CN112190670A - Chinese medicinal compound preparation for treating alopecia and scalp itch and preparation method thereof - Google Patents
Chinese medicinal compound preparation for treating alopecia and scalp itch and preparation method thereof Download PDFInfo
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- CN112190670A CN112190670A CN202010804643.7A CN202010804643A CN112190670A CN 112190670 A CN112190670 A CN 112190670A CN 202010804643 A CN202010804643 A CN 202010804643A CN 112190670 A CN112190670 A CN 112190670A
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Abstract
The invention relates to a Chinese medicinal compound preparation for treating alopecia and scalp pruritus and a preparation method thereof, belonging to the field of alopecia beautifying medicaments, wherein the Chinese medicinal compound preparation mainly comprises scutellaria baicalensis, gardenia, poria cocos, coix seeds, bighead atractylodes rhizome, rhizoma atractylodis, rhizoma pinellinae praeparata, mangnolia officinalis, radix sophorae flavescentis, cortex dictamni, fructus cnidii, fructus kochiae, rhizoma acori graminei and liquorice; mixing the above Chinese medicinal materials according to formula ratio, extracting with water or alcohol, and centrifuging or filtering to separate extractive solution; concentrating, drying, pulverizing, and making into medicinal powder; the medicinal powder is used as main raw material to prepare external disintegrating tablet, external effervescent granule, external effervescent tablet, external emulsion, etc. The formula provided by the invention is compatible according to monarch and minister medicines, not only can clear heat and dry dampness, promote diuresis and conduct heat downward, but also can kill parasites and relieve itching, can effectively reduce grease and alopecia on the head and relieve scalp itching, and has small toxic and side effects.
Description
Technical Field
The invention belongs to the field of alopecia and beauty treatment medicines, and particularly relates to a traditional Chinese medicine compound preparation for treating alopecia and scalp pruritus and a preparation method thereof.
Background
Alopecia is a common disease in dermatology and has high morbidity. Modern pathological studies have shown that causes of hair loss include bacterial, fungal infections, hair follicle damage, abnormal hormone metabolism, immune disorders, and the like. Scalp itching is a common complication of alopecia, and subjective scalp itching is taken as a main symptom, and symptoms such as eruption, scratch, blood crusting, lichenification and the like can be accompanied sometimes.
The traditional Chinese medicine has a long history of treating alopecia and scalp pruritus, the traditional Chinese medicine considers that the alopecia is closely related to qi, blood, liver, kidney and qi activity of human bodies, and the scalp pruritus is mostly caused by internal excess of damp-heat, external attack of wind evil, internal disturbance of blood heat or blood deficiency malnutrition and the like. The traditional Chinese medicine has the characteristics of multiple components and multiple target points, can adjust the body state from the overall view angle, realizes the effect of treating both principal and secondary aspect of disease, and has small toxic and side effects. The invention provides a pharmaceutical composition which can effectively reduce alopecia and relieve scalp itching symptoms by combining the consideration of factors of alopecia and scalp itching from multiple angles.
Disclosure of Invention
In order to overcome the problems in the background technology, the invention provides a traditional Chinese medicine compound preparation for treating alopecia and scalp pruritus and a preparation method thereof, and the provided formula is compatible according to monarch and minister medicines, so that the traditional Chinese medicine compound preparation not only can clear damp-heat in upper jiao, refresh mind and induce resuscitation, but also can eliminate dampness and promote diuresis, kill parasites and relieve itching, can effectively reduce the conditions of greasy hair, pruritus and alopecia, and can effectively relieve scalp pruritus symptoms, and has small toxic and side effects.
In order to realize the purpose, the invention is realized by the following technical scheme:
a Chinese medicinal compound preparation for treating alopecia and scalp pruritus is prepared from Scutellariae radix, Poria, Coicis semen, Atractylodis rhizoma, rhizoma Atractylodis, rhizoma Pinelliae Preparata, cortex Magnolia officinalis fructus Gardeniae, radix Sophorae Flavescentis, cortex Dictamni Radicis, fructus Cnidii, Kochiae fructus, rhizoma Acori Graminei, and Glycyrrhrizae radix.
Preferably, the traditional Chinese medicine compound preparation comprises, by weight, 5-30 parts of scutellaria baicalensis, 5-30 parts of gardenia, 10-30 parts of poria cocos, 10-30 parts of semen coicis, 10-30 parts of bighead atractylodes rhizome, 10-30 parts of rhizoma atractylodis, 10-60 parts of rhizoma pinellinae praeparata, 5-30 parts of mangnolia officinalis, 10-60 parts of radix sophorae flavescentis, 5-60 parts of cortex dictamni, 10-60 parts of fructus cnidii, 10-60 parts of fructus kochiae, 5-10 parts of rhizoma acori graminei and 10-20 parts of liquorice.
