CN112220706A - Anti-aging composition, cream and preparation method thereof - Google Patents

Anti-aging composition, cream and preparation method thereof Download PDF

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Publication number
CN112220706A
CN112220706A CN202011235709.1A CN202011235709A CN112220706A CN 112220706 A CN112220706 A CN 112220706A CN 202011235709 A CN202011235709 A CN 202011235709A CN 112220706 A CN112220706 A CN 112220706A
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parts
cream
mixture
hydrolyzed
aging composition
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CN202011235709.1A
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CN112220706B (en
Inventor
李樟浩
张娇
韩志东
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Quanhou Guangzhou Research Institute Of Biotechnology Co ltd
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Quanhou Guangzhou Research Institute Of Biotechnology Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/645Proteins of vegetable origin; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9706Algae
    • A61K8/9722Chlorophycota or Chlorophyta [green algae], e.g. Chlorella
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9794Liliopsida [monocotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18

Abstract

The invention discloses an anti-aging composition, a face cream and a preparation method thereof, and belongs to the technical field of daily cosmetics. The anti-aging composition of the present invention comprises hydrolyzed lupin protein, algae extract, zingiber zerumbet extract, and hydrolyzed collagen. The cream prepared from the anti-aging composition has good anti-aging performance, can reduce wrinkles and increase skin elasticity, has a simple preparation method, and is suitable for industrial production.

