN201980025718.7A 2018-04-13 2019-04-12 喹唑啉类化合物作为egfr三突变抑制剂及其应用 Active CN112236422B (zh)

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Application Number Priority Date Filing Date Title
CN201810332709.XA CN110372666B (zh) 2018-04-13 2018-04-13 喹唑啉类化合物作为egfr三突变抑制剂及其应用
CN201810332709X 2018-04-13
PCT/CN2019/082498 WO2019196938A1 (zh) 2018-04-13 2019-04-12 喹唑啉类化合物作为egfr三突变抑制剂及其应用

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US (1) US20210155604A1 (zh)
EP (1) EP3778586A4 (zh)
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Publication number Priority date Publication date Assignee Title
CN112778217B (zh) * 2019-11-08 2024-01-26 沈阳化工研究院有限公司 一种喹唑啉类化合物及其应用
KR102267662B1 (ko) * 2019-11-19 2021-06-22 한국화학연구원 벤즈아미드 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물

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CN1391562A (zh) * 1999-09-21 2003-01-15 阿斯特拉曾尼卡有限公司 用作药物的喹唑啉衍生物
WO2004013091A2 (en) * 2002-08-01 2004-02-12 Yissum Research Development Company Of The Hebrew University Of Jerusalem 4-anilido substituted quinazolines and use thereof as inhibitors of epidermal growth factor receptor kinases
CN101248059A (zh) * 2005-04-27 2008-08-20 安姆根有限公司 作为蛋白激酶抑制剂的取代的酰胺衍生物
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JPS5538325A (en) * 1978-09-11 1980-03-17 Sankyo Co Ltd 4-anilinoquinazoline derivative and its preparation
WO2000020402A1 (en) * 1998-10-01 2000-04-13 Astrazeneca Ab Chemical compounds
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Also Published As

Publication number Publication date
CN112236422B (zh) 2023-05-16
CN110372666A (zh) 2019-10-25
EP3778586A4 (en) 2022-03-16
US20210155604A1 (en) 2021-05-27
JP2021521215A (ja) 2021-08-26
KR20210003807A (ko) 2021-01-12
CN110372666B (zh) 2022-11-08
WO2019196938A1 (zh) 2019-10-17
EP3778586A1 (en) 2021-02-17

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