Scutellaria baicalensis: bitter taste and cold nature, entering lung, gallbladder, spleen, large intestine and small intestine channels, clearing heat and drying dampness, purging fire and removing toxicity, and can be used for treating damp-heat in upper jiao and summer-heat dampness.
Gardenia: bitter and cold in flavor, entering heart, lung and triple energizer meridians. Purging pathogenic fire, relieving restlessness, clearing away heat, promoting diuresis, cooling blood, and removing toxic substances; is used for clearing away damp-heat in the triple energizer, purging pathogenic fire, relieving restlessness, promoting function of gallbladder, resisting microorganism, and relieving inflammation.
Tuckahoe, poria cocos: sweet and bland in flavor, neutral in nature, and entering heart, lung, spleen and kidney meridians. Promoting diuresis, eliminating dampness, invigorating spleen, and nourishing; has diuretic and antibacterial effects.
Coix seed: sweet and light in flavor, cool in nature, and entering spleen, stomach and lung meridians. Has effects in promoting water penetration, invigorating spleen, relieving diarrhea, clearing away heat, and expelling pus.
White atractylodes rhizome: bitter, sweet and warm, entering spleen and stomach meridians. Has effects in eliminating dampness, promoting diuresis, invigorating spleen and invigorating qi. Can be used for treating spleen deficiency, retention of water and dampness.
Rhizoma atractylodis: pungent and bitter in flavor, warm in nature, entering spleen, stomach and liver meridians. It is often combined with Bai Zhu to dry dampness and move qi, because it can dry dampness and invigorate spleen, dispel wind and dispel cold. Also has antibacterial and disinfectant effects.
Rhizoma pinelliae preparata: pungent in flavor and warm in nature, enter spleen, stomach and lung meridians. Can be used for eliminating dampness and phlegm, and dredging collaterals.
Magnolia officinalis: bitter and pungent in flavor, warm in nature, entering spleen, stomach, lung and large intestine meridians. It is used together with ban Xia to dry dampness, remove fullness, resolve phlegm and dredge collaterals.
Flavescent sophora root: bitter taste and cold nature, entering heart, liver, stomach, large intestine and bladder meridians. Clearing heat and drying dampness, killing parasites and promoting urination, and is used for treating vulvar swelling and pruritus vulvae, eczema, skin pruritus, scabies, tinea and leprosy. Has diuretic, anti-pathogen, anti-tumor, and antiallergic effects.
And (3) preparing cortex dictamni: bitter and cold in flavor, it enters spleen, stomach and bladder meridians. Clearing heat, eliminating dampness, dispelling pathogenic wind, removing toxic substance, removing damp heat, removing toxic substance, dripping yellow water, eczema, rubella, scabies, sore, scabies, rheumatism, and arthralgia due to pathogenic wind, and has antibacterial and anticancer effects.
Fructus cnidii: pungent and bitter in flavor, warm in nature, entering kidney meridian. Eliminating dampness and dispelling pathogenic wind, killing parasite and relieving itching, warming kidney and tonifying yang, can be used for treating pruritus vulvae, leukorrhagia, eczema, pruritus, rheumatism, lumbago, kidney deficiency and sexual impotence, and has antifungal, antiasthmatic, antiarrhythmic, and skin allergy resisting effects.
The preparation method comprises the following steps of (1) preparing broom cypress fruit: pungent and bitter in flavor and cold in nature, it enters kidney and bladder meridians. Clearing heat, promoting diuresis, dispelling pathogenic wind and relieving itching, and can be used for treating urination pain, pudendal pruritus and leukorrhagia, rubella, eczema, and skin pruritus, and has antibacterial and antiallergic effects.
Grassleaf sweelflag rhizome: pungent, bitter and warm in flavor, enter heart and stomach meridians. Inducing resuscitation, eliminating phlegm, regulating qi-flowing, promoting blood circulation, dispelling pathogenic wind, eliminating dampness, inducing resuscitation, refreshing mind, and inhibiting fungi.
Licorice root: sweet and neutral in nature, they enter heart, lung, spleen and stomach meridians. Spleen invigorating qi, clearing away heat and toxic material, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the drugs. Can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal distention, spasm and pain of limbs, carbuncle, suppurative sore, and relieving drug toxicity and pungency, and has effects of removing toxic substance, resisting inflammation, eliminating phlegm, and resisting cancer.
Furthermore, the dosage forms of the traditional Chinese medicine compound preparation are external disintegrating tablets, external effervescent granules, external effervescent tablets and external emulsion.
A preparation method of a traditional Chinese medicine compound preparation for treating alopecia and scalp itch comprises the following specific steps:
1) preparing a traditional Chinese medicine compound extracting solution: mixing the Chinese medicinal components according to the formula, extracting by water extraction or alcohol extraction, and separating the extractive solution by centrifugation or filtration;
2) concentrating, drying and crushing the extracting solution obtained in the step 1) to prepare medicinal powder;
3) preparation: preparing the medicinal powder prepared in the step 2) as a main raw material according to different formulations.