Description

Anti-aging composition, cream and preparation method thereof
Technical Field
The invention belongs to the technical field of daily cosmetics, and particularly relates to an anti-aging composition, a face cream and a preparation method thereof.
Background
In recent years, the topic heat of anti-aging is continuously rising, which indicates that people have an increasing demand for anti-aging products. The visible appearance and texture of skin changes with the age of a person, and it is desirable to minimize, and even reverse, the changes in the appearance and texture of skin through the use of cosmetics. Therefore, raw materials and anti-aging products having anti-aging effects are continuously released in the market. However, the products on the market are not good and uniform at present, and have more false propaganda, so that the requirements of people cannot be well met.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide a composition with good anti-aging performance, a facial cream and a preparation method thereof.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows: an anti-aging composition comprises hydrolyzed lupin protein, algae extract, Zingiber zerumbet extract, and hydrolyzed collagen.
Hydrolyzed lupin protein acts on the junction of dermis and epidermis, i.e., the dej (German Epidermal junction) structure, to promote the synthesis of collagen and restore the elasticity of skin, thereby preventing photoaging and aging with time; the algae extract is derived from Caulerpa lentillifera, contains various amino acids, and is effective in enhancing skin immune system and keeping skin elasticity; the Zingiber zerumbet Smith extract is extracted from rhizome of Zingiber zerumbet Smith, and can promote collagen production by inhibiting elastase; the hydrolyzed collagen can improve endogenous antioxidant enzyme activity and prevent aging caused by ultraviolet rays. The applicant of the invention verifies through multiple experiments that the composition prepared by compounding the four materials has a synergistic anti-aging effect.
Preferably, the anti-aging composition comprises the following components in parts by weight: 0.2-1 part of hydrolyzed lupin protein, 1-2 parts of algae extract, 0.5-1.5 parts of red ball ginger extract and 0.1-0.75 part of hydrolyzed collagen.
In the anti-aging composition, each component and the content thereof influence the anti-aging performance of the composition. Through a large amount of researches, the inventor finds that when the components in parts by weight are adopted, the components are matched with each other, so that the anti-aging composition disclosed by the invention not only has a good wrinkle removing effect, but also can obviously improve the skin elasticity.
Preferably, the anti-aging composition comprises the following components in parts by weight: 0.4-0.8 part of hydrolyzed lupin protein, 1.3-1.7 parts of algae extract, 0.8-1.2 parts of red globe ginger extract and 0.2-0.6 part of hydrolyzed collagen. When the anti-aging composition is prepared according to the proportion, the wrinkle removing effect and the capability of improving the skin elasticity are better.
Preferably, the anti-aging composition comprises the following components in parts by weight: 0.6 part of hydrolyzed lupin protein, 1.5 parts of algae extract, 1 part of red ball ginger extract and 0.5 part of hydrolyzed collagen. The applicant of the invention proves that the anti-aging composition prepared according to the proportion has the optimal anti-aging performance through a plurality of experiments.
In addition, the invention also discloses a facial cream containing the anti-aging composition.
Preferably, the cream further comprises a chelating agent, a humectant, a thickener, a skin conditioner, an emulsifier, and an emollient.
Preferably, the chelating agent is disodium EDTA, the moisturizer comprises glycerin, 1, 3-butanediol, trehalose, and 1, 2-hexanediol, the thickener is xanthan gum, the skin conditioner is p-hydroxyacetophenone, the emulsifier is PEG-8C 12-20 acid, and the emollient comprises caprylic/capric triglyceride, cetyl alcohol, beeswax, white mineral oil, and dimethicone.
Preferably, the cream comprises the following components in percentage by mass: 0.02-0.05% of EDTA disodium, 12-15% of glycerol, 5-8% of 1, 3-butanediol, 3-5% of trehalose, 0.5-0.6% of 1, 2-hexanediol, 4-5% of caprylic/capric triglyceride, 3-5% of cetyl alcohol, 2-3% of beeswax, 1-2.5% of white mineral oil, 1-1.8% of polydimethylsiloxane, 4-5% of C12-20 acid PEG-8 ester, 1-1.5% of xanthan gum, 0.2-1% of hydrolyzed lupin protein, 1-2% of algae extract, 0.5-1.5% of red globe ginger extract, 0.1-0.75% of hydrolyzed collagen and 0.5-0.6% of p-hydroxyacetophenone.
Meanwhile, the invention also discloses a preparation method of the face cream, which comprises the following steps:
(1) adding a chelating agent, a humectant, a thickening agent and a skin conditioner into deionized water, heating to 80-85 ℃, and uniformly stirring to obtain a mixture A;
(2) adding the emulsifier and the emollient into the mixture A, and uniformly stirring to obtain a mixture B;
(3) cooling the mixture B to 45-50 ℃, adding the anti-aging composition, and uniformly stirring to obtain a mixture C;
(4) and cooling the mixture C to room temperature, filtering and discharging to obtain the face cream.
Preferably, in the preparation step (1) of the face cream, the face cream is heated to 80-85 ℃ and then is homogenized in vacuum for 2-10 min; in the step (2), the emulsifier and the emollient are heated to 80-85 ℃, mixed uniformly and then added into the mixture A, and then vacuum homogenized at the temperature of more than 80 ℃ for 2-10 min.
Compared with the prior art, the invention has the beneficial effects that: the anti-aging composition and the cream disclosed by the invention have good anti-aging performance, wrinkles are obviously reduced after the cream is used, the skin elasticity is obviously improved, the preparation method of the cream is simple, the required equipment is less, and the cream is suitable for industrial production.