The preparation form of the externally applied disintegrating tablet comprises the following steps: 10-60% of medicinal powder, 1-30% of croscarmellose sodium, 1-30% of crospovidone, 0.5-5% of aromatic flavoring agent, 10-70% of dextrin or soluble starch, 0-5% of magnesium stearate, 0-10% of PEG and 0-10% of magnesium lauryl sulfate, uniformly mixing the components according to a proportion, and tabletting the mixture to prepare the disintegrating tablet.
The preparation form of the effervescent granule for external use comprises the following steps: mixing the powder with 0.5-5 times of dextrin or soluble starch, and dividing into A, B parts; mixing sodium carbonate or sodium bicarbonate with the powder A, spraying 50-90% ethanol as wetting agent, granulating, drying, and grading; mixing citric acid or tartaric acid with powder B, spraying 50% -90% ethanol as wetting agent, granulating, drying, and grading; mixing the above two kinds of granules.
The preparation form is external effervescent tablets and comprises the following preparation steps: mixing the powder with 0.5-5 times of dextrin or soluble starch, and dividing into A, B parts; mixing sodium carbonate or sodium bicarbonate with the powder A, spraying 50-90% ethanol as wetting agent, granulating, drying, and grading; mixing citric acid or tartaric acid with powder B, spraying 50% -90% ethanol as wetting agent, granulating, drying, and grading; mixing the above two granules, and tabletting with a tabletting machine to obtain effervescent tablet.
The preparation form of the external emulsion comprises the following steps: a. concentrating the extracting solution obtained in the step 1) to thick paste of 1.02-1.5 g/ml; b. taking 1-90 parts of thick paste, 1-30 parts of cocoamidopropyl betaine, 1-30 parts of ammonium lauryl ether sulfate, 1-30 parts of sodium lauryl amphoglycinate and C8-C160-20 parts of alkyl glycoside, 0-30 parts of coconut monoethanolamide, 0-30 parts of coconut diethanolamide, 0-20 parts of acrylic copolymer, 0-20 parts of polydimethylsiloxane emulsion, 0-20 parts of ethylene glycol distearate, 0-30 parts of polysiloxane linoleic acid phospholipid, 0-10 parts of benzyl alcohol, 0-10 parts of methyl paraben, 0-10 parts of ethylparaben, 0-10 parts of propyl paraben, 0-10 parts of Glydant plus, 160-10 parts of organosilicon quaternary ammonium salt, 910-10 parts of polyquaternary ammonium salt, 0-10 parts of hydroxyethyl cellulose ether quaternary ammonium salt, 0-10 parts of hydroxypropyl guar gum trimethyl ammonium oxide, 0-5 parts of pigment, 0-10 parts of essence, 0-20 parts of trimethyl glycine, 0-20 parts of D-panthenol, 0-20 parts of glycerol, 0-20 parts of propylene glycol, 0-20 parts of citric acid and 0-20 parts of tartaric acid, 0-20 parts of quaternized wheat protein and 5-90 parts of deionized water are uniformly mixed to prepare the emulsion.
The invention has the beneficial effects that: the formula provided by the invention is compatible according to monarch and minister medicines, not only can invigorate spleen and eliminate turbid pathogen, open and close and relieve stagnation, but also can clear heat and dry dampness, inhibit bacteria and relieve itching, can effectively reduce alopecia and relieve scalp itching symptoms, and has small toxic and side effects.
Drawings
Fig. 1 is a diagram of scalp examination before and after a typical case of wu-za treatment;
fig. 2 is a diagram of scalp examination before and after a treatment for a typical case.
Detailed Description
The Chinese herbal compound preparation for treating alopecia and scalp itch comprises, by weight, 5-30 parts of scutellaria baicalensis, 5-30 parts of gardenia, 10-30 parts of poria cocos, 10-30 parts of coix seeds, 10-30 parts of bighead atractylodes rhizome, 10-30 parts of rhizoma atractylodis, 10-60 parts of rhizoma pinellinae praeparata, 5-30 parts of mangnolia officinalis, 10-60 parts of radix sophorae flavescentis, 5-60 parts of cortex dictamni, 10-60 parts of fructus cnidii, 10-60 parts of fructus kochiae, 5-10 parts of rhizoma acori graminei and 10-20 parts of liquorice.
The above components are mixed to prepare an extracting solution, the extracting method can be a water extracting method and an alcohol extracting method, and specifically, the water extracting method comprises the following steps: mixing the components according to the formula amount, adding 5-20 times of water, soaking for 1-2h, decocting for 0.5-2h, repeatedly extracting for 3 times, centrifuging to separate decoctions, and mixing the decoctions to obtain an extract.
The alcohol extraction method comprises the following steps: mixing the components according to the formula amount, crushing to 60-80 meshes, adopting 30-80% ethanol as an extracting agent, adding 20-30 times of the formula amount, soaking for 2-4 hours at 40-65 ℃, repeatedly extracting for 3 times, separating the maceration extract by adopting a centrifugal mode, and mixing the maceration extracts to obtain an extracting solution.
The extractive solution can be used as main ingredient of Chinese medicinal compound preparation, and can be made into various dosage forms such as topical disintegrating tablet, topical effervescent granule, topical effervescent tablet, topical emulsion, etc.; or making into teabag.
The external disintegrating tablet is prepared by the following steps:
a. concentrating the extractive solution, drying, and pulverizing to obtain medicinal powder;
b. mixing the medicinal powder 10-60%, croscarmellose sodium 1-30%, crospovidone 1-30%, aromatic flavoring agent 0.5-5%, dextrin or soluble starch 10-70%, magnesium stearate 0-5%, PEG 0-10%, and magnesium lauryl sulfate 0-10%, and tabletting to obtain disintegrating tablets.
The external effervescent granule is prepared by the following steps:
a. concentrating the extractive solution, drying, and pulverizing to obtain medicinal powder;
b. mixing the powder with 0.5-5 times of dextrin or soluble starch, and dividing into A, B parts;
c. mixing sodium carbonate or sodium bicarbonate with the powder A, spraying 50-90% ethanol as wetting agent, granulating, drying, and grading; mixing citric acid or tartaric acid with powder B, spraying 50% -90% ethanol as wetting agent, granulating, drying, and grading;
d. mixing the above two granules, and making into effervescent granule.
The external effervescent tablet is prepared by the following steps:
a. concentrating the extractive solution, drying, and pulverizing to obtain medicinal powder;
b. mixing the powder with 0.5-5 times of dextrin or soluble starch, and dividing into A, B parts;
c. mixing sodium carbonate or sodium bicarbonate with the powder A, spraying 50-90% ethanol as wetting agent, granulating, drying, and grading; mixing citric acid or tartaric acid with powder B, spraying 50% -90% ethanol as wetting agent, granulating, drying, and grading;
d. mixing the above two granules, and tabletting with a tabletting machine to obtain effervescent tablet.
The external emulsion is prepared by the following steps:
a. concentrating the traditional Chinese medicine extracting solution to thick paste of 1.02-1.5 g/ml;
b. taking 1-90 parts of thick paste, 1-30 parts of cocoamidopropyl betaine, 1-30 parts of ammonium lauryl ether sulfate, 1-30 parts of sodium lauryl amphoglycinate and C8-C160-20 parts of alkyl glycoside, 0-30 parts of coconut monoethanolamide, 0-30 parts of coconut diethanolamide, 0-20 parts of acrylic copolymer, 0-20 parts of polydimethylsiloxane emulsion, 0-20 parts of ethylene glycol distearate, 0-30 parts of polysiloxane linoleic acid phospholipid, 0-10 parts of benzyl alcohol, 0-10 parts of methyl paraben, 0-10 parts of ethyl paraben, 0-10 parts of propyl paraben and 0-0 part of Glydant plus10 parts of organosilicon quaternary ammonium salt-160-10 parts, 910-10 parts of polyquaternary ammonium salt, 0-10 parts of hydroxyethyl cellulose ether quaternary ammonium salt, 0-10 parts of hydroxypropyl guar gum trimethyl ammonium oxide, 0-5 parts of pigment, 0-10 parts of essence, 0-20 parts of trimethyl glycine, 0-20 parts of D-panthenol, 0-20 parts of glycerol, 0-20 parts of propylene glycol, 0-20 parts of citric acid, 0-20 parts of tartaric acid, 0-20 parts of quaternized wheat protein, 0-5 parts of azone and 5-90 parts of deionized water, and uniformly mixing to prepare the emulsion.
The tea bag is prepared by the following steps:
a. mixing the components of the Chinese medicinal composition, pulverizing, and sieving with No. 1 sieve or No. 2 sieve;
b. extracting the oversize product with water or 10-90% ethanol, concentrating the extractive solution, spraying onto the sieved powder, mixing, oven drying, and packaging into filter bag for external washing or drinking.
Example 1
The traditional Chinese medicine compound preparation for treating alopecia and scalp itch comprises, by weight, 15g of scutellaria baicalensis, 10g of gardenia, 10g of poria cocos, 10g of coix seeds, 15g of bighead atractylodes rhizome, 15g of rhizoma atractylodis, 20g of rhizoma pinellinae praeparata, 10g of mangnolia officinalis, 30g of radix sophorae flavescentis, 30g of cortex dictamni, 50g of fructus cnidii, 50g of fructus kochiae, 5g of rhizoma acori graminei and 10g of liquorice. Mixing the above materials, pulverizing to 80 mesh, adding 50% ethanol as lixiviant 30 times of the formula amount, soaking at 65 deg.C for 2 hr, repeatedly leaching for 3 times, centrifuging to separate maceration extract, and mixing maceration extracts to obtain extractive solution.