Detailed Description
To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific examples.
Example 1
In an embodiment of the anti-aging composition of the present invention, the anti-aging composition comprises the following components in parts by weight: 0.6 part of hydrolyzed lupin protein, 1.5 parts of algae extract, 1 part of red ball ginger extract and 0.5 part of hydrolyzed collagen.
Example 2
In an embodiment of the anti-aging composition of the present invention, the anti-aging composition comprises the following components in parts by weight: 0.4 part of hydrolyzed lupin protein, 1.7 parts of algae extract, 0.8 part of red ball ginger extract and 0.6 part of hydrolyzed collagen.
Example 3
In an embodiment of the anti-aging composition of the present invention, the anti-aging composition comprises the following components in parts by weight: 0.8 part of hydrolyzed lupin protein, 1.3 parts of algae extract, 1.2 parts of red ball ginger extract and 0.2 part of hydrolyzed collagen.
Example 4
In an embodiment of the anti-aging composition of the present invention, the anti-aging composition comprises the following components in parts by weight: 0.2 part of hydrolyzed lupin protein, 2 parts of algae extract, 0.5 part of red ball ginger extract and 0.75 part of hydrolyzed collagen.
Example 5
In an embodiment of the anti-aging composition of the present invention, the anti-aging composition comprises the following components in parts by weight: 1 part of hydrolyzed lupin protein, 1 part of algae extract, 1.5 parts of red ball ginger extract and 0.1 part of hydrolyzed collagen.
Examples 6 to 12 are anti-aging creams according to the present invention, the formulations of which are shown in table 1; the anti-aging creams of examples 8 to 12 respectively comprise the anti-aging compositions of examples 1 to 5. The preparation method of the embodiment 6 to 12 includes the steps of:
(1) adding a chelating agent, a humectant, a thickening agent and a skin conditioner into deionized water, heating to 80-85 ℃, homogenizing in vacuum for 3 minutes, and stirring for 5 minutes under the condition of heat preservation to obtain a mixture A;
(2) heating the emulsifier and the emollient to 80-85 ℃, uniformly mixing the emulsifier and the emollient, adding the mixture into the mixture A, keeping the temperature above 80 ℃, homogenizing for 5 minutes in vacuum, and stirring for 15 minutes under the condition of heat preservation to obtain a mixture B;
(3) cooling the mixture B to 45-50 ℃, adding the anti-aging composition, and stirring for 5 minutes to obtain a mixture C;
(4) and cooling the mixture C to room temperature, filtering and discharging to obtain the face cream.
Comparative examples 1 to 5 are creams, the formulation of which is shown in table 2, and the preparation method is the same as in example 1.
Table 1 formulation tables of examples 6 to 12 (% by mass)
Figure BDA0002764915070000041
Figure BDA0002764915070000051
TABLE 2 formulation tables for comparative examples 1 to 5 (% by mass)
Figure BDA0002764915070000052
Figure BDA0002764915070000061
Performance testing
1) Stability test
The stability tests of examples 6 to 12 and comparative examples 1 to 5 were carried out, wherein the pH (dilution test) test was carried out by diluting the cream according to the mass ratio (deionized water: cream) ═ 9: 1, then the pH was tested by using a pH meter, and the heat resistance test was carried out by standing at 45 ± 2 ℃ for one month, and observing the appearance, color and smell of the cream; the cold resistance test is to stand for one month at the temperature of minus 18 +/-2 ℃, and observe the appearance, color and smell of the cream; the cold and hot cycle resistance test is that the face cream is stored for 24 hours at the temperature of 45 ℃, normal temperature and minus 18 ℃ respectively, and the appearance, color and smell of the face cream are observed after 3 times of cycle. The test results are shown in table 3.
Table 3 stability test results
Figure BDA0002764915070000062
As can be seen from Table 3, the anti-aging cream of the present invention has good temperature tolerance and can ensure the constant properties at high temperature, low temperature and in a circulating state.
2) Anti-aging test
Anti-aging performance is characterized by the wrinkle condition of the skin and the elasticity condition of the skin. The test subjects were 72 female volunteers with no history of skin allergy, and the ages were between 30 and 35 years. The test area is the skin measured in the forearm, the left arm test area is used as the test area, and the right arm test area is used as the control area.
Test samples: examples 6 to 12 and comparative examples 1 to 5.
The test method comprises the following steps: the test area was coated with the corresponding test sample once in the morning and evening, and the control area was untreated once in the morning and evening for one month.
Before use, the skin wrinkles and skin elasticity condition of the test zone and the control zone were measured separately. After use, the skin wrinkles and skin elasticity were measured in the test and control zones, respectively. Wherein, the Skin wrinkle condition is determined by using a Skin image analysis system (Skin Visiometer SV 600); skin elasticity was measured using a skin elasticity tester MPA580 from CK, germany, using a Reviscometer RV600 probe. The test results are shown in table 4.
Table 4 anti-aging test results
Figure BDA0002764915070000071
Figure BDA0002764915070000081
As can be seen from Table 4, example 8 has the optimal ability to remove wrinkles and improve skin elasticity, and examples 6 to 12 are all significantly superior to comparative examples 1 to 5 in performance, indicating that the anti-aging composition composed of the materials in item 4 of the present invention has the ability to synergistically improve skin anti-aging properties.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.