Concentrating the above Chinese medicinal extractive solution, drying, and pulverizing to obtain medicinal powder; mixing the medicinal powder with 3 times of dextrin, and dividing into A, B parts; mixing sodium bicarbonate with the powder A, spraying 50-90% ethanol as wetting agent, granulating, drying, and grading; mixing citric acid with the powder B, spraying 50-90% ethanol as wetting agent, granulating, drying, and grading; mixing the above two granules, and tabletting with a tabletting machine to obtain effervescent tablet.
Example 2
The traditional Chinese medicine compound preparation for treating alopecia and scalp itch comprises, by weight, 9g of scutellaria baicalensis, 9g of cape jasmine, 10g of poria cocos, 10g of coix seeds, 10g of bighead atractylodes rhizome, 10g of rhizoma atractylodis, 15g of rhizoma pinellinae praeparata, 5g of mangnolia officinalis, 20g of sophora flavescens, 20g of cortex dictamni, 30g of fructus cnidii, 30g of fructus kochiae, 5g of rhizoma acori graminei and 10g of liquorice. Mixing the above materials, adding 10 times of water, soaking for 1 hr, decocting for 1 hr, repeatedly extracting for 3 times, centrifuging to separate decoctions, and mixing decoctions to obtain extractive solution.
Concentrating the traditional Chinese medicine extracting solution to thick paste of 1.02-1.5 g/ml; taking 40 parts of thick paste, mixing with 10 parts of cocamidopropyl betaine, 5 parts of lauryl alcohol ether ammonium sulfate, 5 parts of sodium lauryl amphoglycinate, 1 part of polydimethylsiloxane emulsion, 2 parts of ethylene glycol distearate, 2 parts of benzyl alcohol, 2 parts of methyl paraben, 1 part of D-panthenol, 2 parts of glycerol, 3 parts of citric acid and 20 parts of deionized water uniformly, and preparing into an emulsion.
Example 3
The traditional Chinese medicine compound preparation for treating alopecia and scalp itch comprises, by weight, 30g of scutellaria baicalensis, 9g of gardenia, 5g of poria cocos, 5g of coix seeds, 10g of bighead atractylodes rhizome, 10g of rhizoma atractylodis, 10g of rhizoma pinellinae praeparata, 5g of mangnolia officinalis, 30g of sophora flavescens, 20g of cortex dictamni, 20g of fructus cnidii, 20g of fructus kochiae, 5g of rhizoma acori graminei and 10g of liquorice. Mixing the above materials, pulverizing to 80 mesh, adding 50% ethanol as lixiviant 30 times of the formula amount, soaking at 65 deg.C for 2 hr, repeatedly leaching for 3 times, centrifuging to separate maceration extract, and mixing maceration extracts to obtain extractive solution.
Concentrating the extractive solution, drying, and pulverizing to obtain medicinal powder; mixing the medicinal powder with 3 times of dextrin, and dividing into A, B parts; mixing sodium bicarbonate with the powder A, spraying 50-90% ethanol as wetting agent, granulating, drying, and grading; mixing citric acid with the powder B, spraying 50-90% ethanol as wetting agent, granulating, drying, and grading; mixing the above two granules, and tabletting with a tabletting machine to obtain effervescent tablet.
Example 4
The traditional Chinese medicine compound preparation for treating alopecia and scalp itch comprises, by weight, 9g of scutellaria baicalensis, 5g of cape jasmine, 5g of poria cocos, 10g of coix seeds, 15g of bighead atractylodes rhizome, 15g of rhizoma atractylodis, 25g of rhizoma pinellinae praeparata, 10g of mangnolia officinalis, 30g of sophora flavescens, 10g of cortex dictamni, 20g of fructus cnidii, 20g of fructus kochiae, 10g of rhizoma acori graminei and 10g of liquorice. Mixing the above materials, pulverizing to 60 mesh, adding 50% ethanol as lixiviant 20 times of the formula amount, soaking at 60 deg.C for 2 hr, repeatedly leaching for 3 times, centrifuging to separate maceration extract, and mixing maceration extracts to obtain extractive solution.
Concentrating the traditional Chinese medicine extracting solution to thick paste of 1.02-1.5 g/ml; taking 40 parts of thick paste, mixing with 10 parts of cocamidopropyl betaine, 5 parts of lauryl alcohol ether ammonium sulfate, 5 parts of sodium lauryl amphoglycinate, 1 part of polydimethylsiloxane emulsion, 2 parts of ethylene glycol distearate, 2 parts of benzyl alcohol, 2 parts of methyl paraben, 1 part of D-panthenol, 2 parts of glycerol, 3 parts of citric acid and 20 parts of deionized water uniformly, and preparing into an emulsion.
Example 5
The traditional Chinese medicine compound preparation for treating alopecia and scalp itch comprises, by weight, 9g of scutellaria baicalensis, 5g of cape jasmine, 5g of poria cocos, 10g of coix seeds, 15g of bighead atractylodes rhizome, 15g of rhizoma atractylodis, 25g of rhizoma pinellinae praeparata, 10g of mangnolia officinalis, 30g of sophora flavescens, 10g of cortex dictamni, 20g of fructus cnidii, 20g of fructus kochiae, 10g of rhizoma acori graminei and 10g of liquorice. Mixing the above materials, pulverizing to 60 mesh, adding 50% ethanol as lixiviant 20 times of the formula amount, soaking at 60 deg.C for 2 hr, repeatedly leaching for 3 times, centrifuging to separate maceration extract, and mixing maceration extracts to obtain extractive solution.
Concentrating the traditional Chinese medicine extracting solution to thick paste of 1.02-1.5 g/ml; taking 60 parts of thick paste, uniformly mixing with 15 parts of cocamidopropyl betaine, 10 parts of ammonium lauryl ether sulfate, 5 parts of sodium lauryl amphoglycinate, 3 parts of coconut monoethanolamide, 2 parts of polydimethylsiloxane emulsion, 2 parts of ethylene glycol distearate, 2 parts of methyl paraben, 2 parts of ethylparaben, 163 parts of organic silicon quaternary ammonium salt, 1 part of D-panthenol, 2 parts of glycerol, 2 parts of propylene glycol, 1 part of citric acid, 1 part of tartaric acid and 30 parts of deionized water, and preparing into an emulsion.
Test for alopecia preventing and itching relieving effects
1. Volunteer selection: selecting damp-heat alopecia volunteers with age of 18-50 years, alopecia accompanied with scalp pruritus, which have no obvious abnormality in health, organ function, etc., and have no hormone, immunosuppressant, hair-growing medicine or related product recently. Subject 30, 21 males and 9 females.
2. The traditional Chinese medicine compound of embodiment 3 of the invention is used as a sample, the test period is 4 weeks, the sample is used for washing for 1 time every 2 days, the soaking time is not less than 20min each time, and excessive scratching is avoided during washing; during the test period, the subjects were asked to work and rest regularly, to relax mood, and to have a light diet.
3. The test adopts self-control design, and before and after the test, the follow-up records observe indexes (pruritus, heavy feeling of head, greasiness, dandruff, skin damage condition and hair loss) and adverse reaction occurrence conditions.
The pruritus patients self-adopt a quantitative scoring mode, and the score is carried out from 0 to 10 minutes from 'none' to 'intolerable (the scratching times are large and difficult to relieve every day').
The patients with heaviness in head self-score in a quantitative scoring mode from 'none' to 'heaviness in head (heaviness in head)' from 0 to 10 minutes.
The greasiness is divided into 0, 2, 4 and 6 according to different degrees.
The dandruff is 0, 2, 4 and 6 according to different degrees of integration.
The area and degree of skin damage are divided into 0, 2, 4 and 6 according to different degrees.
The hair loss number is divided into 0, 2, 4 and 6 according to different degrees.
The hair loss counting and recording method comprises the following steps: comprises three parts, namely a first part for recording the number of hairs on the pillow towel used per day; the second part, recording the number of hair removed in each combing; third, if the hair is washed, the number of hairs in the sink or basin is recorded.
The treatment effect evaluation standard is as follows:
(1) and (3) healing: the integral drops by over 90%; the scalp has no pruritus, scurf and skin damage; the head is fresh; the daily hair loss amount and the hair thickness and color are normal; the secretion of head oil is moderate;
(2) the effect is shown: integral drop > 70%; scalp itch and grease secretion are obviously improved; the skin damage area is obviously reduced; the sleepiness is obviously reduced; the scurf index is obviously improved; the hair loss quantity is reduced;
(3) the method has the following advantages: the integral is reduced to 30% -70%; itching, dandruff and reduced secretion of scalp oil; the skin damage area is reduced;
(4) and (4) invalidation: integral drop < 30%; the secretion of the grease is not improved or slightly reduced, and the pruritus feeling is not reduced or slightly reduced; no or slight reduction of hair loss
(5) The symptom integral reduction index is calculated as follows:
symptom integral reduction index (%) - (total integral before treatment-total integral after treatment)/total integral before treatment x 100%
The total effective rate is (curing case + significant case + effective case)/total number of cases is multiplied by 100 percent
4. And (3) test results:
the score values of the observation indexes before and after the treatment of the subject are counted, the average values are taken for comparison, and the comparison result is shown in table 1.