Claims (10)

1. An anti-aging composition comprising hydrolyzed lupin protein, algae extract, zingiber zerumbet extract, and hydrolyzed collagen.
2. The anti-aging composition according to claim 1, comprising the following ingredients in parts by weight: 0.2-1 part of hydrolyzed lupin protein, 1-2 parts of algae extract, 0.5-1.5 parts of red ball ginger extract and 0.1-0.75 part of hydrolyzed collagen.
3. The anti-aging composition according to claim 2, comprising the following ingredients in parts by weight: 0.4-0.8 part of hydrolyzed lupin protein, 1.3-1.7 parts of algae extract, 0.8-1.2 parts of red globe ginger extract and 0.2-0.6 part of hydrolyzed collagen.
4. The anti-aging composition according to claim 3, comprising the following ingredients in parts by weight: 0.6 part of hydrolyzed lupin protein, 1.5 parts of algae extract, 1 part of red ball ginger extract and 0.5 part of hydrolyzed collagen.
5. A cream characterized by comprising the antiaging composition as claimed in any one of claims 1 to 4.
6. The cream of claim 5 further comprising chelating agents, humectants, thickeners, skin conditioning agents, emulsifiers, and emollients.
7. The cream of claim 6, wherein the chelating agent is disodium EDTA, the moisturizer comprises glycerin, 1, 3-butanediol, trehalose, and 1, 2-hexanediol, the thickener is xanthan gum, the skin conditioner is p-hydroxyacetophenone, the emulsifier is PEG-8C 12-20 acid, and the emollient comprises caprylic/capric triglyceride, cetyl alcohol, beeswax, white mineral oil, and dimethicone.
8. The cream according to claim 7, comprising the following components in mass percent: 0.02-0.05% of EDTA disodium, 12-15% of glycerol, 5-8% of 1, 3-butanediol, 3-5% of trehalose, 0.5-0.6% of 1, 2-hexanediol, 4-5% of caprylic/capric triglyceride, 3-5% of cetyl alcohol, 2-3% of beeswax, 1-2.5% of white mineral oil, 1-1.8% of polydimethylsiloxane, 4-5% of C12-20 acid PEG-8 ester, 1-1.5% of xanthan gum, 0.2-1% of hydrolyzed lupin protein, 1-2% of algae extract, 0.5-1.5% of red globe ginger extract, 0.1-0.75% of hydrolyzed collagen and 0.5-0.6% of p-hydroxyacetophenone.
9. A method of preparing a cream as claimed in any one of claims 6 to 8, comprising the steps of:
(1) adding a chelating agent, a humectant, a thickening agent and a skin conditioner into deionized water, heating to 80-85 ℃, and uniformly stirring to obtain a mixture A;
(2) adding the emulsifier and the emollient into the mixture A, and uniformly stirring to obtain a mixture B;
(3) cooling the mixture B to 45-50 ℃, adding the anti-aging composition, and uniformly stirring to obtain a mixture C;
(4) and cooling the mixture C to room temperature, filtering and discharging to obtain the face cream.
10. The method according to claim 9, wherein in the step (1), the mixture is heated to 80-85 ℃ and then homogenized in vacuum for 2-10 min; in the step (2), the emulsifier and the emollient are heated to 80-85 ℃, mixed uniformly and then added into the mixture A, and then vacuum homogenized at the temperature of more than 80 ℃ for 2-10 min.
CN202011235709.1A 2020-11-06 2020-11-06 Anti-aging composition, cream and preparation method thereof Active CN112220706B (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113730314A (en) * 2021-10-22 2021-12-03 广州市胜梅化妆品有限公司 Anti-aging and relieving composition and application thereof

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WO2015030702A2 (en) * 2013-08-26 2015-03-05 Keith Desanto High purity rhamnolipid cosmetic application
CN108136027A (en) * 2015-06-19 2018-06-08 全球健康方案有限责任公司 For the delivery system based on vaseline of active constituent
CN107961208A (en) * 2017-12-06 2018-04-27 广州蜜妆生物科技有限公司 A kind of small molecule modeling face is compacted spraying and preparation method thereof

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Publication number Priority date Publication date Assignee Title
CN113730314A (en) * 2021-10-22 2021-12-03 广州市胜梅化妆品有限公司 Anti-aging and relieving composition and application thereof

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