TABLE 1 comparison table of scores of observation indexes before and after treatment
| Observation index | Before treatment | After treatment |
| Feeling of itching | 6.47 | 2.97 |
| Heaviness of the head | 6.73 | 3.2 |
| Degree of greasiness | 5.4 | 2.93 |
| Dandruff | 4.07 | 2.27 |
| Area of skin damage | 3.4 | 1.67 |
| Degree of skin damage | 3.2 | 0.87 |
| Number of hair losing | 3.6 | 1.67 |
The results of the treatment efficacy evaluation of the subjects were counted and are shown in Table 2.
TABLE 2 curative effect evaluation result statistics table
| Evaluation effect | Recovery method | Show effect | Is effective | Invalidation | Total effective rate |
| Number of people | 1 | 7 | 18 | 4 | 86.67％ |
No adverse reaction is fed back by the subject.
Typical cases are as follows:
Wu-Chi, male, age 36, severe oral alopecia and scalp itching; aging of hair follicle, shriveling and shrinking, and thin and soft hair (see a in fig. 1, a photograph taken before treatment); after 3 weeks of shampooing, scalp environment was improved and hairs were dense and thick using the cream of example 4 of the present invention (i.e., shampoo), and each hair follicle had 2 to 3 hairs (see detail b of fig. 1, photograph taken after treatment). The comparison of the pictures before and after treatment shows that the product of the invention has obvious treatment effect after being used.
Zhongji, female, age 29, severe oral alopecia, scalp itching; aging of hair follicle, shriveling and atrophy, and attachment of large pieces of dandruff (see a in fig. 2, photograph taken before treatment); after 3 weeks of shampooing, scalp environment was improved and hairs were dense and thick using the cream of example 5 of the present invention (i.e., shampoo), and each hair follicle had 2 to 3 hairs (see b of fig. 2 for details, photograph taken after treatment). The comparison of the pictures before and after treatment shows that the product of the invention has obvious treatment effect after being used.
In conclusion, the formula provided by the invention is compatible according to monarch and minister medicines, can clear heat, purge fire, eliminate dampness and relieve itching by bitter and dry heat clearing and elimination, is suitable for damp-heat alopecia patients, can effectively reduce alopecia and relieve scalp itching symptoms, has small toxic and side effects, and is suitable for popularization and use.
Finally, it is noted that the above-mentioned preferred embodiments illustrate rather than limit the invention, and that, although the invention has been described in detail with reference to the above-mentioned preferred embodiments, it will be understood by those skilled in the art that various changes in form and detail may be made therein without departing from the scope of the invention as defined by the appended claims.
Claims (8)
1. A traditional Chinese medicine compound preparation for treating alopecia and scalp itch is characterized in that: the Chinese medicinal compound preparation mainly comprises Scutellariae radix, fructus Gardeniae, Poria, Coicis semen, Atractylodis rhizoma, rhizoma Atractylodis, rhizoma Pinelliae Preparata, cortex Magnolia officinalis, radix Sophorae Flavescentis, cortex Dictamni Radicis, fructus Cnidii, Kochiae fructus, rhizoma Acori Graminei, and Glycyrrhrizae radix.
2. The compound traditional Chinese medicine preparation for treating alopecia and scalp pruritus as claimed in claim 1, is characterized in that: the traditional Chinese medicine compound preparation comprises, by weight, 5-30 parts of scutellaria baicalensis, 5-30 parts of gardenia, 10-30 parts of poria cocos, 10-30 parts of semen coicis, 10-30 parts of bighead atractylodes rhizome, 10-30 parts of rhizoma atractylodis, 10-60 parts of rhizoma pinellinae praeparata, 5-30 parts of mangnolia officinalis, 10-60 parts of radix sophorae flavescentis, 5-60 parts of cortex dictamni, 10-60 parts of fructus cnidii, 10-60 parts of fructus kochiae, 5-10 parts of rhizoma acori graminei and 10-20 parts of liquorice.
3. The compound traditional Chinese medicine preparation for treating alopecia and scalp pruritus as claimed in claim 1 or 2, is characterized in that: the dosage forms of the Chinese medicinal compound preparation are external disintegrating tablets, external effervescent granules, external effervescent tablets and external emulsion.
4. The preparation method of the traditional Chinese medicine compound preparation for treating alopecia and scalp pruritus according to claim 3 is characterized by comprising the following specific steps:
1) preparing a traditional Chinese medicine compound extracting solution: mixing the Chinese medicinal components according to the formula, extracting by water extraction or alcohol extraction, and separating the extractive solution by centrifugation or filtration;
2) concentrating, drying and crushing the extracting solution obtained in the step 1) to prepare medicinal powder;
3) preparation: preparing the medicinal powder prepared in the step 2) as a main raw material according to different formulations.
5. The preparation method of the compound traditional Chinese medicine preparation for treating alopecia and scalp pruritus as claimed in claim 4, is characterized in that: in the step 3), the preparation form of the externally used disintegrating tablet comprises the following steps: 10-60% of medicinal powder, 1-30% of croscarmellose sodium, 1-30% of crospovidone, 0.5-5% of aromatic flavoring agent, 10-70% of dextrin or soluble starch, 0-5% of magnesium stearate, 0-10% of PEG and 0-10% of magnesium lauryl sulfate, uniformly mixing the components according to a proportion, and tabletting the mixture to prepare the disintegrating tablet.
6. The preparation method of the compound traditional Chinese medicine preparation for treating alopecia and scalp pruritus as claimed in claim 4, is characterized in that: in the step 3), the preparation form of the externally applied effervescent granule comprises the following steps: mixing the powder with 0.5-5 times of dextrin or soluble starch, and dividing into A, B parts; mixing sodium carbonate or sodium bicarbonate with the powder A, spraying 50-90% ethanol as wetting agent, granulating, drying, and grading; mixing citric acid or tartaric acid with powder B, spraying 50% -90% ethanol as wetting agent, granulating, drying, and grading; mixing the above two kinds of granules.
7. The preparation method of the compound traditional Chinese medicine preparation for treating alopecia and scalp pruritus as claimed in claim 4, is characterized in that: in the step 3), the preparation form of the external effervescent tablet comprises the following steps: mixing the powder with 0.5-5 times of dextrin or soluble starch, and dividing into A, B parts; mixing sodium carbonate or sodium bicarbonate with the powder A, spraying 50-90% ethanol as wetting agent, granulating, drying, and grading; mixing citric acid or tartaric acid with powder B, spraying 50% -90% ethanol as wetting agent, granulating, drying, and grading; mixing the above two granules, and tabletting with a tabletting machine to obtain effervescent tablet.
8. The preparation method of the compound traditional Chinese medicine preparation for treating alopecia and scalp pruritus as claimed in claim 4, is characterized in that: the preparation form of the external emulsion comprises the following steps: a. concentrating the extracting solution obtained in the step 1) to thick paste of 1.02-1.5 g/ml; b. taking 1-90 parts of thick paste, 1-30 parts of cocoamidopropyl betaine, 1-30 parts of ammonium lauryl ether sulfate, 1-30 parts of sodium lauryl amphoglycinate and C8-C160-20 parts of alkyl glycoside, 0-30 parts of coconut monoethanolamide, 0-30 parts of coconut diethanolamide, 0-20 parts of acrylic copolymer, 0-20 parts of polydimethylsiloxane emulsion, 0-20 parts of ethylene glycol distearate, 0-30 parts of polysiloxane linoleic acid phospholipid, 0-10 parts of benzyl alcohol, 0-10 parts of methyl paraben, 0-10 parts of ethylparaben, 0-10 parts of propyl paraben, 0-10 parts of Glydant plus, 160-10 parts of organosilicon quaternary ammonium salt, 910-10 parts of polyquaternary ammonium salt, 0-10 parts of hydroxyethyl cellulose ether quaternary ammonium salt, 0-10 parts of hydroxypropyl guar gum trimethyl ammonium oxide, 0-5 parts of pigment, 0-10 parts of essence, 0-20 parts of trimethyl glycine, 0-20 parts of D-panthenol, 0-20 parts of glycerol, 0-20 parts of propylene glycol, 0-20 parts of citric acid and 0-20 parts of tartaric acid, 0-20 parts of quaternized wheat protein and 5-90 parts of deionized water are uniformly mixed to prepare the emulsion.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114558068A (en) * | 2022-03-16 | 2022-05-31 | 薛辉 | Preparation technology of ointment for removing dandruff and treating stubborn tinea and pruritus |
Citations (3)
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|---|---|---|---|---|
| CN102552500A (en) * | 2011-12-16 | 2012-07-11 | 郭文喜 | Chinese medicinal composition for treating alopecia seborrheica |
| CN107744510A (en) * | 2017-10-25 | 2018-03-02 | 广东罗浮山国药股份有限公司 | A kind of preparation method of micro-pill type granule |
| CN109646334A (en) * | 2018-12-21 | 2019-04-19 | 佛山市南海施乐华化妆品有限公司 | The hair composition and preparation method thereof of anti-alopecia seborrheica |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552500A (en) * | 2011-12-16 | 2012-07-11 | 郭文喜 | Chinese medicinal composition for treating alopecia seborrheica |
| CN107744510A (en) * | 2017-10-25 | 2018-03-02 | 广东罗浮山国药股份有限公司 | A kind of preparation method of micro-pill type granule |
| CN109646334A (en) * | 2018-12-21 | 2019-04-19 | 佛山市南海施乐华化妆品有限公司 | The hair composition and preparation method thereof of anti-alopecia seborrheica |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114558068A (en) * | 2022-03-16 | 2022-05-31 | 薛辉 | Preparation technology of ointment for removing dandruff and treating stubborn tinea and pruritus |
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